Research Topics
Species | Y HirataSummaryAffiliation: University of Tokyo Country: Japan Publications
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Publications
Sitafloxacin resistance in Helicobacter pylori isolates and sitafloxacin-based triple therapy as a third-line regimen in JapanYoshihiro Hirata
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Int J Antimicrob Agents 39:352-5. 2012..These results suggest that STX could be active against most clinical H. pylori isolates and that STX-based triple therapy is a promising and safe third-line therapy...
Helicobacter pylori CagA protein activates serum response element-driven transcription independently of tyrosine phosphorylationYoshihiro Hirata
Department of Gastroenterology, University of Tokyo, Japan
Gastroenterology 123:1962-71. 2002..Here we identify a new role for CagA protein as an activator of host cell signaling...
Helicobacter pylori activates the cyclin D1 gene through mitogen-activated protein kinase pathway in gastric cancer cellsY Hirata
Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Infect Immun 69:3965-71. 2001..pylori activates cyclin D1 through the mitogen-activated protein kinase pathway and not through NF-kappaB activation in AGS cells. This activation of cyclin D1 is partly dependent on the cag pathogenicity island but not on vacA...- Functional variability of cagA gene in Japanese isolates of Helicobacter pyloriYoshihiro Hirata
Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Gene 343:165-72. 2004..pylori induces distinct diseases on host... - Effects of vasodilatory beta-adrenoceptor antagonists on endothelium-derived nitric oxide release in rat kidneyM Kakoki
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
Hypertension 33:467-71. 1999..These results suggest that several beta-blockers exert their vasodilatory action through the 5-HT1A receptor/NO pathway and that treatment with these beta-blockers may protect against endothelial injury in hypertension... - Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pyloriS Maeda
Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Mol Pathol 55:286-93. 2002..Although it is reported that Helicobacter pylori induces apoptosis on gastric epithelial cells, the mechanism remains unknown. Antiapoptotic effects generated by H pylori have not yet been evaluated... - H. pylori activates NF-kappaB through a signaling pathway involving IkappaB kinases, NF-kappaB-inducing kinase, TRAF2, and TRAF6 in gastric cancer cellsS Maeda
Department of Gastroenterology, University of Tokyo, Tokyo, Japan
Gastroenterology 119:97-108. 2000..The aim of this study was to analyze the molecular mechanism responsible for H. pylori-mediated NF-kappaB activation on gastric cancer cells... - Helicobacter pylori induced transactivation of SRE and AP-1 through the ERK signalling pathway in gastric cancer cellsY Mitsuno
Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Gut 49:18-22. 2001..c-Fos is important for transactivation of AP-1 which has SRE in the promoter region. We conducted this study to confirm H pylori induced transactivation of these binding sites... - cDNA microarray analysis of Helicobacter pylori-mediated alteration of gene expression in gastric cancer cellsS Maeda
Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo, Bunkyo ku, 113 8655, Japan
Biochem Biophys Res Commun 284:443-9. 2001..Taken together, these results indicate the importance of microarray technology as a tool for analyzing the complex interplay between H. pylori and the host... - Distinct mechanism of Helicobacter pylori-mediated NF-kappa B activation between gastric cancer cells and monocytic cellsS Maeda
Department of Gastroenterology, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
J Biol Chem 276:44856-64. 2001..pylori-induced NF-kappaB activation in epithelial cells is dependent on cag PAI and contact but does not involve CD14 and IRAK, whereas in macrophage/monocytic cells it is independent of cag PAI or contact but involves CD14 and TLR4... - Receptor subtype for vasopressin-induced release of nitric oxide from rat kidneyY Hirata
Second Department of Internal Medicine, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan
Hypertension 29:58-64. 1997..These results directly demonstrate that vasopressin stimulates NO release via the endothelial V1 receptor in the rat kidney... - Transcriptional activation of the cyclin D1 gene is mediated by multiple cis-elements, including SP1 sites and a cAMP-responsive element in vascular endothelial cellsD Nagata
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
