Kenji Hibi

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint FBN2 methylation is detected in the serum of colorectal cancer patients with hepatic metastasis
    Kenji Hibi
    Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 32:4371-4. 2012
  2. ncbi request reprint Methylation of TFPI2 no longer detected in the serum DNA of colorectal cancer patients after curative surgery
    Kenji Hibi
    Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 32:787-90. 2012
  3. ncbi request reprint Demethylation of the CD133 gene is frequently detected in advanced colorectal cancer
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:2235-7. 2009
  4. ncbi request reprint CD133 gene overexpression is frequently observed in early colorectal carcinoma
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Hepatogastroenterology 56:995-7. 2009
  5. ncbi request reprint Methylation of the TFPI2 gene is frequently detected in advanced gastric carcinoma
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama, Japan
    Anticancer Res 30:4131-3. 2010
  6. ncbi request reprint WNT5A gene is aberrantly methylated from the early stages of colorectal cancers
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Hepatogastroenterology 56:1007-9. 2009
  7. ncbi request reprint Frequent CDH3 demethylation in advanced gastric carcinoma
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:3945-7. 2009
  8. ncbi request reprint Methylation of TFPI2 gene is frequently detected in advanced well-differentiated colorectal cancer
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama, Japan
    Anticancer Res 30:1205-7. 2010
  9. ncbi request reprint Demethylation of the CD133 gene is frequently detected in early gastric carcinoma
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 30:1201-3. 2010
  10. ncbi request reprint MGMT gene is aberrantly methylated from the early stages of colorectal cancers
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Hepatogastroenterology 56:1642-4. 2009

Collaborators

  • Koji Kishimoto
  • A Nakao
  • Y Kodera
  • K Ito
  • Masahiko Koike
  • Genshu Tate
  • Goro Nakayama
  • Takumi Sakakibara
  • Tomohiro Ito
  • Wasaburo Koizumi
  • Toru Sasaki
  • Takashi Yasuda
  • Shin Takeda
  • Masae Tatematsu
  • Seiji Ito
  • Takafumi Ando
  • Hayao Nakanishi
  • Atsushi Shirahata
  • Tetsuhiro Goto
  • Hiroshi Nemoto
  • Gaku Kigawa
  • Mitsuo Saito
  • Kazuma Sakuraba
  • Kazuyoshi Ishibashi
  • Yutaka Sanada
  • Hiroki Mizukami
  • Makiko Sakata
  • Kazuaki Yokomizo
  • Seiji Akiyama
  • Youhei Kitamura
  • Fan Wu
  • Yohei Kitamura
  • Kazuki Shinmura
  • Mitsuru Sakai
  • Yo Hei Kitamura
  • Michitaka Fujiwara
  • Osamu Okochi
  • Hiroshi Nakayama
  • Soichiro Inoue
  • Yuki Morioka
  • Yoshikuni Harada
  • Tetsuya Kaneko
  • Yasushi Kasai
  • Taiji Yamazaki
  • Tomoki Fukuoka
  • Yoshinao Komatsu
  • Tamotsu Inoue
  • Kazuhiro Kijima
  • Taketo Matsubara
  • Tetsuro Nagasaka
  • Takanori Uemura
  • Hirohi Mizukami
  • Tsunenobu Takase
  • Mizunobu Kinoshita
  • Akiharu Ishiyama
  • Jun Kawai
  • Yasuhiro Imamura
  • Tsuyoshi Nishiwaki
  • Masahiko Imazawa
  • Yoshinari Mochizuki
  • Shinichi Fujitake
  • Yasuaki Kanyama
  • Toshiyuki Mitsuya
  • Mitsuo Saitou
  • Takehiro Umemoto
  • Tetsurou Gotou
  • Hitoshi Soda
  • Wu Fan
  • Yasuo Yoshizawa
  • Norifumi Ohashi
  • Yuichi Ito
  • Shingo Kawasaki
  • Sawako Kato
  • Kazuo Kusugami
  • Kenji Ina
  • Naohito Kanazumi
  • Tomoyuki Tsuzuki
  • Ryuichi Furuta
  • Shuji Nomoto
  • Shin ichi Fujitake
  • Hidemi Goto
  • Osamu Watanabe
  • Tomoyuki Kato
  • Katsumi Koshikawa
  • Yoshitaka Yamamura
  • Ekmel Tezel
  • Masumi Taguchi

Detail Information

Publications91

  1. ncbi request reprint FBN2 methylation is detected in the serum of colorectal cancer patients with hepatic metastasis
    Kenji Hibi
    Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 32:4371-4. 2012
    ..For the purpose of colorectal cancer detection, we investigated fibrillin-2 (FBN2) methylation in the serum of colorectal cancer patients using quantitative methylation-specific polymerase chain reaction (qMSP)...
