S Chiba

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Notch signaling in stem cell systems
    Shigeru Chiba
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Stem Cells 24:2437-47. 2006
  2. ncbi request reprint Hematopoietic stem cells expanded by fibroblast growth factor-1 are excellent targets for retrovirus-mediated gene delivery
    Aleksandra Crcareva
    Department of Hematology Oncology, University of Tokyo, Japan
    Exp Hematol 33:1459-69. 2005
  3. ncbi request reprint Homeobox genes in normal hematopoiesis and leukemogenesis
    S Chiba
    Department of Hematology Oncology, University of Tokyo Hospital, Japan
    Int J Hematol 68:343-53. 1998
  4. pmc Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells
    Shigeru Chiba
    Departments of Biology and Human Genetics, Yale University, New Haven, CT 06520 8103, USA
    Proc Natl Acad Sci U S A 100:15577-82. 2003
  5. ncbi request reprint Mutations of the Smad4 gene in acute myelogeneous leukemia and their functional implications in leukemogenesis
    Y Imai
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    Oncogene 20:88-96. 2001
  6. ncbi request reprint Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression
    K Kumano
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Blood 98:3283-9. 2001
  7. ncbi request reprint Predictors for severe cardiac complications after hematopoietic stem cell transplantation
    M Sakata-Yanagimoto
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Bone Marrow Transplant 33:1043-7. 2004
  8. ncbi request reprint Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation
    K Shimizu
    Department of Hematology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 276:25753-8. 2001
  9. ncbi request reprint High-grade cytomegalovirus antigenemia after hematopoietic stem cell transplantation
    Y Asano-Mori
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Tokyo, Japan
    Bone Marrow Transplant 36:813-9. 2005
  10. ncbi request reprint AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1
    M Takeshita
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Leukemia 22:1241-9. 2008

Collaborators

Detail Information

Publications111 found, 100 shown here

  1. ncbi request reprint Notch signaling in stem cell systems
    Shigeru Chiba
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Stem Cells 24:2437-47. 2006
    ..One main focus in mammalian studies is the role of Notch in embryonic and postembryonic stem cell systems. In this review, the roles of Notch signaling in various mammalian stem and early progenitor cells are summarized...
  2. ncbi request reprint Hematopoietic stem cells expanded by fibroblast growth factor-1 are excellent targets for retrovirus-mediated gene delivery
    Aleksandra Crcareva
    Department of Hematology Oncology, University of Tokyo, Japan
    Exp Hematol 33:1459-69. 2005
    ..The objective of this study is to examine whether the use of fibroblast growth factor-1 (FGF-1)-expanded bone marrow cells provide an improved source for retroviral gene delivery to HSCs...
  3. ncbi request reprint Homeobox genes in normal hematopoiesis and leukemogenesis
    S Chiba
    Department of Hematology Oncology, University of Tokyo Hospital, Japan
    Int J Hematol 68:343-53. 1998
    ..Currently available information will be discussed separately on HOX and non-HOX genes, in normal and leukemic hematopoiesis, respectively...
  4. pmc Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells
    Shigeru Chiba
    Departments of Biology and Human Genetics, Yale University, New Haven, CT 06520 8103, USA
    Proc Natl Acad Sci U S A 100:15577-82. 2003
    ..Taken together, these data suggest that DLX1 may function as a regulator of multiple signals from TGF-beta superfamily members in broad biological contexts during blood production...
  5. ncbi request reprint Mutations of the Smad4 gene in acute myelogeneous leukemia and their functional implications in leukemogenesis
    Y Imai
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    Oncogene 20:88-96. 2001
    ..Oncogene (2001) 20, 88 - 96...
  6. ncbi request reprint Notch1 inhibits differentiation of hematopoietic cells by sustaining GATA-2 expression
    K Kumano
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Blood 98:3283-9. 2001
    ..These results indicate that GATA-2 activity is necessary for the Notch signaling in hematopoietic cells...
  7. ncbi request reprint Predictors for severe cardiac complications after hematopoietic stem cell transplantation
    M Sakata-Yanagimoto
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Bone Marrow Transplant 33:1043-7. 2004
    ..We conclude that the cumulative dose of anthracyclines is the most potent predictor of cardiac complications and the administration of anthracyclines should be avoided within two months before transplantation...
  8. ncbi request reprint Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation
    K Shimizu
    Department of Hematology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 276:25753-8. 2001
    ..Taking these findings together, we propose that the difference in modulatory function of multiple fringe proteins may result from the distinct amino acid sequence specificity targeted by these glycosyltransferases...
  9. ncbi request reprint High-grade cytomegalovirus antigenemia after hematopoietic stem cell transplantation
    Y Asano-Mori
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Tokyo, Japan
    Bone Marrow Transplant 36:813-9. 2005
    ..Although CMV disease frequently developed in HG-antigenemia patients, antiviral therapy could prevent a fatal outcome...