J Biol Chem 276:662-9. 2001..The results suggested that the activation of the cyclin D1 gene in vascular ECs was regulated by a dual system; one was inducible in the G(1) phase, and the other was constitutively active... - Molecular mechanisms of endothelin-1-induced cell-cycle progression: involvement of extracellular signal-regulated kinase, protein kinase C, and phosphatidylinositol 3-kinase at distinct pointsE Suzuki
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
Circ Res 84:611-9. 1999.... - CagA protein secreted by the intact type IV secretion system leads to gastric epithelial inflammation in the Mongolian gerbil modelW Shibata
Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
J Pathol 210:306-14. 2006..It is concluded that CagA protein may be essential for the induction of severe gastritis in the Mongolian gerbil model... - Adrenomedullin induces endothelium-dependent vasorelaxation via the phosphatidylinositol 3-kinase/Akt-dependent pathway in rat aortaH Nishimatsu
Department of Urology, Faculty of Medicine, University of Tokyo, Japan
Circ Res 89:63-70. 2001.... - Reentry into the cell cycle of contact-inhibited vascular endothelial cells by a phosphatase inhibitor. Possible involvement of extracellular signal-regulated kinase and phosphatidylinositol 3-kinaseE Suzuki
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
J Biol Chem 275:3637-44. 2000.... - A mouse model of vascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasiaM Sata
Department of Cardiovascular Medicine, University of Tokyo, Tokyo, 113 8655, Japan
J Mol Cell Cardiol 32:2097-104. 2000..Similar exuberant hyperplasia could be induced in all strains examined (C57BL/6J, C3H/HeJ, BALB/c, and 129/SVj). This model may be widely used to study the molecular mechanism of post-angioplasty restenosis at the genetic level... - Effects of vasodilatory antihypertensive agents on endothelial dysfunction in rats with ischemic acute renal failureM Kakoki
Department of Internal Medicine, University of Tokyo, Japan
Hypertens Res 23:527-33. 2000..Calcium channel blockers, converting-enzyme inhibitors, and endothelial NO synthase-activating beta-blockers had beneficial effects on renovascular endothelial dysfunction due to ischemia... - Analysis of apoptotic and antiapoptotic signalling pathways induced by Helicobacter pyloriS Maeda
Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Gut 50:771-8. 2002..Although it is reported that Helicobacter pylori induces apoptosis on gastric epithelial cells, the mechanism remains unknown. Antiapoptotic effects generated by H pylori have not yet been evaluated... - Endothelial nitric oxide synthase is essential for the HMG-CoA reductase inhibitor cerivastatin to promote collateral growth in response to ischemiaM Sata
Department of Cardiovascular Medicine, University of Tokyo Graduate School of Medicine, Tokyo 113 8655, Japan
FASEB J 15:2530-2. 2001..The angiogenic effect of cerivastatin was abrogated in eNOS deficient (eNOS-/-) mice. These results indicate that eNOS is essential for cerivastatin to promote collateral growth in response to ischemia... - Effect of inhaled nitric oxide on gas exchange in patients with congestive heart failure. A randomized, controlled trialA Matsumoto
University of Tokyo, Japan
Ann Intern Med 130:40-4. 1999..However, the effects of nitric oxide inhalation on ventilatory and gas exchange values in patients with congestive heart failure are not known... - The by-products generated during sarin synthesis in the Tokyo sarin disaster induced inhibition of natural killer and cytotoxic T lymphocyte activityQ Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
Toxicology 146:209-20. 2000..The effect of DIMP and DEMP on the splenic NK activity of mice was stronger than on the splenic CTL activity, and the human lymphocytes is more sensitive to DIMP and DEMP than the splenocytes of mice... - Negative inotropic effect of adrenomedullin in isolated adult rabbit cardiac ventricular myocytesH Ikenouchi
Second Department of Internal Medicine, University of Tokyo, Japan
Circulation 95:2318-24. 1997..Both AM and binding sites for this peptide have been found in cardiac tissue, indicating the possible existence of an autocrine or paracrine system of AM in the heart... - L-Arginine given after ischaemic preconditioning can enhance cardioprotection in isolated rat heartsY Suematsu
Department of Cardiothoracic Surgery, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
Eur J Cardiothorac Surg 19:873-9. 2001..The ability of nitric oxide (NO) to enhance ischaemic preconditioning was assessed, and the role of L-arginine-induced ischaemic preconditioning in myocardial protection was determined... - Acute and chronic smooth muscle cell apoptosis after mechanical vascular injury can occur independently of the Fas-death pathwayM Sata
