Yasuhito Fujino

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi request reprint Prevalence of hematological abnormalities and detection of infected bone marrow cells in asymptomatic cats with feline immunodeficiency virus infection
    Yasuhito Fujino
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Vet Microbiol 136:217-25. 2009
  2. doi request reprint Molecular cytogenetic analysis of feline leukemia virus insertions in cat lymphoid tumor cells
    Yasuhito Fujino
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Virol Methods 163:344-52. 2010
  3. doi request reprint Identification of a novel common proviral integration site, flit-1, in feline leukemia virus induced thymic lymphoma
    Yasuhito Fujino
    Department of Pathology, University of Southern California School of Medicine, Los Angeles, CA 90033, USA
    Virology 386:16-22. 2009
  4. doi request reprint Molecular pathogenesis of feline leukemia virus-induced malignancies: insertional mutagenesis
    Yasuhito Fujino
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 123:138-43. 2008
  5. doi request reprint Increased expression of fractalkine and its receptor CX3CR1 in canine inflammatory bowel disease and their possible role in recruitment of intraepithelial lymphocytes
    Shingo Maeda
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 148:226-35. 2012
  6. ncbi request reprint Value of the 13C-urea breath test for detection of gastric Helicobacter spp. infection in dogs undergoing endoscopic examination
    Sanae Kubota
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Vet Med Sci 75:1049-54. 2013
  7. ncbi request reprint Inhibitory effect of newly developed CXC-chemokine receptor 4 antagonists on the infection with feline immunodeficiency virus
    Fuminori Mizukoshi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    J Vet Med Sci 71:121-4. 2009
  8. doi request reprint Mucosal imbalance of interleukin-1β and interleukin-1 receptor antagonist in canine inflammatory bowel disease
    Shingo Maeda
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet J 194:66-70. 2012
  9. ncbi request reprint Effect of mosapride on prednisolone-induced gastric mucosal injury and gastric-emptying disorder in dog
    Atsushi Tsukamoto
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Vet Med Sci 74:1103-8. 2012
  10. doi request reprint Molecular cloning and expression analysis of the canine chemokine receptor CCR9
    Shingo Maeda
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 145:534-9. 2012

Collaborators

Detail Information

Publications71

  1. doi request reprint Prevalence of hematological abnormalities and detection of infected bone marrow cells in asymptomatic cats with feline immunodeficiency virus infection
    Yasuhito Fujino
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Vet Microbiol 136:217-25. 2009
    ..Present results suggest that FIV infection of BM cells can cause peripheral blood cytopenia and myelodysplasia even if the cat is asymptomatic. Such FIV-related hematological abnormalities are supposed to be diagnosed as FIV-myelopathy...
  2. doi request reprint Molecular cytogenetic analysis of feline leukemia virus insertions in cat lymphoid tumor cells
    Yasuhito Fujino
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Virol Methods 163:344-52. 2010
    ..The cytogenetic analysis used in this study can promptly screen FeLV insertions and provide tags for identifying the novel common integration site...
  3. doi request reprint Identification of a novel common proviral integration site, flit-1, in feline leukemia virus induced thymic lymphoma
    Yasuhito Fujino
    Department of Pathology, University of Southern California School of Medicine, Los Angeles, CA 90033, USA
    Virology 386:16-22. 2009
    ..Therefore, flit-1 appears to represent a novel FeLV proviral common integration domain that may influence lymphomagenesis as insertional mutagenesis...
  4. doi request reprint Molecular pathogenesis of feline leukemia virus-induced malignancies: insertional mutagenesis
    Yasuhito Fujino
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 123:138-43. 2008
    ..Especially, polymerase chain reaction (PCR)-based strategies and chromosome analyses with fluorescence in situ hybridization (FISH) will be applicable for studies on FeLV...
  5. doi request reprint Increased expression of fractalkine and its receptor CX3CR1 in canine inflammatory bowel disease and their possible role in recruitment of intraepithelial lymphocytes
    Shingo Maeda
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 148:226-35. 2012
    ..These results suggest that the fractalkine-CX(3)CR1 interaction may contribute to the pathogenesis of canine IBD through migration of IELs...