  10. ncbi request reprint AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1
    M Takeshita
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Leukemia 22:1241-9. 2008
    ..Thus, leukemogenic activity of AML1-Evi-1 may be due to activation of molecular mechanisms distinct from those activated by MLL-ENL or AML1-ETO in the hematopoietic stem cell fractions...
  11. ncbi request reprint Increased incidence of acute graft-versus-host disease with the continuous infusion of cyclosporine A compared to twice-daily infusion
    N Ogawa
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Bone Marrow Transplant 33:549-52. 2004
    ..039), but not in standard-risk patients (72 vs 80%, P=0.45). CIF of CsA with a target level of 250-400 ng/ml may not be appropriate for GVHD prophylaxis in standard-risk patients...
  12. ncbi request reprint Cardiac complications after haploidentical HLA-mismatched hematopoietic stem cell transplantation using in vivo alemtuzumab
    K Oshima
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
    Bone Marrow Transplant 36:821-4. 2005
    ..Patient selection and close monitoring of cardiac function may be important in HLA-mismatched HSCT using in vivo alemtuzumab...
  13. ncbi request reprint Identification of Ki23819, a highly potent inhibitor of kinase activity of mutant FLT3 receptor tyrosine kinase
    Y Komeno
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Leukemia 19:930-5. 2005
    ..FLT3-ITD-dependent activation of the downstream signaling proteins ERK and STAT5 was also inhibited within similar concentration ranges. Thus, Ki23819 is a potent in vitro inhibitor of FLT3...
  14. ncbi request reprint Characterization and molecular features of the cell surface receptor for human granulocyte-macrophage colony-stimulating factor
    S Chiba
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Leukemia 4:29-36. 1990
    ..In experiments using U-937 cells, only the latter two bands appeared to be labeled in a dose-dependent manner in a low-affinity state. These results suggest that the human GM-CSF receptor possibly forms a multichain complex...
  15. ncbi request reprint Frequent expression of receptors for granulocyte-macrophage colony-stimulating factor on human nonhematopoietic tumor cell lines
    K Miyagawa
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    J Cell Physiol 143:483-7. 1990
    ..The high affinity receptors identified on hematopoietic cells were not detected on human nonhematopoietic tumor cells which we studied, and we could detect no effects of GM-CSF on cell growth of these tumor cells...
  16. ncbi request reprint Recovery of Valpha24+ NKT cells after hematopoietic stem cell transplantation
    K Haraguchi
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Bone Marrow Transplant 34:595-602. 2004
    ..Our results raise the possibility that the number of Valpha24+ NKT cells could be related to the development of GVHD...
  17. ncbi request reprint Stem cell leukemia protein directs hematopoietic stem cell fate
    Atsushi Kunisato
    Department of Hematology Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Blood 103:3336-41. 2004
    ..We conclude that the up-regulation or down-regulation of SCL directs HSCs toward myeloid or lymphoid lineage, respectively, although SCL does not affect their long-term repopulating capacity...
  18. ncbi request reprint FDG-PET in T-cell and NK-cell neoplasms
    S Kako
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Ann Oncol 18:1685-90. 2007
    ..The results of FDG-PET, however, have not been studied extensively for T-cell and natural killer (NK)-cell neoplasms...
  19. ncbi request reprint A high incidence of late-onset neutropenia following rituximab-containing chemotherapy as a primary treatment of CD20-positive B-cell lymphoma: a single-institution study
    E Nitta
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Ann Oncol 18:364-9. 2007
    ..Late-onset neutropenia (LON) has been reported following rituximab-containing chemotherapy. Its incidence and risk factors, however, have not been extensively studied...
  20. ncbi request reprint Thyroid function after bone marrow transplantation: possible association between immune-mediated thyrotoxicosis and hypothyroidism
    M Kami
    Department of Hematology and Oncology, Faculty of Medicine, University of Tokyo, Japan
    Transplantation 71:406-11. 2001
    ..Immune-mediated thyroid injury may contribute to the development of posttransplant hypothyroidism...
  21. doi request reprint Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells
    Susumu Goyama
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, The University of Tokyo Hospital, Tokyo 113 8655, Japan
    Cell Stem Cell 3:207-20. 2008
    ..Thus, Evi-1 is a common and critical regulator essential for proliferation of embryonic/adult HSCs and transformed leukemic cells...
  22. ncbi request reprint Genomic analysis of a new mammalian distal-less gene: Dlx7
    S Nakamura
    Department of Biology, Yale University, New Haven, Connecticut 06511, USA
    Genomics 38:314-24. 1996
    ..These mapping results support the possibility that vertebrate distal-less genes have been duplicated in concert with the Hox clusters...
  23. ncbi request reprint The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3
    M Kurokawa
    The Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Nature 394:92-6. 1998
    ..These results define a new function of Evi-1 as a repressor of signalling through TGF-beta...
