F Higa

Summary

Affiliation: University of the Ryukyus
Country: Japan

Publications

  1. ncbi request reprint Clinical evaluation of high mobility group box 1 protein in Legionella pneumophila pneumonia
    Futoshi Higa
    Department of Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, 903 0215 Okinawa, Japan Electronic address
    J Infect Chemother 20:289-92. 2014
  2. ncbi request reprint Imported malaria cases in Okinawa Prefecture, Japan
    Futoshi Higa
    Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Jpn J Infect Dis 66:32-5. 2013
  3. doi request reprint Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study
    Futoshi Higa
    Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Influenza Other Respir Viruses 6:299-303. 2012
  4. doi request reprint Legionella pneumophila contamination in a steam towel warmer in a hospital setting
    F Higa
    Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of Ryukyus, Okinawa, Japan
    J Hosp Infect 80:259-61. 2012
  5. pmc Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone
    Makoto Furugen
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara Town, Okinawa 903 0215, Japan
    Respir Res 9:39. 2008
  6. pmc Mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells
    Hiromitsu Teruya
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    BMC Microbiol 7:102. 2007
  7. pmc Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells
    Reika Takamatsu
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    BMC Microbiol 10:1. 2010
  8. pmc Hepatocyte growth factor levels in Legionella pneumonia: a retrospective study
    Futoshi Higa
    Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    BMC Infect Dis 11:74. 2011
  9. ncbi request reprint In vitro activity of pazufloxacin, tosufloxacin and other quinolones against Legionella species
    Futoshi Higa
    First Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    J Antimicrob Chemother 56:1053-7. 2005
  10. ncbi request reprint Efficacy of pazufloxacin mesilate in Legionnaires' disease: a case report and in vitro study of the isolate
    Futoshi Higa
    Department of Internal Medicine and Infectious Diseases, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0215, Japan
    J Infect Chemother 11:164-8. 2005

Collaborators

Detail Information

Publications87

  1. ncbi request reprint Clinical evaluation of high mobility group box 1 protein in Legionella pneumophila pneumonia
    Futoshi Higa
    Department of Infectious, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, 903 0215 Okinawa, Japan Electronic address
    J Infect Chemother 20:289-92. 2014
    ..HMGB-1 levels in BA fluids were relatively higher in pneumonia cases with ALI than those without ALI. Our findings suggest that intra-pulmonary HMGB-1 may be involved in the pathophysiology of pneumonia caused by L. pneumophila. ..
  2. ncbi request reprint Imported malaria cases in Okinawa Prefecture, Japan
    Futoshi Higa
    Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Jpn J Infect Dis 66:32-5. 2013
    ..The clinical data from these patients highlights the importance of collecting patient travel history and ensuring an adequate supply of both diagnostic test and drug treatments in Okinawa...
  3. doi request reprint Role of neuraminidase inhibitor chemoprophylaxis in controlling nosocomial influenza: an observational study
    Futoshi Higa
    Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Influenza Other Respir Viruses 6:299-303. 2012
    ..An influenza outbreak might result in disruption of services at acute care setting hospitals...
  4. doi request reprint Legionella pneumophila contamination in a steam towel warmer in a hospital setting
    F Higa
    Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of Ryukyus, Okinawa, Japan
    J Hosp Infect 80:259-61. 2012
    ..We abandoned the use of all steam towel warmers in our hospital. Based on this finding, we recommend that steam towel warmers in hospital settings be avoided. Otherwise, the apparatus should be drained, cleaned and dried every day...
  5. pmc Legionella pneumophila infection induces programmed cell death, caspase activation, and release of high-mobility group box 1 protein in A549 alveolar epithelial cells: inhibition by methyl prednisolone
    Makoto Furugen
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara Town, Okinawa 903 0215, Japan
    Respir Res 9:39. 2008
    ..In this study, we investigated the precise mechanism by which A549 alveolar epithelial cells induced by L. pneumophila undergo apoptosis. We also studied the effect of methyl prednisolone on apoptosis in these cells...
  6. pmc Mechanisms of Legionella pneumophila-induced interleukin-8 expression in human lung epithelial cells
    Hiromitsu Teruya
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    BMC Microbiol 7:102. 2007
    ..We investigated the effect of L. pneumophila on the expression of interleukin-8 (IL-8) in human A549 alveolar and NCI-H292 tracheal epithelial cell lines...