  6. ncbi request reprint Value of the 13C-urea breath test for detection of gastric Helicobacter spp. infection in dogs undergoing endoscopic examination
    Sanae Kubota
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Vet Med Sci 75:1049-54. 2013
    ..Using our reference range, UBT displayed 89% (16/18) sensitivity and 89% (8/9) specificity, indicating that UBT was quite useful for the detection of gastric Helicobacter spp. infection in dogs. ..
  7. ncbi request reprint Inhibitory effect of newly developed CXC-chemokine receptor 4 antagonists on the infection with feline immunodeficiency virus
    Fuminori Mizukoshi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    J Vet Med Sci 71:121-4. 2009
    ..These results indicated that TF14016 and TF14013 could be useful as antiviral drugs for cats infected with FIV...
  8. doi request reprint Mucosal imbalance of interleukin-1β and interleukin-1 receptor antagonist in canine inflammatory bowel disease
    Shingo Maeda
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet J 194:66-70. 2012
    ..The IL-1Ra:IL-1β protein ratio was negatively correlated with clinical severity in dogs with IBD. An intestinal imbalance between IL-1β and IL-1Ra production may play a role in the pathogenesis of canine IBD...
  9. ncbi request reprint Effect of mosapride on prednisolone-induced gastric mucosal injury and gastric-emptying disorder in dog
    Atsushi Tsukamoto
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Vet Med Sci 74:1103-8. 2012
    ..The use of mosapride in combination with prednisolone is effective for attenuating prednisolone-induced gastrointestinal adverse events...
  10. doi request reprint Molecular cloning and expression analysis of the canine chemokine receptor CCR9
    Shingo Maeda
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 145:534-9. 2012
    ..88%; SD, 2.15%) in the normal canine PBMCs. This study will be useful in understanding canine intestinal immunity and the immunopathogenesis of canine IBD...
  11. ncbi request reprint Quantitative analysis of mRNA for 10 different drug resistance factors in dogs with lymphoma
    Hirotaka Tomiyasu
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    J Vet Med Sci 72:1165-72. 2010
    ..A possible association of ABCB1 with resistance to UW-25 was shown, but no uniform mechanism associated with drug resistance could be identified in dogs with lymphoma...
  12. doi request reprint GeneScan analysis to detect clonality of T-cell receptor γ gene rearrangement in feline lymphoid neoplasms
    Hiroyuki Mochizuki
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 145:402-9. 2012
    ..The PCR assay system to detect clonal TCRγ gene rearrangement in feline lymphoid cells, using GeneScan analysis, would be a useful molecular diagnostic tool for feline T-cell neoplasms, with high fidelity...
  13. ncbi request reprint A retrospective study of inflammatory colorectal polyps in miniature dachshunds
    Aki Ohmi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Vet Med Sci 74:59-64. 2012
    ..The results of this study indicate that miniature dachshunds are predisposed to develop inflammatory colorectal multiple polyps, for which immunosuppressive therapy may be a treatment option...
  14. doi request reprint Quantification of chemokine and chemokine receptor gene expression in duodenal mucosa of dogs with inflammatory bowel disease
    Shingo Maeda
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 144:290-8. 2011
    ..The present results suggest that several chemokines may play important roles in the pathogenesis of canine IBD...
  15. doi request reprint CT characteristics of primary hepatic mass lesions in dogs
    Kenjiro Fukushima
    Department of Veterinary Internal Medicine, University of Tokyo, Tokyo, Japan
    Vet Radiol Ultrasound 53:252-7. 2012
    ..e. contrast retention, was more frequent in hepatic adenoma than in the other groups (P = 0.037 and 0.037, respectively). Nodular hyperplasia was more frequently isoattenuating in the equilibrium phase (P = 0.043)...
  16. doi request reprint Multiplex PCR and Genescan analysis to detect immunoglobulin heavy chain gene rearrangement in feline B-cell neoplasms
    Hiroyuki Mochizuki
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 143:38-45. 2011
    ..The multiplex PCR-based assay and Genescan analysis developed in the present study would be useful and practical tools to detect clonal IGHV gene rearrangement in feline B-cell neoplasms...
