Yasuhiro Fujisawa

Summary

Affiliation: University of Tsukuba
Country: Japan

Publications

  1. ncbi request reprint The benefit of a sentinel lymph node biopsy and adjuvant therapy in thick (>4 mm) melanoma: multicenter, retrospective study of 291 Japanese patients
    Yasuhiro Fujisawa
    Department of Dermatology, University of Tsukuba, Ibaraki, Japan
    Melanoma Res 22:362-7. 2012
  2. ncbi request reprint Indocyanine green fluorescence-navigated sentinel node biopsy showed higher sensitivity than the radioisotope or blue dye method, which may help to reduce false-negative cases in skin cancer
    Yasuhiro Fujisawa
    Division of Dermatology, University of Tsukuba, Tsukuba City, Ibaraki, Japan
    J Surg Oncol 106:41-5. 2012
  3. doi request reprint Extension of a malignant tailgut cyst to a subcutaneous space in the buttock
    Yasuhiro Fujisawa
    Department of Dermatology, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Ibaraki, Japan
    Eur J Dermatol 20:788-91. 2010
  4. doi request reprint A custom-made, low-cost intraoperative fluorescence navigation system with indocyanine green for sentinel lymph node biopsy in skin cancer
    Yasuhiro Fujisawa
    Department of Dermatology, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Dermatology 222:261-8. 2011
  5. doi request reprint Pituitary tumor-transforming gene 1 as a proliferation marker lacking prognostic value in cutaneous squamous cell carcinoma
    Yosuke Ishitsuka
    Department of Dermatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Exp Dermatol 22:318-22. 2013
  6. ncbi request reprint Improvement of the sentinel lymph node detection rate of cervical sentinel lymph node biopsy using real-time fluorescence navigation with indocyanine green in head and neck skin cancer
    Yasuhiro Nakamura
    Department of Dermatology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Dermatol 40:453-7. 2013
  7. doi request reprint Pituitary tumor transforming gene 1 induces tumor necrosis factor-α production from keratinocytes: implication for involvement in the pathophysiology of psoriasis
    Yosuke Ishitsuka
    Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
    J Invest Dermatol 133:2566-75. 2013
  8. ncbi request reprint The POU domain transcription factors Oct-6 and Oct-11 negatively regulate loricrin gene expression in keratinocytes: association with AP-1 and Sp1/Sp3
    Yasuhiro Kawachi
    Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Arch Dermatol Res 305:371-8. 2013
  9. doi request reprint Intraoperative mapping with isosulfan blue of lymphatic leakage during inguinal lymph node dissection (ILND) for skin cancer for the prevention of postoperative lymphocele
    Yasuhiro Nakamura
    Department of Dermatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Surg Oncol 104:657-60. 2011
  10. doi request reprint Pituitary tumor-transforming gene 1 enhances proliferation and suppresses early differentiation of keratinocytes
    Yosuke Ishitsuka
    Department of Dermatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    J Invest Dermatol 132:1775-84. 2012