Department of Cardiovascular Medicine, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
Arterioscler Thromb Vasc Biol 21:1733-7. 2001..2, and lpr 1.3+/-0.2) or in the number of apoptotic nuclei among the 3 groups. These findings suggest the existence of other signaling pathways for acute and chronic VSMC apoptosis, at least that induced by mechanical vascular injury... - Crucial role of type 1, but not type 3, inositol 1,4,5-trisphosphate (IP(3)) receptors in IP(3)-induced Ca(2+) release, capacitative Ca(2+) entry, and proliferation of A7r5 vascular smooth muscle cellsY Wang
Human Genome Center, Second Department of Internal Medicine, University of Tokyo, Tokyo, Japan
Circ Res 88:202-9. 2001..We conclude that IP(3)R(1), but not IP(3)R(3), is crucial for IICR, CCE, and proliferation of vascular smooth muscle cells... - Kinetics of oxygen uptake at onset of exercise related to cardiac output, but not to arteriovenous oxygen difference in patients with chronic heart failureA Matsumoto
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
Am J Cardiol 83:1573-6, A8. 1999..The kinetics of oxygen uptake are primarily determined by cardiac output; these kinetics are useful in evaluating exercise intolerance and cardiac output response during exercise... - Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin geneT Shindo
Department of Cardiovascular Medicine, University of Tokyo, and Institute for Adult Disease, Asahi Life Foundation, Tokyo, Japan
Circulation 104:1964-71. 2001..Levels of AM are markedly increased in the fetoplacental circulation during pregnancy, although its function there remains unknown. To clarify the physiological functions of AM, we chose a gene-targeting strategy in mice... - S-Methylisothiourea sulfate improves renal, but not hepatic dysfunction in canine endotoxic shock modelC Mitaka
Department of Emergency and Critical Care Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
Intensive Care Med 26:117-24. 2000..This study was designed to see whether S-methylisothiourea sulfate (SMT), a selective inhibitor for iNOS, prevents cardiovascular changes and multiple organ damage in the canine endotoxic shock model... - Processing of high-molecular-weight form adrenocorticotropin in human adrenocorticotropin-secreting tumor cell line (DMS-79) after transfection of prohormone convertase 1/3 geneT Tateno
Department of Clinical and Molecular Endocrinology, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
J Endocrinol Invest 33:113-7. 2010..Thus, we have established PC1/3 stably-expressing cell line (DMS-79T) capable of proteolytically processing ACTH precursor molecule(s) into mature ACTH and beta-END... - Bioimaging of nitric oxide with fluorescent indicators based on the rhodamine chromophoreH Kojima
Graduate School of Pharmaceutical Sciences, and Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
Anal Chem 73:1967-73. 2001..The detection limit of NO was 7 nM, and the fluorescence showed no pH dependency above pH 4. DAR-4M AM was successfully applied to practical bioimaging of NO produced in bovine aortic endothelial cells... - Renal effects of atrial natriuretic peptide during dopamine infusionY Hirata
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
Am J Hypertens 3:866-9. 1990..However, in contrast with dopamine, ANP increased efferent resistance and nephrogenous cGMP, suggesting that the renal effects of ANP are different from those of dopamine... - Possible associations of rectal carcinoma with Schistosoma japonicum infection and membranous nephropathy: a case report with a reviewK Matsuda
Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, Japan
Jpn J Clin Oncol 29:576-81. 1999..japonicum, gastrointestinal malignancy should be ruled out as an etiological factor. Sigmoidoscopy would be useful for colorectal carcinoma surveillance in S. japonicum patients... - A day trip to a forest park increases human natural killer activity and the expression of anti-cancer proteins in male subjectsQing Li
Department of Hygiene and Public Health, Nippon Medical School, Bunkyo ku, Tokyo, Japan
J Biol Regul Homeost Agents 24:157-65. 2010..Phytoncides released from trees and decreased stress hormone levels may partially contribute to the increased NK activity... - Measurement of plasma brain natriuretic peptide level as a guide for cardiac overloadY Hirata
Department of Cardiovascular Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
