H Hohjoh

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Case-control study with narcoleptic patients and healthy controls who, like the patients, possess both HLA-DRB1*1501 and -DQB1*0602
    H Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Tissue Antigens 57:230-5. 2001
  2. ncbi request reprint Possible association of human leucocyte antigen DR1 with delayed sleep phase syndrome
    H Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan
    Psychiatry Clin Neurosci 53:527-9. 1999
  3. ncbi request reprint RNA interference (RNA(i)) induction with various types of synthetic oligonucleotide duplexes in cultured human cells
    Hirohiko Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan
    FEBS Lett 521:195-9. 2002
  4. ncbi request reprint Significant association of the tumor necrosis factor receptor 2 (TNFR2) gene with human narcolepsy
    H Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan
    Tissue Antigens 56:446-8. 2000
  5. ncbi request reprint Allele-specific binding of the ubiquitous transcription factor OCT-1 to the functional single nucleotide polymorphism (SNP) sites in the tumor necrosis factor-alpha gene (TNFA) promoter
    H Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan
    Genes Immun 2:105-9. 2001
  6. ncbi request reprint Significant association of a single nucleotide polymorphism in the tumor necrosis factor-alpha (TNF-alpha) gene promoter with human narcolepsy
    H Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan
    Tissue Antigens 54:138-45. 1999
  7. ncbi request reprint Haplotype analyses with the human leucocyte antigen and tumour necrosis factor-alpha genes in narcolepsy families
    H Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan
    Psychiatry Clin Neurosci 55:37-9. 2001
  8. ncbi request reprint Profiling of genes expressed in human monocytes and monocyte-derived dendritic cells using cDNA expression array
    N Lapteva
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Br J Haematol 114:191-7. 2001
  9. ncbi request reprint Haplotype-specific sequence encoding the protein kinase, interferon-inducible double-stranded RNA-dependent activator in the human leukocyte antigen class II region
    S Chida
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan
    Immunogenetics 52:186-94. 2001
  10. ncbi request reprint Support for an association between HLA-DR1 and schizophrenia in the Japanese population
    R Akaho
    Section of Mental Health, Health Service Center, University of Tokyo, Tokyo, Japan
    Am J Med Genet 96:725-7. 2000

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Case-control study with narcoleptic patients and healthy controls who, like the patients, possess both HLA-DRB1*1501 and -DQB1*0602
    H Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Tissue Antigens 57:230-5. 2001
    ..In addition, a significant association of the TNF-alpha(-857T) homozygote with the disorder and an increase in a rare haplotype carrying DRB1*1501 and TNF-alpha(-857T) in the patients were also observed in the present study...
  2. ncbi request reprint Possible association of human leucocyte antigen DR1 with delayed sleep phase syndrome
    H Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan
    Psychiatry Clin Neurosci 53:527-9. 1999
    ..069) for multiple comparisons almost reached the significance level, the results indicated a possible association of the HLA-DR1 antigen with DSPS. This study suggests that there are genetic predispositions to DSPS...
  3. ncbi request reprint RNA interference (RNA(i)) induction with various types of synthetic oligonucleotide duplexes in cultured human cells
    Hirohiko Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan
    FEBS Lett 521:195-9. 2002
    ..e. short interfering RNAs (siRNAs), between human RNAi and invertebrate RNAi. The data further show that different siRNAs induce different levels of RNAi...
  4. ncbi request reprint Significant association of the tumor necrosis factor receptor 2 (TNFR2) gene with human narcolepsy
    H Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan
    Tissue Antigens 56:446-8. 2000
    ....
  5. ncbi request reprint Allele-specific binding of the ubiquitous transcription factor OCT-1 to the functional single nucleotide polymorphism (SNP) sites in the tumor necrosis factor-alpha gene (TNFA) promoter
    H Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan
    Genes Immun 2:105-9. 2001
    ..The evidence presented here, therefore, suggests the possibility that OCT-1 could contribute to the modulation of TNFA expression by means of its allele-specific binding manner...
  6. ncbi request reprint Significant association of a single nucleotide polymorphism in the tumor necrosis factor-alpha (TNF-alpha) gene promoter with human narcolepsy
    H Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan
    Tissue Antigens 54:138-45. 1999
    ..Altogether, the data presented here lead us to propose that TNF-alpha could be a new susceptibility gene in human narcolepsy...
  7. ncbi request reprint Haplotype analyses with the human leucocyte antigen and tumour necrosis factor-alpha genes in narcolepsy families
    H Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan
    Psychiatry Clin Neurosci 55:37-9. 2001
    ..From the chromosomal recombination observed in a few members, it is possible that chromosomal recombination could play a role in the generation of the rare DRB1*1501-TNF-alpha(-857T) haplotype...
  8. ncbi request reprint Profiling of genes expressed in human monocytes and monocyte-derived dendritic cells using cDNA expression array
    N Lapteva
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Br J Haematol 114:191-7. 2001
    ..Moreover, our data show the presence of a 'switch-on' step for the TNF-alpha and TNFRII gene expression in immature DCs for further differentiation into mature DCs...
  9. ncbi request reprint Haplotype-specific sequence encoding the protein kinase, interferon-inducible double-stranded RNA-dependent activator in the human leukocyte antigen class II region
    S Chida
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan
    Immunogenetics 52:186-94. 2001
    ..2-q32.1...
