O Hino

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint A novel renal carcinoma predisposing gene of the Nihon rat maps on chromosome 10
    O Hino
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Toshima ku, Tokyo 170 8455
    Jpn J Cancer Res 92:1147-9. 2001
  2. ncbi request reprint Multistep renal carcinogenesis as gene expression disease in tumor suppressor TSC2 gene mutant model--genotype, phenotype and environment
    O Hino
    Department of Experimental Pathology, Cancer Institute, 1 37 1 Kami Ikebukuro, Toshima ku, 170 8455, Tokyo, Japan
    Mutat Res 477:155-64. 2001
  3. ncbi request reprint Hereditary renal carcinogenesis fitting Knudson's two-hit model: genotype, environment, and phenotype
    Okio Hino
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Genes Chromosomes Cancer 38:357-67. 2003
  4. ncbi request reprint Renal carcinogenesis: genotype, phenotype and dramatype
    Okio Hino
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455
    Cancer Sci 94:142-7. 2003
  5. pmc A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
    T Kobayashi
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Proc Natl Acad Sci U S A 98:8762-7. 2001
  6. ncbi request reprint Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis (Tsc2)
    O Hino
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Mol Carcinog 14:23-7. 1995
  7. ncbi request reprint Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene
    Y Togashi
    Department of Pathology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Oncogene 25:2885-9. 2006
  8. pmc cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat model
    T Kobayashi
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Nucleic Acids Res 23:2608-13. 1995
  9. ncbi request reprint Analysis of all exons of TSC1 and TSC2 genes for germline mutations in Japanese patients with tuberous sclerosis: report of 10 mutations
    Y Yamashita
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Am J Med Genet 90:123-6. 2000
  10. ncbi request reprint A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer
    T Kobayashi
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Nat Genet 9:70-4. 1995

Collaborators

Detail Information

Publications69

  1. ncbi request reprint A novel renal carcinoma predisposing gene of the Nihon rat maps on chromosome 10
    O Hino
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Toshima ku, Tokyo 170 8455
    Jpn J Cancer Res 92:1147-9. 2001
    ..1). We also detected loss of the wild-type allele at the MYHSE locus, fitting Knudson's "two hit" model. Thus, the Nihon rat should have a mutation of a novel tumor suppressor gene related to renal carcinogenesis...
  2. ncbi request reprint Multistep renal carcinogenesis as gene expression disease in tumor suppressor TSC2 gene mutant model--genotype, phenotype and environment
    O Hino
    Department of Experimental Pathology, Cancer Institute, 1 37 1 Kami Ikebukuro, Toshima ku, 170 8455, Tokyo, Japan
    Mutat Res 477:155-64. 2001
    ..g. cell stage and tissue/cell-type-specific tumorigenesis, multistep carcinogenesis, species-specific differences in tumorigenesis, modifier gene(s) in renal carcinogenesis and cancer prevention...
  3. ncbi request reprint Hereditary renal carcinogenesis fitting Knudson's two-hit model: genotype, environment, and phenotype
    Okio Hino
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Genes Chromosomes Cancer 38:357-67. 2003
    ....
  4. ncbi request reprint Renal carcinogenesis: genotype, phenotype and dramatype
    Okio Hino
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455
    Cancer Sci 94:142-7. 2003
    ....
  5. pmc A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
    T Kobayashi
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Proc Natl Acad Sci U S A 98:8762-7. 2001
    ..The Tsc1 knockout mouse described here will be a useful model to elucidate the function of Tsc1 and Tsc2 products as well as pathogenesis of TS...
  6. ncbi request reprint Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis (Tsc2)
    O Hino
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Mol Carcinog 14:23-7. 1995
    ..Microsatellite instability was not observed in 26 Eker rat tumors...
  7. ncbi request reprint Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene
    Y Togashi
    Department of Pathology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Oncogene 25:2885-9. 2006
    ..This transgenic rescue system will be useful to analyse Bhd gene function, its relation to tumorigenesis in vivo, and genetic-environmental interactions in carcinogenesis...
  8. pmc cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat model
    T Kobayashi
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Nucleic Acids Res 23:2608-13. 1995
    ....