  2. ncbi request reprint Methylation of TFPI2 no longer detected in the serum DNA of colorectal cancer patients after curative surgery
    Kenji Hibi
    Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 32:787-90. 2012
    ..Taken together, our results confirm that detection of methylated TFPI2 in serum DNA was derived from colorectal cancer and could serve as a marker of surgical outcome...
  3. ncbi request reprint Demethylation of the CD133 gene is frequently detected in advanced colorectal cancer
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:2235-7. 2009
    ..Furthermore, it has been reported that CD133 expression is directly regulated by epigenetic modifications. Therefore, it is possible that CD133 expression by gene demethylation is related to colorectal carcinogenesis...
  4. ncbi request reprint CD133 gene overexpression is frequently observed in early colorectal carcinoma
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Hepatogastroenterology 56:995-7. 2009
    ..The present study examined the CD133 gene expression in colorectal carcinomas we surgically removed...
  5. ncbi request reprint Methylation of the TFPI2 gene is frequently detected in advanced gastric carcinoma
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama, Japan
    Anticancer Res 30:4131-3. 2010
    ..Recently, Glockner et al. identified the methylation of TFPI2 as a frequent event in human colorectal cancer using a gene expression array-based strategy...
  6. ncbi request reprint WNT5A gene is aberrantly methylated from the early stages of colorectal cancers
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Hepatogastroenterology 56:1007-9. 2009
    ..Recently, it has been reported that WNT5A methylation was frequently detected in colorectal cancers. However, the relationship between the WNT5A methylation and the characteristics of these cancers remains unknown...
  7. ncbi request reprint Frequent CDH3 demethylation in advanced gastric carcinoma
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:3945-7. 2009
    ..We recently found that CDH3 was frequently demethylated in advanced colorectal carcinomas. This prompted us to examine the demethylation status of the CDH3 gene in gastric carcinomas...
  8. ncbi request reprint Methylation of TFPI2 gene is frequently detected in advanced well-differentiated colorectal cancer
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama, Japan
    Anticancer Res 30:1205-7. 2010
    ..The aim of this study therefore was to examine whether the TFPI2 methylation in surgically removed colorectal cancers was correlated to the clinicopathological features...
  9. ncbi request reprint Demethylation of the CD133 gene is frequently detected in early gastric carcinoma
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 30:1201-3. 2010
    ..Furthermore, it has been reported that CD133 expression is directly regulated by epigenetic modifications. Therefore, it is possible that CD133 expression by gene demethylation is related to colorectal and gastric carcinogenesis...
  10. ncbi request reprint MGMT gene is aberrantly methylated from the early stages of colorectal cancers
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Hepatogastroenterology 56:1642-4. 2009
    ..Recently, Herfarth et al. reported that a subset of colorectal cancers was characterized by a specific methylation pattern in the MGMT promoter associated with reduced MGMT expression...
  11. ncbi request reprint Changes in UNC5C gene methylation during human gastric carcinogenesis
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:4397-9. 2009
    ..Recently, aberrant methylation of the UNC5C gene was found in 34 out of 49 (69%) primary colon carcinomas...
  12. ncbi request reprint Aberrant methylation of the UNC5C gene is frequently detected in advanced colorectal cancer
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:271-3. 2009
    ..Recently, two reports indicated that UNC5C methylation was closely associated with loss of gene expression in colorectal cancer...
  13. ncbi request reprint Highly-methylated colorectal cancers show poorly-differentiated phenotype
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 26:4263-6. 2006
    ..0041) was observed when the number of methylated genes of poorly-differentiated colorectal cancers was compared to that of other differentiated ones. Poorly-differentiated colorectal cancers preferentially exhibited gene methylation...
  14. doi request reprint Aberrant methylation of the netrin-1 receptor genes UNC5C and DCC detected in advanced colorectal cancer
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    World J Surg 33:1053-7. 2009
    ..These results prompted us to examine the methylation status of the UNC5C and DCC genes in the colorectal carcinomas we surgically removed...
  15. ncbi request reprint Mucinous cystadenoma of the appendix associated with muscular and neuromatous hyperplasia: report of a case
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, Yokohama 227 8501, Japan
    Nagoya J Med Sci 70:35-40. 2008
    ..In this study, we presented for the first time a mucinous cystadenoma of the appendix associated with muscular and neuromatous hyperplasia...
