Noriko Gotoh

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Epidermal growth factor receptor tyrosine kinase defines critical prognostic genes of stage I lung adenocarcinoma
    Mai Yamauchi
    Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
    PLoS ONE 7:e43923. 2012
  2. pmc FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells
    Takuya Sato
    Division of Systems Biomedical Technology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Stem Cells 28:1661-73. 2010
  3. pmc Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells
    M Murohashi
    Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Br J Cancer 102:206-12. 2010
  4. pmc Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study
    Masaharu Nomura
    Dept, of Surgery I, Tokyo Medical University, Tokyo, Japan
    J Clin Bioinforma 1:23. 2011
  5. doi request reprint The FRS2 family of docking/scaffolding adaptor proteins as therapeutic targets of cancer treatment
    Takuya Sato
    The University of Tokyo, Institute of Medical Science, Division of Systems Biomedical Technology, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Expert Opin Ther Targets 13:689-700. 2009
  6. ncbi request reprint Theme: Oncology - Molecular mechanisms determining the efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates
    Mai Yamauchi
    Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biomark Med 3:139-51. 2009
  7. ncbi request reprint Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells
    Noriko Gotoh
    Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Curr Stem Cell Res Ther 4:9-15. 2009
  8. doi request reprint Feedback inhibitors of the epidermal growth factor receptor signaling pathways
    Noriko Gotoh
    Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Int J Biochem Cell Biol 41:511-5. 2009
  9. doi request reprint Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins
    Noriko Gotoh
    Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo
    Cancer Sci 99:1319-25. 2008
  10. ncbi request reprint FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts
    Noriko Gotoh
    Department of Pharmacology, Yale University School of Medicine, Sterling Hall of Medicine, 333 Cedar Street, B 204, New Haven, CT 06520, USA
    FEBS Lett 564:14-8. 2004

Detail Information

Publications32

  1. pmc Epidermal growth factor receptor tyrosine kinase defines critical prognostic genes of stage I lung adenocarcinoma
    Mai Yamauchi
    Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
    PLoS ONE 7:e43923. 2012
    ..To identify stage I lung adenocarcinoma patients with a poor prognosis who will benefit from adjuvant therapy...
  2. pmc FRS2α regulates Erk levels to control a self-renewal target Hes1 and proliferation of FGF-responsive neural stem/progenitor cells
    Takuya Sato
    Division of Systems Biomedical Technology, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Stem Cells 28:1661-73. 2010
    ..Thus, FRS2α fine-tunes the FGF-signaling to control qualitatively different biological activities, self-renewal at least partly through Hes1 versus proliferation of NSPCs...
  3. pmc Gene set enrichment analysis provides insight into novel signalling pathways in breast cancer stem cells
    M Murohashi
    Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Br J Cancer 102:206-12. 2010
    ..Tumour-initiating cells (TICs) or cancer stem cells can exist as a small population in malignant tissues. The signalling pathways activated in TICs that contribute to tumourigenesis are not fully understood...
  4. pmc Preferential expression of potential markers for cancer stem cells in large cell neuroendocrine carcinoma of the lung. An FFPE proteomic study
    Masaharu Nomura
    Dept, of Surgery I, Tokyo Medical University, Tokyo, Japan
    J Clin Bioinforma 1:23. 2011
    ..abstract:..
  5. doi request reprint The FRS2 family of docking/scaffolding adaptor proteins as therapeutic targets of cancer treatment
    Takuya Sato
    The University of Tokyo, Institute of Medical Science, Division of Systems Biomedical Technology, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Expert Opin Ther Targets 13:689-700. 2009
    ..Therefore, both proteins could be good therapeutic targets for the treatment of cancer...
  6. ncbi request reprint Theme: Oncology - Molecular mechanisms determining the efficacy of EGF receptor-specific tyrosine kinase inhibitors help to identify biomarker candidates
    Mai Yamauchi
    Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biomark Med 3:139-51. 2009
    ..Towards the end of this article, we discuss recent ongoing projects validating potential biomarkers and future prospects...
  7. ncbi request reprint Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells
    Noriko Gotoh
    Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Curr Stem Cell Res Ther 4:9-15. 2009
    ..Recent emerging evidence suggests that the FGF-ERK axis controls stemness via multiple modes of action. I would like to summarize current understanding of this subject from recent discoveries in this field...
  8. doi request reprint Feedback inhibitors of the epidermal growth factor receptor signaling pathways
    Noriko Gotoh
    Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Int J Biochem Cell Biol 41:511-5. 2009
    ..Although only fragmentary evidence is available regarding these inhibitors, they might be useful as cancer biomarkers, and the development of drugs that target them would certainly advance personalized medicine in the near future...