  9. ncbi request reprint Analysis of all exons of TSC1 and TSC2 genes for germline mutations in Japanese patients with tuberous sclerosis: report of 10 mutations
    Y Yamashita
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Am J Med Genet 90:123-6. 2000
    ..e., (1) TSC1 mutations are rarer in sporadic cases than in familial cases, (2) substantial numbers of sporadic cases arise from mutations in the TSC2 gene, and (3) mutations of the TSC1 gene may cause premature truncation of hamartin...
  10. ncbi request reprint A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer
    T Kobayashi
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Nat Genet 9:70-4. 1995
    ..The Eker rat may therefore provide insights into species-specific differences in tumourigenesis and/or phenotype-specific mutations...
  11. ncbi request reprint Mapping and determination of the cDNA sequence of the Erc gene preferentially expressed in renal cell carcinoma in the Tsc2 gene mutant (Eker) rat model
    Y Yamashita
    Department of Experimental Pathology, Cancer Institute, Tokyo, 170 8455, Japan
    Biochem Biophys Res Commun 275:134-40. 2000
    ..We also found that Erc was expressed at higher levels in primary RCs compared with the normal kidney of the Eker rat. Erc may be related to carcinogenesis in the Tsc2 gene mutant (Eker) rat model...
  12. doi request reprint The G1556S-type tuberin variant suppresses tumor formation in tuberous sclerosis 2 mutant (Eker) rats despite its deficiency in mTOR inhibition
    M Shiono
    Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo, Japan
    Oncogene 27:6690-7. 2008
    ..Identification of such a novel pathway will provide clear implications for generation of new therapeutic targets in the treatment of these tumors...
  13. doi request reprint Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein
    Y Takagi
    Department of Pathology and Oncology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Oncogene 27:5339-47. 2008
    ..These results suggest that Flcn-FnipL/Fnip2 and Flcn-Fnip1 complexes positively regulate S6K1 phosphorylation and that FnipL/Fnip2 provides an important clue to elucidating the function of Flcn and the pathogenesis of BHD...
  14. ncbi request reprint Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice
    T Kobayashi
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Cancer Res 59:1206-11. 1999
    ..The mouse strain described here should provide a valuable experimental model to analyze the function of tuberin and its association with tumorigenesis...
  15. pmc Transgenic rescue from embryonic lethality and renal carcinogenesis in the Eker rat model by introduction of a wild-type Tsc2 gene
    T Kobayashi
    Department of Experimental Pathology, Cancer Institute, Toshima ku, Tokyo, Japan
    Proc Natl Acad Sci U S A 94:3990-3. 1997
    ..This transgenic rescue system will be useful to analyze Tsc2 gene function, its relation to tumorigenesis in vivo, and genetic-environmental interactions in carcinogenesis...
  16. ncbi request reprint Identification of a leader exon and a core promoter for the rat tuberous sclerosis 2 (Tsc2) gene and structural comparison with the human homolog
    T Kobayashi
    Department of Experimental Pathology, Cancer Institute, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170, Japan
    Mamm Genome 8:554-8. 1997
    ..Characterization of the 5' region of Tsc2 and TSC2 will facilitate studies of the regulation of the gene and its disregulation in tumorigenesis...
  17. ncbi request reprint Overexpression of members of the AP-1 transcriptional factor family from an early stage of renal carcinogenesis and inhibition of cell growth by AP-1 gene antisense oligonucleotides in the Tsc2 gene mutant (Eker) rat model
    S Urakami
    Department of Experimental Pathology, Cancer Institute, 1 37 1 Kami Ikebukuro, Tokyo, Toshima ku, 170, Japan
    Biochem Biophys Res Commun 241:24-30. 1997
    ..Thus, the data suggest that overexpression of AP-1 genes might play a crucial role in renal carcinogenesis in the Eker rat model...
  18. ncbi request reprint Recombination hot spot of hepatitis B virus genome binds to members of the HMG domain protein family and the Y box binding protein family; implication of these proteins in genomic instability
    K Kajino
    Department of Experimental Pathology, Cancer Institute, Kami-Ikebukuro, Toshima-ku, Tokyo, Japan
    Intervirology 44:311-6. 2001
    ..We report them here because several documents have already suggested the possible association of these families and DNA recombination...
