Akiteru Goto

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Loss of TSLC1 expression in lung adenocarcinoma: relationships with histological subtypes, sex and prognostic significance
    Akiteru Goto
    Department of Human Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Cancer Sci 96:480-6. 2005
  2. ncbi request reprint Lung adenocarcinoma associated with familial adenomatous polyposis. Clear cell carcinoma with beta-catenin accumulation accompanied by atypical adenomatous hyperplasia
    Akiteru Goto
    Department of Human Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, 113 0033 Tokyo, Japan
    Virchows Arch 446:73-7. 2005
  3. ncbi request reprint Prevalence of CD99 protein expression in pancreatic endocrine tumours (PETs)
    A Goto
    Department of Human Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Histopathology 45:384-92. 2004
  4. ncbi request reprint Immunohistochemical study of Skp2 and Jab1, two key molecules in the degradation of P27, in lung adenocarcinoma
    Akiteru Goto
    Department of Human Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Pathol Int 54:675-81. 2004
  5. ncbi request reprint Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines
    Yu Nakamura
    Department of Human Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku 113 0033, Tokyo, Japan
    Cancer Sci 99:14-22. 2008
  6. doi request reprint AKR1B10 in usual interstitial pneumonia: expression in squamous metaplasia in association with smoking and lung cancer
    Chih Ping Li
    Department of Human Pathology, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Pathol Res Pract 204:295-304. 2008
  7. ncbi request reprint p63 - Key molecule in the early phase of epithelial abnormality in idiopathic pulmonary fibrosis
    Kengo Murata
    Department of Human Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Exp Mol Pathol 83:367-76. 2007
  8. doi request reprint Aberrant expression of tumor suppressors CADM1 and 4.1B in invasive lesions of primary breast cancer
    Yuka Takahashi
    Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, 108 8639, Tokyo, Japan
    Breast Cancer 19:242-52. 2012
  9. doi request reprint Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer
    Kousuke Watanabe
    Department of Respiratory Medicine, The University of Tokyo Hospital, Hongo, Bunkyo ku, Tokyo, Japan
    Int J Cancer 130:2580-90. 2012
  10. ncbi request reprint Hypoxia increases the motility of lung adenocarcinoma cell line A549 via activation of the epidermal growth factor receptor pathway
    Tao Wang
    Department of Human Pathology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 0033, Tokyo, Japan
    Cancer Sci 98:506-11. 2007

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Loss of TSLC1 expression in lung adenocarcinoma: relationships with histological subtypes, sex and prognostic significance
    Akiteru Goto
    Department of Human Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Cancer Sci 96:480-6. 2005
    ..We conclude that TSLC1 is expressed in a subset of lung adenocarcinomas, especially in those with bronchiolo-alveolar spread pattern. Loss of TSLC1 is associated with lower patient survival, supporting its role as a tumor suppressor...
  2. ncbi request reprint Lung adenocarcinoma associated with familial adenomatous polyposis. Clear cell carcinoma with beta-catenin accumulation accompanied by atypical adenomatous hyperplasia
    Akiteru Goto
    Department of Human Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, 113 0033 Tokyo, Japan
    Virchows Arch 446:73-7. 2005
    ..Immunohistochemical and loss of heterozygosity studies revealed unique features of the lesions reflecting a disruption of the adenomatous poliposis coli-beta-catenin pathway...
  3. ncbi request reprint Prevalence of CD99 protein expression in pancreatic endocrine tumours (PETs)
    A Goto
    Department of Human Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Histopathology 45:384-92. 2004
    ..To determine the prevalence of CD99 expression in pancreatic endocrine tumours (PETs). We evaluated CD99 expression and analysed Ki67 labelling by immunohistochemistry in PETs...