  17. ncbi request reprint Vascular and Kupffer imaging of canine liver and spleen using the new contrast agent Sonazoid
    Hideyuki Kanemoto
    Department of Veterinary Internal Medicine, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 70:1265-8. 2008
    ..No adverse effect was observed after Sonazoid injection in all the dogs that we examined. Contrast enhanced ultrasound using Sonazoid is believed to be useful for observing the parenchyma of canine liver and spleen...
  18. doi request reprint Serum amyloid A as a prognostic marker in cats with various diseases
    Takashi Tamamoto
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Vet Diagn Invest 25:428-32. 2013
    ..015). Serum amyloid A concentration in diseased cats is a useful predictive indicator of prognosis regardless of diagnosis...
  19. ncbi request reprint A case of canine multiple inflammatory colorectal polyps treated by endoscopic polypectomy and argon plasma coagulation
    Atsushi Tsukamoto
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    J Vet Med Sci 74:503-6. 2012
    ..Endoscopic treatment by polypectomy and APC is suggested to be a therapeutic option for refractory cases of inflammatory colorectal polyps in dogs...
  20. ncbi request reprint Screening of therapeutic targets for canine mast cell tumors from a variety of kinase molecules
    Yoshinori Takeuchi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 73:1295-302. 2011
    ..Further studies and clinical trials are warranted to apply the inhibitors for the treatment of the tumor...
  21. doi request reprint Evaluation of the prognostic significance of BCL6 gene expression in canine high-grade B-cell lymphoma
    Masahiko Sato
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Science, The University of Tokyo, 1 1 1 Yayoi, Tokyo 113 8657, Japan
    Vet J 191:108-14. 2012
    ..The results suggest that most canine high-grade B-cell lymphomas correspond to human diffuse large B-cell lymphoma with no immunohistochemical expression of BCL6...
  22. ncbi request reprint A retrospective study in 21 Shiba dogs with chronic enteropathy
    Aki Ohmi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 73:1-5. 2011
    ..The results obtained here demonstrated that the Shiba dog is predisposed to chronic enteropathy and shows severe duodenum lesions and poor outcomes, indicating a breed-specific disease...
  23. ncbi request reprint Long term survival of primary skeletal muscle lymphoma in a miniature dachshund
    Yoshinori Takeuchi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Vet Med Sci 72:673-7. 2010
    ..Although the dog suffered at least three relapses by combination chemotherapy, the dog survived 713 days after the initial presentation...
  24. ncbi request reprint Hypereosinophilic syndrome in two cats
    Yoshinori Takeuchi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Vet Med Sci 70:1085-9. 2008
    ..Although cytoreductive chemotherapy with hydroxycarbamide and prednisolone was performed, these two cats died 48 days and 91 days after the initial presentation...
  25. doi request reprint Quantitative assessment of minimal residual disease (MRD) in canine lymphoma by using real-time polymerase chain reaction
    Jumpei Yamazaki
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 126:321-31. 2008
    ..The MRD level detected by the real-time PCR method described here would be useful for investigating the kinetics of tumor cell growth and its regression in canine lymphoma patients...
  26. ncbi request reprint Inhibition of the replication of feline immunodeficiency virus by lentiviral vector-mediated RNA interference in feline cell lines
    Kenji Baba
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Vet Med Sci 70:777-83. 2008
    ..Therefore, abolishment of the silencing effect of shGag may be due to reasons other than the emergence of escape mutants. These results are useful for developing an RNAi-based gene therapy strategy for controlling FIV infection...
  27. ncbi request reprint Simultaneous inactivation of the p16, p15 and p14 genes encoding cyclin-dependent kinase inhibitors in canine T-lymphoid tumor cells
    Aki Fujiwara-Igarashi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Vet Med Sci 75:733-42. 2013
    ..Deletion of the p15-p14-p16 genomic locus could be one of the molecular aberrations in canine lymphoid tumor cells. ..