  16. ncbi request reprint Aberrant methylation of the HACE1 gene is frequently detected in advanced colorectal cancer
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 28:1581-4. 2008
    ..It has been recently reported that HACE1, the E3 ubiquitin ligase, is epigenetically inactivated in human Wilms' tumors and HACE1 expression was also down-regulated in colon carcinomas...
  17. ncbi request reprint Methylation of the DCC gene is lost in advanced gastric cancer
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 30:107-9. 2010
    ..This result prompted us to examine the methylation status of the DCC gene in gastric carcinoma...
  18. ncbi request reprint Detection of TFPI2 methylation in the serum of gastric cancer patients
    Kenji Hibi
    Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 31:3835-8. 2011
    ....
  19. ncbi request reprint Methylation of OSMR gene is frequently observed in non-invasive colorectal cancer
    Kenji Hibi
    Showa University Fujigaoka Hospital, Aoba ku, Yokohama, Japan
    Anticancer Res 31:1293-5. 2011
    ..We examined the methylation status of the OSMR gene in primary carcinomas and the corresponding normal tissues derived from 56 patients with colorectal cancer...
  20. ncbi request reprint Demethylation of the CDH3 gene is frequently detected in advanced colorectal cancer
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:2215-7. 2009
    ..These results indicated that epigenetic demethylation of the CDH3 promoter in the human intestine permits its ectopic expression in colorectal cancer...
  21. ncbi request reprint Methylation of the MGMT gene is frequently detected in advanced gastric carcinoma
    Kenji Hibi
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:5053-5. 2009
    ..Recently, Herfarth et al. reported that a subset of colorectal tumors was characterized by a specific methylation pattern in the MGMT promoter associated with reduced MGMT expression...
  22. ncbi request reprint Frequent methylation of Vimentin in well-differentiated gastric carcinoma
    Yo Hei Kitamura
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:2227-9. 2009
    ..Recently, it was shown that the vimentin gene, usually activated in mesenchymal cells, was highly methylated in colorectal carcinoma...
  23. ncbi request reprint Methylation of HACE1 in gastric carcinoma
    Makiko Sakata
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:2231-3. 2009
    ..0612), suggesting that HACE1 might present a malignant potential in colorectal cancer. These results prompted us to examine the methylation status of the HACE1 gene in gastric carcinomas...
  24. ncbi request reprint MACC1 as a marker for advanced colorectal carcinoma
    Atsushi Shirahata
    Department of Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 30:2689-92. 2010
    ..Recently, Stein et al. identified the metastasis-associated in colon cancer 1 (MACC1) gene by genome-wide search for differentially expressed genes in human colon cancer tissues and metastases...
  25. ncbi request reprint MACC 1 as a marker for peritoneal-disseminated gastric carcinoma
    Atsushi Shirahata
    Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 30:3441-4. 2010
    ..Previously, the MACC1 expression levels were examined in colorectal carcinomas and it was found that MACC1 expression showed significant correlation with peritoneal dissemination and higher stage of TNM classification...
  26. doi request reprint Methylation of the WNT5A gene is frequently detected in early gastric carcinoma
    Kenji Hibi
    Showa University, Yokohama, Japan
    Hepatogastroenterology 59:2661-3. 2012
    ..Recently, it has been reported that WNT5A methylation was frequently detected in colorectal cancers. However, the relationship between the WNT5A methylation and the characteristics of gastric cancer remains unknown...
  27. doi request reprint Methylation of the UNC5C gene is frequently detected in hepatocellular carcinoma
    Kenji Hibi
    Showa University, Yokohama, Japan
    Hepatogastroenterology 59:2573-5. 2012
    ..Recently, we detected that UNC5C expression was downregulated in colon and gastric cancer...
  28. ncbi request reprint Methylation of the p16 gene is frequently detected in lymphatic-invasive gastric cancer
    Tetsuhiro Goto
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 30:2701-3. 2010
    ..A tumor suppressor gene, p16, was found to harbor promoter methylation associated with the loss of protein expression in cancer cells, suggesting that p16 inactivation due to promoter methylation may be important for gastric tumorigenesis...
  29. ncbi request reprint Detection of p16 promoter hypermethylation in serum of gastric cancer patients
    Yasuaki Kanyama
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    Cancer Sci 94:418-20. 2003
    ..No methylation was found in serum DNA of these control groups. Our results suggest that p16 methylation would be a good marker for the detection of tumor DNA in the serum of primary gastric cancer patients...
  30. ncbi request reprint S100A2 overexpression is frequently observed in esophageal squamous cell carcinoma
    Masahiko Imazawa
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Anticancer Res 25:1247-50. 2005
    ..We identified S100A2, a Ca2+-binding protein, as a novel downstream mediator of deltaNp63...