  24. ncbi request reprint HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo
    Atsushi Kunisato
    Departments of Hematology and Oncology, Graduate School of Medicine, and Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, University of Tokyo, Japan
    Blood 101:1777-83. 2003
    ..Up-regulation of HES-1 protein in the 34-KSL population before unnecessary cell division, that is, without retrovirus transduction, may represent a potent approach to absolute expansion of hematopoietic stem cells...
  25. ncbi request reprint Male predominance among Japanese adult patients with late-onset hemorrhagic cystitis after hematopoietic stem cell transplantation
    Y Asano
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
    Bone Marrow Transplant 32:1175-9. 2003
    ..Male predominance was detected in LHC after HSCT, as has been previously shown in children with AdV-induced acute HC. The detection of AdV DNA in serum did not predict a poor outcome...
  26. ncbi request reprint Unbalanced translocation der(1;7)(q10;p10) defines a unique clinicopathological subgroup of myeloid neoplasms
    M Sanada
    Department of Regeneration Medicine for Hematopoiesis, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Leukemia 21:992-7. 2007
    ..0001). In conclusion, der(1;7)(q10;p10) defines a discrete entity among myeloid neoplasms, showing unique clinical and cytogenetic characteristics...
  27. ncbi request reprint Preservation of ovarian function by ovarian shielding when undergoing total body irradiation for hematopoietic stem cell transplantation: a report of two successful cases
    K Nakagawa
    Department of Radiology, University of Tokyo Hospital, Tokyo, Japan
    Bone Marrow Transplant 37:583-7. 2006
    ..3, and serum estradiol was transiently detected above 20 pg/ml. The preservation of ovarian function was made possible by ovarian shielding. However, a longer follow-up is needed to know if normal pregnancy and delivery can occur...
  28. ncbi request reprint AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis
    Motoshi Ichikawa
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Nat Med 10:299-304. 2004
    ..AML-1 is thus required for maturation of megakaryocytes and differentiation of T and B cells, but not for maintenance of hematopoietic stem cells (HSCs) in adult hematopoiesis...
  29. ncbi request reprint Reduced-intensity bone marrow transplantation from an alternative unrelated donor for myelodysplastic syndrome of first-donor origin
    Yukiko Komeno
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Japan
    Am J Hematol 72:220-2. 2003
    ..Reduced-intensity second BMT from an alternative donor appeared to be a tolerable treatment option for donor-derived leukemia/MDS after the first conventional transplantation...
  30. ncbi request reprint Functional domains of Runx1 are differentially required for CD4 repression, TCRbeta expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte development
    Masahito Kawazu
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 174:3526-33. 2005
    ..These results suggest that the activation domain is essential for Runx1 to establish thymocyte development and that Runx1 has both TLE-dependent and TLE-independent functions in thymocyte development...
  31. pmc Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2
    K Shimizu
    Departments of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Mol Cell Biol 20:6913-22. 2000
    ..Moreover, the findings of rapid cleavage, nuclear translocation, and phosphorylation of Notch2 after ligand binding facilitate the understanding of the Notch signaling...
  32. ncbi request reprint Identification of homeobox genes expressed in human T-lymphocytes
    K Inamori
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Biochem Biophys Res Commun 196:203-8. 1993
    ..Together with the recent observations, these results suggest that the protein products of these genes may participate in normal functions and/or transformation of T-cells...
  33. ncbi request reprint Serum levels of fluconazole in patients after cytotoxic chemotherapy for hematological malignancy
    M Kami
    Department of Hematology and Oncology, Faculty of Medicine, The University of Tokyo, Japan
    Am J Hematol 66:85-91. 2001
    ..These variations may be associated with disturbance of body water balance, such as massive hemorrhage and dehydration...
  34. ncbi request reprint Serum levels of soluble interleukin-2 receptor after bone marrow transplantation: a true marker of acute graft-versus-host disease
    M Kami
    Dept of Hematology, Toranomon Hospital, Tokyo, Japan
    Leuk Lymphoma 38:533-40. 2000
    ..Some factors other than GVHD contribute to the elevation of serum sIL-2R levels, and we should recognize the limitations of the measurement of this cytokine...
  35. ncbi request reprint Decreased incidence of acute graft-versus-host disease by continuous infusion of cyclosporine with a higher target blood level
    Kumi Oshima
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Am J Hematol 83:226-32. 2008
    ..We conclude that the toxicity of the continuous CsA infusion with a target level of 450-550 ng/ml is acceptable and the efficacy to prevent acute GVHD is significant. A larger comparative study is warranted to confirm these findings...
  36. doi request reprint Multicenter prospective trial evaluating the tolerability of imatinib for Japanese patients with chronic myelogenous leukemia in the chronic phase: does body weight matter?
