Ichiro Hayakawa

Summary

Affiliation: University of Tsukuba
Country: Japan

Publications

  1. doi request reprint Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone
    Ichiro Hayakawa
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305 8571, Japan
    Bioorg Med Chem 20:5745-56. 2012
  2. doi request reprint Total synthesis and cytotoxicity of haterumalides NA and B and their artificial analogues
    Mitsuru Ueda
    Department of Chemistry, Graduate School of Pure and Applied Sciences, and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki 305 8571, Japan
    J Org Chem 74:3370-7. 2009
  3. doi request reprint Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound
    Kenichi Kobayashi
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305 8571, Japan
    Org Lett 14:1290-3. 2012
  4. doi request reprint Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells
    Akiyuki Ikedo
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305 8571, Japan
    Bioorg Med Chem Lett 20:5402-4. 2010
  5. doi request reprint Total synthesis of (-)-13-oxyingenol and its natural derivative
    Takayuki Ohyoshi
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Japan
    Angew Chem Int Ed Engl 51:4972-5. 2012
  6. doi request reprint Toward the second generation synthesis of aplyronine A: stereocontrolled assembly of the C1-C19 segment by using an asymmetric Nozaki-Hiyama-Kishi coupling
    Kenichi Kobayashi
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Ibaraki, Japan
    Org Lett 13:900-3. 2011
  7. doi request reprint Glaziovianin A Prevents Endosome Maturation via Inhibiting Microtubule Dynamics
    Takumi Chinen
    Faculty of Life and Environmental Sciences, University of Tsukuba, Tennodai, Tsukuba 305 8572, Japan
    ACS Chem Biol 8:884-9. 2013
  8. ncbi request reprint Marine cytotoxic macrolides haterumalides and biselides, and related natural products
    Hideo Kigoshi
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305 8571, Japan
    Chem Rec 7:254-64. 2007
  9. doi request reprint Second-generation total synthesis of haterumalide NA using B-alkyl Suzuki-Miyaura coupling
    Ichiro Hayakawa
    Department of Chemistry, Graduate School of Pure and Applied Sciences, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan
    Org Lett 10:1859-62. 2008
  10. doi request reprint Synthetic studies toward 13-oxyingenol: construction of the fully substituted tetracyclic compound
    Takayuki Ohyoshi
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305 8571, Japan
    Org Lett 13:2160-3. 2011

Collaborators

  • Hideo Kigoshi
  • Takeo Usui
  • Hiroyuki Osada
  • Akihito Yokosuka
  • Naoko Imamoto
  • Kenichi Kobayashi
  • Takayuki Ohyoshi
  • Akiyuki Ikedo
  • Takumi Chinen
  • Sayaka Kazami
  • Yamato Miyazawa
  • Yusuke Fujii
  • Mitsuru Ueda
  • Yoshihiro Mimaki
  • Masatoshi Takagi
  • Yoko Nagumo
  • Keisuke Niida
  • Shota Funakubo
  • Shinichi Kobayashi
  • Yuichiro Hirayama
  • Kenta Aoki
  • Satomi Ohmura
  • Yuki Asuma
  • Yoichi Ikeda
  • Yuta Suzuki
  • Masashi Yamaura
  • Kensaku Yoshizato

Detail Information

Publications10

  1. doi request reprint Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone
    Ichiro Hayakawa
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305 8571, Japan
    Bioorg Med Chem 20:5745-56. 2012
    ..Furthermore, O(7)-modified molecular probes of glaziovianin A were synthesized for biological studies...
  2. doi request reprint Total synthesis and cytotoxicity of haterumalides NA and B and their artificial analogues
    Mitsuru Ueda
    Department of Chemistry, Graduate School of Pure and Applied Sciences, and Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki 305 8571, Japan
    J Org Chem 74:3370-7. 2009
    ..Furthermore, the structure-cytotoxicity relationships of haterumalides were investigated. The combination of macrolide and side chain parts proved to be important to the cytotoxicity...
  3. doi request reprint Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound
    Kenichi Kobayashi
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305 8571, Japan
    Org Lett 14:1290-3. 2012
    ..In contrast, the hybrid compound possessed about 1000-fold less cytotoxicity than aplyronine A. These results indicated that there is no direct correlation between actin-depolymerizing activity and cytotoxicity...
  4. doi request reprint Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells
    Akiyuki Ikedo
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305 8571, Japan
    Bioorg Med Chem Lett 20:5402-4. 2010
    ..Compared to glaziovianin A, the O7-allyl derivative was found to be more cytotoxic against HeLa S3 cells and a more potent M-phase inhibitor...
  5. doi request reprint Total synthesis of (-)-13-oxyingenol and its natural derivative
    Takayuki Ohyoshi
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Japan
    Angew Chem Int Ed Engl 51:4972-5. 2012
    ..This synthesis provides access to (-)-13-oxyingenol and its natural derivative in 21 steps from a synthetic intermediate previously prepared by Kigoshi and co-workers...
  6. doi request reprint Toward the second generation synthesis of aplyronine A: stereocontrolled assembly of the C1-C19 segment by using an asymmetric Nozaki-Hiyama-Kishi coupling
    Kenichi Kobayashi
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Ibaraki, Japan
    Org Lett 13:900-3. 2011
    ..An efficient synthesis of the C1-C19 segment of aplyronine A is described. Stereoselective construction of the C14-C15 (E)-trisubstituted double bond and the C13 stereocenter was achieved by using an asymmetric Nozaki-Hiyama-Kishi coupling...
  7. doi request reprint Glaziovianin A Prevents Endosome Maturation via Inhibiting Microtubule Dynamics
    Takumi Chinen
    Faculty of Life and Environmental Sciences, University of Tsukuba, Tennodai, Tsukuba 305 8572, Japan
    ACS Chem Biol 8:884-9. 2013
    ....
  8. ncbi request reprint Marine cytotoxic macrolides haterumalides and biselides, and related natural products
    Hideo Kigoshi
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305 8571, Japan
    Chem Rec 7:254-64. 2007
    ..This review highlights the isolation, structures, bioactivities, and total synthesis of haterumalides, biselides, and related natural products...
  9. doi request reprint Second-generation total synthesis of haterumalide NA using B-alkyl Suzuki-Miyaura coupling
    Ichiro Hayakawa
    Department of Chemistry, Graduate School of Pure and Applied Sciences, Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Ibaraki, Japan
    Org Lett 10:1859-62. 2008
    ..2% in 33 steps). Compared to our first-generation approach, the second-generation synthesis is much improved in the yield of key intermediate...
  10. doi request reprint Synthetic studies toward 13-oxyingenol: construction of the fully substituted tetracyclic compound
    Takayuki Ohyoshi
    Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305 8571, Japan
    Org Lett 13:2160-3. 2011
    ..13-Oxyingenol and its derivatives have high levels of anti-HIV activity. A fully substituted tetracyclic skeleton of 13-oxyingenol is constructed by using spiro-cyclization and ring-closing olefin metathesis as key steps...