Collaborators

Detail Information

Publications30

  1. ncbi request reprint The benefit of a sentinel lymph node biopsy and adjuvant therapy in thick (>4 mm) melanoma: multicenter, retrospective study of 291 Japanese patients
    Yasuhiro Fujisawa
    Department of Dermatology, University of Tsukuba, Ibaraki, Japan
    Melanoma Res 22:362-7. 2012
    ..Therefore, we suggest that an SLN biopsy and adjuvant IFN should be considered for patients with thick melanoma irrespective of the Breslow thickness or ethnicity...
  2. ncbi request reprint Indocyanine green fluorescence-navigated sentinel node biopsy showed higher sensitivity than the radioisotope or blue dye method, which may help to reduce false-negative cases in skin cancer
    Yasuhiro Fujisawa
    Division of Dermatology, University of Tsukuba, Tsukuba City, Ibaraki, Japan
    J Surg Oncol 106:41-5. 2012
    ..We tested a new lymphatic navigation method using indocyanine green fluorescence imaging (ICG-FI) to detect such "occult" SLNs...
  3. doi request reprint Extension of a malignant tailgut cyst to a subcutaneous space in the buttock
    Yasuhiro Fujisawa
    Department of Dermatology, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Ibaraki, Japan
    Eur J Dermatol 20:788-91. 2010
    ..Thus, a tailgut cyst should be completely removed, even if radiological examination cannot detect malignant features. Measurement of serum CEA may be helpful when the tumor expresses this antigen...
  4. doi request reprint A custom-made, low-cost intraoperative fluorescence navigation system with indocyanine green for sentinel lymph node biopsy in skin cancer
    Yasuhiro Fujisawa
    Department of Dermatology, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Dermatology 222:261-8. 2011
    ..Recently, indocyanine green (ICG) fluorescence imaging has been reported as new method to detect sentinel lymph nodes (SLNs). However, high introduction costs limit its use...
  5. doi request reprint Pituitary tumor-transforming gene 1 as a proliferation marker lacking prognostic value in cutaneous squamous cell carcinoma
    Yosuke Ishitsuka
    Department of Dermatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Exp Dermatol 22:318-22. 2013
    ..These results suggest that PTTG1 may represent a proliferation marker associated with mutated p53 proteins but is not an informative predictor of poor clinical outcomes in SCC...
  6. ncbi request reprint Improvement of the sentinel lymph node detection rate of cervical sentinel lymph node biopsy using real-time fluorescence navigation with indocyanine green in head and neck skin cancer
    Yasuhiro Nakamura
    Department of Dermatology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Dermatol 40:453-7. 2013
    ..Fluorescence navigation with indocyanine green may improve the cervical sentinel node detection rate. However, greater collection of data regarding the usefulness of cervical sentinel node biopsy using indocyanine green is necessary...
  7. doi request reprint Pituitary tumor transforming gene 1 induces tumor necrosis factor-α production from keratinocytes: implication for involvement in the pathophysiology of psoriasis
    Yosuke Ishitsuka
    Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan
    J Invest Dermatol 133:2566-75. 2013
    ..Therefore, enhanced expression of PTTG1 in the psoriatic epidermis may result in aberrant regulation of the cell cycle and impaired differentiation via the interplay between PTTG1 and TNF-α. ..
  8. ncbi request reprint The POU domain transcription factors Oct-6 and Oct-11 negatively regulate loricrin gene expression in keratinocytes: association with AP-1 and Sp1/Sp3
    Yasuhiro Kawachi
    Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Arch Dermatol Res 305:371-8. 2013
    ..These findings indicate that Oct-6 and Oct-11 contribute to the regulation of loricrin gene transcription via interaction with AP-1 factors and Sp1/Sp3. ..
  9. doi request reprint Intraoperative mapping with isosulfan blue of lymphatic leakage during inguinal lymph node dissection (ILND) for skin cancer for the prevention of postoperative lymphocele
    Yasuhiro Nakamura
    Department of Dermatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Surg Oncol 104:657-60. 2011
    ..Isosulfan blue has been used to identify and treat lymphoceles arising from lymphatics injured during surgery of the groin. However, the preventive use at the time of lymph node dissection has not been reported...
