Y Hirata

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi request reprint Sitafloxacin resistance in Helicobacter pylori isolates and sitafloxacin-based triple therapy as a third-line regimen in Japan
    Yoshihiro Hirata
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Antimicrob Agents 39:352-5. 2012
  2. ncbi request reprint Helicobacter pylori CagA protein activates serum response element-driven transcription independently of tyrosine phosphorylation
    Yoshihiro Hirata
    Department of Gastroenterology, University of Tokyo, Japan
    Gastroenterology 123:1962-71. 2002
  3. pmc Helicobacter pylori activates the cyclin D1 gene through mitogen-activated protein kinase pathway in gastric cancer cells
    Y Hirata
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Infect Immun 69:3965-71. 2001
  4. ncbi request reprint Functional variability of cagA gene in Japanese isolates of Helicobacter pylori
    Yoshihiro Hirata
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gene 343:165-72. 2004
  5. ncbi request reprint Effects of vasodilatory beta-adrenoceptor antagonists on endothelium-derived nitric oxide release in rat kidney
    M Kakoki
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Hypertension 33:467-71. 1999
  6. pmc Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mol Pathol 55:286-93. 2002
  7. ncbi request reprint H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells
    S Maeda
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gastroenterology 119:97-108. 2000
  8. pmc Helicobacter pylori induced transactivation of SRE and AP-1 through the ERK signalling pathway in gastric cancer cells
    Y Mitsuno
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gut 49:18-22. 2001
  9. ncbi request reprint cDNA microarray analysis of Helicobacter pylori-mediated alteration of gene expression in gastric cancer cells
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo, Bunkyo ku, 113 8655, Japan
    Biochem Biophys Res Commun 284:443-9. 2001
  10. ncbi request reprint Distinct mechanism of Helicobacter pylori-mediated NF-kappa B activation between gastric cancer cells and monocytic cells
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 276:44856-64. 2001

Collaborators

Detail Information

Publications61

  1. doi request reprint Sitafloxacin resistance in Helicobacter pylori isolates and sitafloxacin-based triple therapy as a third-line regimen in Japan
    Yoshihiro Hirata
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Antimicrob Agents 39:352-5. 2012
    ..These results suggest that STX could be active against most clinical H. pylori isolates and that STX-based triple therapy is a promising and safe third-line therapy...
  2. ncbi request reprint Helicobacter pylori CagA protein activates serum response element-driven transcription independently of tyrosine phosphorylation
    Yoshihiro Hirata
    Department of Gastroenterology, University of Tokyo, Japan
    Gastroenterology 123:1962-71. 2002
    ..Here we identify a new role for CagA protein as an activator of host cell signaling...
  3. pmc Helicobacter pylori activates the cyclin D1 gene through mitogen-activated protein kinase pathway in gastric cancer cells
    Y Hirata
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Infect Immun 69:3965-71. 2001
    ..pylori activates cyclin D1 through the mitogen-activated protein kinase pathway and not through NF-kappaB activation in AGS cells. This activation of cyclin D1 is partly dependent on the cag pathogenicity island but not on vacA...
  4. ncbi request reprint Functional variability of cagA gene in Japanese isolates of Helicobacter pylori
    Yoshihiro Hirata
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gene 343:165-72. 2004
    ..pylori induces distinct diseases on host...
  5. ncbi request reprint Effects of vasodilatory beta-adrenoceptor antagonists on endothelium-derived nitric oxide release in rat kidney
    M Kakoki
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Hypertension 33:467-71. 1999
    ..These results suggest that several beta-blockers exert their vasodilatory action through the 5-HT1A receptor/NO pathway and that treatment with these beta-blockers may protect against endothelial injury in hypertension...
  6. pmc Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mol Pathol 55:286-93. 2002
    ..Although it is reported that Helicobacter pylori induces apoptosis on gastric epithelial cells, the mechanism remains unknown. Antiapoptotic effects generated by H pylori have not yet been evaluated...