  9. doi request reprint Regulation of growth factor signaling by FRS2 family docking/scaffold adaptor proteins
    Noriko Gotoh
    Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo
    Cancer Sci 99:1319-25. 2008
    ....
  10. ncbi request reprint FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts
    Noriko Gotoh
    Department of Pharmacology, Yale University School of Medicine, Sterling Hall of Medicine, 333 Cedar Street, B 204, New Haven, CT 06520, USA
    FEBS Lett 564:14-8. 2004
    ..We propose that the FRS2 family proteins have distinct roles in vivo through activation of common signaling proteins including MAP kinase...
  11. doi request reprint An FGF4-FRS2alpha-Cdx2 axis in trophoblast stem cells induces Bmp4 to regulate proper growth of early mouse embryos
    Michiko Murohashi
    Division of Genetics, University of Tokyo, Tokyo 108 863, Japan
    Stem Cells 28:113-21. 2010
    ..Moreover, exogenous Bmp4 is able to rescue the defective growth of Frs2alpha-null ICM. These findings suggest an important role of Cdx2 for production of Bmp4 in TS cells to promote the proper growth of early mouse embryos...
  12. ncbi request reprint A state space representation of VAR models with sparse learning for dynamic gene networks
    Kaname Kojima
    Human Genome Center, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Genome Inform 22:56-68. 2010
    ....
  13. ncbi request reprint Collocation-based sparse estimation for constructing dynamic gene networks
    Teppei Shimamura
    Human Genome Center, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Genome Inform 24:164-78. 2010
    ....
  14. ncbi request reprint Predicting differences in gene regulatory systems by state space models
    Rui Yamaguchi
    Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Genome Inform 21:101-13. 2008
    ..We also discussed differences in regulatory systems for the unpredictable genes. The proposed method would be a promising tool for identifying biomarkers and drug target genes...
  15. pmc Identifying regulational alterations in gene regulatory networks by state space representation of vector autoregressive models and variational annealing
    Kaname Kojima
    Human Genome Center, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    BMC Genomics 13:S6. 2012
    ..Thus, approaches that identify changes on regulations by using time series data on both conditions in an efficient manner are demanded...
  16. doi request reprint Adaptor protein complex of FRS2β and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation
    Yuriko Minegishi
    Division of Systems Biomedical Technology, The University of Tokyo, Tokyo, Japan
    Cancer Sci 104:345-52. 2013
    ..Molecular targeting drugs that can increase or stabilize the ErbB2-FRS2β-CIN85/CD2AP-Cbl axis may have promise for the control of ErbB2-overexpressing tumors...
  17. ncbi request reprint Prominent expression of FRS2beta protein in neural cells and its association with intracellular vesicles
    Yuriko Minegishi
    Division of Systems Biomedical Technology, Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai Minato ku, Tokyo 108 8639, Japan
    FEBS Lett 583:807-14. 2009
    ..These results suggest a probable role of FRS2beta in the intracellular degradation systems of neural cells, which involves lysosomes...
  18. pmc Integrated quantitative analysis of the phosphoproteome and transcriptome in tamoxifen-resistant breast cancer
    Masaaki Oyama
    Medical Proteomics Laboratory, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 286:818-29. 2011
    ..Thus, the combined phosphoproteome and transcriptome data set analyses revealed distinct signal transcription programs in tumor cells and provided a novel molecular target to understand tamoxifen resistance...
  19. doi request reprint Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas
    Hirokazu Okayama
    Divisions of Multistep Carcinogenesis, Genome Biology, Cancer Genomics and Genetics, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 72:100-11. 2012
    ....
  20. pmc Phosphoproteomics-based modeling defines the regulatory mechanism underlying aberrant EGFR signaling
    Shinya Tasaki
    Medical Proteomics Laboratory, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    PLoS ONE 5:e13926. 2010
    ..Here, we report a phosphoproteomics-based methodology for characterizing the regulatory mechanism underlying aberrant EGFR signaling using computational network modeling...
  21. doi request reprint Recent understanding of the molecular mechanisms for the efficacy and resistance of EGF receptor-specific tyrosine kinase inhibitors in non-small cell lung cancer
    Asuka Nakata
    University of Tokyo, Institute of Medical Science, Division of Systems Biomedical Technology, 4 6 1 Shirokanedai, Minatoku, Tokyo, 108 8639, Japan
    Expert Opin Ther Targets 16:771-81. 2012
    ..However, patients who are initially sensitive to EGFR-TKIs eventually relapse within few years...