  31. ncbi request reprint TIP60 as a potential marker for the malignancy of gastric cancer
    Kazuma Sakuraba
    Department of Gastroenterological Surgery, Showa University Fujigaoka Hospital, Yokohama, Japan
    Anticancer Res 31:77-9. 2011
    ..Recently, it has been shown that the loss of the human histone acetyl transferase, TIP60, led to an accumulation of double-strand DNA breaks and has been linked to a growing number of cancer types...
  32. ncbi request reprint Aberrant methylation of the p16 gene is frequently detected in advanced colorectal cancer
    Tetsuhiro Goto
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:275-7. 2009
    ....
  33. ncbi request reprint Aberrant methylation is frequently observed in advanced esophageal squamous cell carcinoma
    Tomoki Fukuoka
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Anticancer Res 26:3333-5. 2006
    ..ESCC with methylation-positive genes showed a trend towards larger tumor size and deeper invasion (p = 0.139 and p = 0.0664, respectively). Thus, the methylation of the p16, HLTF and CDH13 genes is a high malignancy factor in ESCC...
  34. ncbi request reprint Vimentin methylation as a marker for advanced colorectal carcinoma
    Atsushi Shirahata
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:279-81. 2009
    ..Moreover, Vimentin methylation can be applied for the screening or as a diagnostic tool of colorectal carcinomas in the fecal DNA test...
  35. doi request reprint Methylation of the HACE1 gene is frequently detected in hepatocellular carcinoma
    Makiko Sakata
    Department of Surgery, Showa University Fujigaoka Hospital, Yokohama, Japan
    Hepatogastroenterology 60:781-3. 2013
    ..Recently, it has been reported that HACE1, the E3 ubiquitin ligase, is epigenetically inactivated in human Wilms' tumors and HACE 1 expression was also down-regulated in colorectal and gastric carcinomas...
  36. ncbi request reprint Expression levels of thymidylate synthase, dihydropyrimidine dehydrogenase, and thymidine phosphorylase in patients with colorectal cancer
    Tetsuhiro Goto
    Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 32:1757-62. 2012
    ..Predictors of the response of colorectal cancer to chemotherapy remain poorly understood. We analyzed the mRNA expression levels of enzymes related to sensitivity to 5-fluorouracil derivatives in patients with colorectal cancer...
  37. ncbi request reprint Aberrant methylation of the CHFR gene is frequently detected in non-invasive colorectal cancer
    Yuki Morioka
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    Anticancer Res 26:4267-70. 2006
    ..In order to define the role of CHFR in the tumorigenic pathway of the colorectum, the methylation of CHFR was examined in tumors from colorectal cancer patients...
  38. ncbi request reprint Aberrant methylation of the Vimentin gene in hepatocellular carcinoma
    Yohei Kitamura
    Gastroenterological Surgery, Showa University Fujigaoka Hospital, Yokohama, Japan
    Anticancer Res 31:1289-91. 2011
    ..Recently, it was shown that the Vimentin gene, usually activated in mesenchymal cells, was highly methylated in colorectal carcinoma...
  39. ncbi request reprint PGP9.5 was less frequently methylated in advanced gastric carcinoma
    Hirohi Mizukami
    Department of Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama 227 8501, Japan
    Hepatogastroenterology 56:1576-9. 2009
    ..029), suggesting that PGP9.5 was less frequently methylated in metastatic colorectal cancer. This result prompted us to examine the methylation status of the PGP9.5 gene in gastric cancers...
  40. ncbi request reprint Plasminogen activator inhibitor-1 is a downstream mediator of the PGP9.5-related oncogenic pathway in esophageal squamous cell carcinoma
    Kenji Hibi
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Anticancer Res 24:3731-4. 2004
    ..To examine the PGP9.5-related oncogenic pathway, we tested for global patterns of gene expression in cancer cells following PGP9.5 gene introduction using an oligonucleotide microarray approach...
  41. ncbi request reprint Aberrant methylation of the CHFR gene in digestive tract cancer
    Yuki Morioka
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Anticancer Res 26:1791-5. 2006
    ..Recently, aberrant methylation of the CHFR gene associated with gene silencing has been reported in several cancers. The methylation status of the CHFR gene was examined in primary esophageal and gastric carcinomas...
  42. ncbi request reprint PGP9.5 methylation as a marker for metastatic colorectal cancer
    Hiroki Mizukami
    Department of Surgery, Showa University Fujigaoka Hospital, Yokohama 227 8501, Japan
    Anticancer Res 28:2697-700. 2008
    ..5 expression is related to tumor progression and may be useful as a marker for invasive colorectal cancer. These results prompted us to examine the methylation status of the PGP9.5 gene in colorectal cancer...