  7. pmc Molecular characterization of Legionella pneumophila-induced interleukin-8 expression in T cells
    Reika Takamatsu
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    BMC Microbiol 10:1. 2010
    ..pneumophila to infect and stimulate the production of interleukin-8 (IL-8) in T cells. The objective of this study was to assess whether L. pneumophila interferes with the immune system by interacting and infecting T cells...
  8. pmc Hepatocyte growth factor levels in Legionella pneumonia: a retrospective study
    Futoshi Higa
    Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    BMC Infect Dis 11:74. 2011
    ..Legionella pneumonia is sometimes complicated by acute lung injury. Our study aimed to determine the role of serum HGF levels in Legionella pneumonia...
  9. ncbi request reprint In vitro activity of pazufloxacin, tosufloxacin and other quinolones against Legionella species
    Futoshi Higa
    First Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    J Antimicrob Chemother 56:1053-7. 2005
    ..The activities of pazufloxacin and tosufloxacin against Legionella spp. were evaluated in vitro and compared with those of other quinolones, macrolides and azithromycin...
  10. ncbi request reprint Efficacy of pazufloxacin mesilate in Legionnaires' disease: a case report and in vitro study of the isolate
    Futoshi Higa
    Department of Internal Medicine and Infectious Diseases, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0215, Japan
    J Infect Chemother 11:164-8. 2005
    ..An in vitro study confirmed that PZFX had excellent extracellular and intracellular activity against the isolate from the patient. This case suggests that PZFX is an option for treating Legionnaires' disease...
  11. ncbi request reprint In vitro and in vivo activity of olamufloxacin (HSR-903) against Legionella spp
    Futoshi Higa
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    J Antimicrob Chemother 52:920-4. 2003
    ..Olamufloxacin was as effective as levofloxacin in a guinea pig model of Legionnaires' disease. These data warrant further study of whether olamufloxacin is an option for the treatment of Legionella infections...
  12. ncbi request reprint Epidemiology of influenza from 2007 to 2008 in naha area, okinawa prefecture: surveillance of rapid antigen test results
    Futoshi Higa
    Department of Medicine and Therapeutics, Prevention and Control of Infectious Diseases, School of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Jpn J Infect Dis 62:399-401. 2009
    ..This finding warrants further study in this region, including study of the influences of climate and socio-behavior patterns of the residents in the region on influenza epidemics...
  13. ncbi request reprint Malignant epithelioid angiomyolipoma in the kidney and liver of a patient with pulmonary lymphangioleiomyomatosis: lack of response to sirolimus
    Futoshi Higa
    Department of Medicine and Therapeutics, Prevention, Control of Infectious Diseases, School of Medicine, University of the Ryukyus, Okinawa
    Intern Med 48:1821-5. 2009
    ..This finding suggests that sirolimus might not be effective against epithelioid AML, and in such cases, complete surgical resection should be the treatment of choice...
  14. doi request reprint Detection of Legionella pneumophila serogroup 1 antigen in respiratory samples using an immunochromatographic membrane test
    Futoshi Higa
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, University of the Ryukyus, Okinawa 903 0215, Japan
    J Microbiol Methods 74:121-2. 2008
    ..The ICT results using respiratory samples agreed well with isolation of L. pneumophila SG1 and ICT using urines...
  15. ncbi request reprint Assessment of serum anti-Bordetella pertussis antibody titers among medical staff members
    Futoshi Higa
    Infection Control Team, Ryukyu University Hospital, Okinawa 903 0215, Japan
    Jpn J Infect Dis 61:371-4. 2008
    ..Prompt and accurate diagnostic tools are crucial for infection control in the hospital setting...
  16. pmc Simplified quantitative assay system for measuring activities of drugs against intracellular Legionella pneumophila
    F Higa
    The First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    J Clin Microbiol 36:1392-8. 1998
    ..Our results indicated that the MTT assay system allows comparative and quantitative evaluations of the intracellular activities of antibiotics and efficient processing of a large number of samples...
  17. ncbi request reprint [Identification of Legionella pneumophila strains by polymerase chain reaction method which isolated from cooling tower water]
    M Koide
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
    Kansenshogaku Zasshi 69:79-84. 1995
    ..Conversely, there were some strains that were positive in mip-primer PCR and negative in LEG-primer simultaneously. Therefore, mip-primers is recommended to detect L. pneumophila in clinical specimens by PCR method...