  28. ncbi request reprint Regulations of ABCB1 and ABCG2 expression through MAPK pathways in acute lymphoblastic leukemia cell lines
    Hirotaka Tomiyasu
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Anticancer Res 33:5317-23. 2013
    ..In the present study, the regulation of the expression of two genes that encode efflux pumps, ATP-binding cassette, sub-family B, member 1 (ABCB1) and ABCG2, through mitogen-activated protein kinase (MAPK) pathways was examined...
  29. doi request reprint Validation of the prognostic value of histopathological grading or c-kit mutation in canine cutaneous mast cell tumours: a retrospective cohort study
    Yoshinori Takeuchi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet J 196:492-8. 2013
    ..These findings demonstrate that the Kiupel grading system is a useful prognostic tool for canine cutaneous MCTs in predicting OS and PFS, while the occurrence of ITD-Exon11 appeared to be a useful predictor for PFS...
  30. ncbi request reprint Intestinal T-cell lymphoma with severe hypereosinophilic syndrome in a cat
    Yoshinori Takeuchi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Tokyo 113 8657, Japan
    J Vet Med Sci 74:1057-62. 2012
    ..Immunohistochemical examination supports a diagnosis of intestinal T-cell lymphoma with severe hypereosinophilic syndrome...
  31. doi request reprint Molecular cloning and characterization of canine fractalkine and its receptor CX3CR1
    Shingo Maeda
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 145:100-9. 2012
    ..The present study will be useful in understanding the canine immune system and the immunopathogenesis of canine inflammatory diseases...
  32. ncbi request reprint Plasma high-mobility group box 1 (HMGB1) in dogs with various diseases: comparison with C-reactive protein
    Asami Ishida
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Vet Med Sci 73:1127-32. 2011
    ..The present study indicates that HMGB1 is a novel canine inflammatory marker and is distinct from CRP. However, the additional clinical value of HMGB1 measurement remains unclear, and further studies are warranted...
  33. ncbi request reprint Eosinophilia and eosinophilic infiltration into splenic B-cell high-grade lymphoma in a dog
    Hirotaka Tomiyasu
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Vet Med Sci 72:1367-70. 2010
    ..This is the first report of eosinophilia and eosinophilic infiltrations into neoplastic lesions in a dog with high-grade B-cell lymphoma...
  34. ncbi request reprint Characterization of monocyte-derived dendritic cells from cats infected with feline immunodeficiency virus
    Fuminori Mizukoshi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 71:865-71. 2009
    ..In this study, monocytes obtained from FIV-infected cats could differentiate into functional DCs, suggesting that they might be used in a DC-based immunotherapy against FIV infection...
  35. ncbi request reprint A case of recovery from canine destructive cholangitis in a Miniature Dachshund
    Takafumi Osumi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 73:937-9. 2011
    ..Although we could not determine which treatment was effective in this case, destructive cholangitis in dogs may be recoverable with long-term supportive therapies...
  36. ncbi request reprint Polypoid adenomas secondary to inflammatory colorectal polyps in 2 miniature dachshunds
    Hirotaka Igarashi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Science, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    J Vet Med Sci 75:535-8. 2013
    ..ICRPs are a nonneoplastic disease, but their long-term prognosis is unknown. Careful follow-up seems to be important, and repetitive biopsy is recommended when growth of polyps is identified in miniature dachshunds with ICRPs...
  37. doi request reprint Comparison of the antitumor effects of an MDM2 inhibitor, nutlin-3, in feline lymphoma cell lines with or without p53 mutation
    Hiroyuki Mochizuki
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 147:187-94. 2012
    ..The present study suggests that inhibition of P53-MDM2 interaction using nutlin-3 may be a new therapeutic strategy for treating feline lymphoma retaining the wt-p53 gene...
  38. doi request reprint Perfusion method for harvesting bone marrow cells from dogs
    Masahiko Sato
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo, Japan
    Am J Vet Res 72:1344-8. 2011
    ..To compare composition and colony formation of bone marrow mononuclear cells (BMMCs) harvested from dogs by means of a new perfusion method and the conventional aspiration method...