  43. ncbi request reprint Plasminogen activator inhibitor-1 as a potential marker for the malignancy of gastric cancer
    Takumi Sakakibara
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Cancer Sci 97:395-9. 2006
    ..0450). These results suggested that PAI-1 might serve as a new and promising parameter for the prediction of prognosis in gastric cancer...
  44. ncbi request reprint P16 methylation in serum as a potential marker for the malignancy of colorectal carcinoma
    Goro Nakayama
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Anticancer Res 27:3367-70. 2007
    ....
  45. ncbi request reprint Detection of vimentin (VIM) methylation in the serum of colorectal cancer patients
    Atsushi Shirahata
    Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 30:5015-8. 2010
    ..Detection of colorectal cancer using serum assay of vimentin methylation...
  46. ncbi request reprint MACC 1 as a marker for vascular invasive hepatocellular carcinoma
    Atsushi Shirahata
    Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 31:777-80. 2011
    ..Previously, MACC1 expression was examined in colorectal carcinomas and gastric carcinomas and was found to show significant correlation with peritoneal dissemination...
  47. ncbi request reprint Methylation of the DFNA5 gene is frequently detected in colorectal cancer
    Kazuaki Yokomizo
    Gastroenterological Surgery, Showa University Fujigaoka Hospital, Aoba ku, Yokohama, Japan
    Anticancer Res 32:1319-22. 2012
    ..Recently, the human deafness, autosomal dominant 5 gene, DFNA5, has frequently been detected in cancer tissues. The methylation status of the DFNA5 gene in colorectal cancer was examined and was compared to the clinocopathological findings...
  48. ncbi request reprint Methylation of the homeobox gene, HOPX, is frequently detected in poorly differentiated colorectal cancer
    Yoshikuni Harada
    Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 31:2889-92. 2011
    ..Homeodomein only protein x (HOPX) gene methylation has frequently been detected in cancer tissues. The methylation status of the HOPX gene in colorectal cancer was examined and compared to the clinocopathological findings...
  49. ncbi request reprint Detection of vimentin methylation in the serum of patients with gastric cancer
    Atsushi Shirahata
    Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 32:791-4. 2012
    ..Detection of gastric cancer using serum assay of vimentin methylation...
  50. doi request reprint Detection of TFPI2 methylation in the serum of colorectal cancer patients
    Kenji Hibi
    Gastroenterological Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Cancer Lett 311:96-100. 2011
    ..In principle, the methylation status of a primary tumor is not required in advance to detect circulating tumor DNA, suggesting the potential of qMSP as a cancer screening method...
  51. ncbi request reprint A highly sensitive method for the detection of p16 methylation in the serum of colorectal cancer patients
    Goro Nakayama
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    Anticancer Res 27:1459-63. 2007
    ..An attempt to increase the sensitivity of this assay is reported for colorectal cancer...
  52. ncbi request reprint TAOS1, a novel marker for advanced esophageal squamous cell carcinoma
    Yoshinao Komatsu
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Anticancer Res 26:2029-32. 2006
    ..TAOS1 (tumor amplified and overexpressed sequence 1) was recently cloned and found to be possibly important in driving the amplification of 11q13 in oral squamous cell carcinoma (SCC)...
  53. ncbi request reprint Aberrant methylation of HLTF, SOCS-1, and CDH13 genes is shown in colorectal cancers without lymph node metastasis
    Kenji Hibi
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Dis Colon Rectum 48:1282-6. 2005
    ....
  54. doi request reprint Heterozygous loss of NF2 is an early molecular alteration in well-differentiated papillary mesothelioma of the peritoneum
    Hiroshi Nemoto
    Department of Surgery, Showa University Fujigaoka Hospital, Yokohama, Japan
    Cancer Genet 205:594-8. 2012
    ....
  55. ncbi request reprint RUNX3 promoter region is specifically methylated in poorly-differentiated colorectal cancer
    Yasuhiro Imamura
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Anticancer Res 25:2627-30. 2005
    ..In this study, we investigated the methylation status of the RUNX3 gene in 92 resected primary colorectal cancers using methylation-specific PCR (MSP) and correlated the results with the clinicopathological features of affected patients...
  56. ncbi request reprint Down-regulation of Tip60 gene as a potential marker for the malignancy of colorectal cancer
    Kazuma Sakuraba
    Department of Surgery, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama 227 8501, Japan
    Anticancer Res 29:3953-5. 2009
    ..Recently, it was shown that the loss of human Tip60 leads to an accumulation of double-strand DNA breaks and is linked to a growing number of cancer types...