Cardiovasc Res 51:585-91. 2001..We examined whether measurement of the plasma BNP concentrations might be useful for the early diagnosis of the existence and severity of disease in patients with heart disease in daily clinical practice... - Tranilast inhibits transplant-associated coronary arteriosclerosis in a murine model of cardiac transplantationA Saiura
Department of Surgery, University of Tokyo, Graduate School of Medicine, Tokyo 113-8655, Japan
Eur J Pharmacol 433:163-8. 2001..Tranilast also suppressed transforming growth factor-beta (TGF-beta) expression. Tranilast may be effective in preventing transplant-associated arteriosclerosis through its anti-inflammatory and anti-proliferative effects... - Relation of 24-h ambulatory blood pressure with plasma potassium in essential hypertensionA Goto
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
Am J Hypertens 10:337-40. 1997.... - Hypertrophic cardiomyopathy with midventricular obstruction and apical aneurysm: a case reportK Harada
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Japan
Jpn Circ J 65:915-9. 2001..Myocardial ischemia may have played an important role in the genesis of the apical aneurysm... - Immunotoxicity of N,N-diethylaniline in mice: effect on natural killer activity, cytotoxic T lymphocyte activity, lymphocyte proliferation response and cellular components of the spleenQ Li
Department of Hygiene and Public Health, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, 113 8602, Tokyo, Japan
Toxicology 150:179-89. 2000..The above findings indicated that N,N-diethylaniline selectively inhibited splenic NK and CTL activity and this inhibition was due to decreased NK and CTL functions, but not due to changes in the numbers of splenic NK and T cells... - Effects of intracavernous administration of adrenomedullin on erectile function in ratsH Nishimatsu
Department of Urology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan
Peptides 22:1913-8. 2001..These results suggest that a NO-cGMP pathway is involved in the regulation of AM-induced rat cavernous vasorelaxation... - Elevated sympathetic nervous activity in mice deficient in alphaCGRPY Oh-hashi
Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
Circ Res 89:983-90. 2001..These findings suggest that alphaCGRP contributes to the regulation of cardiovascular function through inhibitory modulation of sympathetic nervous activity... - The extrarenal effects of atrial natriuretic peptide on body fluid distributionY Hirata
Second Department of Internal Medicine, University of Tokyo, Japan
Am J Hypertens 3:140-7. 1990..03 +/- 0.16 omega.m, P less than .05), but decreased Ri in 7. Changes in urinary Na excretion correlated positively with those in both Re (r = 0.62, P less than .05) and Ri (r = 0.75, P less than .01).(ABSTRACT TRUNCATED AT 250 WORDS).. - Enhancement of endothelial nitric oxide production by chenodeoxycholic acids in patients with hepatobiliary diseasesK Chisaki
Department of Cardiovascular Medicine, School of Medicine, University of Tokyo, Japan
Jpn Heart J 42:339-53. 2001..Thus, nitric oxide production induced by bile acids may be involved in the pathogenesis of circulatory abnormalities in patients with liver diseases... - Factors participating in blood pressure elevation after discharge from the hospital in patients with essential hypertensionY Hirata
Second Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
Am J Hypertens 3:397-9. 1990..05). Thus, increases in NaCl intake seem to play an important role in BP elevation after discharge. Adrenal medullary function may partly contribute also to the BP elevation... - The phosphorylation and DNA binding of the DNA-binding domain of the orphan nuclear receptor NGFI-BY Hirata
Section on Growth Factors, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
J Biol Chem 268:24808-12. 1993..These findings demonstrate that phosphorylation of a nuclear receptor DBD results in a change in DNA binding and provides another potential mechanism for regulating NGFI-B activity... - A basis for differentiating among the multiple human Mu-glutathione S-transferases and molecular cloning of brain GSTM5Y Takahashi
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461
J Biol Chem 268:8893-8. 1993..A general strategy was devised to distinguish among and assign primary structures to individual glutathione S-transferases from human tissue... - Akt phosphorylates and regulates the orphan nuclear receptor Nur77Y Pekarsky
Kimmel Cancer Institute, Thomas Jefferson University, 233 South 10th Street, Philadelphia, PA 19107, USA
Proc Natl Acad Sci U S A 98:3690-4. 2001.... - Forest bathing enhances human natural killer activity and expression of anti-cancer proteinsQ Li