  19. ncbi request reprint A novel gene "Niban" upregulated in renal carcinogenesis: cloning by the cDNA-amplified fragment length polymorphism approach
    S Majima
    Department of Experimental Pathology, Cancer Institute, Toshima ku, Tokyo 170 8455, Japan
    Jpn J Cancer Res 91:869-74. 2000
    ..Chromosome assignment was to RNO 13 in the rat, and HSA 1. This "Niban" gene is a candidate as a marker for renal tumor, especially early-stage renal carcinogenesis...
  20. ncbi request reprint Isolation and characterization of a rat homologue of the human tuberous sclerosis 1 gene (Tsc1) and analysis of its mutations in rat renal carcinomas
    N Satake
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Cancer Res 59:849-55. 1999
    ..This suggests that alterations of the Tsc1 gene may be involved in the development of a subset of rat RCs...
  21. ncbi request reprint Mesothelin gene expression and promoter methylation/hypomethylation in gynecological tumors
    G Obulhasim
    Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo, Japan
    Eur J Gynaecol Oncol 31:63-71. 2010
    ..In this study, we investigated the methylation/hypomethylation status in the promoter region of the mesothelin gene in gynecological tumors...
  22. ncbi request reprint Isolation of genes differentially expressed between the Yoshida sarcoma and long-survival Yoshida sarcoma variants: origin of Yoshida sarcoma revisited
    H Tsuchiya
    Department of Experimental Pathology, Cancer Institute, Tokyo
    Jpn J Cancer Res 85:1099-104. 1994
    ..Thus, our present findings, unexpectedly, raise fundamental questions concerning the cellular origins of YS and LY variants rather than pointing to any specific mechanism to explain the LY phenomenon...
  23. ncbi request reprint Identification of a novel protein (VBP-1) binding to the von Hippel-Lindau (VHL) tumor suppressor gene product
    H Tsuchiya
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Cancer Res 56:2881-5. 1996
    ..However, when coexpressed with VHL, it can translocate to the nucleus. These results indicate that VBP-1 can form a complex with VHL protein in vivo and hence VHL affects the intracellular localization of VBP-1 protein...
  24. ncbi request reprint Subcutaneous sarcomas of probable neuronal origin in a transgenic mouse strain containing an albumin promoter-fused simian virus 40 large T antigen gene
    B Kawabuchi
    Department of Pathology, Cancer Institute, Tokyo
    Jpn J Cancer Res 85:601-9. 1994
    ..Thus, the present investigation suggested the presence of specifically differentiated neurogenic cells in the mouse subcutis with aberrant expression of the transgene...
  25. ncbi request reprint A patient with TSC1 germline mutation whose clinical phenotype was limited to lymphangioleiomyomatosis
    T Sato
    Department of Respiratory Medicine, Juntendo University School of Medicine, Hongo Bunkyo ku, Tokyo, Japan
    J Intern Med 256:166-73. 2004
    ....
  26. ncbi request reprint Cloning of the rat homologue of the von Hippel-Lindau tumor suppressor gene and its non-somatic mutation in rat renal cell carcinomas
    Y Kikuchi
    Department of Experimental Pathology, Cancer Institute, Tokyo
    Jpn J Cancer Res 86:905-9. 1995
    ..These data indicate that mutation of the VHL tumor suppressor gene is not an event in rat renal carcinogenesis, at least in our present systems...
  27. ncbi request reprint Allelic loss analysis of early-stage flat-type colorectal tumors
    H Orita
    Department of Surgery, Juntendo University, Tokyo, Japan
    Ann Oncol 17:43-9. 2006
    ..To identify distinct genetic alterations, loss of heterozygosity (LOH) analysis was performed on microdissected tissues...
  28. pmc Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1
    H Aoki
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    J Virol 74:1736-41. 2000
    ..These results suggest that HCV core protein may represent a novel type of Raf-1 kinase-activating protein through its interaction with 14-3-3 protein and may contribute to hepatocyte growth regulation...