    Yoshinobu Kanda
    Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan
    Am J Hematol 83:835-9. 2008
    ....
  37. ncbi request reprint AML1 is functionally regulated through p300-mediated acetylation on specific lysine residues
    Yuko Yamaguchi
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, USA
    J Biol Chem 279:15630-8. 2004
    ..Taken together, these data indicate that acetylation of AML1 through p300 is a critical manner of posttranslational modification and identify a novel mechanism for regulating the function of AML1...
  38. ncbi request reprint [Investigation of the cause of polyurethane catheter cracking during constant infusion of etoposide (VP-16) injection (2)--Analysis of ethanol eluting materials from catheter]
    Haruko Yokoyama
    Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655 Japan
    Yakugaku Zasshi 123:799-803. 2003
    ..Furthermore, to prevent the elution of BD from PU catheters, we suggest that PU catheters should not be used for the administration of VP-16 injection without dilution in consideration of safety and efficacy...
  39. ncbi request reprint In vivo alemtuzumab enables haploidentical human leukocyte antigen-mismatched hematopoietic stem-cell transplantation without ex vivo graft manipulation
    Yoshinobu Kanda
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Hongo, Tokyo, Japan
    Transplantation 79:1351-7. 2005
    ..This study evaluates the safety of unmanipulated peripheral blood stem-cell transplantation from two or three loci-mismatched related donors using alemtuzumab in vivo...
  40. ncbi request reprint Neoendothelialization after peripheral blood stem cell transplantation in humans: a case report of a Tokaimura nuclear accident victim
    Toru Suzuki
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
    Cardiovasc Res 58:487-92. 2003
    ..We examined the extent of neoendothelialization of the aorta and peripheral arteries in the case of a patient who underwent peripheral blood stem cell transplantation for acute radiation syndrome...
  41. ncbi request reprint Graft-versus-tumor effect against advanced pancreatic cancer after allogeneic reduced-intensity stem cell transplantation
    Yoshinobu Kanda
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Transplantation 79:821-7. 2005
    ....
  42. ncbi request reprint Long-term sustained mixed chimerism after allogeneic stem cell transplantation in a patient with severe aplastic anemia
    Akiko M Saito
    Department of Hematology Oncology, Graduate School of Medicine and Department of Cell Therapy Transplantation Medicine, University of Tokyo Hospital, University of Tokyo, Tokyo
    Intern Med 46:1923-6. 2007
    ..This report describes the most comprehensive case study known to date...
  43. ncbi request reprint Allogeneic hematopoietic stem cell transplantation from family members other than HLA-identical siblings over the last decade (1991-2000)
    Yoshinobu Kanda
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Japan
    Blood 102:1541-7. 2003
    ..In standard-risk patients, however, survival after one-locus-mismatched HSCT is significantly shorter than that after HLA-matched HSCT, and the indications for HSCT should be considered carefully...
  44. ncbi request reprint Highly efficient ex vivo expansion of human hematopoietic stem cells using Delta1-Fc chimeric protein
    Takahiro Suzuki
    Department of Regeneration Medicine for Hematopoiesis, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Stem Cells 24:2456-65. 2006
    ..Interestingly, the CD133-sorted cells contained approximately 4.5 times more SRCs than the CD34-sorted cells. The present study provides a promising method to expand HSCs and encourages future trials on clinical transplantation...
  45. ncbi request reprint Regression of the tumor after withdrawal of cyclosporine in relapsed extranodal natural killer/T cell lymphoma following allogeneic hematopoietic stem cell transplantation
    Shinichi Kako
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Hematol 82:937-9. 2007
    ..The clinical course of the current patient suggests the potent GVL effect against ENKL. Allogeneic HSCT, including that with reduced-intensity regimens, is a promising treatment option for high-risk ENKL...
  46. ncbi request reprint Reverse seroconversion of hepatitis B virus after hematopoietic stem cell transplantation
    S Goyama
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Leuk Lymphoma 43:2159-63. 2002
    ..The use of corticosteroids, the lack of HBsAb in donor, and a decrease in serum HBsAb and HBcAb levels may predict reverse seroconversion after HSCT...
  47. pmc c-fps/fes protein-tyrosine kinase is implicated in a signaling pathway triggered by granulocyte-macrophage colony-stimulating factor and interleukin-3
    Y Hanazono
    Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    EMBO J 12:1641-6. 1993
    ..p92c-fes is therefore a possible signal transducer of several hematopoietic growth factors including GM-CSF and IL-3 through the common beta chain...
  48. ncbi request reprint A case of severe B cell deficiency after allogeneic stem cell transplantation
    T Takahashi
    Department of Hematology and Oncology, University of Tokyo, Japan
    Bone Marrow Transplant 30:397-400. 2002
    ..Other populations appear to be normal. To the best of our knowledge, this is the first report of B-lymphopoiesis being undetectable more than 2 years after allogeneic SCT...
