Masato Homma

Summary

Affiliation: University of Tsukuba
Country: Japan

Publications

  1. ncbi request reprint Effects of hematocrit value on microparticle enzyme immunoassay of tacrolimus concentration in therapeutic drug monitoring
    Takashi Tomita
    Department of Pharmacy, Tsukuba University Hospital, Tsukuba, Ibaraki 305 8576, Japan
    Ther Drug Monit 27:94-7. 2005
  2. ncbi request reprint Liquid chromatographic determination of urinary 6beta-hydroxycortisol to assess cytochrome p-450 3A activity in HIV positive pregnant women
    M Homma
    Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
    J Pharm Biomed Anal 23:629-35. 2000
  3. ncbi request reprint False positive blood tacrolimus concentration in microparticle enzyme immunoassay
    Masato Homma
    Department of Pharmaceutical Sciences, University of Tsukuba, Ibaraki, Japan
    Biol Pharm Bull 25:1119-20. 2002
  4. ncbi request reprint Gender-associated differences in pharmacokinetics and anti-arrhythmic effects of flecainide in Japanese patients with supraventricular tachyarrhythmia
    Kosuke Doki
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ten nodai 1 1 1, Tsukuba, Ibaraki, 305 8575, Japan
    Eur J Clin Pharmacol 63:951-7. 2007
  5. doi request reprint Effects of mexiletine, a CYP1A2 inhibitor, on tizanidine pharmacokinetics and pharmacodynamics
    Kenji Momo
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    J Clin Pharmacol 50:331-7. 2010
  6. ncbi request reprint CYP2C19 genotype affects diazepam pharmacokinetics and emergence from general anesthesia
    Shinichi Inomata
    Departments of Anesthesiology, Legal Medicine, and Pharmaceutical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Clin Pharmacol Ther 78:647-55. 2005
  7. pmc Effects of CYP2D6 genotypes on age-related change of flecainide metabolism: involvement of CYP1A2-mediated metabolism
    Kosuke Doki
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Br J Clin Pharmacol 68:89-96. 2009
  8. ncbi request reprint Effect of lansoprazole and rabeprazole on tacrolimus pharmacokinetics in healthy volunteers with CYP2C19 mutations
    Fumio Itagaki
    Department of Pharmaceutical Sciences, Institute of Clinical Medicine, University of Tsukuba, Ten nodai, Ibaraki 305 8575, Japan
    J Pharm Pharmacol 56:1055-9. 2004
  9. pmc Liquid chromatography assay for routine monitoring of cellular ribavirin levels in blood
    Yoichi Inoue
    Department of Pharmaceutical Sciences, Institute of Clinical Medicine, University of Tsukuba, Ten nodai 1 1 1, Tsukuba, Ibaraki 305 8575, Japan
    Antimicrob Agents Chemother 48:3813-6. 2004
  10. doi request reprint CYP2D6 genotype affects age-related decline in flecainide clearance: a population pharmacokinetic analysis
    Kosuke Doki
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Pharmacogenet Genomics 22:777-83. 2012

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Effects of hematocrit value on microparticle enzyme immunoassay of tacrolimus concentration in therapeutic drug monitoring
    Takashi Tomita
    Department of Pharmacy, Tsukuba University Hospital, Tsukuba, Ibaraki 305 8576, Japan
    Ther Drug Monit 27:94-7. 2005
    ..3 versus 11.0 ng/mL). ELISA or cMEIA should be used for tacrolimus assay in samples obtained from bone marrow transplant recipients with anemia and from liver and kidney transplant recipients with unstable Ht values...
  2. ncbi request reprint Liquid chromatographic determination of urinary 6beta-hydroxycortisol to assess cytochrome p-450 3A activity in HIV positive pregnant women
    M Homma
    Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan
    J Pharm Biomed Anal 23:629-35. 2000
    ..9-5.6 and 4.9-8.1%, respectively. The method was applied to morning urine samples collected from HIV-positive pregnant women managed with protease inhibitor containing anti-retroviral regimens...
  3. ncbi request reprint False positive blood tacrolimus concentration in microparticle enzyme immunoassay
    Masato Homma
    Department of Pharmaceutical Sciences, University of Tsukuba, Ibaraki, Japan
    Biol Pharm Bull 25:1119-20. 2002
    ..Since MEIA potentially overestimates the tacrolimus levels, ELISA should be used for blood tacrolimus monitoring in the patients with anemia...
