Hiroshi Fukamachi

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Mesenchymal transcription factor Fkh6 is essential for the development and differentiation of parietal cells
    H Fukamachi
    Department of Biological Sciences, Graduate School of Science, Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Biochem Biophys Res Commun 280:1069-76. 2001
  2. ncbi request reprint Runx3-/- gastric epithelial cells differentiate into intestinal type cells
    Hiroshi Fukamachi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 321:58-64. 2004
  3. doi request reprint Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer
    Shu Shimada
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Gut 61:344-53. 2012
  4. doi request reprint In vitro differentiation of Runx3-/- p53-/- gastric epithelial cells into intestinal type cells
    Hiroshi Fukamachi
    Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Cancer Sci 99:671-6. 2008
  5. ncbi request reprint Growth regulation of gastric epithelial cells by Runx3
    Hiroshi Fukamachi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Oncogene 23:4330-5. 2004
  6. doi request reprint Loss of E-cadherin in mouse gastric epithelial cells induces signet ring-like cells, a possible precursor lesion of diffuse gastric cancer
    Ayako Mimata
    Department of Molecular Oncology Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 102:942-50. 2011
  7. doi request reprint CD133 is a marker of gland-forming cells in gastric tumors and Sox17 is involved in its regulation
    Hiroshi Fukamachi
    Department of Molecular Oncology, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 102:1313-21. 2011
  8. doi request reprint miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer
    Rie Wada
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Cancer 127:1106-14. 2010
  9. pmc CD49f(high) cells retain sphere-forming and tumor-initiating activities in human gastric tumors
    Hiroshi Fukamachi
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 8:e72438. 2013
  10. ncbi request reprint Reduction of SNAP25 in acid secretion defect of Foxl1-/- gastric parietal cells
    Yasutaka Kato
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 320:766-72. 2004

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Mesenchymal transcription factor Fkh6 is essential for the development and differentiation of parietal cells
    H Fukamachi
    Department of Biological Sciences, Graduate School of Science, Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Biochem Biophys Res Commun 280:1069-76. 2001
    ..We thus concluded that Fkh6 plays essential roles for the development and differentiation of parietal cells via epithelial-mesenchymal interactions...
  2. ncbi request reprint Runx3-/- gastric epithelial cells differentiate into intestinal type cells
    Hiroshi Fukamachi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 321:58-64. 2004
    ..The relationship between loss of function of Runx3, formation of intestinal metaplasia, and gastric cancer was discussed...
  3. doi request reprint Synergistic tumour suppressor activity of E-cadherin and p53 in a conditional mouse model for metastatic diffuse-type gastric cancer
    Shu Shimada
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Gut 61:344-53. 2012
    ..To examine the synergistic effect of the loss of E-cadherin and p53 on gastric carcinogenesis, a mouse line was established in which E-cadherin and p53 are specifically inactivated in the stomach parietal cell lineage...
  4. doi request reprint In vitro differentiation of Runx3-/- p53-/- gastric epithelial cells into intestinal type cells
    Hiroshi Fukamachi
    Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Cancer Sci 99:671-6. 2008
    ..Extracellular matrix, not blood cells, may play a role in the genesis of intestinal metaplasia...
  5. ncbi request reprint Growth regulation of gastric epithelial cells by Runx3
    Hiroshi Fukamachi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Oncogene 23:4330-5. 2004
    ..These observations indicate that Runx3 is a major growth regulator of gastric epithelial cells, and that it is deeply involved in gastric tumorigenesis in both humans and mice...
  6. doi request reprint Loss of E-cadherin in mouse gastric epithelial cells induces signet ring-like cells, a possible precursor lesion of diffuse gastric cancer
    Ayako Mimata
    Department of Molecular Oncology Human Pathology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 102:942-50. 2011
    ..These data indicate that the loss of E-cadherin induces possible pre-cancerous lesions in the gastric mucosa but may not be sufficient for its malignant conversion...
  7. doi request reprint CD133 is a marker of gland-forming cells in gastric tumors and Sox17 is involved in its regulation
    Hiroshi Fukamachi
    Department of Molecular Oncology, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 102:1313-21. 2011
    ..These results indicate that Sox17 might be a key transcription factor controlling CD133 expression, and that it might also play a role in the control of gastric tumor progression...
  8. doi request reprint miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer
    Rie Wada
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Cancer 127:1106-14. 2010
    ..Ectopic expression of miR-212 repressed expression of the MeCP2 protein but not the MECP2 mRNA level. These data suggest that downregulation of miR-212 may be related to gastric carcinogenesis through its target genes, such as MECP2...
  9. pmc CD49f(high) cells retain sphere-forming and tumor-initiating activities in human gastric tumors
    Hiroshi Fukamachi
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 8:e72438. 2013
    ..These results suggest that ECM plays an essential role for the growth of TICs, and that this culture system will be useful to find new drugs targeting gastric TICs. ..
  10. ncbi request reprint Reduction of SNAP25 in acid secretion defect of Foxl1-/- gastric parietal cells
    Yasutaka Kato
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 320:766-72. 2004
    ....
