Yoshihide Asano

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis
    Shinji Noda
    Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    PLoS ONE 7:e32272. 2012
  2. pmc Fli1 represses transcription of the human α2(I) collagen gene by recruitment of the HDAC1/p300 complex
    Yoshihide Asano
    Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    PLoS ONE 8:e74930. 2013
  3. ncbi request reprint Animal models of scleroderma: current state and recent development
    Yoshihide Asano
    Department of Dermatology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Curr Rheumatol Rep 15:382. 2013
  4. doi request reprint Serum adiponectin levels inversely correlate with the activity of progressive skin sclerosis in patients with diffuse cutaneous systemic sclerosis
    Y Masui
    Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Eur Acad Dermatol Venereol 26:354-60. 2012
  5. doi request reprint Future treatments in systemic sclerosis
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Dermatol 37:54-70. 2010
  6. doi request reprint Altered dynamics of transforming growth factor β(TGF-β) receptors in scleroderma fibroblasts
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Ann Rheum Dis 70:384-7. 2011
  7. ncbi request reprint Multiple small pulmonary emboli associated with transient antiphospholipid syndrome in human Parvovirus B19 infection
    Yoshihide Asano
    Department of Dermatology, Kanto Medical Center NTT EC, 5 9 22, Higashigotanda, Shinagawa ku, Tokyo, 141 8625, Japan
    Clin Rheumatol 25:585-7. 2006
  8. pmc The impact of Fli1 deficiency on the pathogenesis of systemic sclerosis
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Dermatol Sci 59:153-62. 2010
  9. ncbi request reprint Linear connective tissue nevus
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Pediatr Dermatol 24:439-41. 2007
  10. ncbi request reprint Serum visfatin levels in patients with atopic dermatitis and cutaneous T-cell lymphoma
    Hiraku Suga
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur J Dermatol 23:629-35. 2013

Collaborators

Detail Information

Publications100

  1. pmc A possible contribution of altered cathepsin B expression to the development of skin sclerosis and vasculopathy in systemic sclerosis
    Shinji Noda
    Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    PLoS ONE 7:e32272. 2012
    ....
  2. pmc Fli1 represses transcription of the human α2(I) collagen gene by recruitment of the HDAC1/p300 complex
    Yoshihide Asano
    Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    PLoS ONE 8:e74930. 2013
    ..TGF-β-dependent phosphorylation of Fli1 at threonine 312 is a critical step regulating the remodeling of the Fli1 transcription repressor complex, leading to transcriptional activation of the COL1A2 gene. ..
  3. ncbi request reprint Animal models of scleroderma: current state and recent development
    Yoshihide Asano
    Department of Dermatology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Curr Rheumatol Rep 15:382. 2013
    ..These new animal models provide important insights into specific pathological processes of SSc and novel therapeutic targets that may lead to more effective treatment of this incurable disease. ..
  4. doi request reprint Serum adiponectin levels inversely correlate with the activity of progressive skin sclerosis in patients with diffuse cutaneous systemic sclerosis
    Y Masui
    Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Eur Acad Dermatol Venereol 26:354-60. 2012
    ..Adiponectin has been demonstrated to be one of anti-inflammatory and anti-fibrotic factors, suggesting the potential of this cytokine to be involved in the developmental process of systemic sclerosis (SSc)...
  5. doi request reprint Future treatments in systemic sclerosis
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Dermatol 37:54-70. 2010
    ..Potential therapeutic targets other than those described above are also reviewed...
  6. doi request reprint Altered dynamics of transforming growth factor β(TGF-β) receptors in scleroderma fibroblasts
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Ann Rheum Dis 70:384-7. 2011
    ..To investigate the difference in the dynamics of transforming growth factor β (TGF-β) receptors between normal and scleroderma fibroblasts...
  7. ncbi request reprint Multiple small pulmonary emboli associated with transient antiphospholipid syndrome in human Parvovirus B19 infection
    Yoshihide Asano
    Department of Dermatology, Kanto Medical Center NTT EC, 5 9 22, Higashigotanda, Shinagawa ku, Tokyo, 141 8625, Japan
    Clin Rheumatol 25:585-7. 2006
    ..Considering the high prevalence of Parvovirus B19 infection, we should be aware of thrombosis associated with transient aPL antibodies in this infectious disease...