  4. ncbi request reprint Immunohistochemical study of Skp2 and Jab1, two key molecules in the degradation of P27, in lung adenocarcinoma
    Akiteru Goto
    Department of Human Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Pathol Int 54:675-81. 2004
    ..Thus, Skp2 and Jab1 regulate P27 degradation, and might contribute to the development and progression of lung AD through P27-mediated and -unmediated mechanisms...
  5. ncbi request reprint Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines
    Yu Nakamura
    Department of Human Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku 113 0033, Tokyo, Japan
    Cancer Sci 99:14-22. 2008
    ....
  6. doi request reprint AKR1B10 in usual interstitial pneumonia: expression in squamous metaplasia in association with smoking and lung cancer
    Chih Ping Li
    Department of Human Pathology, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Pathol Res Pract 204:295-304. 2008
    ..Our results demonstrate that AKR1B10 is involved in the development of LC in UIP in association with smoking. AKR1B10 might be useful as a new marker for identification of high LC risk patients in UIP...
  7. ncbi request reprint p63 - Key molecule in the early phase of epithelial abnormality in idiopathic pulmonary fibrosis
    Kengo Murata
    Department of Human Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Exp Mol Pathol 83:367-76. 2007
    ..Thus, the p63-jag1 pathway may be up-regulated at an early phase of epithelial abnormalities in IPF, which can be overcome by NAC even in the TGF beta1-rich milieu...
  8. doi request reprint Aberrant expression of tumor suppressors CADM1 and 4.1B in invasive lesions of primary breast cancer
    Yuka Takahashi
    Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, 108 8639, Tokyo, Japan
    Breast Cancer 19:242-52. 2012
    ..1B are frequently inactivated by promoter methylation in non-small cell lung cancer. The proteins they encode, CADM1 and 4.1B, form a complex in human epithelial cells and are involved in cell-cell adhesion...
  9. doi request reprint Genome structure-based screening identified epigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer
    Kousuke Watanabe
    Department of Respiratory Medicine, The University of Tokyo Hospital, Hongo, Bunkyo ku, Tokyo, Japan
    Int J Cancer 130:2580-90. 2012
    ..007) and c-Met expression (p = 0.005) were significantly associated with lymphatic invasion in a multivariate analysis. The DNA methylation of mir-34b can be used as a biomarker for an invasive phenotype of lung cancer...
  10. ncbi request reprint Hypoxia increases the motility of lung adenocarcinoma cell line A549 via activation of the epidermal growth factor receptor pathway
    Tao Wang
    Department of Human Pathology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 0033, Tokyo, Japan
    Cancer Sci 98:506-11. 2007
    ..Thus, the present study demonstrates the importance of the EGFR pathway in the increased motility of cancer cells that occurs in a hypoxic tumor environment...
  11. doi request reprint Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma
    Masayoshi Nagata
    Division of Molecular Pathology, Institute of Medical Science, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int J Cancer 130:1329-37. 2012
    ..Finally, introduction of CADM4 into an RCC cell line, 786-O, dramatically suppressed tumor formation in nude mice. These findings suggest that CADM4 is a novel tumor suppressor candidate in RCCC acting with its binding partner 4.1B...
  12. ncbi request reprint c-Met activation in lung adenocarcinoma tissues: an immunohistochemical analysis
    Yu Nakamura
    Department of Human Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 98:1006-13. 2007
    ..c-Met activation may play special roles in the papillary subtype and in well differentiated lung adenocarcinomas...
  13. ncbi request reprint Differential expression of S100A2 and S100A4 in lung adenocarcinomas: clinicopathological significance, relationship to p53 and identification of their target genes
    Daisuke Matsubara
    Department of Human Pathology, School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer Sci 96:844-57. 2005
    ..Thus, the present study demonstrates involvement of S100A2 and S100A4 in the progression of lung adenocarcinomas and an inverse association between S100A4 and p53 expression, and provides a list of targets regulated by S100A2 and S100A4...