  49. ncbi request reprint Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells
    Keiki Kumano
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Immunity 18:699-711. 2003
    ..In contrast, Notch2(-/-) embryos showed no hematopoietic deficiency. These data indicate that Notch1, but not Notch2, is essential for generating hematopoietic stem cells from endothelial cells...
  50. ncbi request reprint Notch1 oncoprotein antagonizes TGF-beta/Smad-mediated cell growth suppression via sequestration of coactivator p300
    Shigeo Masuda
    Department of Hematology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Cancer Sci 96:274-82. 2005
    ..Taken together, we propose that Notch oncoproteins promote cell growth and cancer development partly by suppressing the growth inhibitory effects of TGF-beta through sequestrating p300 from Smad3...
  51. doi request reprint Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis
    Keiki Kumano
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
    Pigment Cell Melanoma Res 21:70-8. 2008
    ..Furthermore, Notch1 and Notch2 cooperates with c-kit signaling during embryogenesis, and they cooperate with each other to regulate melanocyte homeostasis after birth...
  52. doi request reprint Influence of pretransplantation serum ferritin on nonrelapse mortality after myeloablative and nonmyeloablative allogeneic hematopoietic stem cell transplantation
    Keisuke Kataoka
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Biol Blood Marrow Transplant 15:195-204. 2009
    ..019). Similar results were observed after dividing the patients according to the intensity of conditioning regimens. These findings emphasize the prognostic impact of pretransplantation serum ferritin in HSCT recipients...
  53. ncbi request reprint Late onset of autoimmune hemolytic anemia and pure red cell aplasia after allogeneic hematopoietic stem cell transplantation using in vivo alemtuzumab
    Shinichi Kako
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Hematol 83:247-9. 2008
    ..The clinical course suggested that AIHA was mainly caused by humoral immune response, while PRCA was mainly caused by cell-mediated immune response in this patient, although these immune responses might be related to each other...
  54. ncbi request reprint Expression profiling of immature thymocytes revealed a novel homeobox gene that regulates double-negative thymocyte development
    Masahito Kawazu
    Department of Hematology and Oncology, University of Tokyo, Japan
    J Immunol 179:5335-45. 2007
    ....
  55. doi request reprint A myeloablative conditioning regimen for patients with impaired cardiac function undergoing allogeneic stem cell transplantation: reduced cyclophosphamide combined with etoposide and total body irradiation
    Akihide Yoshimi
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Hematol 83:635-9. 2008
    ..There is a possibility that VP/rCY/TBI regimen can be safely administered for patients with pretransplantation cardiac comorbidity while preserving antineoplastic effects. These observations merit further prospective study...
  56. ncbi request reprint Ischemic colitis as a manifestation of thrombotic microangiopathy following bone marrow transplantation
    Yukiko Komeno
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo
    Intern Med 42:1228-32. 2003
    ..Autopsy revealed endothelial injuries of arterioles and ischemic changes in the intestines and kidneys. Clinical and pathological characteristics of ischemic colitis due to BMT-associated TMA are described...
  57. ncbi request reprint The transcriptionally active form of AML1 is required for hematopoietic rescue of the AML1-deficient embryonic para-aortic splanchnopleural (P-Sp) region
    Susumu Goyama
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Blood 104:3558-64. 2004
    ..Thus, this experimental system will become a valuable tool to analyze the physiologic function and domain contribution of Runx proteins in hematopoiesis...
  58. ncbi request reprint Host-residual invariant NK T cells attenuate graft-versus-host immunity
    Kyoko Haraguchi
    Departments of Hematology Oncology, Cell Therapy Transplantation Medicine, University of Tokyo Graduate School of Medicine and Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Immunol 175:1320-8. 2005
    ..These results indicate that host-residual iNKT cells attenuate graft-vs-host immunity rather than host-vs-graft immunity...
  59. ncbi request reprint Transplantation for accidental acute high-dose total body neutron- and gamma-radiation exposure
    S Chiba
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
    Bone Marrow Transplant 29:935-9. 2002
    ..Random chromatid breaks were observed in donor cells suggesting a bystander effect of neutron exposure. The subject died 82 days after the accident (75 days post transplant) from multi-organ failure...
  60. ncbi request reprint Cloning and sequencing of an alpha-glucosidase gene from Aspergillus niger and its expression in A. nidulans
    A Nakamura
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, University of Tokyo, Japan
    J Biotechnol 53:75-84. 1997
    ....
  61. ncbi request reprint Acute eosinophilic pneumonia is a non-infectious lung complication after allogeneic hematopoietic stem cell transplantation
    Mayumi Yoshimi
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int J Hematol 89:244-8. 2009
    ..We made a diagnosis of AEP and steroid was started. AEP remitted with other GVHD symptoms but exacerbated partially when steroid was decreased. This case suggests a potential link between AEP and GVHD...
