Bin Gotoh

Summary

Affiliation: University of Fukui
Country: Japan

Publications

  1. ncbi request reprint Inhibition of the gamma interferon response by a Sendai virus C protein mutant with no STAT1-binding ability
    Bin Gotoh
    Microbiology Section, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Shimoaizuki 23 3, Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
    FEBS Lett 567:291-6. 2004
  2. ncbi request reprint The C-terminal half-fragment of the Sendai virus C protein prevents the gamma-activated factor from binding to a gamma-activated sequence site
    Bin Gotoh
    Department of Microbiology, Fukui Medical University School of Medicine, Shimoaizuki 23 3, Matsuoka cho, Yoshida gun, 910 1193, Fukui, Japan
    Virology 316:29-40. 2003
  3. pmc The STAT2 activation process is a crucial target of Sendai virus C protein for the blockade of alpha interferon signaling
    Bin Gotoh
    Department of Microbiology, Fukui Medical University School of Medicine, Yoshida gun, Fukui 910 1193, Japan
    J Virol 77:3360-70. 2003
  4. ncbi request reprint C and V proteins of Sendai virus target signaling pathways leading to IRF-3 activation for the negative regulation of interferon-beta production
    Takayuki Komatsu
    Microbiology Section, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Yoshida gun, Fukui, 910 1193, Japan
    Virology 325:137-48. 2004
  5. ncbi request reprint Bovine parainfluenza virus type 3 accessory proteins that suppress beta interferon production
    Takayuki Komatsu
    Microbiology Section, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, 23 3 Shimoaizuki, Matsuoka, Yoshida gun, Fukui 910 1193, Japan
    Microbes Infect 9:954-62. 2007
  6. ncbi request reprint [Virus interference with the host interferon-induction system]
    Bin Gotoh
    Tanpakushitsu Kakusan Koso 49:511-6. 2004
  7. ncbi request reprint Paramyxovirus strategies for evading the interferon response
    Bin Gotoh
    Department of Microbiology, Fukui Medical University School of Medicine, Shimoaizuki 23 3, Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
    Rev Med Virol 12:337-57. 2002
  8. ncbi request reprint Sendai virus C protein impairs both phosphorylation and dephosphorylation processes of Stat1
    Takayuki Komatsu
    Department of Microbiology, Fukui Medical University School of Medicine, Fukui 910 1193, Japan
    FEBS Lett 511:139-44. 2002
  9. pmc Sendai virus C protein plays a role in restricting PKR activation by limiting the generation of intracellular double-stranded RNA
    Kenji Takeuchi
    Division of Microbiology and Infectious Diseases, Department of Pathology, Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
    J Virol 82:10102-10. 2008
  10. ncbi request reprint Suppression of interferon-related promoter activation by hepatitis C virus proteins expressed in cultured cells
    Akira Hiramatsu
    Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    Hiroshima J Med Sci 55:71-7. 2006

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Inhibition of the gamma interferon response by a Sendai virus C protein mutant with no STAT1-binding ability
    Bin Gotoh
    Microbiology Section, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Shimoaizuki 23 3, Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
    FEBS Lett 567:291-6. 2004
    ..These results suggest that C protein has the STAT1-binding-independent anti-IFN-gamma mechanism, which targets processes after the STAT1 nuclear translocation event...
  2. ncbi request reprint The C-terminal half-fragment of the Sendai virus C protein prevents the gamma-activated factor from binding to a gamma-activated sequence site
    Bin Gotoh
    Department of Microbiology, Fukui Medical University School of Medicine, Shimoaizuki 23 3, Matsuoka cho, Yoshida gun, 910 1193, Fukui, Japan
    Virology 316:29-40. 2003
    ..These results suggest the possibility that the C protein prevents the gamma-activated factor from binding to GAS elements through its interaction with the STAT1 N-terminal domain...
  3. pmc The STAT2 activation process is a crucial target of Sendai virus C protein for the blockade of alpha interferon signaling
    Bin Gotoh
    Department of Microbiology, Fukui Medical University School of Medicine, Yoshida gun, Fukui 910 1193, Japan
    J Virol 77:3360-70. 2003
    ..Furthermore, expression of STAT1 enhanced the inhibitory effect of the C protein on STAT2 activation in U3A cells. The C protein thus appears to participate in the inhibitory process for STAT2 activation through the STAT1 interaction...
  4. ncbi request reprint C and V proteins of Sendai virus target signaling pathways leading to IRF-3 activation for the negative regulation of interferon-beta production
    Takayuki Komatsu
    Microbiology Section, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, Yoshida gun, Fukui, 910 1193, Japan
    Virology 325:137-48. 2004
    ..These results suggest that C, Y1, Y2, and V block signaling pathways leading to IRF-3 activation to downregulate IFN-beta production...
  5. ncbi request reprint Bovine parainfluenza virus type 3 accessory proteins that suppress beta interferon production
    Takayuki Komatsu
    Microbiology Section, Department of Pathological Sciences, Faculty of Medical Sciences, University of Fukui, 23 3 Shimoaizuki, Matsuoka, Yoshida gun, Fukui 910 1193, Japan
    Microbes Infect 9:954-62. 2007
    ..These results demonstrate that the target of the respirovirus C protein is undoubtedly different from that of the V protein...
  6. ncbi request reprint [Virus interference with the host interferon-induction system]
    Bin Gotoh
    Tanpakushitsu Kakusan Koso 49:511-6. 2004
  7. ncbi request reprint Paramyxovirus strategies for evading the interferon response
    Bin Gotoh
    Department of Microbiology, Fukui Medical University School of Medicine, Shimoaizuki 23 3, Matsuoka cho, Yoshida gun, Fukui 910 1193, Japan
    Rev Med Virol 12:337-57. 2002
    ....
  8. ncbi request reprint Sendai virus C protein impairs both phosphorylation and dephosphorylation processes of Stat1
    Takayuki Komatsu
    Department of Microbiology, Fukui Medical University School of Medicine, Fukui 910 1193, Japan
    FEBS Lett 511:139-44. 2002
    ..Interestingly, the dephosphorylation process of pY-Stat1 was also impaired. These effects on both phosphorylation and dephosphorylation processes were attributable to the function of the C protein...
  9. pmc Sendai virus C protein plays a role in restricting PKR activation by limiting the generation of intracellular double-stranded RNA
    Kenji Takeuchi
    Division of Microbiology and Infectious Diseases, Department of Pathology, Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
    J Virol 82:10102-10. 2008
    ..Taken together, these results demonstrate that the SeV C protein limits generation of dsRNA, thereby keeping PKR inactive to maintain intracellular protein synthesis...
  10. ncbi request reprint Suppression of interferon-related promoter activation by hepatitis C virus proteins expressed in cultured cells
    Akira Hiramatsu
    Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734 8551, Japan
    Hiroshima J Med Sci 55:71-7. 2006
    ..These results suggest that multiple HCV proteins have a function in suppression of the anti-viral effect by interferon and may indicate a novel role of E1 and NS4B proteins in interferon antagonism...