  14. doi request reprint Pulmonary venous invasion, determined by chest computed tomographic scan, as a potential early indicator of zygomycosis infection: a case series
    Hiroshi Kitagawa
    Department of Respiratory Medicine, Tokyo University Hospital, Bunkyo ku, Tokyo, Japan
    J Thorac Imaging 27:W97-9. 2012
    ..These distinguishing radiologic and clinical features may contribute to an earlier diagnosis; more radical treatments, such as amphotericin-B or pulmonary resection; and a more successful outcome for patients with zygomycosis...
  15. ncbi request reprint Lung adenocarcinoma associated with atypical adenomatous hyperplasia. A clinicopathological study with special reference to smoking and cancer multiplicity
    Hiroshi Kitagawa
    Department of Internal Medicine, Kanto Chuo Hospital, Tokyo, Japan
    Pathol Int 53:823-7. 2003
    ....
  16. doi request reprint Pleural cavity angiosarcoma arising in chronic expanding hematoma after pneumonectomy
    Hideki Miyazaki
    Department of Human Pathology, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Hum Pathol 42:1576-9. 2011
    ..The final diagnosis was pleural cavity angiosarcoma arising in chronic expanding hematoma and its metastases to the right lung...
  17. pmc Recurrent prostatic stromal sarcoma with massive high-grade prostatic intraepithelial neoplasia
    Teppei Morikawa
    Department of Human Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Pathol 60:330-2. 2007
    ..Our findings suggest that not only the stromal component but also and the epithelial components of PSS may have malignant potential...
  18. doi request reprint Human papillomavirus infection in lung and esophageal cancers: analysis of 485 Asian cases
    Akiteru Goto
    Department of Human Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Med Virol 83:1383-90. 2011
    ..Subtype-specific ISH was also performed, which identified the high-risk HPV types 16/18 in the majority (75.7%) of the patients with lung and esophageal cancer positive for HPV...
  19. ncbi request reprint Oncofetal protein glypican-3 in testicular germ-cell tumor
    Satoshi Ota
    Department of Pathology, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo, 113 0033, Japan
    Virchows Arch 449:308-14. 2006
    ..Thus, GPC3 is a unique oncofetal protein, which is useful as an immunohistochemical marker for GCT differentiated to extraembryonic tissue, especially YST...
  20. doi request reprint Multicystic mesothelioma of the pericardium
    Shigeki Morita
    Department of Human Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Pathol Int 61:319-21. 2011
    ..At autopsy, the tumor was found to be directly extending into the right pleural cavity and the right lung, besides the mediastinum and the liver. Neither malignant transformation nor metastatic tumor was identified...
  21. ncbi request reprint Primary pulmonary paraganglioma: report of a functioning case with immunohistochemical and ultrastructural study
    Junji Shibahara
    Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Surg Pathol 28:825-9. 2004
    ..On the basis of our experience, our case is a bona fide primary pulmonary paraganglioma, a tumor heretofore subject to considerable skepticism...
  22. doi request reprint Sperm-associated antigen 4, a novel hypoxia-inducible factor 1 target, regulates cytokinesis, and its expression correlates with the prognosis of renal cell carcinoma
    Kumi Shoji
    Division of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan
    Am J Pathol 182:2191-203. 2013
    ..This defensive mechanism may promote survival of cancer cells under hypoxic conditions, thus leading to poor prognosis...
  23. doi request reprint CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer
    Kentaro Kitano
    Department of Thoracic Surgery, The University of Tokyo Hospital, Tokyo, Japan
    Cancer Sci 102:2126-31. 2011
    ..Our result enlightens the accumulation of aberrant DNA methylation which occurs in concordance with the tumor progression...
  24. doi request reprint Imaging findings of thoracic low-grade fibromyxoid sarcoma: report of three cases
    Eriko Maeda
    Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Jpn J Radiol 27:375-80. 2009
    ..No differences in vasculature densities between the myxoid and fibrous zones were demonstrated...
