Seiji Hitoshi

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint [Understanding the pathogenesis of mood affective disorders through the study of neural stem cell biology]
    Seiji Hitoshi
    Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki 444 8787, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 28:189-94. 2008
  2. pmc Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells
    Seiji Hitoshi
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Genes Dev 16:846-58. 2002
  3. doi request reprint Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells
    Seiji Hitoshi
    Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki, Japan
    Nat Neurosci 14:957-64. 2011
  4. ncbi request reprint Notch signaling is required to maintain all neural stem cell populations--irrespective of spatial or temporal niche
    Tania O Alexson
    Neurobiology Research Group, Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Dev Neurosci 28:34-48. 2006
  5. ncbi request reprint Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival
    Tamaki Wada
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 3E1
    J Neurosci 26:6803-12. 2006
  6. ncbi request reprint Developmental changes in the expression of glycogenes and the content of N-glycans in the mouse cerebral cortex
    Akihiro Ishii
    Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki, Aichi, Japan
    Glycobiology 17:261-76. 2007
  7. ncbi request reprint Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress
    Seiji Hitoshi
    Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, 5 1 Higashiyama, Myodaiji, Okazaki, Japan
    J Neurosci Res 85:3574-85. 2007
  8. ncbi request reprint Bre1a, a histone H2B ubiquitin ligase, regulates the cell cycle and differentiation of neural precursor cells
    Yugo Ishino
    Division of Neurobiology and Bioinformatics, and Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki 444 8787, Japan, Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies, Okazaki 444 8787, Japan, Department of Integrative Physiology, Shiga University of Medical Science, Otsu 520 2192, Japan, Institute of Molecular and Cellular Biosciences, and Department of Neurobiology, The University of Tokyo, Tokyo 113 0032, Japan, Division of Embryology, National Institute for Basic Biology, Okazaki 444 8787, Japan, and Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    J Neurosci 34:3067-78. 2014
  9. doi request reprint Olig2-lineage cells preferentially differentiate into oligodendrocytes but their processes degenerate at the chronic demyelinating stage of proteolipid protein-overexpressing mouse
    Takahiro Shimizu
    Department of Physiological Sciences, School of Life Sciences, Graduate University for Advanced Studies, Kanagawa, Japan
    J Neurosci Res 91:178-86. 2013
  10. ncbi request reprint Adhesion is prerequisite, but alone insufficient, to elicit stem cell pluripotency
    Phillip Karpowicz
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 27:5437-47. 2007