  7. ncbi request reprint H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cells
    S Maeda
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gastroenterology 119:97-108. 2000
    ..The aim of this study was to analyze the molecular mechanism responsible for H. pylori-mediated NF-kappaB activation on gastric cancer cells...
  8. pmc Helicobacter pylori induced transactivation of SRE and AP-1 through the ERK signalling pathway in gastric cancer cells
    Y Mitsuno
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gut 49:18-22. 2001
    ..c-Fos is important for transactivation of AP-1 which has SRE in the promoter region. We conducted this study to confirm H pylori induced transactivation of these binding sites...
  9. ncbi request reprint cDNA microarray analysis of Helicobacter pylori-mediated alteration of gene expression in gastric cancer cells
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo, Bunkyo ku, 113 8655, Japan
    Biochem Biophys Res Commun 284:443-9. 2001
    ..Taken together, these results indicate the importance of microarray technology as a tool for analyzing the complex interplay between H. pylori and the host...
  10. ncbi request reprint Distinct mechanism of Helicobacter pylori-mediated NF-kappa B activation between gastric cancer cells and monocytic cells
    S Maeda
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 276:44856-64. 2001
    ..pylori-induced NF-kappaB activation in epithelial cells is dependent on cag PAI and contact but does not involve CD14 and IRAK, whereas in macrophage/monocytic cells it is independent of cag PAI or contact but involves CD14 and TLR4...
  11. ncbi request reprint Receptor subtype for vasopressin-induced release of nitric oxide from rat kidney
    Y Hirata
    Second Department of Internal Medicine, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
    Hypertension 29:58-64. 1997
    ..These results directly demonstrate that vasopressin stimulates NO release via the endothelial V1 receptor in the rat kidney...
  12. ncbi request reprint Transcriptional activation of the cyclin D1 gene is mediated by multiple cis-elements, including SP1 sites and a cAMP-responsive element in vascular endothelial cells
    D Nagata
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    J Biol Chem 276:662-9. 2001
    ..The results suggested that the activation of the cyclin D1 gene in vascular ECs was regulated by a dual system; one was inducible in the G(1) phase, and the other was constitutively active...
  13. ncbi request reprint Molecular mechanisms of endothelin-1-induced cell-cycle progression: involvement of extracellular signal-regulated kinase, protein kinase C, and phosphatidylinositol 3-kinase at distinct points
    E Suzuki
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Circ Res 84:611-9. 1999
    ....
  14. ncbi request reprint CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil model
    W Shibata
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Pathol 210:306-14. 2006
    ..It is concluded that CagA protein may be essential for the induction of severe gastritis in the Mongolian gerbil model...
  15. ncbi request reprint Adrenomedullin induces endothelium-dependent vasorelaxation via the phosphatidylinositol 3-kinase/Akt-dependent pathway in rat aorta
    H Nishimatsu
    Department of Urology, Faculty of Medicine, University of Tokyo, Japan
    Circ Res 89:63-70. 2001
    ....
  16. ncbi request reprint Reentry into the cell cycle of contact-inhibited vascular endothelial cells by a phosphatase inhibitor. Possible involvement of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase
    E Suzuki
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Biol Chem 275:3637-44. 2000
    ....
  17. ncbi request reprint A mouse model of vascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasia
    M Sata
    Department of Cardiovascular Medicine, University of Tokyo, Tokyo, 113 8655, Japan
    J Mol Cell Cardiol 32:2097-104. 2000
    ..Similar exuberant hyperplasia could be induced in all strains examined (C57BL/6J, C3H/HeJ, BALB/c, and 129/SVj). This model may be widely used to study the molecular mechanism of post-angioplasty restenosis at the genetic level...
  18. ncbi request reprint Effects of vasodilatory antihypertensive agents on endothelial dysfunction in rats with ischemic acute renal failure
    M Kakoki
    Department of Internal Medicine, University of Tokyo, Japan
    Hypertens Res 23:527-33. 2000
    ..Calcium channel blockers, converting-enzyme inhibitors, and endothelial NO synthase-activating beta-blockers had beneficial effects on renovascular endothelial dysfunction due to ischemia...