  18. ncbi request reprint [Serodiagnosis of Legionella pneumonia--data of our laboratory in the recent 3 years]
    Y Yamashiro
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
    Kansenshogaku Zasshi 68:1256-63. 1994
    ..Significant rises (more than four times) of the titer were observed 3 to 4 weeks after onset in most of cases. We would like to emphasize that this should be performed serodiagnosis of Legionella pneumonia...
  19. ncbi request reprint [Usefulness of polymerase chain reaction method in the early diagnosis of Pneumocystis carinii pneumonia]
    T Ishimine
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
    Kansenshogaku Zasshi 68:751-8. 1994
    ..carinii pneumonia...
  20. ncbi request reprint [Mechanism of acquired resistance against Legionella--blastogenic responses of murine spleen lymphoid cells following the stimulation with Legionella antigens]
    F Higa
    First Department of Internal Medicine, School of Medicine, University of the Ryukyus
    Kansenshogaku Zasshi 66:769-75. 1992
    ..pneumophila was small. The epitopes recognized by the cellular immunity might be different in part from those recognized by serum antibodies, and investigations should be made on what the cellular immunity recognizes and how it works...
  21. ncbi request reprint [Study of Legionella pneumophila detection by two step polymerase chain reaction]
    M Koide
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
    Kansenshogaku Zasshi 67:1062-7. 1993
    ..pneumophila, Philadelphia-1 strain. PCR sensitivity by these primers was superior to former primers reported by us using intratracheal aspirates collected from the patient with L. pneumophila serogroup 2 pneumonia...
  22. ncbi request reprint [Evaluation of urinary antigen detection methods for rapid diagnosis of Legionella pneumonia]
    N Arakaki
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyu's
    Kansenshogaku Zasshi 73:421-8. 1999
    ..Its use for the definition of legionellosis should be considered in Japan...
  23. ncbi request reprint Detection of legionella species in clinical samples: Comparison of polymerase chain reaction and urinary antigen detection kits
    M Koide
    Dept of Medicine and Therapeutics, Control and Prevention of Infectious Diseases First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Okinawa 903 0215, Japan
    Infection 34:264-8. 2006
    ..The purpose of the present study is to analyze and evaluate the sensitivity and specificity of three different urinary antigen detection kits as well as PCR...
  24. ncbi request reprint [Detection of Legionella pneumophila using a nested polymerase chain reaction]
    F Higa
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
    Kansenshogaku Zasshi 66:1084-9. 1992
    ..We demonstrated that the Nested PCR method was superior in sensitivity and rapidity for isolation of the bacteria to the conventional using low pH treatment and selective media for Legionella...
  25. ncbi request reprint Comparison of three kinds of commercially available kits for detecting antigen for Legionella in the urine from patients with legionellosis
    Michio Koide
    Department of Internal Medicine, Division of Infectious Diseases, Graduate School and Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa
    Intern Med 44:673-4. 2005
  26. ncbi request reprint [A case report of miliary tuberculosis with acute respiratory failure diagnosed by polymerase chain reaction method]
    N Kohagura
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
    Kansenshogaku Zasshi 68:932-6. 1994
    ..He was extubated after the 13th day and he recovered. It is difficult to separate and identify tubercle bacilli rapidly, but PCR is available for early diagnosis...
  27. ncbi request reprint Comparison of polymerase chain reaction and two urinary antigen detection kits for detecting Legionella in clinical samples
    M Koide
    Department of Internal Medicine, Division of Infectious Diseases, Graduate School and Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, 903 0215 Okinawa, Japan
    Eur J Clin Microbiol Infect Dis 23:221-3. 2004
  28. ncbi request reprint [Clinical and bacteriological features of 12 cases of liver abscess caused by Streptococcus milleri group]
    S Kanamori
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
    Kansenshogaku Zasshi 75:464-8. 2001
    ..SMG was highly isolated from the blood culture in eight of the 11 cases (73%). Liver abscess should be taken into consideration as one of the causes of SMG septicemia...
  29. ncbi request reprint [Effect of biological response modifiers against pulmonary candidiasis in neutropenic mice]
    M Futenma
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
    Kansenshogaku Zasshi 68:513-9. 1994
    ..These results show the possibility that rhG-CSF could be of help for treating human deep candidiasis not successfully treated with antimicrobial agents alone...
