Affiliation: University of Toyama
Sakai M, Suzuki T, Tomita K, Yamashita S, Palikhe S, Hattori K, et al
. Diminished responsiveness to dobutamine as an inotrope in mice with cecal ligation and puncture-induced sepsis: attribution to phosphodiesterase 4 upregulation. Am J Physiol Heart Circ Physiol. 2017;312:H1224-H1237 pubmed publisher
Sakata K, Kondo T, Mizuno N, Shoji M, Yasui H, Yamamori T, et al
. Roles of ROS and PKC-Î²II in ionizing radiation-induced eNOS activation in human vascular endothelial cells. Vascul Pharmacol. 2015;70:55-65 pubmed publisher
Hattori Y, Hattori K, Suzuki T, Palikhe S, Matsuda N. Nucleic-acid based gene therapy approaches for sepsis. Eur J Pharmacol. 2018;833:403-410 pubmed publisher
Tomita K, Takashina M, Mizuno N, Sakata K, Hattori K, Imura J, et al
. Cardiac fibroblasts: contributory role in septic cardiac dysfunction. J Surg Res. 2015;193:874-87 pubmed publisher
..We suggest that cardiac fibroblasts are of pathogenetic importance in inflammation and fibrosis in the heart during sepsis, leading to cardiac dysfunction that would affect the outcome of sepsis syndrome. ..
Ohashi W, Hattori K, Hattori Y. Control of Macrophage Dynamics as a Potential Therapeutic Approach for Clinical Disorders Involving Chronic Inflammation. J Pharmacol Exp Ther. 2015;354:240-50 pubmed publisher
..Controlling the macrophage dynamics to affect the pathologic states is considered to be an important therapeutic approach for many clinical disorders involving chronic inflammation. ..
Yamashita S, Suzuki T, Iguchi K, Sakamoto T, Tomita K, Yokoo H, et al
. Cardioprotective and functional effects of levosimendan and milrinone in mice with cecal ligation and puncture-induced sepsis. Naunyn Schmiedebergs Arch Pharmacol. 2018;: pubmed publisher
..This study represents that levosimendan and milrinone have cardioprotective properties but provide different advantages and drawbacks to cardiac inflammation/dysfunction in sepsis. ..
Sakamoto T, Ohashi W, Tomita K, Hattori K, Matsuda N, Hattori Y. Anti-inflammatory properties of cilostazol: Its interruption of DNA binding activity of NF-?B from the Toll-like receptor signaling pathways. Int Immunopharmacol. 2018;62:120-131 pubmed publisher
..The therapy to specifically intervene in this pathway may be potentially beneficial for the prevention of different inflammatory disorders. ..
Abdelzaher L, Imaizumi T, Suzuki T, Tomita K, Takashina M, Hattori Y. Astaxanthin alleviates oxidative stress insults-related derangements in human vascular endothelial cells exposed to glucose fluctuations. Life Sci. 2016;150:24-31 pubmed publisher
..Taken together, our results suggest that astaxanthin can protect vascular endothelial cells against glucose fluctuation by reducing ROS generation. ..
Hattori M, Yamazaki M, Ohashi W, Tanaka S, Hattori K, Todoroki K, et al
. Critical role of endogenous histamine in promoting end-organ tissue injury in sepsis. Intensive Care Med Exp. 2016;4:36 pubmed
..In the setting of sepsis, histamine, through activation of H1- and H2-receptors, serves as an aggravating mediator to contribute to the development of sepsis-driven major end-organ failure. ..