  39. ncbi request reprint Measurement of intestinal mucosal permeability in dogs with lymphocytic-plasmacytic enteritis
    Saku Kobayashi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo, Tokyo 113 8657, Japan
    J Vet Med Sci 69:745-9. 2007
    ..5 g/dl (P<0.01). In conclusion, permeability of the intestinal mucosa as determined by the urinary L:R ratio could be a useful laboratory parameter for evaluating intestinal damage in LPE dogs...
  40. doi request reprint Antiviral activity of membrane fusion inhibitors that target gp40 of the feline immunodeficiency virus envelope protein
    Fuminori Mizukoshi
    Department of Veterinary Internal Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Microbiol 136:155-9. 2009
    ..FIV-N36, FIV-C35EK2, and FIV-C35EK3 did not show any apparent inhibitory effect. These results indicated that the newly developed membrane fusion inhibitors could facilitate the development of novel anti-lentiviral chemotherapies...
  41. ncbi request reprint Application of RNA interference for inhibiting the replication of feline immunodeficiency virus in chronically infected cell lines
    Kenji Baba
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Tokyo, Japan
    Vet Microbiol 120:207-16. 2007
    ..These results provide useful information for the development of RNAi-based gene therapy strategy to control FIV infection...
  42. ncbi request reprint Disseminated histiocytic sarcoma with excessive hemophagocytosis in a cat
    Kaori Ide
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 71:817-20. 2009
    ..An autopsy revealed the presence of neoplastic histiocytic cells in the bone marrow, liver, pancreatic lymph node and glomeruli. This is the first case of histiocytic sarcoma in a cat to be reported in Japan...
  43. doi request reprint Myeloma-related disorder with leukaemic progression in a cat
    Yoshinori Takeuchi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Feline Med Surg 12:982-7. 2010
    ..Clinical, cytological, histopathological, and immunohistochemical findings in this case supported the diagnosis of myeloma-related disorder (MRD) with leukaemic progression...
  44. ncbi request reprint Characterization of a newly established nonproducer lymphoma cell line for feline leukemia virus
    Yasuhito Fujino
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Science, University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 102:429-39. 2004
    ..The present study showed that the KO-1 cell line established here was a feline T-cell lymphoma cell line having a unique characteristic as an FeLV nonproducer...
  45. ncbi request reprint Sensitivity for the detection of a clonally rearranged antigen receptor gene in endoscopically obtained biopsy specimens from canine alimentary lymphoma
    Kenjiro Fukushima
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    J Vet Med Sci 71:1673-6. 2009
    ..7%, which was lower than that of other lymphoid malignancies. A combination of histipathological examination and findings of PARR analysis may improve the diagnostic accuracy...
  46. ncbi request reprint Cytomorphological and immunological classification of feline lymphomas: clinicopathological features of 76 cases
    Junko Chino
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Vet Med Sci 75:701-7. 2013
    ..Of the present cases, 64% were high-grade subtypes, whereas 36% were low-grade subtypes. The present study indicated that feline lymphomas could be morphologically classified by the modified updated Kiel classification. ..
  47. doi request reprint Prognostic significance of the expression levels of the p16, p15, and p14 genes in dogs with high-grade lymphoma
    Aki Fujiwara-Igarashi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet J 199:236-44. 2014
    ..p16 mRNA level over its cut-off value correlated with a poor prognosis; however, the expression levels of p15 and p14 mRNAs and p16 methylation status did not influence the prognosis in dogs with high-grade lymphoma. ..
  48. doi request reprint Regulation of expression of ABCB1 and LRP genes by mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and its role in generation of side population cells in canine lymphoma cell lines
    Hirotaka Tomiyasu
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Leuk Lymphoma 54:1309-15. 2013
    ..Stimulation of the MAPK/ERK pathway significantly increased the mRNA expression of both ABCB1 and LRP genes. These results indicate increased expression of the efflux pumps through the MAPK/ERK pathway in SP cells...