  30. ncbi request reprint Mechanism of formation of the orange-colored sputum in pneumonia caused by Legionella pneumophila
    Jiro Fujita
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases The First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa
    Intern Med 46:1931-4. 2007
    ..First, orange-colored sputum obtained from a patient with L. pneumophila pneumonia is presented. Then, the formation of an orange-colored pigment in a culture medium (without charcoal) after the growth of L. pneumophila is demonstrated...
  31. ncbi request reprint [Overview of respiratory infection caused by nontuberculous mycobacteria]
    Jiro Fujita
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    Kekkaku 82:721-7. 2007
    ..In addition, disseminated MAC disease in patients with acquired immunodeficiency syndrome should be considered. Further studies concerning transmission route as well as mechanism of MAC disease should be performed...
  32. ncbi request reprint Comparative evaluation of Duopath Legionella lateral flow assay against the conventional culture method using Legionella pneumophila and Legionella anisa strains
    Michio Koide
    Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Jpn J Infect Dis 60:214-6. 2007
    ..It was realized that the sensitivity of this kit is too low for determining the presence of Legionella in water samples. Although this kit may have excellent specificity, it has low sensitivity...
  33. ncbi request reprint Prospective monitoring study: isolating Legionella pneumophila in a hospital water system located in the obstetrics and gynecology ward after eradication of Legionella anisa and reconstruction of shower units
    Michio Koide
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Faculty of Medicine, Univeristy of the Ryukyus, Okinawa 903 0215, Japan
    Jpn J Infect Dis 60:5-9. 2007
    ..In this prospective study, we identified a central contamination by L. pneumophila serogroup 1 and showed that flushing with hot tap water was effective to counter this situation...
  34. ncbi request reprint Radiological findings of mycobacterial diseases
    Jiro Fujita
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Okinawa 903 0125, Japan
    J Infect Chemother 13:8-17. 2007
    ..Therefore, it is very important to know the characteristic radiological findings of mycobacterial diseases. In the present review, key radiological points for diagnosing mycobacterial diseases are discussed...
  35. ncbi request reprint [Mycobacteriosis as zoonotic disease--comparative pathological study on Mycobacterium avium complex infection]
    Kenji Hibiya
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    Kekkaku 82:539-50. 2007
    ..Since the pathogenesis of human MAC respiratory infection has not been well clarified, it may be very important to examine the mechanism of pig MAC infection to find out some clues to explain the mechanism of human MAC infection...
  36. ncbi request reprint Intravenous ciprofloxacin versus erythromycin in the treatment of Legionella pneumonia
    Shusaku Haranaga
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Intern Med 46:353-7. 2007
    ..In this study, we compared the evolution of patients with Legionella pneumonia treated with CPFX to those treated with EM...
  37. ncbi request reprint [The pathogenesis and the development mechanism of Mycobacterium avium complex infection]
    Kenji Hibiya
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Kekkaku 82:903-18. 2007
    ..In this review, we specifically discuss the development mechanism of disseminated MAC disease in recently-identified several pathological conditions...
  38. ncbi request reprint Accidental alveolo-bronchography caused by lung abscess between the esophagus and trachea
    Jiro Fujita
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa
    Intern Med 47:483. 2008
  39. ncbi request reprint Interferon-gamma reverses the evasion of Birc1e/Naip5 gene mediated murine macrophage immunity by Legionella pneumophila mutant lacking flagellin
    Morikazu Akamine
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    Microbiol Immunol 51:279-87. 2007
    ..These findings suggested that IFN-gamma activated macrophages to restrict the intracellular growth of the L. pneumophila flaA mutant by a NO independent pathway...
  40. doi request reprint Emphysematous pyelonephritis successfully treated by early intervention using a renoureteral catheter
    Hiromitsu Teruya
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0215, Japan
    J Infect Chemother 15:195-8. 2009
    ..This early intervention and the appropriate antimicrobial therapy were effective in resolving the infection. Urinary tract infections should be carefully managed in patients with poorly controlled diabetes mellitus...
  41. ncbi request reprint Isolation of Legionella anisa from multiple sites of a hospital water system: the eradication of Legionellacontamination
    Natsuo Yamamoto
    First Department of Internal Medicine, University of the Ryukyus, Okinawa, Japan
    J Infect Chemother 9:122-5. 2003
    ..This is the first description of the isolation of L. anisa from multiple sites within a hospital, and RAPD analysis suggests that these may be the spread of a single clone...