  19. pmc Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pylori
    S Maeda
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gut 50:771-8. 2002
    ..Although it is reported that Helicobacter pylori induces apoptosis on gastric epithelial cells, the mechanism remains unknown. Antiapoptotic effects generated by H pylori have not yet been evaluated...
  20. ncbi request reprint Endothelial nitric oxide synthase is essential for the HMG-CoA reductase inhibitor cerivastatin to promote collateral growth in response to ischemia
    M Sata
    Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo 113 8655, Japan
    FASEB J 15:2530-2. 2001
    ..The angiogenic effect of cerivastatin was abrogated in eNOS deficient (eNOS-/-) mice. These results indicate that eNOS is essential for cerivastatin to promote collateral growth in response to ischemia...
  21. ncbi request reprint Effect of inhaled nitric oxide on gas exchange in patients with congestive heart failure. A randomized, controlled trial
    A Matsumoto
    University of Tokyo, Japan
    Ann Intern Med 130:40-4. 1999
    ..However, the effects of nitric oxide inhalation on ventilatory and gas exchange values in patients with congestive heart failure are not known...
  22. ncbi request reprint The by-products generated during sarin synthesis in the Tokyo sarin disaster induced inhibition of natural killer and cytotoxic T lymphocyte activity
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
    Toxicology 146:209-20. 2000
    ..The effect of DIMP and DEMP on the splenic NK activity of mice was stronger than on the splenic CTL activity, and the human lymphocytes is more sensitive to DIMP and DEMP than the splenocytes of mice...
  23. ncbi request reprint Negative inotropic effect of adrenomedullin in isolated adult rabbit cardiac ventricular myocytes
    H Ikenouchi
    Second Department of Internal Medicine, University of Tokyo, Japan
    Circulation 95:2318-24. 1997
    ..Both AM and binding sites for this peptide have been found in cardiac tissue, indicating the possible existence of an autocrine or paracrine system of AM in the heart...
  24. ncbi request reprint L-Arginine given after ischaemic preconditioning can enhance cardioprotection in isolated rat hearts
    Y Suematsu
    Department of Cardiothoracic Surgery, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
    Eur J Cardiothorac Surg 19:873-9. 2001
    ..The ability of nitric oxide (NO) to enhance ischaemic preconditioning was assessed, and the role of L-arginine-induced ischaemic preconditioning in myocardial protection was determined...
  25. ncbi request reprint Acute and chronic smooth muscle cell apoptosis after mechanical vascular injury can occur independently of the Fas-death pathway
    M Sata
    Department of Cardiovascular Medicine, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 21:1733-7. 2001
    ..2, and lpr 1.3+/-0.2) or in the number of apoptotic nuclei among the 3 groups. These findings suggest the existence of other signaling pathways for acute and chronic VSMC apoptosis, at least that induced by mechanical vascular injury...
  26. ncbi request reprint Crucial role of type 1, but not type 3, inositol 1,4,5-trisphosphate (IP(3)) receptors in IP(3)-induced Ca(2+) release, capacitative Ca(2+) entry, and proliferation of A7r5 vascular smooth muscle cells
    Y Wang
    Human Genome Center, Second Department of Internal Medicine, University of Tokyo, Tokyo, Japan
    Circ Res 88:202-9. 2001
    ..We conclude that IP(3)R(1), but not IP(3)R(3), is crucial for IICR, CCE, and proliferation of vascular smooth muscle cells...
  27. ncbi request reprint Kinetics of oxygen uptake at onset of exercise related to cardiac output, but not to arteriovenous oxygen difference in patients with chronic heart failure
    A Matsumoto
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Am J Cardiol 83:1573-6, A8. 1999
    ..The kinetics of oxygen uptake are primarily determined by cardiac output; these kinetics are useful in evaluating exercise intolerance and cardiac output response during exercise...