  4. ncbi request reprint Gender-associated differences in pharmacokinetics and anti-arrhythmic effects of flecainide in Japanese patients with supraventricular tachyarrhythmia
    Kosuke Doki
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ten nodai 1 1 1, Tsukuba, Ibaraki, 305 8575, Japan
    Eur J Clin Pharmacol 63:951-7. 2007
    ..We examined the effect of gender-associated differences in pharmacokinetics on the anti-arrhythmic effects of flecainide in Japanese patients with supraventricular tachyarrhythmia and in healthy subjects...
  5. doi request reprint Effects of mexiletine, a CYP1A2 inhibitor, on tizanidine pharmacokinetics and pharmacodynamics
    Kenji Momo
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    J Clin Pharmacol 50:331-7. 2010
    ..Present results suggested that coadministration of mexiletine increased blood tizanidine concentrations and enhanced tizanidine pharmacodynamics in terms of reduction in blood pressure and adverse symptoms...
  6. ncbi request reprint CYP2C19 genotype affects diazepam pharmacokinetics and emergence from general anesthesia
    Shinichi Inomata
    Departments of Anesthesiology, Legal Medicine, and Pharmaceutical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Clin Pharmacol Ther 78:647-55. 2005
    ..The objective of this study was to investigate the effects of polymorphism in CYP2C19 and the effects of CYP3A4 messenger ribonucleic acid (mRNA) content in blood on recovery from general anesthesia and on diazepam pharmacokinetics...
  7. pmc Effects of CYP2D6 genotypes on age-related change of flecainide metabolism: involvement of CYP1A2-mediated metabolism
    Kosuke Doki
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Br J Clin Pharmacol 68:89-96. 2009
    ..An in vitro study using microsomes was performed to identify other CYPs responsible for age-related change in flecainide metabolism...
  8. ncbi request reprint Effect of lansoprazole and rabeprazole on tacrolimus pharmacokinetics in healthy volunteers with CYP2C19 mutations
    Fumio Itagaki
    Department of Pharmaceutical Sciences, Institute of Clinical Medicine, University of Tsukuba, Ten nodai, Ibaraki 305 8575, Japan
    J Pharm Pharmacol 56:1055-9. 2004
    ..In contrast, rabeprazole has minimal effect on tacrolimus pharmacokinetics regardless of CYP2C19 genotype status...
  9. pmc Liquid chromatography assay for routine monitoring of cellular ribavirin levels in blood
    Yoichi Inoue
    Department of Pharmaceutical Sciences, Institute of Clinical Medicine, University of Tsukuba, Ten nodai 1 1 1, Tsukuba, Ibaraki 305 8575, Japan
    Antimicrob Agents Chemother 48:3813-6. 2004
    ..9 to 5.8% and 4.3 to 8.3%, respectively. We tested this method by monitoring blood ribavirin concentrations in two hepatitis C patients receiving alpha interferon 2b-plus-ribavirin combination therapy...
  10. doi request reprint CYP2D6 genotype affects age-related decline in flecainide clearance: a population pharmacokinetic analysis
    Kosuke Doki
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Pharmacogenet Genomics 22:777-83. 2012
    ..To investigate the association between age-related decline in flecainide clearance and CYP2D6 genotype, we conducted a population pharmacokinetic analysis of flecainide using routine therapeutic drug monitoring data...
  11. ncbi request reprint Effect of CYP2D6 genotype on flecainide pharmacokinetics in Japanese patients with supraventricular tachyarrhythmia
    Kosuke Doki
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ten nodai 1 1 1, Tsukuba, Ibaraki, 305 8575, Japan
    Eur J Clin Pharmacol 62:919-26. 2006
    ....
  12. ncbi request reprint Assessment of clonidine orally disintegrating tablet for pre-anesthetic medication in pediatric surgery
    Masato Homma
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Biol Pharm Bull 29:321-3. 2006
    ..We conclude that OD is superior preparation of CL for pre-operative sedation in pediatric surgery...
  13. ncbi request reprint Use of sample hematocrit value to correct blood tacrolimus concentration derived by microparticle enzyme immunoassay
    Takashi Tomita
    Department of Pharmacy, Tsukuba University Hospital, Tsukuba, Ibaraki, Japan
    Biol Pharm Bull 31:1250-3. 2008
    ..0 ng/ml, range 1.7-21.4 ng/ml). MEIAcalc can be used to correct the tacrolimus concentration in samples obtained from patients with unstable Ht values...