  29. ncbi request reprint Birt-Hogg-Dubé (BHD) gene mutations in human gastric cancer with high frequency microsatellite instability
    Wenquan Jiang
    Department of Surgery, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Cancer Lett 248:103-11. 2007
    ..Taken together, these findings show that the BHD gene is a rare target in MSI-high gastric cancer, and BHD mutation tends to occur downstream in the mutational events of other major MSI-high target genes...
  30. ncbi request reprint Studies of familial tumors using models: genotype, phenotype, and dramatype in carcinogenesis
    Okio Hino
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Int J Clin Oncol 9:257-61. 2004
  31. pmc Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression
    Li Ma
    Cancer Biology and Genetics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Genes Dev 19:1779-86. 2005
    ....
  32. ncbi request reprint Postoperative fibromatosis-type fibromas in the Bhd gene mutant (Nihon) rat
    Mami Kouchi
    Safety Research Laboratories, Dainippon Sumitomo Pharma Co Ltd, 33 94, Enoki cho, Suita, Osaka 564 0053, Japan
    Exp Toxicol Pathol 59:273-9. 2008
    ..Genetic factor should be involved in the occurrence of the tumor, since it was found only in the Nihon rats among many rats. Our present data suggest that Bhd gene mutation is not likely to be a candidate...
  33. ncbi request reprint Multistep renal carcinogenesis in the Eker (Tsc 2 gene mutant) rat model
    Okio Hino
    Department of Pathology, Juntendo University School of Medicine 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Curr Mol Med 4:807-11. 2004
    ..I will review this unique model for the study of multistep renal carcinogenesis and discuss cancer prevention and delay of carcinogenesis...
  34. ncbi request reprint Natural history of the Nihon rat model of BHD
    Kazuo Okimoto
    Toxicology Group, Safety Research Laboratories, Dainippon Pharmaceutical Co, Ltd, 33 94 Enoki cho, Suita, Osaka 564 0053, Japan
    Curr Mol Med 4:887-93. 2004
    ..Thus, the Nihon rat will contribute to understanding the BHD gene function and renal carcinogenesis...
  35. ncbi request reprint N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo
    Shuji Momose
    Department of Pathology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda tsujimichi, Kawagoe, Saitama 350 8550, Japan
    Biochem Biophys Res Commun 356:693-8. 2007
    ..Thus, the functional domains of N-terminal hamartin binding and C-terminal tumor suppression in tuberin can separate in vivo...
  36. ncbi request reprint Natural history of the Nihon (Bhd gene mutant) rat, a novel model for human Birt-Hogg-Dubé syndrome
    Mami Kouchi
    Toxicology Group, Safety Research Laboratories, Dainippon Sumitomo Pharma Co, Ltd, Enoki cho, Suita, Osaka, Japan
    Virchows Arch 448:463-71. 2006
    ..This rat model of hereditary RCC provides a useful tool for analyzing the series of events leading to renal tumorigenesis and for studying BHD gene functions...
  37. ncbi request reprint Niban gene is commonly expressed in the renal tumors: a new candidate marker for renal carcinogenesis
    Hiroyuki Adachi
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Oncogene 23:3495-500. 2004
    ..Thus, Niban was commonly expressed in renal carcinomas and might be a new marker for renal carcinogenesis...
  38. pmc A germ-line insertion in the Birt-Hogg-Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer
    Kazuo Okimoto
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Proc Natl Acad Sci U S A 101:2023-7. 2004
    ..The Nihon rat may therefore provide insights into a tumor-suppressor gene that is related to renal carcinogenesis and an animal model of human BHD syndrome...
  39. ncbi request reprint Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
    Xinsheng Gao
    Department of Physiology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9040, USA
    Nat Cell Biol 4:699-704. 2002
    ..Our studies identify Tsc1 and Tsc2 as regulators of the amino acid-TOR pathway and provide a new paradigm for how proteins involved in nutrient sensing function as tumour suppressors...
  40. ncbi request reprint Down-regulation of cyclooxygenase-2 expression but up-regulation of cyclooxygenase-1 in renal carcinomas of the Eker (TSC2 gene mutant) rat model
    Toshihiro Okamoto
    Research Laboratories, Nippon Chemiphar Co, Ltd, Saitama 341 0005
    Cancer Sci 94:22-5. 2003
    ..In total, Cox-2 mRNA expression was down-regulated in eight out of ten Eker RCs and cell lines, while Cox-1 mRNA expression was up-regulated in nine out of ten Eker RCs and cell lines...