  28. ncbi request reprint Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene
    T Shindo
    Department of Cardiovascular Medicine, University of Tokyo, and Institute for Adult Disease, Asahi Life Foundation, Tokyo, Japan
    Circulation 104:1964-71. 2001
    ..Levels of AM are markedly increased in the fetoplacental circulation during pregnancy, although its function there remains unknown. To clarify the physiological functions of AM, we chose a gene-targeting strategy in mice...
  29. ncbi request reprint S-Methylisothiourea sulfate improves renal, but not hepatic dysfunction in canine endotoxic shock model
    C Mitaka
    Department of Emergency and Critical Care Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Intensive Care Med 26:117-24. 2000
    ..This study was designed to see whether S-methylisothiourea sulfate (SMT), a selective inhibitor for iNOS, prevents cardiovascular changes and multiple organ damage in the canine endotoxic shock model...
  30. doi request reprint Processing of high-molecular-weight form adrenocorticotropin in human adrenocorticotropin-secreting tumor cell line (DMS-79) after transfection of prohormone convertase 1/3 gene
    T Tateno
    Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    J Endocrinol Invest 33:113-7. 2010
    ..Thus, we have established PC1/3 stably-expressing cell line (DMS-79T) capable of proteolytically processing ACTH precursor molecule(s) into mature ACTH and beta-END...
  31. ncbi request reprint Bioimaging of nitric oxide with fluorescent indicators based on the rhodamine chromophore
    H Kojima
    Graduate School of Pharmaceutical Sciences, and Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Anal Chem 73:1967-73. 2001
    ..The detection limit of NO was 7 nM, and the fluorescence showed no pH dependency above pH 4. DAR-4M AM was successfully applied to practical bioimaging of NO produced in bovine aortic endothelial cells...
  32. ncbi request reprint Renal effects of atrial natriuretic peptide during dopamine infusion
    Y Hirata
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Am J Hypertens 3:866-9. 1990
    ..However, in contrast with dopamine, ANP increased efferent resistance and nephrogenous cGMP, suggesting that the renal effects of ANP are different from those of dopamine...
  33. ncbi request reprint Possible associations of rectal carcinoma with Schistosoma japonicum infection and membranous nephropathy: a case report with a review
    K Matsuda
    Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Japan
    Jpn J Clin Oncol 29:576-81. 1999
    ..japonicum, gastrointestinal malignancy should be ruled out as an etiological factor. Sigmoidoscopy would be useful for colorectal carcinoma surveillance in S. japonicum patients...
  34. ncbi request reprint A day trip to a forest park increases human natural killer activity and the expression of anti-cancer proteins in male subjects
    Qing Li
    Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    J Biol Regul Homeost Agents 24:157-65. 2010
    ..Phytoncides released from trees and decreased stress hormone levels may partially contribute to the increased NK activity...
  35. ncbi request reprint Measurement of plasma brain natriuretic peptide level as a guide for cardiac overload
    Y Hirata
    Department of Cardiovascular Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
    Cardiovasc Res 51:585-91. 2001
    ..We examined whether measurement of the plasma BNP concentrations might be useful for the early diagnosis of the existence and severity of disease in patients with heart disease in daily clinical practice...
  36. ncbi request reprint Tranilast inhibits transplant-associated coronary arteriosclerosis in a murine model of cardiac transplantation
    A Saiura
    Department of Surgery, University of Tokyo, Graduate School of Medicine, Tokyo 113-8655, Japan
    Eur J Pharmacol 433:163-8. 2001
    ..Tranilast also suppressed transforming growth factor-beta (TGF-beta) expression. Tranilast may be effective in preventing transplant-associated arteriosclerosis through its anti-inflammatory and anti-proliferative effects...
  37. ncbi request reprint Relation of 24-h ambulatory blood pressure with plasma potassium in essential hypertension
    A Goto
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Am J Hypertens 10:337-40. 1997
    ....
  38. ncbi request reprint Hypertrophic cardiomyopathy with midventricular obstruction and apical aneurysm: a case report
    K Harada
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Jpn Circ J 65:915-9. 2001
    ..Myocardial ischemia may have played an important role in the genesis of the apical aneurysm...