  14. ncbi request reprint Assessment of serum flecainide trough levels in patients with tachyarrhythmia
    Masato Homma
    Department of Pharmaceutical Sciences, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ten nodai 1 1 1, Tsukuba, Ibaraki 305 8575, Japan
    J Pharm Pharmacol 57:47-51. 2005
    ..110 +/- 0.016 s vs 0.093 +/- 0.019 s, P < 0.05). We concluded that to control paroxysm in patients receiving flecainide for tachyarrhythmia serum flecainide concentrations should be maintained at > or = 300 ng mL(-1)...
  15. ncbi request reprint Effect of rabeprazole on MDR1-mediated transport of Rhodamine 123 in Caco-2 and Hvr100-6 cells
    Fumio Itagaki
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ten nodai, Ibaraki, Japan
    Biol Pharm Bull 27:1694-6. 2004
    ....
  16. ncbi request reprint MDR1 gene polymorphism in Japanese patients with schizophrenia and mood disorders including depression
    Wen Qian
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Biol Pharm Bull 29:2446-50. 2006
    ..These findings suggested that predispose to mood disorders, not schizophrenia, was associated with possible alteration of P-gp activities corresponding MDR1 polymorphism at least partly...
  17. doi request reprint SCN5A promoter haplotype affects the therapeutic range for serum flecainide concentration in Asian patients
    Kosuke Doki
    Department of Pharmaceutical Sciences, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Pharmacogenet Genomics 23:349-54. 2013
    ..We investigated the effect of HapB on the therapeutic range for serum flecainide concentration in Asian patients...
  18. pmc Co-administration of proton pump inhibitors delays elimination of plasma methotrexate in high-dose methotrexate therapy
    Kunihiro Suzuki
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Br J Clin Pharmacol 67:44-9. 2009
    ..To assess whether or not co-administration of proton pump inhibitors (PPIs) is a risk factor for delayed elimination of plasma methotrexate (MTX) in high-dose MTX (HDMTX) therapy for malignant diseases...
  19. ncbi request reprint Effects of lansoprazole and rabeprazole on tacrolimus blood concentration: case of a renal transplant recipient with CYP2C19 gene mutation
    Masato Homma
    Department of Pharmaceutical Sciences, Institute of Clinical Medicine, University of Tsukuba, Ibaraki 305 8575, Japan
    Transplantation 73:303-4. 2002
  20. ncbi request reprint Morphological transformation and phosphatidylserine exposure in erythrocytes treated with ribavirin
    Masato Homma
    Department of Pharmacy, Tsukuba University Hospital, Amakubo, Tsukuba, Ibaraki 305 8576, Japan
    Biol Pharm Bull 32:1940-2. 2009
    ..62%). The results suggest that intracellular ribavirin induces morphological change and PS exposure in erythrocytes and accelerates erythrophagocytosis in the reticuloendothelial system...
  21. ncbi request reprint Impact of solute carrier family 29 member 1 (SLC29A1) single nucleotide polymorphisms on mRNA expression in peripheral blood mononuclear cells
    Yoshiharu Suzuki
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Biol Pharm Bull 36:144-6. 2013
    ..05). Similar results were observed for rs747199, because rs747199 was linked with rs6932345 at a frequency of 84.8%. It was confirmed that wild-type for rs6932345 and rs747199 showed higher SLC29A1 mRNA expression in PBMCs...
  22. ncbi request reprint Liquid chromatographic determination of plasma ropivacaine for assessing pharmacokinetics of the viscous preparation
    Takeshi Kawata
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Ten nodai, Ibaraki 305 0295, Japan
    Biol Pharm Bull 28:2271-3. 2005
    ..Our preliminary pharmacokinetic data showed that ropivacaine viscous could be used safely based on the plasma ropivacaine concentrations (C(max): 89-125 ng/ml) for pain relief in oral mucosa...
  23. doi request reprint A simple chromatographic method for determining norfloxacin and enoxacin in pharmacokinetic study assessing CYP1A2 inhibition
    Toshimi Kobayashi
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Ten nodai, Tsukuba, Ibaraki, Japan
    Biomed Chromatogr 25:435-8. 2011
    ..2 and <5.5%, respectively. This method can be applied to the pharmacokinetic study of norfloxacin and enoxacin after repeated administration to assess changes in CYP1A2 activity in healthy subjects...
  24. ncbi request reprint [Clinical survey of tizanidine-induced adverse effects--impact of concomitant drugs providing cytochrome P450 1A2 modification--]
    Kenji Momo
    Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Yakugaku Zasshi 133:275-81. 2013
    ..The present results suggest that coadministration of tizanidine and CYP1A2 inhibitors enhances tizanidine-induced adverse effects, especially in elderly patients treated with a higher dose of tizanidine...