  10. doi request reprint Pituitary tumor-transforming gene 1 enhances proliferation and suppresses early differentiation of keratinocytes
    Yosuke Ishitsuka
    Department of Dermatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    J Invest Dermatol 132:1775-84. 2012
    ....
  11. doi request reprint NF1 gene silencing induces upregulation of vascular endothelial growth factor expression in both Schwann and non-Schwann cells
    Yasuhiro Kawachi
    Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tennodai, Tsukuba, Japan
    Exp Dermatol 22:262-5. 2013
    ..We also showed that interleukin-6 is upregulated in Nf1 gene knock-down Schwann cells at the protein level...
  12. doi request reprint GATA-3 regulates differentiation-specific loricrin gene expression in keratinocytes
    Yasuhiro Kawachi
    Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Exp Dermatol 21:859-64. 2012
    ..These findings indicate that GATA-3 contributes to keratinocyte differentiation-specific activation of loricrin gene transcription via interaction with c-Fos and Sp1...
  13. doi request reprint Multiple inguinal and pelvic lymph node metastases of malignant melanoma of the heel identified by common iliac lymphadenopathy
    Yoshiyuki Nakamura
    Department of Dermatology, University of Tsukuba, Tsukuba, Japan
    Lymphat Res Biol 10:118-21. 2012
    ..This case indicates that sentinel lymph node biopsy may be worth considering even for stage IA malignant melanoma of the lower extremity...
  14. doi request reprint Comparison between taxane-based chemotherapy with conventional surgery-based therapy for cutaneous angiosarcoma: a single-center experience
    Yasuhiro Fujisawa
    Department of Dermatology, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Japan
    J Dermatolog Treat 25:419-23. 2014
    ..To show the efficacy of taxane-based chemotherapy for the treatment of cutaneous angiosarcoma...
  15. doi request reprint Linear childhood discoid lupus erythematosus following the lines of Blaschko: successfully treated with topical tacrolimus
    Yasuhiro Kawachi
    Department of Dermatology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Pediatr Dermatol 28:205-7. 2011
    ..Topical tacrolimus treatment improved the eruptions. The present case also indicated the important role of epidermal and dermal cells as well as immune cells in the pathogenesis of cutaneous lupus erythematodes...
  16. ncbi request reprint Psoriasiform eruption associated with graft-versus-host disease
    Shijima Taguchi
    Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1 1 1, Tennodai, Tsukuba 305 8575, Japan
    Cutis 92:151-3. 2013
    ..We report the case of a 4-year-old boy who developed a generalized psoriasiform eruption shortly after undergoing an allogeneic BMT. Histologic features of both psoriasis and acute GVHD were present. ..
  17. ncbi request reprint Enforced ROR(gamma)t expression in haematopoietic stem cells increases regulatory T cell number, which reduces immunoreactivity and attenuates hypersensitivity in vivo
    Yasuhiro Fujisawa
    Department of Dermatology, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Asian Pac J Allergy Immunol 29:86-93. 2011
    ..These observations raise questions regarding the role of ROR(gamma)t in the early differentiation process of T cells from haematopoietic stem cells...
  18. doi request reprint The induction of tumor-specific CD4+ T cells via major histocompatibility complex class II is required to gain optimal anti-tumor immunity against B16 melanoma cell line in tumor immunotherapy using dendritic cells
    Yasuhiro Fujisawa
    Division of Clinical and Experimental Hematology, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Exp Dermatol 18:396-403. 2009
    ..These results suggested not only the limitation of current protocols using MHC class I-restricted tumor peptides but also the usefulness of DCs expressing gp100 in vaccine therapy against melanoma...
  19. ncbi request reprint Superimposed segmental dermatitis with chronic prurigo
    Yasuhiro Kawachi
    Department of Dermatology, Institute of Clinical Medicine, University of Tsukuba, 1 1 1, Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Eur J Dermatol 19:337-40. 2009
    ..This case report presents a superimposed segmental dermatitis that arose based on systemic eczematous conditions, such as chronic prurigo...
  20. doi request reprint Overexpression of the transcription factor Yin-Yang-1 suppresses differentiation of HaCaT cells in three-dimensional cell culture