  49. ncbi request reprint Lymphangiomatosis of the systemic skin in an old dog
    Shingo Maeda
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 75:187-90. 2013
    ..Based on the clinical presentation and histopathological features, the dog was diagnosed with lymphangiomatosis. Treatment with anti-inflammatory prednisolone improved the symptoms...
  50. doi request reprint The prognostic significance of minimal residual disease in the early phases of chemotherapy in dogs with high-grade B-cell lymphoma
    Masahiko Sato
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet J 195:319-24. 2013
    ..0002). These results indicate the clinical significance of MRD as a prognostic marker in the early phase of chemotherapy...
  51. doi request reprint Decreased gallbladder emptying in dogs with biliary sludge or gallbladder mucocele
    Taro Tsukagoshi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo Japan
    Vet Radiol Ultrasound 53:84-91. 2012
    ..Thus, biliary stasis occurs not only in dogs with gallbladder mucocele but also in dogs with biliary sludge. Cholestasis may play a role in the pathogenesis or progression of these diseases in dogs...
  52. ncbi request reprint Prokinetic effect of the 5-HT4R agonist mosapride on canine gastric motility
    Atsushi Tsukamoto
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Vet Med Sci 73:1635-7. 2011
    ..37 ± 0.51). Mosapride administration (2.0 mg/kg, BID) for 1 week had no adverse effects on blood tests or health of the animals. In conclusion, 0.75 to 2 mg/kg of mosapride produces gastric prokinetic actions without adverse effects...
  53. ncbi request reprint C-reactive protein concentration in dogs with various diseases
    Masaaki Nakamura
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi, Tokyo, Japan
    J Vet Med Sci 70:127-31. 2008
    ..Thus, CRP can be useful to detect inflammations that cannot be detected by WBC and, or band neutrophil counts, suggesting that the examination of CRP concentration is essential as routine diagnostic test...
  54. ncbi request reprint Comparison between immunohistochemistry and genetic clonality analysis for cellular lineage determination in feline lymphomas
    Hirofumi Sato
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 73:945-7. 2011
    ..Cross-lineage IgH rearrangement was found in 25% of T-cell lymphomas. The present study suggests that the genetic analysis had better be applied as not a definite but an adjunctive tool for lineage determination in feline lymphomas...
  55. ncbi request reprint In vivo expression of GFP transgene delivered via a replicating feline leukemia virus
    Judong Pan
    Department of Pathology, University of Southern California Keck School of Medicine, 2011 Zonal Avenue, HMR 210B, Los Angeles, CA 90033, USA
    Vet Microbiol 110:181-95. 2005
    ..These findings on the detectable in vivo expression of GFP for as long as a period of 3 months could be viewed positively for contemplating a therapeutic strategy for control of FeLV infection in the cats...
  56. doi request reprint Protease-activated receptor-2 induces proinflammatory cytokine and chemokine gene expression in canine keratinocytes
    Shingo Maeda
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 153:17-25. 2013
    ....
  57. ncbi request reprint Evaluation of prognostic factors and establishment of a prognostic scoring system for canine primary immune-mediated hemolytic anemia
    Masahiro Ishihara
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
    J Vet Med Sci 72:465-70. 2010
    ..Using the scoring system for prognostication in dogs with pIMHA may enable veterinarians to predict a prognosis easily and accurately...
  58. doi request reprint Establishment of a novel feline leukemia virus (FeLV)-negative B-cell cell line from a cat with B-cell lymphoma
    Hiroyuki Mochizuki
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Vet Immunol Immunopathol 140:307-11. 2011
    ..The MS4 cell line is the first FeLV-negative feline B-cell lymphoma cell line, and may be used to investigate the pathogenesis of spontaneously occurring feline lymphoma and the development of new therapies...
  59. ncbi request reprint Gastrointestinal and hematologic adverse events after administration of vincristine, cyclophosphamide, and doxorubicin in dogs with lymphoma that underwent a combination multidrug chemotherapy protocol
    Hirotaka Tomiyasu
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 72:1391-7. 2010
    ..Findings obtained in this study will be helpful in predicting the adverse events that could occur when dogs with lymphoma are treated with UW-25...