  8. pmc The impact of Fli1 deficiency on the pathogenesis of systemic sclerosis
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Dermatol Sci 59:153-62. 2010
    ..In this article, we review the impact of Fli1 deficiency on the pathogenesis of SSc and discuss a new therapeutic strategy for SSc by targeting the transcription factor Fli1...
  9. ncbi request reprint Linear connective tissue nevus
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Pediatr Dermatol 24:439-41. 2007
    ..Since the distribution was along Blaschko's lines, not dermatomes, we propose that the diagnosis "linear connective tissue nevus" is suitable for this clinical study...
  10. ncbi request reprint Serum visfatin levels in patients with atopic dermatitis and cutaneous T-cell lymphoma
    Hiraku Suga
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur J Dermatol 23:629-35. 2013
    ..These results suggest that visfatin may also be important in the development of Th2-dominant diseases as well as in Th1-type diseases. ..
  11. pmc Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation
    Koichi Yanaba
    1 Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Leukoc Biol 94:563-73. 2013
    ..The present findings provide direct evidence that B10 cells regulate imiquimod-induced skin inflammation and offer insights into regulatory B cell-based therapies for the treatment of psoriasis. ..
  12. pmc Constitutive thrombospondin-1 overexpression contributes to autocrine transforming growth factor-beta signaling in cultured scleroderma fibroblasts
    Yoshihiro Mimura
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Pathol 166:1451-63. 2005
    ..These results indicate that the constitutive overexpression of TSP-1 may play an important role in autocrine TGF-beta signaling and accumulation of ECM in scleroderma fibroblasts...
  13. doi request reprint Increased production of soluble inducible costimulator in patients with diffuse cutaneous systemic sclerosis
    Koichi Yanaba
    Department of Dermatology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Arch Dermatol Res 305:17-23. 2013
    ..ICOS may contribute to the development of SSc. In addition, measurement of serum sICOS level in patients with early SSc may offer an important means for further evaluation of SSc disease severity...
  14. doi request reprint Decreased cathepsin V expression due to Fli1 deficiency contributes to the development of dermal fibrosis and proliferative vasculopathy in systemic sclerosis
    Shinji Noda
    Department of Dermatology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Rheumatology (Oxford) 52:790-9. 2013
    ..We aimed to investigate the clinical association of serum CTSV levels and the mechanism by which CTSV expression is altered in SSc...
  15. doi request reprint Clinical significance of serum decoy receptor 3 levels in patients with systemic sclerosis
    Daisuke Yamada
    Department of Dermatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Eur J Dermatol 22:351-7. 2012
    ..Collectively, the elevation of serum DcR3 levels is associated with the development of pulmonary arterial hypertension and systemic inflammation in SSc...
  16. doi request reprint Low herpesvirus entry mediator (HVEM) expression on dermal fibroblasts contributes to a Th2-dominant microenvironment in advanced cutaneous T-cell lymphoma
    Tomomitsu Miyagaki
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Invest Dermatol 132:1280-9. 2012
    ..These results suggest that low HVEM expression on dermal fibroblasts in advanced CTCL skin attenuates expression of Th1 chemokines, which may contribute to a shift to a Th2-dominant microenvironment as disease progresses...
  17. pmc Increased expression of integrin alphavbeta5 induces the myofibroblastic differentiation of dermal fibroblasts
    Yoshihide Asano
    Department of Dermatology, University of Tokyo, Tokyo, Japan
    Am J Pathol 168:499-510. 2006
    ....
  18. pmc Matrix metalloproteinase-1 up-regulation by hepatocyte growth factor in human dermal fibroblasts via ERK signaling pathway involves Ets1 and Fli1
    Masatoshi Jinnin
    Department of Dermatology, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nucleic Acids Res 33:3540-9. 2005
    ..These results suggest that HGF up-regulates MMP-1 expression via ERK signaling pathway through the balance of Ets1 and Fli1, which may be a novel mechanism of regulating MMP-1 gene expression...
