Hirotaka Chikuda

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Optimal treatment for spinal cord injury associated with cervical canal stenosis (OSCIS): a study protocol for a randomized controlled trial comparing early versus delayed surgery
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Trials 14:245. 2013
  2. doi request reprint Mortality and morbidity in dialysis-dependent patients undergoing spinal surgery: analysis of a national administrative database in Japan
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Bone Joint Surg Am 94:433-8. 2012
  3. ncbi request reprint Acute cervical spinal cord injury complicated by preexisting ossification of the posterior longitudinal ligament: a multicenter study
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 36:1453-8. 2011
  4. pmc Correlation between pyramidal signs and the severity of cervical myelopathy
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur Spine J 19:1684-9. 2010
  5. doi request reprint Radiographic analysis of the cervical spine in patients with retro-odontoid pseudotumors
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 34:E110-4. 2009
  6. ncbi request reprint Mutation in cGMP-dependent protein kinase II causes dwarfism in a rat mutant KMI through uncoupling of proliferation and differentiation of chondrocytes
    Hirotaka Chikuda
    Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Bone Miner Metab 23:200-4. 2005
  7. pmc Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes
    Yosuke Kawasaki
    Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 118:2506-15. 2008
  8. ncbi request reprint Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation
    Fumitaka Kugimiya
    Division of Tissue Engineering, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo, 113 8655, Japan
    J Biol Chem 280:35704-12. 2005
  9. pmc Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes
    Hirotaka Chikuda
    Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Bunkyo, Tokyo 113 8655, Japan
    Genes Dev 18:2418-29. 2004
  10. pmc GSK-3beta controls osteogenesis through regulating Runx2 activity
    Fumitaka Kugimiya
    Center for Disease Biology and Integrative Medicine, University of Tokyo, Tokyo, Japan
    PLoS ONE 2:e837. 2007