  62. doi request reprint Clinical features of late cytomegalovirus infection after hematopoietic stem cell transplantation
    Yuki Asano-Mori
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo, 113 8655, Japan
    Int J Hematol 87:310-8. 2008
    ..Low-level antigenemia may not require antiviral treatments...
  63. ncbi request reprint Functional diversity among Notch1, Notch2, and Notch3 receptors
    Kiyoshi Shimizu
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 291:775-9. 2002
    ....
  64. ncbi request reprint Rapid diagnosis of invasive pulmonary aspergillosis by quantitative polymerase chain reaction using bronchial lavage fluid
    Masahito Kawazu
    Department of Hematology and Oncology, University of Tokyo, Tokyo, Japan
    Am J Hematol 72:27-30. 2003
    ..This novel tool will provide rapid, sensitive, and specific diagnosis of pulmonary aspergillosis...
  65. ncbi request reprint Clinical significance of peripheral blood erythroblastosis after hematopoietic stem cell transplantation
    Susumu Goyama
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Japan
    Leuk Lymphoma 45:2439-43. 2004
    ..As for post-transplant events, a high EBL concentration was frequently preceded by graft-vs.-host disease, thrombotic microangiopathy, hypoxia, and hematological relapse...
  66. doi request reprint Molecular and cytogenetic response of chronic myelogenous leukemia treated with imatinib mesylate: one institutional experience in Japan
    Yasuhito Nannya
    Department of Hematology and Oncology, Graduate School of Medicine, Tokyo University, 7 3 1 Hongo, Tokyo, 113 8655, Japan
    Int J Hematol 88:159-64. 2008
    ..However, patients who showed persistent intolerance with adequate dose of IM (300 mg/day or more) showed poor molecular response...
  67. ncbi request reprint Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP
    Eriko Nitta
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Oncogene 24:6165-73. 2005
    ..These results suggest that oligomerization may contribute to the oncogenic potential of Evi-1-containing proteins...
  68. ncbi request reprint Case report: persistent cytomegalovirus (CMV) infection after haploidentical hematopoietic stem cell transplantation using in vivo alemtuzumab: emergence of resistant CMV due to mutations in the UL97 and UL54 genes
    Kumi Oshima
    Department of Hematology and Oncology, University of Tokyo, Tokyo, Japan
    J Med Virol 80:1769-75. 2008
    ..In conclusion, the in vitro susceptibility assay as well as nucleotide sequence of clinical isolate is important to choose appropriate antiviral agents for patients who have persistent CMV reactivation after stem cell transplantation...
  69. ncbi request reprint Early relapse of JAK2 V617F-positive chronic neutrophilic leukemia with central nervous system infiltration after unrelated bone marrow transplantation
    Shinichi Kako
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Hematol 82:386-90. 2007
    ..Accumulation of experiences is required to establish a definite role of HSCT in the treatment of CNL and a prognostic significance of JAK2 mutation in CNL...
  70. doi request reprint Long-term ultra-low-dose acyclovir against varicella-zoster virus reactivation after allogeneic hematopoietic stem cell transplantation
    Yuki Asano-Mori
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Hematol 83:472-6. 2008
    ..Prolongation of prophylactic acyclovir on profound immunosuppression might be important for thorough suppression of VZV reactivation...
  71. ncbi request reprint Serotypes of human rotaviruses in 7 regions of Japan from 1984 to 1997
    Y Zhou
    Department of Developmental Medical Sciences, Graduate School of Medicine, University of Tokyo, Japan
    Kansenshogaku Zasshi 73:35-42. 1999
    ..Twenty two, 2, 3 and 1 among 57 specimens of "others" by EIA from Tokyo, Maizuru, Sapporo and Kurume in 1995-1996 and 1996-1997 were determined as serotypes 1, 2, 3, and 9 by RT-PCR, respectively...
  72. pmc Identification and cellular distribution of distinct proteins forming human GM-CSF receptor
    S Chiba
    Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Japan
    Cell Regul 1:327-35. 1990
    ..In contrast, the distribution of the beta-chain is restricted on hemopoietic cells. The alpha-chain probably corresponds to the low-affinity GM-CSF receptor whose cDNA has been cloned and sequenced...
  73. ncbi request reprint Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma
    Suk young Lee
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo 113 8655, Japan
    Cancer Sci 100:920-6. 2009
    ..These findings implicate Notch2 gain-of-function mutations in the pathogenesis of a subset of B-cell lymphomas, and suggest broader roles for Notch gene mutations in human cancers...
  74. doi request reprint Conventional allogeneic hematopoietic stem cell transplantation for lymphoma may overcome the poor prognosis associated with a positive FDG-PET scan before transplantation
    Akihide Yoshimi
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Hematol 83:477-81. 2008
    ..Thus, conventional allo-SCT could be an attractive modality compared to ASCT for patients with positive FDG-PET after the completion of conventional salvage chemotherapy, and particularly for patients with T and NK-cell lymphomas...