    Shijima Taguchi
    Department of Dermatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    J Invest Dermatol 131:37-45. 2011
    ....
  21. doi request reprint Malignant blue nevus arising in a giant congenital cellular blue nevus in an infant
    Yasuhiro Nakamura
    Department of Dermatology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    Pediatr Dermatol 29:651-5. 2012
    ..We report a case of MBN arising in a GCBN on the back. There have been three previous reports of MBN associated with GCBN on the trunk; our case had the earliest onset of MBN arising in a GCBN...
  22. pmc Angiosarcoma of the scalp diagnosed by the presence of neck inflammation: a case report
    Rei Karube
    Department of Oral and Maxillofacial Surgery, University of Tsukuba, Tsukuba City, Japan
    Int J Oral Sci 4:166-9. 2012
    ..A revised diagnostic protocol should note that cervical lymph node metastasis of unknown primary origin may result from angiosarcoma of the scalp...
  23. doi request reprint Indolent subcutaneous panniculitis-like T cell lymphoma in a 1-year-old child
    Yasuhiro Kawachi
    Department of Dermatology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan
    Pediatr Dermatol 29:374-7. 2012
    ..The subcutaneous nodules gradually disappeared spontaneously, and the girl showed excellent prognosis with no aggressive treatment...
  24. ncbi request reprint High-grade mucoepidermoid carcinoma of the columella successfully reconstructed using bilateral nasolabial flaps set up in a sandwich shape and an auricular cartilage graft after surgical resection
    Yoshiyuki Nakamura
    Department of Dermatology, University of Tsukuba, Tsukuba, Japan
    J Dermatol 40:911-4. 2013
    ..This reconstructive technique is particularly useful for correcting the large defect of the columella with nasal septum and/or nasal floor defects. ..
  25. ncbi request reprint B-Myb enhances proliferation and suppresses differentiation of keratinocytes in three-dimensional cell culture
    Hiroshi Maruyama
    Department of Dermatology, Faculty of Medicine, University of Tsukuba, 1 1 1, Tennodai, Tsukuba, 305 8575, Japan
    Arch Dermatol Res 306:375-84. 2014
    ..These findings suggested that B-Myb plays an important role in maintenance of the undifferentiated phenotype of keratinocytes in the basal epidermal layer. ..
  26. doi request reprint Penile preservation surgery in a case of extramammary Paget's disease involving the glans penis and distal urethra
    Yasuhiro Fujisawa
    Department of Dermatology, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Dermatol Surg 34:823-30; discussion 830-1. 2008
  27. ncbi request reprint Coexistence of pemphigus vulgaris and bullous pemphigoid in the upper aerodigestive tract
    Keiji Tabuchi
    Department of Otolaryngology, Doctorial Program in Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
    Auris Nasus Larynx 33:231-3. 2006
    ..The diagnosis was made based on the circulating autoantibodies and direct immunofluorescent studies. The literature on this subject is reviewed...
  28. ncbi request reprint Attenuation of UVB-induced sunburn reaction and oxidative DNA damage with no alterations in UVB-induced skin carcinogenesis in Nrf2 gene-deficient mice
    Yasuhiro Kawachi
    Department of Dermatology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Invest Dermatol 128:1773-9. 2008
    ..Journal of Investigative Dermatology (2008) 128, 1773-1779; doi:10.1038/sj.jid.5701245; published online 17 January 2008...
  29. doi request reprint A case of sterile transient neonatal pustulosis presenting with large flaccid pustules
    Yasuhiro Fujisawa
    Departments of Dermatology, University of Tsukuba, Tsukuba City, Ibaraki, Japan
    Pediatr Dermatol 30:e238-9. 2013
    ..The pustules resolved without leaving pigmentation after 2 weeks. We diagnosed this case as sterile transient neonatal pustulosis. ..
  30. ncbi request reprint Chemoradiation using low-dose cisplatin and 5-fluorouracil in locally advanced squamous cell carcinoma of the skin: a report of two cases
    Yasuhiro Fujisawa
    Department of Dermatology, University of Tsukuba, Japan
    J Am Acad Dermatol 55:S81-5. 2006
    ..Several randomized studies have shown concurrent chemoradiation to be superior to radiation alone. This regimen is an option in managing patients who have unresectable primary tumors or who require preservation of local function...