  41. ncbi request reprint N-ethyl-N-hydroxyethylnitrosamine (EHEN)-induced renal and hepatocarcinogenesis in the tumor suppressor Tsc2 transgenic rat
    Nobuo Satake
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo 170 8455, Japan
    Cancer Lett 184:157-63. 2002
    ..These results suggest the presence of other target RC gene(s) in chemically (EHEN)-induced renal carcinogenesis. We observed no difference in the numbers and areas of the hepatic glutathione S-transferase placental type positive foci...
  42. ncbi request reprint Mutation analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangioleiomyomatosis
    Teruhiko Sato
    Department of Respiratory Medicine Juntendo University, School of Medicine, Tokyo, Japan
    J Hum Genet 47:20-8. 2002
    ..However, our study indicates that a fraction of sporadic LAM can be a TSC1 disease; therefore, both TSC genes should be examined, even for patients with sporadic LAM...
  43. ncbi request reprint Human bladder tumors with 2-hit mutations of tumor suppressor gene TSC1 and decreased expression of p27
    Hiroyuki Adachi
    Department of Urology, Shimane Medical University, Izumo, Japan
    J Urol 170:601-4. 2003
    ..3. Furthermore, we also examined the expression of p27 because the TSC1 product is reported to influence the level of p27...
  44. ncbi request reprint Ets protein Elf-1 bidirectionally suppresses transcriptional activities of the tumor suppressor Tsc2 gene and the repair-related Nth1 gene
    Satoshi Honda
    Department of Urology, Shimane Medical University, Shimane, Japan
    Mol Carcinog 37:122-9. 2003
    ..Our observations suggest that mechanisms that inactivate Tsc2 gene expression, such as promoter suppression, may exist...
  45. ncbi request reprint Absence of allelic loss in cytomegalic neurons of cortical tuber in the Eker rat model of tuberous sclerosis
    Masashi Mizuguchi
    Department of Pediatrics, Jichi Medical School, Tochigi, 3, 311 1 Yakushiji, Minamikawachi, Kawachi gun, 329 0498, Tochigi, Japan
    Acta Neuropathol 107:47-52. 2004
    ..These findings were in sharp contrast to those of renal carcinoma cells deriving from allelic loss. Our results provide evidence that many if not all cytomegalic neurons of a cortical tuber occur in the absence of allelic loss...
  46. doi request reprint siRNA-mediated Erc gene silencing suppresses tumor growth in Tsc2 mutant renal carcinoma model
    Osamu Imamura
    Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo, Japan
    Cancer Lett 268:278-85. 2008
    ..Then, by using siRNA microspheres, we found that the suppression of Erc/mesothelin caused growth inhibition of Tsc2 mutant renal carcinoma cells in tumor implantation experiments in mice...
  47. ncbi request reprint Presence of a modifier gene(s) affecting early renal carcinogenesis in the Tsc2 mutant (Eker) rat model
    Yasushi Kikuchi
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan
    Int J Oncol 24:75-80. 2004
    ..We used this ENU system to perform a backcross experiment [F1(Eker x BN) x Eker] and finally succeeded in mapping a new modifier locus on rat chromosome 5 (the LOD score of the D5Rat12 was 3.13)...
  48. ncbi request reprint Identification of the coding sequences responsible for Tsc2-mediated tumor suppression using a transgenic rat system
    Shuji Momose
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, 1 37 1 Kami Ikebukuro, Toshima ku, Tokyo, Japan
    Hum Mol Genet 11:2997-3006. 2002
    ..Tuberin could function as a tumor suppressor without binding to hamartin. The requirement of the functional domain(s) of tuberin might differ for prevention of embryonic lethality and for suppression of renal carcinogenesis...
  49. ncbi request reprint Neuromuscular abundance of RB1CC1 contributes to the non-proliferating enlarged cell phenotype through both RB1 maintenance and TSC1 degradation
    Tokuhiro Chano
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Int J Mol Med 18:425-32. 2006
    ..RB1CC1 preserved cell size without cell cycle progression especially in neuromuscular tissues, and the abundance contributed to the non-proliferating enlarged cell phenotype...