  57. ncbi request reprint PTCH gene expression as a potential marker for esophageal squamous cell carcinoma
    Akiharu Ishiyama
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Anticancer Res 26:195-8. 2006
    ..The PTCH expression level in esophageal squamous cell carcinoma (SCC) was examined...
  58. ncbi request reprint [Complete response to S-1/CDDP combination in a patient with obstructive jaundice secondary to lymph node metastasis by gastric cancer - a case report]
    Tetsuhiro Goto
    Dept of Gastroenterological Surgery, Showa University Fujigaoka Hospital, Japan
    Gan To Kagaku Ryoho 38:1197-200. 2011
    ..We report this case in which improvement of activity of daily living (ADL) was achieved relatively safely by treatment with S-1/CDDP, together with a brief discussion based on the literature...
  59. ncbi request reprint Molecular detection of p16 promoter methylation in the serum of recurrent colorectal cancer patients
    Hiroshi Nakayama
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya, Japan
    Int J Cancer 105:491-3. 2003
    ..These results suggested that MSP might be a sensitive and useful method to detect recurrent colorectal cancer in serum...
  60. ncbi request reprint Plasminogen activator inhibitor-1 as a potential marker for the malignancy of esophageal squamous cell carcinoma
    Takumi Sakakibara
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Clin Cancer Res 10:1375-8. 2004
    ....
  61. ncbi request reprint Lymph node metastasis is infrequent in patients with highly-methylated colorectal cancer
    Kenji Hibi
    Department of Surgery, Seirei Hospital, 56 Kawanayama machi, Showa Ku, Nagoya 466 8633, Japan
    Anticancer Res 26:55-8. 2006
    ..There was also a significant gender difference (p = 0.0248) when the methylation status was compared. Colorectal cancer without lymph node metastasis frequently exhibited aberrant methylation of the p16, p14, HLTF, CDH13 and RUNX3 genes...
  62. ncbi request reprint Expression level of thymidylate synthase is a good predictor of chemosensitivity to 5-fluorouracil in colorectal cancer
    Tamotsu Inoue
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8560, Japan
    J Gastroenterol 40:143-7. 2005
    ..To avoid unnecessary medication and uncomfortable side effects, it is important to estimate the chemosensitivity of cancers to 5-fluorouracil (5-FU) before chemotherapy...
  63. ncbi request reprint Identification of S100A2 as a target of the DeltaNp63 oncogenic pathway
    Kenji Hibi
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8560, Japan
    Clin Cancer Res 9:4282-5. 2003
    ..To gain additional insight into this pathway, we examined global patterns of gene expression in cancer cells after DeltaNp63 gene introduction using the oligonucleotide microarray approach...
  64. ncbi request reprint A new method of thermo-chemotherapy using a stent for patients with esophageal cancer
    Seiji Akiyama
    Department of Surgery, Ichinomiya Municipal Hospital, 2 2 22 Bunkyo, Ichinomiya, Aichi 491 8558, Japan
    Surg Today 36:19-24. 2006
    ..To our knowledge, there are no other reports of thermotherapy using metallic stents. We report our clinical results of treating patients with this new technique...
  65. pmc Strangulation caused by a small bowel epiploic appendage: report of a case
    Hiroshi Nemoto
    Department of Surgery, Showa University Fujigaoka Hospital, Yokohama, Japan
    Case Rep Gastroenterol 2:214-8. 2008
    ..This band was released, and approximately 80 cm of gangrenous bowel was resected. Four epiploic appendages 5-6 cm in length were attached to the ileum at the mesenteric border, beginning at a point 70 cm proximal to the terminal ileum...
  66. ncbi request reprint Down-regulation of Mus81 as a potential marker for the malignancy of gastric cancer
    Fan Wu
    Department of General Surgery, Guangzhou Red Cross Hospital, Fourth Affiliated Hospital of Jinan University, Guangzhou, China
    Anticancer Res 30:5011-4. 2010
    ..The Mus81 gene encodes a critical endonuclease involved in DNA repair and tumor suppression. In the present study, the role of Mus81 in gastric cancer was explored...
  67. ncbi request reprint Down-regulation of EGFL8: a novel biomarker for advanced gastric cancer
    Fan Wu
    Department of General Surgery, Guangzhou Red Cross Hospital Fourth Affiliated Hospital of Jinan University, Guangzhou, China
    Anticancer Res 31:3377-80. 2011
    ..However, the function of EGFL8 in the other human gastroenterological malignancies such as gastric cancer remains largely unknown...