  42. ncbi request reprint Pulmonary Mycobacterium parascrofulaceum infection as an immune reconstitution inflammatory syndrome in an AIDS patient
    Hiromitsu Teruya
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Intern Med 49:1817-21. 2010
    ..parascrofulaceum infection was not observed. M. parascrofulaceum was isolated from several clinical specimens for the first time in 2004. To date, only five cases have been reported...
  43. ncbi request reprint Trends in antimicrobial susceptibility of the Streptococcus milleri group
    Natsuo Yamamoto
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    J Infect Chemother 8:134-7. 2002
    ..Almost all of the SMG strains were susceptible to fluoroquinolones (except for 1% of the strains nonsusceptible to levofloxacin), and sitafloxacin (DU-6859a) was the most active agent among the 12 tested antibiotics...
  44. doi request reprint Chest CT findings of influenza virus-associated pneumonia in 12 adult patients
    Jiro Fujita
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa, Japan
    Influenza Other Respir Viruses 1:183-7. 2007
    ..In this study, we describe the chest computed tomography findings of influenza virus-associated pneumonia in adult patients...
  45. ncbi request reprint Characteristics of Legionella pneumophila serogroup 2 strains by colony morphology
    Michio Koide
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases First Department of Internal Medicine, University of the Ryukyus, Okinawa, Japan
    Jpn J Infect Dis 61:487-9. 2008
    ..It may be useful to conduct an investigation of this rare serogroup...
  46. ncbi request reprint [A case of pulmonary infection caused by Mycobacterium szulgai]
    Shusaku Haranaga
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Nishihara cho, Nakagami gun, Okinawa 903 0215, Japan
    Kekkaku 77:421-5. 2002
    ..Culture of his sputum and gastric fluid showed no growth of mycobacteria after starting treatment...
  47. doi request reprint Legionella pneumonia caused by Legionella pneumophila serogroup 2: second case report in Japan
    Makoto Furugen
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, 903 0215, Japan
    J Infect Chemother 14:161-5. 2008
    ..This was considered to be the causative organism. In our literature search, this was only the second case of Legionella pneumonia caused by Legionella pneumophila serogroup 2 in Japan...
  48. ncbi request reprint Induction of apoptosis of human macrophages in vitro by Legionella longbeachae through activation of the caspase pathway
    Noriko Arakaki
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    J Med Microbiol 51:159-68. 2002
    ..Furthermore, induction of apoptosis of L. longbeachae-infected macrophages was mediated by activation of the caspase pathway but might be independent of tumour necrosis factor-alpha- and Fas-mediated signal transduction pathways...
  49. ncbi request reprint Alcoholic liver cirrhosis complicated with torsade de pointes during plasma exchange and hemodiafiltration
    H Nakasone
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    J Gastroenterol 36:564-8. 2001
    ..Furthermore, hemodiafiltration may cause hypomagnesemia. Careful observation for electrolytic imbalance is necessary when clinicians treat patients with alcoholic liver failure with a liver support system...
  50. ncbi request reprint [A case of loiasis]
    S Yara
    First Department of Internal Medicine, University of the Ryukyus
    Kansenshogaku Zasshi 75:151-4. 2001
    ..IVM therapy was effective, and decreased the counts of microfilarias in the patient's blood. No adverse effect was seen in this patient. This case suggested that IVM is an useful drug for loiasis, and further study is warranted...
  51. pmc Differential roles of Toll-like receptors 2 and 4 in in vitro responses of macrophages to Legionella pneumophila
    Morikazu Akamine
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Infect Immun 73:352-61. 2005
    ..Our results show that TLR2, but not TLR4, is involved in murine innate immunity against L. pneumophila, although other TLRs may also contribute to innate immunity against this organism...
  52. ncbi request reprint In vitro activity of sitafloxacin against clinical strains of Streptococcus pneumoniae with defined amino acid substitutions in QRDRs of gyrase A and topoisomerase IV
    Masato Touyama
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    J Antimicrob Chemother 58:1279-82. 2006
    ..In vitro activities of sitafloxacin were evaluated against clinical isolates of S. pneumoniae resistant to levofloxacin (MIC of levofloxacin > or = 4 mg/L), which were characterized genetically...