Department of Hygiene and Public Health, Nippon Medical School, Tokyo
Int J Immunopathol Pharmacol 20:3-8. 2007.... - Molecular cloning of a chloride channel that is regulated by dehydration and expressed predominantly in kidney medullaS Uchida
Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan
J Biol Chem 268:3821-4. 1993..The site of expression and the regulation by dehydration suggest that CIC-K1 function may be important in urinary concentrating mechanisms... - Cutaneous infiltration with Waldenström macroglobulinemiaT Yokote
First Department of Intenal Medicine, Osaka Medical College, 2 7 Daigakumachi, Takatsuki City, Osaka 569 8686, Japan
Leuk Res 30:1207-10. 2006..PCR analysis of the skin biopsy showed immunoglobulin heavy chain rearrangement. As the rearrangement band occurred at the same site as that of the bone marrow aspiration, skin infiltration with abnormal cells was proven... - Molecular cloning of a novel vascular endothelial growth factor, VEGF-DY Yamada
Gene Search Program, Chugai Research Institute for Molecular Medicine, Niihari, Ibaraki, Japan
Genomics 42:483-8. 1997..The high level of conservation between mouse and human VEGF-D may emphasize the biological importance of this gene. Recently the murine gene, FIGF, which is identical to mouse VEGF-D, was reported... - A forest bathing trip increases human natural killer activity and expression of anti-cancer proteins in female subjectsQ Li
Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
J Biol Regul Homeost Agents 22:45-55. 2008..Phytoncides released from trees and decreased stress hormone levels may partially contribute to the increased NK activity... - The cellular mechanism of action by vasoconstrictor hormones in cultured rat vascular smooth muscle cellsS Takata
Department of Medicine, Kobe University School of Medicine, Japan
Am J Hypertens 3:227S-230S. 1990..These data suggest that receptor-mediated increases in IP3 production, [Ca2+]i, and phosphorylation of 20 kDa MLC by these vasoconstrictors are closely interrelated... - The chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factorS Nagata
EMBO J 5:575-81. 1986..When the G-CSF chromosomal gene was expressed in monkey COS cells by using the SV40 enhancer two mRNAs were detected by S1 mapping analysis... - Major histocompatibility complex class I molecules are down-regulated at the cell surface by the K5 protein encoded by Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8M Haque
Department of Microbiology, Osaka University Medical School, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan
J Gen Virol 82:1175-80. 2001..These results suggest that the down-regulation of MHC-I molecules by K5 gene expression during reactivation may be important for evading immunological surveillance in the host... - Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptorK Yamasaki
Division of Immunology, Osaka University, Japan
Science 241:825-8. 1988..The cytoplasmic domain of approximately 82 amino acids lacks a tyrosine/kinase domain, unlike other growth factor receptors... - Conservation of K1 immunoreactivity against early cortical neurones in the vertebrate telencephalonK Ishii
Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Neurosci Res 39:115-21. 2001..The dorsal ventricular ridge and pallial thickening in either the reptile or chick were not stained. The K1 antigen could be a good marker for evolutional study of the mammalian neocortex... - Yeast glycogen synthase kinase 3 is involved in protein degradation in cooperation with Bul1, Bul2, and Rsp5T Andoh
Department of Biochemistry, Hiroshima University School of Medicine, Minami Ku, Hiroshima, Japan
Mol Cell Biol 20:6712-20. 2000..Furthermore, Rog1 is stabilized in the npi1 mutant, in which RSP5 expression levels are reduced. These results suggest that yeast GSK-3 regulates the stability of Rog1 in cooperation with Bul1, Bul2, and Rsp5... - Cloning and expression of apical membrane water channel of rat kidney collecting tubuleK Fushimi
Second Department of Internal Medicine, Tokyo Medical and Dental University, Japan
Nature 361:549-52. 1993..The functional expression and the limited localization of WCH-CD to the apical region of the kidney collecting tubule suggest that WCH-CD is the vasopressin-regulated water channel... - Human BST-1 expressed on myeloid cells functions as a receptor moleculeY Okuyama
Department of Molecular Oncology, Osaka University Medical School, Japan
Biochem Biophys Res Commun 228:838-45. 1996..These results suggest that BST-1 can deliver signals into cells and function as a receptor... - Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factorS Nagata
Nature 319:415-8. 1986....