  25. ncbi request reprint Phyllodes tumor of the prostate with exuberant glandular hyperplasia
    Teppei Morikawa
    Department of Human Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Pathol Int 56:158-61. 2006
    ..The final diagnosis was then made as 'phyllodes tumor of the prostate with exuberant glandular hyperplasia'. Atypical stromal cells might provide a clue for the recognition of this rare tumor at initial diagnosis by needle biopsy...
  26. ncbi request reprint Sclerosing hemangioma of the lung with cystic appearance
    Hiroshi Kitagawa
    Department of Internal Medicine, Kanto Chuo Hospital, Tokyo, Japan
    Jpn J Clin Oncol 33:360-3. 2003
    ..Differential diagnosis of the cystic lesion of the lung should include cystic sclerosing hemangioma as observed in this case...
  27. doi request reprint B cells regulate antibody responses through the medullary remodeling of inflamed lymph nodes
    Jun Abe
    Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Int Immunol 24:17-27. 2012
    ..We propose that non-cognate B cells mediate the expansion of the plasma cell niche in LN through medullary remodeling, thereby regulating the size of the LN plasma cell pool...
  28. ncbi request reprint Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin
    Yuichi Itoh
    Laboratory of Cancer Biology and Molecular Immunology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    Glycobiology 18:74-83. 2008
    ..This is a novel transmembrane mucin and designated as MUC21...
  29. ncbi request reprint Magnetic resonance findings of bile duct adenoma with calcification
    Eriko Maeda
    Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Radiat Med 24:459-62. 2006
    ..Preoperatively, the diagnoses considered included metastatic carcinoma, cholangiocarcinoma, tuberculosis, and rare tumors such as epithelioid hemangioendothelioma. The radiological findings were confirmed by pathological investigation...
  30. ncbi request reprint Clinical utility of grading criteria for submucosal invasion in the prognosis of T1 colorectal carcinomas
    Tadahiko Masaki
    First Department of Surgery, Kyorin University, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Gastroenterol 38:37-44. 2003
    ..The clinical utility of relative and absolute grading criteria for submucosal invasion in T1 colorectal carcinomas has been controversial...
  31. ncbi request reprint Laminin-5 gamma 2 chain and matrix metalloproteinase-2 may trigger colorectal carcinoma invasiveness through formation of budding tumor cells
    Tadahiko Masaki
    First Department of Surgery, Kyorin University, 6 20 2, Shinkawa, Mitaka City, Tokyo 181 8611, Japan
    Anticancer Res 23:4113-9. 2003
    ..Tumor budding has been reported to be significantly associated with lymph node or distant metastasis in colorectal carcinomas. We attempted to elucidate the contributing factors for the formation of budding tumor cells...
  32. ncbi request reprint Overexpression of cdk4/cyclin D1, a possible mediator of apoptosis and an indicator of prognosis in human primary lung carcinoma
    Yoh Dobashi
    Department of Pathology, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
    Int J Cancer 110:532-41. 2004
    ..Moreover, inactivation of Rb protein renders cells more prone to apoptosis by abnormal expression of any cell-cycle protein...
  33. ncbi request reprint Invasive lymphangioma of the lung manifesting as a large pulmonary mass with hemoptysis: report of a case
    Jun Nakajima
    Department of Cardiothoracic Surgery, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Surg Today 37:418-22. 2007
    ..We suggest that these pathological findings might be consistent with the intermediate type of localized lymphangioma of the lung and diffuse lymphangiomatosis...
  34. ncbi request reprint Molecular identification of a novel carnitine transporter specific to human testis. Insights into the mechanism of carnitine recognition
    Atsushi Enomoto
    Department of Pharmacology and Toxicology, Kyorin University, School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    J Biol Chem 277:36262-71. 2002
    ..The identification of CT2 represents an interesting evolutionary link between OCT/OCTNs and OATs, as well as provides us with an important insight into the maturation of human spermatozoa...