  53. ncbi request reprint Genetic analyses of beta-lactamase negative ampicillin-resistant strains of Haemophilus influenzae isolated in Okinawa, Japan
    Toru Kubota
    First Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Jpn J Infect Dis 59:36-41. 2006
    ....
  54. ncbi request reprint Accumulation of gamma/delta T cells in the lungs and their roles in neutrophil-mediated host defense against pneumococcal infection
    Chikara Nakasone
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Microbes Infect 9:251-8. 2007
    ..Our results demonstrate that Vgamma4(+) gammadelta T cells play an important role in the neutrophil-mediated host defense against S. pneumoniae infection by promoting the synthesis of TNF-alpha and possibly of MIP-2 in the lungs...
  55. ncbi request reprint [Radiological analysis of pathogens which cause respiratory infections]
    Jiro Fujita
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
    Nihon Rinsho 65:225-30. 2007
  56. ncbi request reprint HRCT shows variations in appearance in disseminated tuberculosis in adults
    J Fujita
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Faculty of Medicine, Ryukyus University, Okinawa, Japan
    Int J Tuberc Lung Dis 10:222-6. 2006
    ..To examine patterns of high resolution computed tomography (HRCT) of lungs of adults with disseminated tuberculosis (TB)...
  57. ncbi request reprint [Two cases of pulmonary aspergillosis successfully treated with combinated micafungin and itraconazole therapy]
    Makoto Furugen
    Department of Medicine and Infectious Diseases, Graduate School of Medicine, University of the Ryukyus
    Kansenshogaku Zasshi 79:951-6. 2005
    ..We found that combination micafungin and itraconazole therapy is tolerable and effective in these cases...
  58. ncbi request reprint In vitro activity of sitafloxacin compared with several fluoroquinolones against Streptococcus anginosus and Streptococcus constellatus
    Natsuo Yamamoto
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Okinawa 903 0125, Japan
    Int J Antimicrob Agents 27:171-3. 2006
    ..In conclusion, several fluoroquinolones have low MICs against SMG, but sitafloxacin has the lowest...
  59. ncbi request reprint Active tuberculosis in patients undergoing hemodialysis for end-stage renal disease: a 9-year retrospective analysis in a single center
    Hideta Nakamura
    Department of Medicine and Prevention and Control of Infectious Diseases, University of the Ryukyus, Okinawa
    Intern Med 48:2061-7. 2009
    ..This report was designed to describe this condition and to determine the mortality rate and risk factors associated with mortality. In addition, the study evaluated the usefulness of QuantiFERON TB-2G((R)) (QFT-2G)...
  60. ncbi request reprint Pulmonary strongyloidiasis in a patient receiving prednisolone therapy
    Shun Namisato
    First Department of Internal Medicine, Faculty of Medicine University of the Ryukyus, 207 Uehara, Nishihara cho, Nakagami gun, Okinawa 903 0215
    Intern Med 43:731-6. 2004
    ..stercoralis, pulmonary strongyloidiasis should be considered as part of a differential diagnosis if chest imaging findings like alveolar and interstitial shadow patterns or lobar pneumonia are seen in patients with immunodeficiencies...
  61. ncbi request reprint Lung abscess caused by Legionella species: implication of the immune status of hosts
    Hui Yu
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, China
    Intern Med 48:1997-2002. 2009
    ..Clinical factors like corticosteroid treatment, which causes impaired cellular immunity and subsequent neutrophil accumulation in the lesion, might function as predisposing factors for Legionella abscess...
  62. ncbi request reprint Legionella pneumophila pneumonia successfully treated with intravenous ciprofloxacin
    Shusaku Haranaga
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Nakagami gun, Okinawa
    Intern Med 41:1024-8. 2002
    ..Our findings strongly suggest that intravenous treatment with fluoroquinolones including CPFX should also be a first choice for Legionella pneumonia in Japan...
  63. ncbi request reprint High plasma osteopontin level and its relationship with interleukin-12-mediated type 1 T helper cell response in tuberculosis
    Yoshinobu Koguchi
    First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Am J Respir Crit Care Med 167:1355-9. 2003
    ..Our results suggest that OPN may be involved in the pathologic process associated with active pulmonary tuberculosis by inducing IL-12-mediated type 1 T helper cell responses...
