Kent Doi


Affiliation: University of Tokyo
Country: Japan


  1. Doi K, Hamasaki Y, Noiri E, Nosaka K, Suzuki T, Toda A, et al. Role of leukotriene B4 in accelerated hyperlipidaemic renal injury. Nephrology (Carlton). 2011;16:304-9 pubmed publisher
    ..These results suggest that LTB4 directly contributes to accelerated hyperlipidaemic renal injury and the therapeutic potential of LTB4 antagonist for renal damage induced by hyperlipidaemia. ..
  2. Fujii T, Uchino S, Doi K, Sato T, Kawamura T. Diagnosis, management, and prognosis of patients with acute kidney injury in Japanese intensive care units: The JAKID study. J Crit Care. 2018;47:185-191 pubmed publisher
    ..Septic AKI was diagnosed in three-fourths of patients with sepsis, while the impact of AKI on hospital mortality among sepsis was not observed. ..
  3. Doi K, Noiri E, Fujita T. Role of vascular endothelial growth factor in kidney disease. Curr Vasc Pharmacol. 2010;8:122-8 pubmed
    ..Although administrating VEGF or novel drugs that activate VEGF pathway may improve the progression of CKD, careful monitoring will be required when CKD patients have complications of diabetes, atherosclerosis or sepsis. ..
  4. Iwagami M, Yasunaga H, Noiri E, Horiguchi H, Fushimi K, Matsubara T, et al. Choice of renal replacement therapy modality in intensive care units: data from a Japanese Nationwide Administrative Claim Database. J Crit Care. 2015;30:381-5 pubmed publisher
    ..1%). Continuous RRT is apparently preferred in actual ICU practice, especially for hemodynamically unstable patients, and subsequent RRT modality switch is associated with mortality. ..
  5. Yamashita T, Doi K, Hamasaki Y, Matsubara T, Ishii T, Yahagi N, et al. Evaluation of urinary tissue inhibitor of metalloproteinase-2 in acute kidney injury: a prospective observational study. Crit Care. 2014;18:716 pubmed publisher
    ..80. Furthermore, urinary TIMP-2 was associated with mortality. Sepsis appeared to have only a limited impact on urinary TIMP-2, in contrast to plasma NGAL. ..
  6. Sumida M, Doi K, Ogasawara E, Yamashita T, Hamasaki Y, Kariya T, et al. Regulation of Mitochondrial Dynamics by Dynamin-Related Protein-1 in Acute Cardiorenal Syndrome. J Am Soc Nephrol. 2015;26:2378-87 pubmed publisher
    ..Furthermore, cardiac dysfunction induced by renal IR was improved by Drp1 inhibition. These data suggest that mitochondrial fragmentation by fission machinery may be a new therapeutic target in cardiac dysfunction induced by AKI. ..
  7. Doi K, Ishizu T, Fujita T, Noiri E. Lung injury following acute kidney injury: kidney-lung crosstalk. Clin Exp Nephrol. 2011;15:464-70 pubmed publisher
    ..These findings will enable us to develop new therapeutic strategies against lung injury associated with AKI and improve the outcomes of critically ill patients in intensive care units. ..
  8. Matsuura R, Komaru Y, Miyamoto Y, Yoshida T, Yoshimoto K, Isshiki R, et al. Response to different furosemide doses predicts AKI progression in ICU patients with elevated plasma NGAL levels. Ann Intensive Care. 2018;8:8 pubmed publisher
    ..This suggests that a combination of FR and biomarkers can stratify the risk of AKI progression in a clinical setting. ..
  9. Hiruma T, Tsuyuzaki H, Uchida K, Trapnell B, Yamamura Y, Kusakabe Y, et al. Interferon-? Improves Sepsis-related Alveolar Macrophage Dysfunction and Post-septic ARDS-related Mortality. Am J Respir Cell Mol Biol. 2018;: pubmed publisher

More Information


  1. Doi K, Rabb H. Impact of acute kidney injury on distant organ function: recent findings and potential therapeutic targets. Kidney Int. 2016;89:555-64 pubmed publisher
    ..This review serves to update the topic of organ cross talk in AKI and focuses on potential therapeutic targets to improve patient outcomes during AKI-associated multiple organ failure. ..
  2. Hamasaki Y, Doi K, Maeda Mamiya R, Ogasawara E, Katagiri D, Tanaka T, et al. A 5-hydroxytryptamine receptor antagonist, sarpogrelate, reduces renal tubulointerstitial fibrosis by suppressing PAI-1. Am J Physiol Renal Physiol. 2013;305:F1796-803 pubmed publisher
    ..In conclusion, SG reduces renal fibrosis not only by the antithrombotic effect of maintaining peritubular blood flow but also by suppressing PAI-1 expression in renal tubular cells. ..