  68. ncbi request reprint Down-regulation of EGFL8: a novel prognostic biomarker for patients with colorectal cancer
    Fan Wu
    Department of General Surgery, Guangzhou Red Cross Hospital, Jinan University, Guangzhou, PR China
    Anticancer Res 31:2249-54. 2011
    ..However, the role of EGFL8, the only known paralog of EGFL7, in human malignancies is currently unclear...
  69. ncbi request reprint Methylation pattern of HLTF gene in digestive tract cancers
    Kenji Hibi
    Gastroenterological Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Int J Cancer 104:433-6. 2003
    ..These results suggested that HLTF might play a variety of roles depending on the tissue type and could be inactivated at an early stage in the tumorigenic pathway...
  70. ncbi request reprint PAI-1 expression levels in gastric cancers are closely correlated to those in corresponding normal tissues
    Takumi Sakakibara
    Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tusrumai cho, Showa Ku, Nagoya 466 8560, Japan
    Hepatogastroenterology 55:1480-3. 2008
    ..To investigate the mechanism of PAI-1 overexpression in gastric cancers, the PAI-1 expression levels in gastric cancers were compared to those in the corresponding normal tissues...
  71. ncbi request reprint Detection of K-ras mutations in the plasma DNA of pancreatic cancer patients
    Takanori Uemura
    Gastroenterological Surgery, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Gastroenterol 39:56-60. 2004
    ..To diagnose pancreatic cancer correctly at an early stage, we attempted to detect tumor DNA in the plasma of pancreatic cancer patients using a more sensitive and specific method...
  72. doi request reprint Allelic loss of the PTEN gene and mutation of the TP53 gene in choriocarcinoma arising from gastric adenocarcinoma: analysis of loss of heterozygosity in two male patients with extragonadal choriocarcinoma
    Genshu Tate
    Department of Pathology, Showa University Fujigaoka Hospital, Fujigaoka 1 30, Aoba ku, Yokohama 227 8501, Japan
    Cancer Genet Cytogenet 193:104-8. 2009
    ..In addition, it was found that expression of PTEN is significantly decreased in the nuclei of syncytiotrophoblast-like cancer cells, compared with those of cytotrophoblast-like cancer cells in choriocarcinoma...
  73. ncbi request reprint TNF-alpha promotes progression of peritoneal metastasis as demonstrated using a green fluorescence protein (GFP)-tagged human gastric cancer cell line
    Yoshinari Mochizuki
    Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Clin Exp Metastasis 21:39-47. 2004
    ....
  74. doi request reprint Downregulation of Mus81 as a novel prognostic biomarker for patients with colorectal carcinoma
    Fan Wu
    Department of General Surgery, Guangzhou Red Cross Hospital Fourth Affiliated Hospital of Jinan University, Guangzhou, China
    Cancer Sci 102:472-7. 2011
    ..678; P = 0.040). In conclusion, the reduced expression of Mus81 is closely related to hepatic metastasis and poor prognosis of colorectal carcinoma, indicating Mus81 as a novel prognostic marker for colorectal carcinoma...
  75. ncbi request reprint Prolonged cytostatic tumor dormancy induced by serial exchange of chemotherapy in colorectal carcinoma
    Katsuki Ito
    Department of Gastroenterological Surgery, Nagoya University School of Medicine, Japan
    Nagoya J Med Sci 67:9-15. 2004
    ..To improve quality of life cytostatic effect of serially changed chemotherapy was investigated...
  76. ncbi request reprint Colorectal cancers with both p16 and p14 methylation show invasive characteristics
    Kenji Hibi
    Second Department of Surgery, Nagoya University School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Jpn J Cancer Res 93:883-7. 2002
    ..Inactivation of both p16 and p14 genes may result in a malignant change in colorectal cancer cells, leading to advanced cancers with a smaller size than those with p16 or p14 activity...
  77. ncbi request reprint Molecular detection of p16 promoter methylation in the serum of colorectal cancer patients
    Hiroshi Nakayama
    Second Department of Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550, Nagoya, Japan
    Cancer Lett 188:115-9. 2002
    ..Moreover, abnormal methylation was found in the serum of patients in all clinical stages, suggesting that early colorectal cancer could be detected using the MSP method...
  78. ncbi request reprint Detection of mitochondrial DNA alterations in the serum of hepatocellular carcinoma patients
    Osamu Okochi
    Second Department of Surgery, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Clin Cancer Res 8:2875-8. 2002
    ..These mutations could possibly be detected in serum because mtDNA has a higher copy number than nuclear DNA. Thus, we examined genetic alterations in the D-loop region of mtDNA in hepatocellular carcinoma (HCC) patients...