  64. doi request reprint Repetitive element-polymerase chain reaction for genotyping of clinical and environmental isolates of Legionella spp
    Attiya Haroon
    Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Diagn Microbiol Infect Dis 68:7-12. 2010
    ..anisa isolates, while other Legionella spp. were present at discrete levels. Our findings show that rep-PCR is an effective, rapid, and simple technique for differentiation of L. pneumophila strains as well as Legionella spp...
  65. ncbi request reprint Susceptibility of several macrolides and a ketolide against clinically isolated 'Streptococcus milleri' group
    Natsuo Yamamoto
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    Int J Antimicrob Agents 27:253-5. 2006
    ..Of the four macrolides and the ketolide, telithromycin was the most effective antibiotic against the SMG, including the erythromycin-resistant strains...
  66. ncbi request reprint NKT cells play a limited role in the neutrophilic inflammatory responses and host defense to pulmonary infection with Pseudomonas aeruginosa
    Takeshi Kinjo
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Microbes Infect 8:2679-85. 2006
    ..Our data indicate that NKT cells play a limited role in the development of neutrophilic inflammatory responses and host defense to pulmonary infection with P. aeruginosa...
  67. ncbi request reprint Clinical features of two cases of Legionnaires' disease with persistence of Legionella urinary antigen excretion
    Futoshi Higa
    Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Intern Med 47:173-8. 2008
    ..Unusual clinical and radiological findings as well as a review of the literature are presented...
  68. ncbi request reprint 4. Legionella pneumonia: present status in Japan
    Masao Tateyama
    The First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Uehara, Okinawa
    Intern Med 41:60-1. 2002
  69. ncbi request reprint Influence of human T lymphotropic virus type I infection on the etiology of community-acquired pneumonia
    Eriko Atsumi
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa
    Intern Med 48:959-65. 2009
    ..However, the relationship between pulmonary infections and HTLV-I infection is still unclear...
  70. ncbi request reprint Appropriate use of antibiotics and guideline(s) for this purpose. The appropriate use of antimicrobial agents in the treatment of infectious diseases and guidelines future trends, "global standard ?" or "regional standard ?"
    Atsushi Saito
    Division of Infectious Diseases, Department of Internal Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa
    Intern Med 44:382-5. 2005
  71. doi request reprint Inhibition of Akt/GSK3beta signalling pathway by Legionella pneumophila is involved in induction of T-cell apoptosis
    Reika Takamatsu
    Division of Molecular Virology and Oncology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Biochem J 427:57-67. 2010
    ..In conclusion, L. pneumophila induces mitochondria-mediated T-cell apoptosis through inhibition of the Akt/GSK3beta signalling pathway...
  72. ncbi request reprint [A case of loxoprofen-induced pneumonitis pathologically resembling hypersensitivity pneumonitis]
    Masaki Tohyama
    First Department of Internal Medicine, School of Medicine, University of the Ryukyus, Nishihara cho, Uehara 207, Okinawa 903 0215, Japan
    Nihon Kokyuki Gakkai Zasshi 40:123-8. 2002
    ..There was no recurrence of systemic or respiratory symptoms during overnight stays at home. On the basis of these findings, we arrived at a diagnosis of drug-induced pneumonitis caused by loxoprofen...
  73. doi request reprint Nonspecific interstitial pneumonia pattern as pulmonary involvement in human T-cell lymphotropic virus type 1 carriers
    Hui Yu
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara cho, Okinawa 903 0215, Japan
    J Infect Chemother 15:284-7. 2009
    ..The present study demonstrates that the NSIP pattern is a significant pathological classification of interstitial pneumonia associated with HTLV-1 carriers...
  74. ncbi request reprint [Tuberculosis of the tongue initially suspected of tongue cancer: a case report--including the search for recent 16 cases in Japan]
    Makoto Furugen
    Department of Medicine and Infectious Diseases, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    Kekkaku 84:605-10. 2009
    ....
  75. ncbi request reprint Clinical utility of serum beta-D-glucan and KL-6 levels in Pneumocystis jirovecii pneumonia
    Hideta Nakamura
    Department of Medicine and Prevention and Control of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa
    Intern Med 48:195-202. 2009
    ..This study was aimed to evaluate the utility of beta-D-glucan and KL-6 for the diagnosis of PCP in patients with HIV infection (HIV PCP) and non-HIV PCP...