  10. ncbi request reprint Support for an association between HLA-DR1 and schizophrenia in the Japanese population
    R Akaho
    Section of Mental Health, Health Service Center, University of Tokyo, Tokyo, Japan
    Am J Med Genet 96:725-7. 2000
    ..7%) vs. 93 of 942 comparison subjects (9.9%). However, no difference was observed in DR4 frequencies between the patients (51%) and comparison subjects (44%). Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:725-727, 2000...
  11. ncbi request reprint Epigenetic aberration of the human REELIN gene in psychiatric disorders
    Y Tamura
    National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    Mol Psychiatry 12:519, 593-600. 2007
    ..These data suggest the possibility that epigenetic aberration from the normal DNA methylation status of RELN may confer susceptibility to psychiatric disorders...
  12. ncbi request reprint Estimation of the species-specific mutation rates at the DRB1 locus in humans and chimpanzee
    J Ohashi
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Tissue Antigens 68:427-31. 2006
    ..Our results strongly suggest that the mutation rate at DRB1 locus differs among species...
  13. doi request reprint Disease-causing allele-specific silencing against the ALK2 mutants, R206H and G356D, in fibrodysplasia ossificans progressiva
    M Takahashi
    Department of Molecular Pharmacology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    Gene Ther 19:781-5. 2012
    ..Thus, the siRNAs presented here may become novel therapeutic agents for FOP, and their induced ASP-RNAi may pave the way for the achievement of radical treatment of FOP and/or for the relief of its severe symptoms...
  14. doi request reprint Variation of gene silencing involving endogenous microRNA in mammalian cells
    Yoshiko Tamura
    National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    Mol Biol Rep 36:1413-20. 2009
    ..The data presented here suggest that not only microRNA level but also target transcript level likely participate in the generation of a variety of gene silencing...
  15. pmc Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi
    Yusuke Ohnishi
    Department of Molecular Genetics, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    PLoS ONE 3:e2248. 2008
    ....
  16. ncbi request reprint Long-lasting RNAi activity in mammalian neurons
    Kazuya Omi
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    FEBS Lett 558:89-95. 2004
    ....
  17. pmc Small RNA class transition from siRNA/piRNA to miRNA during pre-implantation mouse development
    Yusuke Ohnishi
    Department of Molecular Genetics, National Institute of Neuroscience, NCNP, Tokyo, Japan
    Nucleic Acids Res 38:5141-51. 2010
    ..Taken together, our current study reveals a major reprogramming of functional small RNAs during early mouse development from oocyte to blastocyst...
  18. doi request reprint Allele-specific silencing by RNA interference
    Hirohiko Hohjoh
    National Institute of Neuroscience, NCNP, Tokyo, Japan
    Methods Mol Biol 623:67-79. 2010
    ....
  19. ncbi request reprint Recent divergence of the HLA-DRB1*04 allelic lineage from the DRB1*0701 lineage after the separation of the human and chimpanzee species
    Hirohiko Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Immunogenetics 54:856-61. 2003
    ....
  20. ncbi request reprint Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome
    Hirohiko Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Neurogenetics 4:151-3. 2003
    ..The frequency of the 129 threonine allele is significantly higher in the patients than in the controls ( P=0.0029). The data suggest that AA-NAT could be a susceptibility gene for DSPS...
  21. ncbi request reprint Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population
    Yoshiko Tamura
    National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Lett 379:149-51. 2005
    ..Therefore, the data presented here suggests that the CXCL1 gene could not be associated with the susceptibility to AD in a Japanese population...
  22. ncbi request reprint Influence of assembly of siRNA elements into RNA-induced silencing complex by fork-siRNA duplex carrying nucleotide mismatches at the 3'- or 5'-end of the sense-stranded siRNA element
    Yusuke Ohnishi
    National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 329:516-21. 2005
    ..In addition, we further suggest the possibility that there could be a positional effect of siRNA duplex on RNAi activity...
  23. ncbi request reprint RNAi induction and activation in mammalian muscle cells where Dicer and eIF2C translation initiation factors are barely expressed
    Noriko Sago
    National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 319:50-7. 2004
    ..Altogether, the data presented here suggest that muscle cells retain the ability to induce RNAi, although Dicer and eIF2C1 approximately 4 appear to be barely expressed in them...
  24. ncbi request reprint Enhancement of RNAi activity by improved siRNA duplexes
    Hirohiko Hohjoh
    National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    FEBS Lett 557:193-8. 2004
    ....
  25. ncbi request reprint Gene silencing analyses against amyloid precursor protein (APP) gene family by RNA interference
    Tokiko Sakai
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Cell Biol Int 30:952-6. 2006
    ..The results demonstrated that cell viability and neurite outgrowth of N2a cells undergoing knockdown of Aplp1 were significantly reduced, compared with N2a cells undergoing knockdown of either App or Aplp2...
  26. pmc Genomewide association analysis of human narcolepsy and a new resistance gene
    Minae Kawashima
    Department of Sleep Disorder Research Alfresa, Graduate School of Medicine, University of Tokyo, Japan
    Am J Hum Genet 79:252-63. 2006
    ..Therefore, NLC1-A is considered to be a new resistance gene for human narcolepsy...
  27. pmc Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines
    Yoshimitsu Doi
    Departments of Immunology and Molecular Genetics, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Proc Natl Acad Sci U S A 105:8381-6. 2008
    ..Thus, NR4A2 is an essential transcription factor for triggering the inflammatory cascade of MS/EAE and may serve as a therapeutic target...