  25. ncbi request reprint Simultaneous determination of serum flecainide and its metabolites by using high performance liquid chromatography
    Kosuke Doki
    Department of Pharmaceutical Sciences, Institute of Clinical Medicine, University of Tsukuba, Ten nodai 1 1 1, Tsukuba, Ibaraki 305 8575, Japan
    J Pharm Biomed Anal 35:1307-12. 2004
    ..The CVs for inter-day assay were 7.0-8.4% for flecainide, 3.3-6.7% for MODF, and 4.4-7.7% for MODLF, respectively. This assay method can be used for assessing the metabolic ability of flecainide in the patients with tachyarrhythmia...
  26. ncbi request reprint Marked elevation of erythrocyte ribavirin levels in interferon and ribavirin-induced anemia
    Masato Homma
    Department of Pharmaceutical Sciences, University of Tsukuba, Ibaraki, Japan
    Clin Gastroenterol Hepatol 2:337-9. 2004
    ....
  27. ncbi request reprint Sedation and plasma concentration of clonidine hydrochloride for pre-anesthetic medication in pediatric surgery
    Kenji Sumiya
    Department of Pharmacy, Tsukuba University Hospital, Ibaraki, Japan
    Biol Pharm Bull 26:421-3. 2003
    ..Plasma clonidine concentration of 0.3-0.8 ng/ml would be sufficient to produce satisfactory sedation without changes in hemodynamic parameters in pediatric surgery...
  28. ncbi request reprint [Effects of long term administration of Shakuyaku-kanzo-To and Shosaiko-To on serum potassium levels]
    Masato Homma
    Department of Pharmaceutical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, and Department of Pharmacy, Tsukuba University Hospital, Ibaraki, Japan
    Yakugaku Zasshi 126:973-8. 2006
    ..It was suggested that patient age (>60 y) and dosing period of SKT (>30 days) might be risk factors for developing pseudoaldosteronism or hypokalemia as well as coadministration of drugs inducing hypokalemia...
  29. ncbi request reprint High performance liquid chromatography for routine monitoring of serum flecainide
    Rei Nakagawa
    Faculty of Pharmaceutical Sciences, Josai University, Keyakidai 1 1, Sakado, Saitama 350 0295, Japan
    J Pharm Biomed Anal 30:171-4. 2002
    ..The coefficient of variations (CVs) for intra- and inter-day assay were 1.3-4.8 and 3.2-6.9%, respectively. The method could be applied to routine monitoring of serum flecainide in the patients with tachyarrhythmia...
  30. ncbi request reprint [Combination use of kampo-medicines and drugs affecting intestinal bacterial flora]
    Miya Ishihara
    Department of Pharmacy, Tsukuba University Hospital, 2 1 1, Amakubo, Tsukuba, Ibaraki 305 8576, Japan
    Yakugaku Zasshi 122:695-701. 2002
    ..The present results suggested that the drug interactions of kampo-medicines with antibiotics and bacterial preparations should be confirmed in clinical studies...
  31. ncbi request reprint Drug interaction of tizanidine and fluvoxamine
    Kenji Momo
    Clin Pharmacol Ther 76:509-10. 2004
  32. pmc Impact of CYP3A5 genetic polymorphism on pharmacokinetics of tacrolimus in healthy Japanese subjects
    Yoshiharu Suzuki
    Br J Clin Pharmacol 66:154-5. 2008
  33. doi request reprint Tizanidine-induced hypotension in patients with liver cirrhosis
    Kenji Momo
    Eur J Clin Pharmacol 64:647-8. 2008
  34. ncbi request reprint Drug interaction of tizanidine and ciprofloxacin: case report
    Kenji Momo
    Clin Pharmacol Ther 80:717-9. 2006
  35. ncbi request reprint Liquid chromatographic determination of unbound flecainide in therapeutic drug monitoring
    Kumi Katori
    Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
    J Pharm Biomed Anal 32:375-80. 2003
    ..The percentage unbound tended to increase in the samples with lower alpha(1)-acid glycoprotein (<60 mg/dl). The assay method can be applied to routine determination of unbound flecainide in therapeutic drug monitoring...
  36. ncbi request reprint [Case of intractable ventricula fibrillation by a multicomponent dietary supplement containing ephedra and caffeine overdose]
    Satoru Takeuchi
    Department of Emergency Medicine, National Hospital Organization Disaster Medical Center
    Chudoku Kenkyu 20:269-71. 2007
    ..The direct cardiotoxity of ephedra, synergistic effect of caffeine and ephedra, and hypokalemia may cause refractory ventricular arrhythmia...