  76. ncbi request reprint [A-DROP system might result in underestimation of severity of cases with Legionnaires' disease]
    Shusaku Haranaga
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Disease First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
    Nihon Kokyuki Gakkai Zasshi 46:351-5. 2008
    ..However all the fatal cases were ranked as severe in the IDSA guidelines. This study suggested that the A-DROP system might underestimate the severity of pneumonia in cases with legionella pneumonia...
  77. ncbi request reprint Necrotizing fasciitis caused by Pseudomonas aeruginosa
    Morikazu Akamine
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, University of the Ryukyus, Okinawa
    Intern Med 47:553-6. 2008
    ..aeruginosa. This is a rare case and its clinical presentation was atypical. The clinical diagnosis of this infection may be difficult, and therefore such cases warrant the careful attention of physicians...
  78. ncbi request reprint Adjuvant effect of CpG-oligodeoxynucleotide in anti-fungal chemotherapy against fatal infection with Cryptococcus neoformans in mice
    Takeshi Kinjo
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Microbiol Immunol 51:741-6. 2007
    ..Cytokine balance in the infected lungs was biased to Th1-type response by CpGODN, while FLCZ did not further promote. These results suggest that CpG-ODN is a promising adjuvant in chemotherapy against this infection...
  79. ncbi request reprint [A case of acute eosinophilic pneumonia that developed after changing cigarette brands]
    Teruhito Uchihara
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus
    Nihon Kokyuki Gakkai Zasshi 45:943-6. 2007
    ..This case suggested that the presence of a filter or a difference in ingredients, or both, between brands of cigarette might contribute to the development of acute eosinophilic pneumonia...
  80. ncbi request reprint Elsberg syndrome with eosinophilic meningoencephalitis caused by Angiostrongylus cantonensis
    Makoto Furugen
    Department of Medicine and Therapeutics, Control and Prevention of Infectious Diseases First Department of Internal Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Intern Med 45:1333-6. 2006
    ..Therefore his case was considered to be Elsberg syndrome with eosinophilic meningoencephalitis caused by A. cantonensis...
  81. ncbi request reprint [Proper use of antibiotics and related guidelines. The future image for the guidelines--global or regional standard?]
    Atsushi Saito
    Nihon Naika Gakkai Zasshi 93:1858-63. 2004
  82. ncbi request reprint [Physiopathology of Mycobacterium avium intracellulare complex pulmonary disease]
    Jiro Fujita
    Nihon Naika Gakkai Zasshi 96:347-52. 2007
  83. ncbi request reprint Low-dose multislice CT and high-resolution CT assessment of pulmonary emphysema in public school teachers
    Noriaki Horiuchi
    Department of Internal Medicine, Health Insurance Naruto Hospital, Tokushima, Japan
    Lung 185:25-30. 2007
    ..The FEV(1)/FVC and FEV(1)% predicted were significantly lower for subjects with PE compared with those for subjects without PE. Our study clearly demonstrated the incidence of emphysematous change in smokers in accordance with age...
  84. pmc lvgA, a novel Legionella pneumophila virulence factor
    Paul H Edelstein
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4283, USA
    Infect Immun 71:2394-403. 2003
    ..lvgA is a novel virulence gene that is responsible for pleiotropic functions involving both extracellular and intracellular bacterial resistance mechanisms...
  85. ncbi request reprint [Pneumocystis jiroveci pneumonia]
    Jiro Fujita
    Nihon Naika Gakkai Zasshi 95:1019-24. 2006
  86. ncbi request reprint [A case of multisystem Langerhans' cell histiocytosis with lung deterioration over 15 years]
    Eriko Atsumi
    First Department of Internal Medicine, Ryukyu University School of Medicine
    Nihon Kokyuki Gakkai Zasshi 44:442-6. 2006
    ..Pulmonary LCH is thought to have a good prognosis, but in recent studies, its survival rate appears low. We report a case of multisystem LCH with lung deterioration over about 15 years...
  87. ncbi request reprint Overwhelming pneumococcal bacteremia revealed by a peripheral blood smear in a 74-year-old healthy woman
    Hideta Nakamura
    Division of Pulmonary Medicine, Urasoe General Hospital, Okinawa
    Intern Med 46:303-6. 2007
    ..We suggest that, in cases of severe septicemia, an examination of a peripheral blood smear is therefore useful for the rapid detection of organisms in comparison to a traditional blood culture...