  50. ncbi request reprint GADD34 inhibits mammalian target of rapamycin signaling via tuberous sclerosis complex and controls cell survival under bioenergetic stress
    Ryosuke Watanabe
    Department of Clinical Laboratory Medicine, Shiga University of Medical Science, Shiga 520 2192, Japan
    Int J Mol Med 19:475-83. 2007
    ..GADD34 may find clinical potential as a target drug for the treatment of mTOR-associated diseases...
  51. doi request reprint Tuberous sclerosis complex 2 loss-of-function mutation regulates reactive oxygen species production through Rac1 activation
    Tsukasa Suzuki
    Department of Applied Biology and Chemistry, Tokyo University of Agriculture, 1 1 1 Sakuragaoka, Setagaya Ku, Tokyo 156 8502, Japan
    Biochem Biophys Res Commun 368:132-7. 2008
    ..These results indicate that loss-of-function mutated tuberin can activate Rac1 and thereby increase ROS production...
  52. ncbi request reprint Establishment of the enzyme-linked immunosorbent assay system to detect the amino terminal secretory form of rat Erc/Mesothelin
    Masayuki Nakaishi
    Department of Urology, Ehime University School of Medicine, Shizukawa, Toh on, Ehime, Japan
    Cancer Sci 98:659-64. 2007
    ..We hope our ELISA to detect the soluble form of rat Erc/Mesothelin is useful in the rat model system to exploit the antimesothelioma therapy to be used in human cases...
  53. ncbi request reprint The endoplasmic reticulum stress-inducible protein Niban regulates eIF2alpha and S6K1/4E-BP1 phosphorylation
    Guo Dong Sun
    Department of Pathology and Oncology, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo 113 8421, Japan
    Biochem Biophys Res Commun 360:181-7. 2007
    ..Additionally, suppression of NIBAN expression in HeLa cells promoted apoptosis. Together these results suggest that Niban is involved in the ER stress response, and that Niban can modulate cell death signaling by regulating translation...
  54. pmc Biphasic response of pancreatic beta-cell mass to ablation of tuberous sclerosis complex 2 in mice
    Yutaka Shigeyama
    Department of Internal Medicine, Division of Diabetes, Metabolism, and Endocrinology, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Mol Cell Biol 28:2971-9. 2008
    ..These results thus indicate that TSC2 regulates pancreatic beta-cell mass in a biphasic manner...
  55. ncbi request reprint Revisit: Yamagiwa's Carcinogenesis
    Okio Hino
    Department of Pathology and Oncology, Juntendo University School of Medicine, Tokyo, Japan
    Oncology 72:1. 2007
  56. ncbi request reprint Interaction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway
    Yongheng Cao
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Disease, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    J Biol Chem 281:40242-51. 2006
    ..These data suggest a novel mechanism by which FoxO1 regulates the insulin signaling pathway through negative regulation of TSC2 function...
  57. ncbi request reprint Molecular tumor markers for asbestos-related mesothelioma: serum diagnostic markers
    Masahiro Maeda
    Immuno Biological Laboratories, Fujioka, Gunma, Japan
    Pathol Int 56:649-54. 2006
    ..It has also been found that N-ERC/mesothelin is very stable and plentiful in the blood. In the present paper the potential utility of molecular diagnostic markers is reviewed, including ELISA systems for asbestos-related mesothelioma...
  58. ncbi request reprint Molecular aspects of human hepatocarcinogenesis mediated by inflammation: from hypercarcinogenic state to normo- or hypocarcinogenic state
    Tomoyuki Umeda
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Oncology 62:38-42. 2002
    ..Our goal, then, should be directed to the reversion of the 'hypercarcinogenic state' to the 'normo- or hypocarcinogenic state' so as to hopefully prevent or at least postpone the development of hepatocellular carcinoma...