  60. ncbi request reprint Blood hyaluronic acid as a marker for canine cirrhosis
    Hideyuki Kanemoto
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 71:1251-4. 2009
    ..Measurement of the blood HA levels of dogs with suspected liver disease can be a useful diagnostic aid for canine cirrhosis...
  61. ncbi request reprint Quantitative analysis of mRNA transcripts of Hox, SHH, PTCH, Wnt, and Fzd genes in canine hematopoietic progenitor cells and various in vitro colonies differentiated from the cells
    Kaori Ide
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Science, The University of Tokyo, 1 1 1 Yayoi, Bunkyo, Tokyo, Japan
    J Vet Med Sci 71:69-77. 2009
    ..These results suggested important roles of the products of these genes in self-renewal, expansion, and survival of hematopoietic progenitor cells in dogs as shown in humans and rodents...
  62. doi request reprint Aberrant autophosphorylation of c-Kit receptor in canine mast cell tumor cell lines
    Yoshinori Takeuchi
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 137:208-16. 2010
    ..As the four canine MCT cell lines had various aberrations associated with c-Kit receptor phosphorylation, KIT mutation and SCF expression, such molecular biological diversity might reflect the different biological behavior in canine MCT...
  63. ncbi request reprint Induction of chemoresistance in a cultured canine cell line by retroviral transduction of the canine multidrug resistance 1 gene
    Shinobu Matsuura
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Am J Vet Res 68:95-100. 2007
    ..To induce chemoresistance in a normal canine cell line through the transduction of the canine multidrug resistance 1 gene (mdr1)...
  64. ncbi request reprint Characterization of canine focal liver lesions with contrast-enhanced ultrasound using a novel contrast agent-sonazoid
    Hideyuki Kanemoto
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan
    Vet Radiol Ultrasound 50:188-94. 2009
    ..The enhancement pattern of Sonazoid, especially in the parenchymal phase, has potential as a diagnostic tool for canine focal liver lesions...
  65. ncbi request reprint C-reactive protein concentration in canine idiopathic polyarthritis
    Koichi Ohno
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 68:1275-9. 2006
    ..These results suggest that the initial response of CRP to corticosteroid treatment may be a prognostic factor of canine IPA...
  66. ncbi request reprint Investigation of various methods for the cryopreservation of canine bone marrow-derived CD34(+) cells
    Kaori Ide
    Department of Veterinary Internal Medicine, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 70:1211-7. 2008
    ..This method will be useful for clinical applications involving the use of canine bone marrow-derived CD34(+) cells...
  67. doi request reprint Serum amyloid A uptake by feline peripheral macrophages
    Takashi Tamamoto
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 150:47-52. 2012
    ..Further investigation is needed to determine the molecules that influence SAA uptake by macrophages and the effect of clinical glucocorticoid usage on the SAA concentration in cats...
  68. ncbi request reprint Real-time ultrasonographic evaluation of canine gastric motility in the postprandial state
    Atsushi Tsukamoto
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    J Vet Med Sci 73:1133-8. 2011
    ..By using this method, further studies for the pathogenesis of canine gastric motility disorders are warranted...
  69. doi request reprint Characterization of canine BCL6 cDNA and detection systems for its protein expression
    Masahiko Sato
    Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Vet Immunol Immunopathol 140:166-9. 2011
    ..This study will be useful for the molecular classification of canine B-cell lymphomas with different prognoses...
  70. ncbi request reprint Prognostic factors associated with survival in dogs with lymphocytic-plasmacytic enteritis
    Koichi Ohno
    Department of Veterinary Internal Medicine Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Vet Med Sci 68:929-33. 2006
    ..Based on these clinical and laboratory parameters such as anorexia, hypoproteinemia and initial response to treatment, it may be possible to predict poor prognosis in canine LPE...
  71. ncbi request reprint Thymoma in a dog with a part of granular cell proliferation and concurrent lymphoma cells
    Ayumi Fukuoka
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    J Vet Med Sci 66:713-5. 2004
    ..Based on these findings, the present case was diagnosed as thymoma with a part of granular cell proliferation and concurrent lymphoma cells...