  19. ncbi request reprint Platelet derived growth factor induced tenascin-C transcription is phosphoinositide 3-kinase/Akt-dependent and mediated by Ets family transcription factors
    Masatoshi Jinnin
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Cell Physiol 206:718-27. 2006
    ..On the other hand, the interaction of Fli1 with Sp1 decreased after PDGF treatment. These results suggest that the upregulation of TN-C expression by PDGF involves Ets family transcription factors, co-operating with Sp1...
  20. ncbi request reprint The Role of IL-32 in Cutaneous T-Cell Lymphoma
    Hiraku Suga
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Invest Dermatol 134:1428-35. 2014
    ..In conclusion, our results suggest that IL-32 has a role in the formation and maintenance of CTCL lesions, providing a possible therapeutic target for patients with this disease. ..
  21. ncbi request reprint Association of the numbers of CD163(+) cells in lesional skin and serum levels of soluble CD163 with disease progression of cutaneous T cell lymphoma
    Makoto Sugaya
    Department of Dermatology, University of Tokyo, Tokyo, Japan
    J Dermatol Sci 68:45-51. 2012
    ..Tumor-associated macrophages exhibit M2 phenotype, whose presence has been associated with poor prognosis in various tumors...
  22. ncbi request reprint Upregulation of tenascin-C expression by IL-13 in human dermal fibroblasts via the phosphoinositide 3-kinase/Akt and the protein kinase C signaling pathways
    Masatoshi Jinnin
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Invest Dermatol 126:551-60. 2006
    ....
  23. ncbi request reprint Epidermal growth factor up-regulates transforming growth factor-beta receptor type II in human dermal fibroblasts via p38 mitogen-activated protein kinase pathway
    Kenichi Yamane
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 352:69-77. 2007
    ..The EGF-mediated induction of TbetaRII expression may participate in a synergistic interplay between EGF and TGF-beta signaling pathway...
  24. ncbi request reprint Involvement of alphavbeta5 integrin in the establishment of autocrine TGF-beta signaling in dermal fibroblasts derived from localized scleroderma
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Kumamoto University, Kumamoto, Japan
    J Invest Dermatol 126:1761-9. 2006
    ..Anti-alphavbeta5 antibody reversed the myofibroblastic features of LSc fibroblasts. These results indicate that upregulated expression of alphavbeta5 contributes to autocrine TGF-beta signaling in LSc fibroblasts...
  25. pmc Alpha2(I) collagen gene regulation by protein kinase C signaling in human dermal fibroblasts
    Masatoshi Jinnin
    Department of Dermatology, Faculty of Medicine, University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nucleic Acids Res 33:1337-51. 2005
    ..Alteration of the balance of Ets1 and Fli1 may be a novel mechanism regulating alpha2(I) collagen expression...
  26. ncbi request reprint Increased expression of integrin alpha(v)beta3 contributes to the establishment of autocrine TGF-beta signaling in scleroderma fibroblasts
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 175:7708-18. 2005
    ..These results suggest that the up-regulated expression of alpha(v)beta3 contributes to the establishment of autocrine TGF-beta loop in scleroderma fibroblasts, and this integrin is a potent target for the treatment of scleroderma...
  27. doi request reprint Visfatin enhances the production of cathelicidin antimicrobial peptide, human β-defensin-2, human β-defensin-3, and S100A7 in human keratinocytes and their orthologs in murine imiquimod-induced psoriatic skin
    Carren S Hau
    Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan
    Am J Pathol 182:1705-17. 2013
    ..Visfatin may potentiate the development of psoriasis via antimicrobial peptides...
  28. ncbi request reprint A possible contribution of visfatin to the resolution of skin sclerosis in patients with diffuse cutaneous systemic sclerosis via a direct anti-fibrotic effect on dermal fibroblasts and Th1 polarization of the immune response
    Yuri Masui
    Department of Dermatology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Rheumatology (Oxford) 52:1239-44. 2013
    ..In this study, we investigated THE CLINICAL SIGNIFICANCE OF SERUM VISFATIN LEVELS AND ITS CONTRIBUTION TO THE DEVELOPMENTAL PROCESS IN SSC...