  39. ncbi request reprint Immunotoxicity of N,N-diethylaniline in mice: effect on natural killer activity, cytotoxic T lymphocyte activity, lymphocyte proliferation response and cellular components of the spleen
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, 113 8602, Tokyo, Japan
    Toxicology 150:179-89. 2000
    ..The above findings indicated that N,N-diethylaniline selectively inhibited splenic NK and CTL activity and this inhibition was due to decreased NK and CTL functions, but not due to changes in the numbers of splenic NK and T cells...
  40. ncbi request reprint Effects of intracavernous administration of adrenomedullin on erectile function in rats
    H Nishimatsu
    Department of Urology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan
    Peptides 22:1913-8. 2001
    ..These results suggest that a NO-cGMP pathway is involved in the regulation of AM-induced rat cavernous vasorelaxation...
  41. ncbi request reprint Elevated sympathetic nervous activity in mice deficient in alphaCGRP
    Y Oh-hashi
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Circ Res 89:983-90. 2001
    ..These findings suggest that alphaCGRP contributes to the regulation of cardiovascular function through inhibitory modulation of sympathetic nervous activity...
  42. ncbi request reprint The extrarenal effects of atrial natriuretic peptide on body fluid distribution
    Y Hirata
    Second Department of Internal Medicine, University of Tokyo, Japan
    Am J Hypertens 3:140-7. 1990
    ..03 +/- 0.16 omega.m, P less than .05), but decreased Ri in 7. Changes in urinary Na excretion correlated positively with those in both Re (r = 0.62, P less than .05) and Ri (r = 0.75, P less than .01).(ABSTRACT TRUNCATED AT 250 WORDS)..
  43. ncbi request reprint Enhancement of endothelial nitric oxide production by chenodeoxycholic acids in patients with hepatobiliary diseases
    K Chisaki
    Department of Cardiovascular Medicine, School of Medicine, University of Tokyo, Japan
    Jpn Heart J 42:339-53. 2001
    ..Thus, nitric oxide production induced by bile acids may be involved in the pathogenesis of circulatory abnormalities in patients with liver diseases...
  44. ncbi request reprint Factors participating in blood pressure elevation after discharge from the hospital in patients with essential hypertension
    Y Hirata
    Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Am J Hypertens 3:397-9. 1990
    ..05). Thus, increases in NaCl intake seem to play an important role in BP elevation after discharge. Adrenal medullary function may partly contribute also to the BP elevation...
  45. ncbi request reprint The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-B
    Y Hirata
    Section on Growth Factors, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 268:24808-12. 1993
    ..These findings demonstrate that phosphorylation of a nuclear receptor DBD results in a change in DNA binding and provides another potential mechanism for regulating NGFI-B activity...
  46. ncbi request reprint A basis for differentiating among the multiple human Mu-glutathione S-transferases and molecular cloning of brain GSTM5
    Y Takahashi
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461
    J Biol Chem 268:8893-8. 1993
    ..A general strategy was devised to distinguish among and assign primary structures to individual glutathione S-transferases from human tissue...
  47. pmc Akt phosphorylates and regulates the orphan nuclear receptor Nur77
    Y Pekarsky
    Kimmel Cancer Institute, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
    Proc Natl Acad Sci U S A 98:3690-4. 2001
    ....
  48. ncbi request reprint Forest bathing enhances human natural killer activity and expression of anti-cancer proteins
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo
    Int J Immunopathol Pharmacol 20:3-8. 2007
    ....
  49. ncbi request reprint Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medulla
    S Uchida
    Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan
    J Biol Chem 268:3821-4. 1993
    ..The site of expression and the regulation by dehydration suggest that CIC-K1 function may be important in urinary concentrating mechanisms...