  79. ncbi request reprint Aberrant methylation of the CHFR gene in advanced hepatocellular carcinoma
    Mitsuru Sakai
    Department of Surgery II, Graduate School of Medicine, Nagoya University, Japan
    Hepatogastroenterology 52:1854-7. 2005
    ..We examined the methylation status of the CHFR gene in primary hepatocellular carcinomas (HCCs) and evaluated the correlation between the methylation status and the malignancy of HCC...
  80. ncbi request reprint Gene expression profile of 5-fluorouracil metabolic enzymes in primary colorectal cancer: potential as predictive parameters for response to fluorouracil-based chemotherapy
    Mizunobu Kinoshita
    Department of Surgery II, Nagoya University Graduate School of Medicine, 65, Tsurumai cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Anticancer Res 27:851-6. 2007
    ..Therapy guided by chemotherapy sensitivity and resistance assays may lead to rational treatment decisions...
  81. ncbi request reprint Telomerase activity as prognostic factor in gastrointestinal stromal tumors of the stomach
    Jun Kawai
    Department of Surgery II, Nagoya University Graduate School of Medicine, Nagoya University Hospital, Nagoya, Japan
    Hepatogastroenterology 52:959-64. 2005
    ..Telomerase activity, often detected in malignant tumors, may have a role as a marker for high-grade malignancy...
  82. ncbi request reprint PGP9.5 as a marker for invasive colorectal cancer
    Taiji Yamazaki
    Second Department of Surgery, Japan
    Clin Cancer Res 8:192-5. 2002
    ..In this study, we examined the expression of PGP9.5 in primary colorectal cancers using immunohistochemistry and correlated the result with the clinicopathological features...
  83. ncbi request reprint A cancer-prone case with a background of methylation of p16 tumor suppressor gene
    Kenji Hibi
    Second Department of Surgery, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Clin Cancer Res 9:1053-6. 2003
    ..In this study, we tested for the methylation status of p16 promoter in normal tissue specimens using the methylation-specific PCR technique to examine whether p16 methylation already existed in the background of tumors...
  84. ncbi request reprint Possible involvement of the interleukin-15 and interleukin-15 receptor system in a heightened state of lamina propria B cell activation and differentiation in patients with inflammatory bowel disease
    Tsuyoshi Nishiwaki
    Department of Therapeutic Medicine, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, 466 8550, Japan
    J Gastroenterol 40:128-36. 2005
    ..We investigated the possible roles of the interleukin (IL)-15 and IL-15 receptor (IL-15R) system in a heightened state of B-cell activation and differentiation in intestinal mucosa with inflammatory bowel disease (IBD)...
  85. ncbi request reprint Methylation-mediated silencing of SOCS-1 gene in hepatocellular carcinoma derived from cirrhosis
    Osamu Okochi
    Second Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan
    Clin Cancer Res 9:5295-8. 2003
    ..Recently, it was demonstrated that SOCS-1 gene was silenced frequently by methylation of CpG island in human hepatocellular carcinoma (HCC). We examined the methylation-mediated silencing of SOCS-1 in tumors of HCC patients...
  86. ncbi request reprint [Molecular detection of tumor DNA in the serum of colorectal cancer patients]
    Kenji Hibi
    Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine
    Nihon Rinsho 61:197-200. 2003
  87. ncbi request reprint Aberrant methylation of SOCS-1 was observed in younger colorectal cancer patients
    Shinichi Fujitake
    Gastrointestinal Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Gastroenterol 39:120-4. 2004
    ..To define the role of SOCS-1 in the tumorigenic pathway of the colorectum, we examined the methylation of SOCS-1 in tumors of colorectal cancer patients...
  88. ncbi request reprint Frequent promoter methylation and gene silencing of CDH13 in pancreatic cancer
    Mitsuru Sakai
    Department of Surgery II, Nagoya University School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    Cancer Sci 95:588-91. 2004
    ..Our results suggest that the aberrant methylation of CDH13 occurs frequently in pancreatic cancer, even at a relatively early stage...
  89. ncbi request reprint [Genetic changes in colorectal cancer]
    Kenji Hibi
    Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine
    Nihon Rinsho 61:77-80. 2003
  90. ncbi request reprint [Colorectal cancers with both p16 and p14 methylation showing invasive characteristics]
    Kenji Hibi
    Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine
    Nihon Rinsho 61:225-8. 2003
  91. ncbi request reprint Detection of tumor DNA in serum of colorectal cancer patients
    Seiji Ito
    Second Department of Surgery, Nagoya University School of Medicine, Showa Ku, Nagoya 466 8550, Japan
    Jpn J Cancer Res 93:1266-9. 2002
    ..K-ras mutation was found even in serum DNA of patients with Dukes A cancer, suggesting that colorectal cancer might be detected even in patients without symptoms by using this ligation assay...