  29. doi request reprint P2Y6 receptor signaling pathway mediates inflammatory responses induced by monosodium urate crystals
    Hideya Uratsuji
    Department of Dermatology, University of Tokyo, Tokyo, Japan
    J Immunol 188:436-44. 2012
    ..Thus, these results indicate that the P2Y(6) receptor signaling pathway may be a potential therapeutic target for MSU-associated inflammatory diseases, such as tophaceous gout...
  30. ncbi request reprint Epidermal growth factor affects the synthesis and degradation of type I collagen in cultured human dermal fibroblasts
    Yoshihiro Mimura
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Matrix Biol 25:202-12. 2006
    ..The MEK/ERK signaling pathway was shown to be involved in EGF-mediated type I collagen and MMP-1 expression...
  31. ncbi request reprint Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts
    Masatoshi Jinnin
    University of Tokyo, Tokyo, Japan
    Arthritis Rheum 56:1694-705. 2007
    ..The aim of this study was to examine c-Ski and SnoN, principal molecules in the negative regulation of TGFbeta signaling, to further understand the autocrine TGFbeta loop in scleroderma...
  32. pmc Impaired Smad7-Smurf-mediated negative regulation of TGF-beta signaling in scleroderma fibroblasts
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Invest 113:253-64. 2004
    ..To our knowledge, this is the first report of a disturbed negative regulation of TGF-beta signaling in fibrotic disorders...
  33. doi request reprint Serum levels of galectin-3: possible association with fibrosis, aberrant angiogenesis, and immune activation in patients with systemic sclerosis
    Takashi Taniguchi
    Department of Dermatology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Rheumatol 39:539-44. 2012
    ..We investigated the clinical significance of serum galectin-3 levels in SSc...
  34. pmc CD19 expression in B cells regulates atopic dermatitis in a mouse model
    Koichi Yanaba
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Pathol 182:2214-22. 2013
    ..Furthermore, the present findings may have implications for B-cell-targeted therapies for the treatment of atopic dermatitis...
  35. doi request reprint IL-27 activates Th1-mediated responses in imiquimod-induced psoriasis-like skin lesions
    Sayaka Shibata
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Invest Dermatol 133:479-88. 2013
    ..These results indicate that IL-27 would act in a proinflammatory manner, and thereby exacerbate the psoriasis-like skin inflammation induced by IMQ...
  36. doi request reprint Clinical significance of serum growth differentiation factor-15 levels in systemic sclerosis: association with disease severity
    Koichi Yanaba
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mod Rheumatol 22:668-75. 2012
    ..To determine serum growth differentiation factor-15 (GDF-15) levels and their clinical associations in patients with systemic sclerosis (SSc)...
  37. doi request reprint IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma
    Tomomitsu Miyagaki
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Clin Cancer Res 17:7529-38. 2011
    ..In this study, we investigated expression levels of T(H)22- and T(H)17-related molecules in lesional skin and sera isolated from patients with CTCL...
  38. ncbi request reprint Blocking MAPK signaling downregulates CCL21 in lymphatic endothelial cells and impairs contact hypersensitivity responses
    Tomomitsu Miyagaki
    Department of Dermatology, Faculty of Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Invest Dermatol 131:1927-35. 2011
    ..In summary, these results suggest that the MAPK pathway is important for CCL21 expression by LECs in vitro and in vivo. Blocking MAPK signaling within skin may offer a novel approach to treatment of inflammatory skin diseases...
  39. ncbi request reprint Phosphatidylinositol 3-kinase is involved in alpha2(I) collagen gene expression in normal and scleroderma fibroblasts
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 172:7123-35. 2004
    ....
  40. ncbi request reprint Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1
    Masatoshi Jinnin
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Oncogene 23:1656-67. 2004
    ..These findings demonstrate the existence of a novel, functional binding element in the proximal region of the TN-C promoter mediating responsiveness to TGF-beta involving Smad3/4, Sp1, Ets1, and CBP/p300...