Collaborators

Detail Information

Publications38

  1. pmc Optimal treatment for spinal cord injury associated with cervical canal stenosis (OSCIS): a study protocol for a randomized controlled trial comparing early versus delayed surgery
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Trials 14:245. 2013
    ....
  2. doi request reprint Mortality and morbidity in dialysis-dependent patients undergoing spinal surgery: analysis of a national administrative database in Japan
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Bone Joint Surg Am 94:433-8. 2012
    ....
  3. ncbi request reprint Acute cervical spinal cord injury complicated by preexisting ossification of the posterior longitudinal ligament: a multicenter study
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 36:1453-8. 2011
    ..Retrospective multicenter study...
  4. pmc Correlation between pyramidal signs and the severity of cervical myelopathy
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur Spine J 19:1684-9. 2010
    ..Considering their low sensitivity in patients with mild disability, the pyramidal signs may have limited utility in early diagnosis of cervical myelopathy...
  5. doi request reprint Radiographic analysis of the cervical spine in patients with retro-odontoid pseudotumors
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 34:E110-4. 2009
    ..A retrospective review of 10 consecutive patients with a noninflammatory retro-odontoid pseudotumor...
  6. ncbi request reprint Mutation in cGMP-dependent protein kinase II causes dwarfism in a rat mutant KMI through uncoupling of proliferation and differentiation of chondrocytes
    Hirotaka Chikuda
    Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Bone Miner Metab 23:200-4. 2005
  7. pmc Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes
    Yosuke Kawasaki
    Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 118:2506-15. 2008
    ..These data indicate that hypertrophic differentiation of growth plate chondrocytes during skeletal growth is promoted by phosphorylation and inactivation of GSK-3beta by cGKII...
  8. ncbi request reprint Involvement of endogenous bone morphogenetic protein (BMP) 2 and BMP6 in bone formation
    Fumitaka Kugimiya
    Division of Tissue Engineering, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo, 113 8655, Japan
    J Biol Chem 280:35704-12. 2005
    ..We thus concluded that endogenous BMP2 and BMP6 cooperatively play pivotal roles in bone formation under both physiological and pathological conditions...
  9. pmc Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes
    Hirotaka Chikuda
    Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Bunkyo, Tokyo 113 8655, Japan
    Genes Dev 18:2418-29. 2004
    ....
  10. pmc GSK-3beta controls osteogenesis through regulating Runx2 activity
    Fumitaka Kugimiya
    Center for Disease Biology and Integrative Medicine, University of Tokyo, Tokyo, Japan
    PLoS ONE 2:e837. 2007
    ..These results establish GSK-3beta as a key attenuator of Runx2 activity in bone formation and as a potential molecular target for clinical treatment of bone catabolic disorders like cleidocranial dysplasia...
  11. doi request reprint Factors affecting the occurrence of pulmonary embolism after spinal surgery: data from the national administrative database in Japan
    Kazuhiro Masuda
    Department of Orthopedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Spine J 12:1029-34. 2012
    ..To the best of our knowledge, few large studies have examined the prevalence and risk factors of PE after spinal surgery...
  12. doi request reprint Is a right pedicle screw always away from the aorta in scoliosis?
    Katsushi Takeshita
    Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 36:E1519-24. 2011
    ..Retrospective analysis...
  13. doi request reprint Aorta movement in patients with scoliosis after posterior surgery
    Katsushi Takeshita
    Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 35:E1571-6. 2010
    ..Retrospective analysis...
  14. pmc New parameters to represent the position of the aorta relative to the spine for pedicle screw placement
    Katsushi Takeshita
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Eur Spine J 19:815-20. 2010
    ..These new parameters enable surgeons to intuitively understand the position of the aorta in surgical planning or in placement of a pedicle screw...
  15. ncbi request reprint Inhibition of Cdk6 expression through p38 MAP kinase is involved in differentiation of mouse prechondrocyte ATDC5
    Toru Moro
    Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Japan
    J Cell Physiol 204:927-33. 2005
    ..These results indicate that Cdk6 may be a regulator of chondrocyte differentiation and that its p38-mediated downregulation is involved in the efficient differentiation...
  16. ncbi request reprint The canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner
    Fumiko Yano
    Division of Tissue Engineering, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 333:1300-8. 2005
    ..The response of Sox9-deficient cells was restored by the adenoviral expression of Sox9. Thus, the canonical Wnt signaling pathway promotes chondrocyte differentiation in a Sox9-dependent manner...
  17. doi request reprint Normative score and cut-off value of the Neck Disability Index
    So Kato
    The Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Surgical Sciences, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0003, Japan
    J Orthop Sci 17:687-93. 2012
    ..The objective of the present study was to determine the normative score and the cut-off value of the NDI...
  18. doi request reprint Natural course and prognostic factors in patients with mild cervical spondylotic myelopathy with increased signal intensity on T2-weighted magnetic resonance imaging
    Yasushi Oshima
    Department of Orthopaedic Surgery, The University of Tokyo, Bunkyo ku, Japan
    Spine (Phila Pa 1976) 37:1909-13. 2012
    ..A retrospective comparative study...
  19. ncbi request reprint Ossification of the posterior atlantoaxial membrane associated with an os odontoideum: a case report
    Junichi Ohya
    Department of Orthopaedic Surgery, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Orthop Surg (Hong Kong) 19:392-4. 2011
    ..Long-standing atlantoaxial instability might have played a role in ectopic ossification of the posterior atlantoaxial membrane...
  20. ncbi request reprint Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability
    Satoru Kamekura
    Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Arthritis Rheum 54:2462-70. 2006
    ..By producing instability in mouse knee joints, we attempted to determine the involvement of runt-related transcription factor 2 (RUNX-2), which is required for chondrocyte hypertrophy, in the development of osteoarthritis (OA)...