  75. pmc Coordinated regulation of transcription factors through Notch2 is an important mediator of mast cell fate
    Mamiko Sakata-Yanagimoto
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Proc Natl Acad Sci U S A 105:7839-44. 2008
    ..Taken together, signaling through Notch2 determines the fate of myeloid progenitors toward mast cell-producing progenitors, via coordinately up-regulating Hes-1 and GATA3...
  76. doi request reprint ESHAP therapy effective in a patient with Langerhans cell sarcoma
    Akihide Yoshimi
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Hematol 87:532-7. 2008
    ..A marked response was obtained after four cycles of this combination chemotherapy. Modified ESHAP may be a very effective combination chemotherapy regimen for LCS...
  77. ncbi request reprint Runx1/AML-1 ranks as a master regulator of adult hematopoiesis
    Motoshi Ichikawa
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cell Cycle 3:722-4. 2004
    ....
  78. ncbi request reprint Crk-associated substrate lymphocyte type is required for lymphocyte trafficking and marginal zone B cell maintenance
    Sachiko Seo
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 175:3492-501. 2005
    ..Thus, Cas-L affects homeostasis of MZB cells and peripheral lymphoid organs, which is considered to be relevant to impaired lymphocyte migration and adhesion...
  79. ncbi request reprint Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development
    Toshiki Saito
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Immunity 18:675-85. 2003
    ..Among Notch target genes, the expression level of Deltex1 is prominent in MZB cells and strictly dependent on that of Notch2, suggesting that Deltex1 may play a role in MZB cell differentiation...
  80. ncbi request reprint Treatment results of chemoradiation therapy for localized aggressive lymphomas: A retrospective 20-year study
    Hideomi Yamashita
    Department of Radiology, University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Ann Hematol 85:523-9. 2006
    ..Significant prognostic factors were not identified by multivariate analysis. Combined chemotherapy and radiation therapy is safe, highly effective, and probably curative for most patients with stage I-II aggressive lymphoma...
  81. ncbi request reprint Identification of a SRC-like tyrosine kinase gene, FRK, fused with ETV6 in a patient with acute myelogenous leukemia carrying a t(6;12)(q21;p13) translocation
    Noriko Hosoya
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genes Chromosomes Cancer 42:269-79. 2005
    ....
  82. ncbi request reprint Mutational analyses of the AML1 gene in patients with myelodysplastic syndrome
    Oich Imai
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Leuk Lymphoma 43:617-21. 2002
    ..In this review, we summarize mutational changes of the AML1 gene in hematological malignancies, especially in MDS and discuss the mechanism whereby the mutant acts as a dominant negative inhibitor of wild-type AML1...
  83. doi request reprint Notch activation induces the generation of functional NK cells from human cord blood CD34-positive cells devoid of IL-15
    Kyoko Haraguchi
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
    J Immunol 182:6168-78. 2009
    ..Together, these results suggest that Notch signaling is important for the physiologic development of NK cells at differentiation stages beyond those previously postulated...
  84. ncbi request reprint Derivation of functional mature neutrophils from human embryonic stem cells
    Yasuhisa Yokoyama
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo Hospital, Tokyo, Japan
    Blood 113:6584-92. 2009
    ..Thus, this is the first description of a detailed functional analysis of mature hESC-derived neutrophils...
  85. ncbi request reprint AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis
    Motoshi Ichikawa
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 180:4402-8. 2008
    ..We also found an increase in HSC number within the AML1-deficient bone marrow using limiting dilution bone marrow transplantation assays. These results indicate that the number of quiescent HSCs is negatively regulated by AML1...
  86. ncbi request reprint Valpha24+ natural killer T-cell responses against T-acute lymphoblastic leukaemia cells: implications for immunotherapy
    Tsuyoshi Takahashi
    Department of Transfusion Medicine, Department of Haematology and Oncology, Faculty of Medicine, University of Tokyo, Japan
    Br J Haematol 122:231-9. 2003
    ..This cytotoxicity was increased in the presence of alpha-GalCer. Our results suggest that T-ALL is a good candidate for Valpha24+ NKT-cell-based immuno-cell therapy...
  87. ncbi request reprint Notch signaling in hematopoietic stem cells
    Takahiro Suzuki
    Department of Regeneration Medicine for Hematopoiesis, Graduate School of Medicine, University of Tokyo, Japan
    Int J Hematol 82:285-94. 2005
    ..In this review, we focus on the role of Notch signaling in the regulation of hematopoietic stem and progenitor cells in both embryo and adult hematopoiesis and clarify what is known regarding the self-renewal of HSCs...