Collaborators

Detail Information

Publications19

  1. ncbi request reprint [Understanding the pathogenesis of mood affective disorders through the study of neural stem cell biology]
    Seiji Hitoshi
    Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki 444 8787, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 28:189-94. 2008
    ..These data provide insights into the molecular mechanisms underlying the pathogenesis of mood affective disorders...
  2. pmc Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells
    Seiji Hitoshi
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Genes Dev 16:846-58. 2002
    ..These data are consistent with a role for Notch signaling in the maintenance of the neural stem cell, and inconsistent with a role in a neuronal/glial fate switch...
  3. doi request reprint Mammalian Gcm genes induce Hes5 expression by active DNA demethylation and induce neural stem cells
    Seiji Hitoshi
    Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Okazaki, Japan
    Nat Neurosci 14:957-64. 2011
    ..5-8.5 Gcm1(-/-); Gcm2(-/-) mice resulted in the impaired induction of neural stem cells. Our data suggest that Hes5 expression is serially activated first by Gcms and later by the canonical Notch pathway...
  4. ncbi request reprint Notch signaling is required to maintain all neural stem cell populations--irrespective of spatial or temporal niche
    Tania O Alexson
    Neurobiology Research Group, Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Dev Neurosci 28:34-48. 2006
    ..Regardless, these findings demonstrate that PS1, and presumably Notch signaling, is required to maintain all NSCs...
  5. ncbi request reprint Vascular endothelial growth factor directly inhibits primitive neural stem cell survival but promotes definitive neural stem cell survival
    Tamaki Wada
    Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario, Canada M5S 3E1
    J Neurosci 26:6803-12. 2006
    ..In conclusion, VEGF-A function through Flk1 mediates survival (and not proliferative or fate change) effects on NSCs, specifically...
  6. ncbi request reprint Developmental changes in the expression of glycogenes and the content of N-glycans in the mouse cerebral cortex
    Akihiro Ishii
    Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki, Aichi, Japan
    Glycobiology 17:261-76. 2007
    ..These findings add to our understanding of the molecular mechanisms responsible for the regulation of N-glycan biosynthesis in the cerebral cortex...
  7. ncbi request reprint Antidepressant drugs reverse the loss of adult neural stem cells following chronic stress
    Seiji Hitoshi
    Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, 5 1 Higashiyama, Myodaiji, Okazaki, Japan
    J Neurosci Res 85:3574-85. 2007
    ..These data provide insights into the molecular mechanisms underlying the pharmacological actions of antidepressant drugs...
  8. ncbi request reprint Bre1a, a histone H2B ubiquitin ligase, regulates the cell cycle and differentiation of neural precursor cells
    Yugo Ishino
    Division of Neurobiology and Bioinformatics, and Center for Genetic Analysis of Behavior, National Institute for Physiological Sciences, Okazaki 444 8787, Japan, Department of Physiological Sciences, School of Life Sciences, The Graduate University for Advanced Studies, Okazaki 444 8787, Japan, Department of Integrative Physiology, Shiga University of Medical Science, Otsu 520 2192, Japan, Institute of Molecular and Cellular Biosciences, and Department of Neurobiology, The University of Tokyo, Tokyo 113 0032, Japan, Division of Embryology, National Institute for Basic Biology, Okazaki 444 8787, Japan, and Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    J Neurosci 34:3067-78. 2014
    ....
  9. doi request reprint Olig2-lineage cells preferentially differentiate into oligodendrocytes but their processes degenerate at the chronic demyelinating stage of proteolipid protein-overexpressing mouse
    Takahiro Shimizu
    Department of Physiological Sciences, School of Life Sciences, Graduate University for Advanced Studies, Kanagawa, Japan
    J Neurosci Res 91:178-86. 2013
    ..These results indicate that in chronic demyelinated lesions more OL-lineage cells are produced as part of the repair process, but their processes degenerate after maturation...
  10. ncbi request reprint Adhesion is prerequisite, but alone insufficient, to elicit stem cell pluripotency
    Phillip Karpowicz
    Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 27:5437-47. 2007
    ..These adhesive differences suggest an evolving compartmentalization in multipotent NSCs during development and serve to illustrate the importance of cell-cell association for revealing cellular contribution...
  11. ncbi request reprint Binding of immunoglobulin G antibodies in Guillain-Barré syndrome sera to a mixture of GM1 and a phospholipid: possible clinical implications
    Susumu Kusunoki
    Department of Neurology, School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Muscle Nerve 27:302-6. 2003
    ..IgG antibody with greater binding activity against a mixture of GM1 and a phospholipid than against GM1 alone may have an important role in the pathogenesis of GBS and has implications for diagnosis...
  12. ncbi request reprint Regulation of glial development by cystatin C
    Akiko Hasegawa
    Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies Sokendai, National Institute for Physiological Sciences, National Institutes of Natural Sciences, Aichi, Japan
    J Neurochem 100:12-22. 2007
    ..The antibody increased the number of oligodendrocytes and their precursors. Therefore, CysC modifies glial development in addition to its activity against neural stem/precursor cells...
  13. ncbi request reprint Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain
    Seiji Hitoshi
    Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Development 129:233-44. 2002
    ..Thus, neural stem cells and their progeny are regionally specified in the developing brain, but this regional identity can be altered by local inductive cues...
  14. ncbi request reprint An N-glycan structure correlates with pulmonary metastatic ability of cancer cells
    Keiichiro Sakuma
    Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, Japan
    Biochem Biophys Res Commun 340:829-35. 2006
    ..Using a B16 melanoma cell metastasis model, we showed that A2G2F-rich B16 cells formed more pulmonary metastatic nodules than A2G2F-poor cells. Our results suggest that A2G2F plays a critical role in pulmonary metastasis...
  15. ncbi request reprint Induction of oligodendrocyte progenitors in dorsal forebrain by intraventricular microinjection of FGF-2
    Masae Naruse
    Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies, Hayama, Miura, Kanagawa 240 0193, Japan
    Dev Biol 297:262-73. 2006
    ..These results demonstrate that the dorsal embryonic forebrain in vivo has the potential to generate OLPs in the presence of normal positional cues and that this can be driven by FGF-2 independent of Shh signaling...
  16. pmc Primitive neural stem cells from the mammalian epiblast differentiate to definitive neural stem cells under the control of Notch signaling
    Seiji Hitoshi
    Department of Neurology, University of Tokyo, Tokyo 113 8655, Japan
    Genes Dev 18:1806-11. 2004
    ....
  17. ncbi request reprint [The generation of neural stem cells: induction of neural stem cells from embryonic stem (ES) cells]
    Seiji Hitoshi
    Department of Neurology, Graduate School of Medicine, University of Tokyo
    Rinsho Shinkeigaku 43:827-9. 2003
    ..We propose that the neural stem cell originates from the pluripotent inner cell mass/epiblast cell via the primitive neural stem cell stage under the control of Notch signaling...
  18. ncbi request reprint Heparan sulfate regulates self-renewal and pluripotency of embryonic stem cells
    Norihiko Sasaki
    Laboratory of Cell Biology, Department of Bioinformatics, Faculty of Engineering, Soka University, 1 236 Tangi cho, Hachioji, Tokyo 192 8577, Japan
    J Biol Chem 283:3594-606. 2008
    ..We propose that HS chains are important for the extrinsic signaling required for mouse ES cell self-renewal and pluripotency...
  19. doi request reprint Mood stabilizing drugs expand the neural stem cell pool in the adult brain through activation of notch signaling
    Mikito Higashi
    Department of Physiological Sciences, School of Life Sciences, Graduate University for Advanced Studies, Kanagawa, Japan
    Stem Cells 26:1758-67. 2008
    ..We suggest that treatment with mood stabilizing drugs could be used to facilitate regeneration following insult to the central nervous system...