  50. ncbi request reprint Cutaneous infiltration with Waldenström macroglobulinemia
    T Yokote
    First Department of Intenal Medicine, Osaka Medical College, 2 7 Daigakumachi, Takatsuki City, Osaka 569 8686, Japan
    Leuk Res 30:1207-10. 2006
    ..PCR analysis of the skin biopsy showed immunoglobulin heavy chain rearrangement. As the rearrangement band occurred at the same site as that of the bone marrow aspiration, skin infiltration with abnormal cells was proven...
  51. ncbi request reprint Molecular cloning of a novel vascular endothelial growth factor, VEGF-D
    Y Yamada
    Gene Search Program, Chugai Research Institute for Molecular Medicine, Niihari, Ibaraki, Japan
    Genomics 42:483-8. 1997
    ..The high level of conservation between mouse and human VEGF-D may emphasize the biological importance of this gene. Recently the murine gene, FIGF, which is identical to mouse VEGF-D, was reported...
  52. ncbi request reprint A forest bathing trip increases human natural killer activity and expression of anti-cancer proteins in female subjects
    Q Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    J Biol Regul Homeost Agents 22:45-55. 2008
    ..Phytoncides released from trees and decreased stress hormone levels may partially contribute to the increased NK activity...
  53. ncbi request reprint The cellular mechanism of action by vasoconstrictor hormones in cultured rat vascular smooth muscle cells
    S Takata
    Department of Medicine, Kobe University School of Medicine, Japan
    Am J Hypertens 3:227S-230S. 1990
    ..These data suggest that receptor-mediated increases in IP3 production, [Ca2+]i, and phosphorylation of 20 kDa MLC by these vasoconstrictors are closely interrelated...
  54. pmc The chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factor
    S Nagata
    EMBO J 5:575-81. 1986
    ..When the G-CSF chromosomal gene was expressed in monkey COS cells by using the SV40 enhancer two mRNAs were detected by S1 mapping analysis...
  55. ncbi request reprint Major histocompatibility complex class I molecules are down-regulated at the cell surface by the K5 protein encoded by Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8
    M Haque
    Department of Microbiology, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
    J Gen Virol 82:1175-80. 2001
    ..These results suggest that the down-regulation of MHC-I molecules by K5 gene expression during reactivation may be important for evading immunological surveillance in the host...
  56. ncbi request reprint Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor
    K Yamasaki
    Division of Immunology, Osaka University, Japan
    Science 241:825-8. 1988
    ..The cytoplasmic domain of approximately 82 amino acids lacks a tyrosine/kinase domain, unlike other growth factor receptors...
  57. ncbi request reprint Conservation of K1 immunoreactivity against early cortical neurones in the vertebrate telencephalon
    K Ishii
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
    Neurosci Res 39:115-21. 2001
    ..The dorsal ventricular ridge and pallial thickening in either the reptile or chick were not stained. The K1 antigen could be a good marker for evolutional study of the mammalian neocortex...
  58. pmc Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5
    T Andoh
    Department of Biochemistry, Hiroshima University School of Medicine, Minami Ku, Hiroshima, Japan
    Mol Cell Biol 20:6712-20. 2000
    ..Furthermore, Rog1 is stabilized in the npi1 mutant, in which RSP5 expression levels are reduced. These results suggest that yeast GSK-3 regulates the stability of Rog1 in cooperation with Bul1, Bul2, and Rsp5...
  59. ncbi request reprint Cloning and expression of apical membrane water channel of rat kidney collecting tubule
    K Fushimi
    Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan
    Nature 361:549-52. 1993
    ..The functional expression and the limited localization of WCH-CD to the apical region of the kidney collecting tubule suggest that WCH-CD is the vasopressin-regulated water channel...
  60. ncbi request reprint Human BST-1 expressed on myeloid cells functions as a receptor molecule
    Y Okuyama
    Department of Molecular Oncology, Osaka University Medical School, Japan
    Biochem Biophys Res Commun 228:838-45. 1996
    ..These results suggest that BST-1 can deliver signals into cells and function as a receptor...
  61. ncbi request reprint Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor
    S Nagata
    Nature 319:415-8. 1986
    ....