  88. ncbi request reprint Generation of Fas-independent CD4+ cytotoxic T-cell clone specific for p190 minor bcr-abl fusion peptide
    Yuji Tanaka
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Leuk Res 26:317-21. 2002
    ..Success in establishment of the p190 bcr-abl fusion peptide-specific T-cell clone encourages us to develop a new approach to an effective immunotherapy for Ph+ALL...
  89. ncbi request reprint Dendritic cell vaccination for patients with chronic myelogenous leukemia
    Tsuyoshi Takahashi
    Department of Hematology and Oncology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    Leuk Res 27:795-802. 2003
    ..The clinical benefits of bcr-abl peptide-specific vaccination in CML remain to be determined. Further vaccine development is necessary to increase the clinical effect...
  90. doi request reprint Herpes simplex encephalitis and subsequent cytomegalovirus encephalitis after chemoradiotherapy for central nervous system lymphoma: a case report and literature review
    Hiroshi I Suzuki
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Hematol 87:538-41. 2008
    ....
  91. ncbi request reprint AML1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis
    Masahiro Nakagawa
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Japan
    Blood 108:3329-34. 2006
    ..Our findings also suggest that Notch signaling may modulate both expression and transcriptional activity of Runx1...
  92. ncbi request reprint Immunotherapy against metastatic renal cell carcinoma with mature dendritic cells
    Akihiko Matsumoto
    Department of Urology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int J Urol 14:277-83. 2007
    ..We performed a clinical trial of immunotherapy using autologous mature dendritic cells (DC) pulsed with autologous tumor lysate, for patients with metastatic renal cell carcinoma (RCC)...
  93. ncbi request reprint Expression of Notch ligands, Jagged1, 2 and Delta1 in antigen presenting cells in mice
    Etsuko Yamaguchi
    Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Immunol Lett 81:59-64. 2002
    ..These findings may represent that expression of various Notch ligands in APCs has a physiological relevance in each organ...
  94. doi request reprint Disseminated adenovirus disease by multiple adenovirus serotypes following allogeneic hematopoietic stem cell transplantation
    Hiroshi I Suzuki
    Biol Blood Marrow Transplant 14:353-5. 2008
  95. ncbi request reprint Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells
    Yoichi Maekawa
    Department of Immunology and Parasitology, School of Medicine, The University of Tokushima, Tokushima 770 8503, Japan
    Immunity 19:549-59. 2003
    ..Our data revealed a clear contribution of Notch pathways to Th1 versus Th2 fate decisions, while also providing insight into another mechanism for inhibition of CD4+ T cell activation...
  96. ncbi request reprint [Establishment of a quantitative method for detecting mixed chimerism using fluorescence-based PCR amplification of short tandem repeat markers after allogeneic hematopoietic stem cell transplantation in a Japanese population]
    Akiko Saito
    Rinsho Ketsueki 43:327-32. 2002
  97. ncbi request reprint Chest computed tomography of late invasive aspergillosis after allogeneic hematopoietic stem cell transplantation
    Rie Kojima
    Hematopoietic Stem Cell Transplantation Unit, The National Cancer Center Hospital, Tokyo, Japan
    Biol Blood Marrow Transplant 11:506-11. 2005
    ..022). Halo is a useful diagnostic marker in late IA as well as early IA, and late IA frequently manifests as bronchopneumonia...
  98. ncbi request reprint F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation
    Qi Dong Hu
    Department of Clinical Research, Singapore General Hospital, 169608, Singapore, Singapore
    Cell 115:163-75. 2003
    ..Expression of constitutively active Notch1 or Notch2 does not upregulate MAG. Thus, F3/contactin specifically initiates a Notch/Deltex1 signaling pathway that promotes oligodendrocyte maturation and myelination...
  99. ncbi request reprint Pharmacokinetics of alemtuzumab after haploidentical HLA-mismatched hematopoietic stem cell transplantation using in vivo alemtuzumab with or without CD52-positive malignancies
    Kumi Oshima
    Department of Hematology, Cell Therapy and Transplantation Medicine, University of Tokyo Graduate School of Medicine and Hospital, Tokyo, Japan
    Am J Hematol 81:875-9. 2006
    ....
  100. ncbi request reprint Incidence of invasive aspergillosis after allogeneic hematopoietic stem cell transplantation with a reduced-intensity regimen compared with transplantation with a conventional regimen
    Rie Kojima
    Hematopoietic Stem Cell Transplantation Unit, National Cancer Center Hospital, Tokyo, Japan
    Biol Blood Marrow Transplant 10:645-52. 2004
    ..03) and the presence of acute and/or chronic GVHD (relative risk, 6.2; 95% confidence interval, 2.4-16.4; P = .0002). IA remains an important complication after allogeneic transplantation, regardless of the type of conditioning regimen...
  101. doi request reprint Simultaneous appearance of central nervous system relapse and subarachnoid hemorrhage during the treatment for acute promyelocytic leukemia
    Sumimasa Nagai
    Ann Hematol 87:593-5. 2008