  22. doi request reprint The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein
    Yoshihito Kano
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Biochem Biophys Res Commun 432:175-81. 2013
    ..In conclusion, the Atoh1 protein regulates malignant potential rather than the differentiation phenotype of MC, suggesting the mechanism by which MC and SRCC are more malignant than non-mucinous adenocarcinoma...
  23. pmc Somatic mutations of the EGF receptor and their signal transducers affect the efficacy of EGF receptor-specific tyrosine kinase inhibitors
    Noriko Gotoh
    Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo Tokyo, Japan
    Int J Clin Exp Pathol 4:403-9. 2011
    ..In this review, I summarize the current understanding of the EGFR-activated signal transduction pathway, which plays important roles in tumorigenesis, and of the molecular mechanisms that determine the sensitivity toward EGFR-TKI...
  24. doi request reprint Inflammatory signaling pathways in self-renewing breast cancer stem cells
    Kunihiko Hinohara
    Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo, Japan
    Curr Opin Pharmacol 10:650-4. 2010
    ....
  25. pmc ErbB receptor tyrosine kinase/NF-κB signaling controls mammosphere formation in human breast cancer
    Kunihiko Hinohara
    Division of Systems Biomedical Technology, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 109:6584-9. 2012
    ..These findings illustrate that HRG/ErbB3 signaling appears to maintain mammosphere formation through a PI3K/NF-κB pathway in human breast cancer...
  26. doi request reprint Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms
    Masashi Sanada
    Cancer Genomics Project, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nature 460:904-8. 2009
    ..Our findings provide a new insight into a role of gain-of-function mutations of a tumour suppressor associated with aUPD in the pathogenesis of some myeloid cancer subsets...
  27. ncbi request reprint SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation
    Lin Huang
    Department of Molecular Cellular Oncology and Microbiology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yujima, Bunkyo ku, Tokyo 113 8510, Japan
    Biochem Biophys Res Commun 324:1011-7. 2004
    ..These observations suggest that SNT-2 negatively regulates ERK2 signaling activated via EGF stimulation through direct binding to ERK2...
  28. ncbi request reprint EGFR phosphorylation-dependent formation of cell-cell contacts by Ras/Erks cascade inhibition
    Eun Sil Kang
    Cancer Research Institute, Department of Molecular and Clinical Oncology, College of Medicine, Seoul National University, 28, Yeongeon Dong, Jongno gu, Seoul 110 799, South Korea
    Biochim Biophys Acta 1773:833-43. 2007
    ..Taken together, this study supports a unique mechanism of cell-cell contact formation through MEK/Erks inhibition-mediated EGFR phosphorylation...
  29. ncbi request reprint Discrimination between phosphotyrosine-mediated signaling properties of conventional and neuronal Shc adapter molecules
    Takeshi Nakamura
    Department of Molecular Genetics, National Institute for Longevity Sciences, Oobu, Aichi 474 8522, Japan
    Oncogene 21:22-31. 2002
    ..These results indicate that N-Shc has specific features of signal-output, and further suggest that the switching between Shc and N-Shc during neural development and regeneration would lead to differentiation of downstream signalings...
  30. doi request reprint FRS2 alpha 2F/2F mice lack carotid body and exhibit abnormalities of the superior cervical sympathetic ganglion and carotid sinus nerve
    Yoko Kameda
    Department of Anatomy, Kitasato University School of Medicine, Sagamihara, Kanagawa 228 8555, Japan
    Dev Biol 314:236-47. 2008
    ..We propose that the sympathetic ganglion provides glomus cell precursors into the third arch artery derivative in the presence of sensory fibers of the glossopharyngeal nerve...
  31. pmc Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules
    Takeshi Nakamura
    Department of Molecular Genetics, National Institute for Longevity Sciences, Program of Protecting the Brain, CREST, JST, Oobu, Aichi 474 8522, Japan
    Mol Cell Biol 22:8721-34. 2002
    ..These results suggest that Grit, a novel TrkA-interacting protein, regulates neurite outgrowth by modulating the Rho family of small GTPases...
  32. ncbi request reprint Direct activation of telomerase by EGF through Ets-mediated transactivation of TERT via MAP kinase signaling pathway
    Yoshiko Maida
    Department of Obstetrics and Gynecology, Kanazawa University, School of Medicine, 13 1, Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Oncogene 21:4071-9. 2002
    ..Our data support the notion that growth factors directly regulate telomerase via specific signal transduction pathways...