  21. doi request reprint A novel disease-modifying osteoarthritis drug candidate targeting Runx1
    Fumiko Yano
    Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Ann Rheum Dis 72:748-53. 2013
    ..To identify a new disease-modifying osteoarthritis drug (DMOAD) candidate that can effectively repair cartilage by promoting chondrogenic differentiation and halt osteoarthritis (OA) progression by suppressing aberrant hypertrophy...
  22. ncbi request reprint Cervical canal stenosis caused by progressive fusion and enlargement of cervical vertebrae with features of Proteus syndrome and Klippel-Feil syndrome
    Shurei Sugita
    Department of Orthopaedic Surgery, The University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo, Japan
    Skeletal Radiol 42:1743-6. 2013
    ..Our report may help expand the knowledge on developmental spine disorders. ..
  23. ncbi request reprint Modified fenestration with restorative spinoplasty for lumbar spinal stenosis
    Ko Matsudaira
    Department of Orthopedics, Faculty of Medicine, Tokyo University, Bunkyo ku, Tokyo, Japan
    J Neurosurg Spine 10:587-94. 2009
    ..The MFRS technique produces an adequate and safe decompression of the spinal canal, even in patients with narrow and steep facet joints in whom conventional fenestration is technically demanding...
  24. doi request reprint Radiographical risk factors for major intraoperative blood loss during laminoplasty in patients with ossification of the posterior longitudinal ligament
    So Kato
    Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Surgical Sciences, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 37:E1588-93. 2012
    ..A retrospective multi-institutional study...
  25. pmc Sleep apnea in rheumatoid arthritis patients with occipitocervical lesions: the prevalence and associated radiographic features
    Naoki Shoda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo, 113 8655, Japan
    Eur Spine J 18:905-10. 2009
    ..Small ADI and short neck, secondary to the vertical translocation by RA, may cause obstructive sleep apnea, probably through mechanical or neurological collapse of the upper airway...
  26. doi request reprint Use of Doppler ultrasonography to detect an elusive communication of a spinal extradural arachnoid cyst
    Masakazu Kanetaka
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Clin Neurosci 18:863-4. 2011
    ..Doppler ultrasonography may be a helpful adjunct for identifying the location of elusive communication in a spinal extradural arachnoid cyst...
  27. doi request reprint Diameter, length, and direction of pedicle screws for scoliotic spine: analysis by multiplanar reconstruction of computed tomography
    Katsushi Takeshita
    Department of Orthopaedic Surgery, The University of Tokyo, Tokyo, Japan
    Spine (Phila Pa 1976) 34:798-803. 2009
    ..A morphometric study of thoracic and lumbar spine in scoliosis...
  28. ncbi request reprint Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding
    Atsuhiko Hikita
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 280:41700-6. 2005
    ..These results suggest that deltaCAPRI is a possible regulator of RANKL shedding by modulating MMP14 expression through Ras signaling cascades other than the Erk pathway...
  29. pmc Distinct roles of Smad pathways and p38 pathways in cartilage-specific gene expression in synovial fibroblasts
    Hiroaki Seto
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    J Clin Invest 113:718-26. 2004
    ....
  30. doi request reprint Usefulness of QuickDASH in patients with cervical laminoplasty
    Hideki Nakamoto
    Department of Orthopedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Orthop Sci 19:218-22. 2014
    ....
  31. ncbi request reprint Clinical characteristics of rheumatoid arthritis patients undergoing cervical spine surgery: an analysis of National Database of Rheumatic Diseases in Japan
    Shurei Sugita
    The Department of Orthopaedic Surgery, The University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo, Japan
    BMC Musculoskelet Disord 15:203. 2014
    ..The aim of this study was to examine the clinical characteristics of rheumatoid arthritis (RA) patients who underwent cervical spine surgery using a multicenter observational database...
  32. ncbi request reprint Mortality and morbidity after high-dose methylprednisolone treatment in patients with acute cervical spinal cord injury: a propensity-matched analysis using a nationwide administrative database
    Hirotaka Chikuda
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Emerg Med J 31:201-6. 2014
    ..To examine the magnitude of the adverse impact of high-dose methylprednisolone treatment in patients with acute cervical spinal cord injury (SCI)...
  33. pmc The normative score and the cut-off value of the Oswestry Disability Index (ODI)
    Juichi Tonosu
    Department of Orthopedic Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Eur Spine J 21:1596-602. 2012
    ..The purpose of this study was to estimate the normative score by adjusting the data for age distribution in Japan, and to determine the cut-off value which separates LBP with disability from LBP without disability...
  34. ncbi request reprint Morphological characteristics of cervical spine in patients with athetoid cerebral palsy and the accuracy of pedicle screw placement
    So Kato
    Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Surgical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan and Department of Orthopaedics, Jichi Medical University, Shimotsuke, Japan
    Spine (Phila Pa 1976) 39:E508-13. 2014
    ..A retrospective study...
  35. doi request reprint Long-term follow-up of the progression of ossification of the posterior longitudinal ligament
    Motoaki Murakami
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Neurosurg Spine 12:577-9. 2010
    ..Segmental-type OPLL developed into mixed-type extensive OPLL. This case shows an accelerating maturation process of OPLL over the course of a few years. Segmental-type OPLL appears to represent an initial stage of extensive OPLL...
  36. doi request reprint Postsurgical spinal magnetic resonance imaging with iterative decomposition of water and fat with echo asymmetry and least-squares estimation
    Mizuho Murakami
    Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Comput Assist Tomogr 35:16-20. 2011
    ..Here, we compared postsurgical spinal MRI with IDEAL versus chemical shift selective saturation (CHESS)...
  37. ncbi request reprint Impairment of bone healing by insulin receptor substrate-1 deficiency
    Takashi Shimoaka
    Departments of Orthopaedic Surgery, Tissue Engineering, and Metabolic Diseases, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo, Tokyo 113 8655, Japan
    J Biol Chem 279:15314-22. 2004
    ....