  11. ncbi request reprint Endothelin-3 controls growth of colonic epithelial cells by mediating epithelial-mesenchymal interaction
    Hiroshi Fukamachi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Dev Growth Differ 47:573-80. 2005
    ..These results suggest that ET-3 plays an important role in the growth control of colonic epithelial cells, possibly by mediating epithelial-mesenchymal interactions...
  12. ncbi request reprint IQGAP2 inactivation through aberrant promoter methylation and promotion of invasion in gastric cancer cells
    Shun Hua Jin
    Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Cancer 122:1040-6. 2008
    ..IQGAP2 knockdown with small interfering RNA increased the invasive capacity of a gastric cancer cell line. These results suggest that silencing of IQGAP2 by promoter methylation may contribute to gastric cancer development...
  13. pmc Human G(salpha) mutant causes pseudohypoparathyroidism type Ia/neonatal diarrhea, a potential cell-specific role of the palmitoylation cycle
    Noriko Makita
    Department of Endocrinology and Nephrology, University of Tokyo School of Medicine, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Proc Natl Acad Sci U S A 104:17424-9. 2007
    ..Hence, palmitoylation may control the activity and localization of G(salpha) in a cell-specific manner...
  14. ncbi request reprint Causal relationship between the loss of RUNX3 expression and gastric cancer
    Qing Lin Li
    Department of Biochemistry, College of Medicine, Institute of Medical Research, Chungbuk National University, 361 763, Cheongju, South Korea
    Cell 109:113-24. 2002
    ....
  15. pmc Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cells
    Masatoshi Ohgushi
    Graduate School of Biostudies, Kyoto University, SCRB Building G, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Mol Cell Biol 25:10017-28. 2005
    ..These results indicate for the first time that TGF-beta is involved in the physiological loss of gastric epithelial cells by activating apoptosis mediated by Smad, Bim, and caspase-9...
  16. doi request reprint RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis
    Kosei Ito
    Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673
    Cancer Cell 14:226-37. 2008
    ..Taken together, these data demonstrate that RUNX3 functions as a tumor suppressor by attenuating Wnt signaling...
  17. ncbi request reprint Foxl1-deficient mice exhibit aberrant epithelial cell positioning resulting from dysregulated EphB/EphrinB expression in the small intestine
    Masumi Takano-Maruyama
    Laboratory for Epithelial Immunobiology, Research Center for Allergy and Immunology, RIKEN, 1 7 22 Suehiro, Tsurumi ku, Yokohama 230 0045, Japan
    Am J Physiol Gastrointest Liver Physiol 291:G163-70. 2006
    ..This interaction is essential for the normal regulation of the Wnt/beta-catenin pathway and the subsequent EphB/EphrinB expression...
  18. doi request reprint Loss of Runx3 affects ovulation and estrogen-induced endometrial cell proliferation in female mice
    Atsuko Sakuma
    The Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama, Japan
    Mol Reprod Dev 75:1653-61. 2008
    ..These results suggest that Runx3 takes part in the regulation of reproductive functions...
  19. ncbi request reprint Runx3 controls growth and differentiation of gastric epithelial cells in mammals
    Hiroshi Fukamachi
    Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo 113 8519, Japan
    Dev Growth Differ 48:1-13. 2006
    ..We conclude that Runx3 is deeply involved in the control of both growth and differentiation of gastric epithelial cells. The role of Runx3 in the specification of gastric epithelial cells is discussed...
  20. pmc The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis
    Takashi Yano
    Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, Singapore 138673, Singapore
    Mol Cell Biol 26:4474-88. 2006
    ..These results demonstrate that RUNX3 is responsible for transcriptional up-regulation of Bim in TGF-beta-induced apoptosis...
  21. ncbi request reprint Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression
    Yasuyo Tani
    Department of Molecular Oncology, Graduate School of Medicine and Dentistry, Tokyo Medical and Dental University, 1 5 45, Yushima, Tokyo 113 8519, Japan
    J Cancer Res Clin Oncol 133:263-9. 2007
    ..Transcription factor SOX2 is expressed in normal gastric mucosae but not in the normal colon. We aimed to clarify the role of SOX2 with reference to pepsinogen expression in the gastrointestinal epithelium...
  22. ncbi request reprint Developmentally regulated expression of matrix metalloproteinases during fetal rat colon morphogenesis
    Hidenori Kurakata
    Division of Gastroenterology and Hepatology, Department of Internal Medicine Ohmori, School of Medicine, Faculty of Medicine, Toho University School of Medicine, Tokyo 143 8540, Japan
    Dev Growth Differ 50:41-8. 2008
    ....
  23. ncbi request reprint Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori
    Akihiro Fujikawa
    Division of Molecular Neurobiology, National Institute for Basic Biology, 38 Nishigonaka, Myodaiji cho, Okazaki 444 8585, Japan
    Nat Genet 33:375-81. 2003
    ..Furthermore, pleiotrophin (PTN), an endogenous ligand of Ptprz, also induced gastritis specifically in Ptprz+/+ mice when administered orally. Taken together, these data indicate that erroneous Ptprz signaling induces gastric ulcers...