  59. ncbi request reprint VBP-1 is necessary for morphogenesis in Caenorhabditis elegans
    Harumi Ichimiya
    Department of Molecular Life Science, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa 259 1193, Japan
    Oncol Rep 10:293-5. 2003
    ..Double-stranded RNA interference (RNAi) against VBP-1 resulted in an arrest of embryogenesis at morula stages. This suggests that the VBP-1 product is necessary for morphogenesis...
  60. ncbi request reprint Tumor suppressor genes and the two-hit model of recessive oncogenesis: celebrating Alfred Knudson's 80th birthday
    Joseph R Testa
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Genes Chromosomes Cancer 38:286-7. 2003
  61. ncbi request reprint Osthole prevents anti-Fas antibody-induced hepatitis in mice by affecting the caspase-3-mediated apoptotic pathway
    Toshihiro Okamoto
    Research Laboratories, Nippon Chemiphar Co, Ltd, 1 22 Hikokawato, Misato, Saitama 341 0005, Japan
    Biochem Pharmacol 65:677-81. 2003
    ..The present results show that osthole prevented anti-Fas antibody-induced hepatitis by inhibiting the Fas-mediated apoptotic pathway...
  62. ncbi request reprint Cloning of the Cav 1.3 (alpha1D) L-type Ca2+ channel from mouse and its expression in the liver
    Toshihiro Okamoto
    Research Laboratories, Nippon Chemiphar Co, Ltd, Saitama 341 0005, Japan
    Int J Mol Med 13:573-6. 2004
    ..The present results indicated that mouse Cav 1.3 exhibited 96% homology with human Cav 1.3 and was expressed in the liver. Thus, mouse hepatitis model seemed to be useful to screen DHP-CCB specific for Cav 1.3...
  63. ncbi request reprint [Molecular mechanism of HBV-related hepatocarcinogenesis]
    Hiroshi Tobita
    Department of Experimental Pathology, Cancer Institute
    Nihon Rinsho 62:367-71. 2004
  64. ncbi request reprint Frequent hypermethylation of RASSF1A in early flat-type colorectal tumors
    Naoto Sakamoto
    Department of Pathology II, Juntendo University, Juntendo University School of Medicine, 2 1 1 Hongo, Tokyo 113 8421, Japan
    Oncogene 23:8900-7. 2004
    ..An alternative cascade of abnormalities in RAS transduction pathways may be responsible for the flat morphology and aggressive nature of flat colorectal neoplasms...
  65. ncbi request reprint A mutation in the SDHC gene of complex II increases oxidative stress, resulting in apoptosis and tumorigenesis
    Takamasa Ishii
    Department of Molecular Life Science, Tokai University School of Medicine, Kanagawa, Japan
    Cancer Res 65:203-9. 2005
    ..These results underscore the notion that mitochondrially generated oxidative stress can contribute to nuclear DNA damage, mutagenesis, and ultimately, tumorigenesis...
  66. ncbi request reprint [Federal headship of carcinogenesis--genotype, phenotype, and dramatype]
    Okio Hino
    Department of Pathology, Juntendo University School of Medicine
    Fukuoka Igaku Zasshi 96:1-4. 2005
  67. ncbi request reprint HZE radiation effects for hereditary renal carcinomas
    Taeko Nakadai
    International Space Radiation Laboratory NIRS, Chiba, Japan
    Biol Sci Space 18:177-8. 2004
    ..Based on the dose-response relationship of the radiation-induced carcinoma, averaged RBE ware calculated to be 1.1 for C-ion, 1.6 for Fe-ion...
  68. ncbi request reprint A novel tumor marker, Niban, is expressed in subsets of thyroid tumors and Hashimoto's thyroiditis
    Fumihiko Matsumoto
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo, Japan
    Hum Pathol 37:1592-600. 2006
    ..3) Niban may be a molecular marker of the oxyphilic phenotype under various conditions. Further functional studies of Niban will clarify the role of Niban in various thyroid lesions...
  69. ncbi request reprint Loss of immunogenecity of liver dendritic cells from mouse with chronic hepatitis
    Masanori Abe
    Department of Experimental Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Toshima ku, Tokyo 170 8455, Japan
    Int J Mol Med 9:71-6. 2002
    ..Defective capacity of liver DC from mouse with chronic hepatitis (IFN-gamma TgM) may be related to impaired magnitude of specific immune response in the liver...