  41. pmc Increased expression levels of integrin alphavbeta5 on scleroderma fibroblasts
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Pathol 164:1275-92. 2004
    ..These results indicate that the up-regulated alphavbeta5 may contribute to the phenotypical alteration of scleroderma fibroblasts, while at the same time suppressing the plasmin-mediated pericellular proteolytic cascade...
  42. ncbi request reprint Potential regulatory elements of the constitutive up-regulated alpha2(I) collagen gene in scleroderma dermal fibroblasts
    Masatoshi Jinnin
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 343:904-9. 2006
    ..The blockade of autocrine TGF-beta signaling is thought to be one of the most reliable approaches in the treatment of scleroderma, and further study targeting Ets1, Smad or Sp1 may contribute to this blockade...
  43. ncbi request reprint Regulation of fibrogenic/fibrolytic genes by platelet-derived growth factor C, a novel growth factor, in human dermal fibroblasts
    Masatoshi Jinnin
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Cell Physiol 202:510-7. 2005
    ..These results suggest that this cytokine plays a role in the tissue remodeling...
  44. ncbi request reprint Serum chemokine levels as prognostic markers in patients with early systemic sclerosis: a multicenter, prospective, observational study
    Minoru Hasegawa
    Department of Dermatology, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa, 920 8641, Japan
    Mod Rheumatol 23:1076-84. 2013
    ..To assess the utility of serum chemokine levels as a prognostic indicator of disease progression in systemic sclerosis (SSc) patients with early onset disease...
  45. ncbi request reprint Dynamics of serum angiopoietin-2 levels correlate with efficacy of intravenous pulse cyclophosphamide therapy for interstitial lung disease associated with systemic sclerosis
    Takehiro Takahashi
    Department of Dermatology, Faculty of Medicine, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Mod Rheumatol 23:884-90. 2013
    ..Therefore, we investigated the clinical significance of monitoring serum Ang2 levels during intravenous pulse cyclophosphamide (IVCY) therapy in SSc patients with interstitial lung disease (ILD)...
  46. doi request reprint Efficacy of low-dose imatinib mesylate for cutaneous involvement in systemic sclerosis: a preliminary report of three cases
    Zenshiro Tamaki
    Department of Dermatology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mod Rheumatol 22:94-9. 2012
    ..These clinical data indicate the tolerability and efficacy of low-dose imatinib in SSc, especially against cutaneous vascular involvement, including Raynaud's phenomenon and nailfold bleeding...
  47. doi request reprint Association of nerve growth factor, chemokine (C-C motif) ligands and immunoglobulin E with pruritus in cutaneous T-cell lymphoma
    Hiraku Suga
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo, Japan
    Acta Derm Venereol 93:144-9. 2013
    ..NGF may be associated with increased dermal nerve fibres and pruritus in Sézary syndrome, and CCL1, CCL26, and IgE may be associated with pruritus in CTCL...
  48. doi request reprint Clinical significance of monitoring serum adiponectin levels during intravenous pulse cyclophosphamide therapy in interstitial lung disease associated with systemic sclerosis
    Yuri Masui
    Department of Dermatology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mod Rheumatol 23:323-9. 2013
    ..To investigate the clinical significance of monitoring serum adiponectin levels during intravenous pulse cyclophosphamide (IVCY) in systemic sclerosis (SSc) patients with interstitial lung disease (ILD)...
  49. doi request reprint Angiogenin levels are increased in lesional skin and sera in patients with erythrodermic cutaneous T cell lymphoma
    Tomomitsu Miyagaki
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Arch Dermatol Res 304:401-6. 2012
    ..As angiogenin acts as an inhibitor of polymorphonuclear leukocyte degranulation, angiogenin may also be linked to impaired host defense in erythrodermic CTCL...
  50. ncbi request reprint Serum levels of soluble CD21 in patients with systemic sclerosis
    Manabu Tomita
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Rheumatol Int 32:317-21. 2012
    ..Our finding may support the notion that B-cell activation is involved in the mechanism for pulmonary fibrosis and skin sclerosis...
  51. ncbi request reprint Differential effects of the immunosuppressant FK-506 on human alpha2(I) collagen gene expression and transforming growth factor beta signaling in normal and scleroderma fibroblasts
    Yoshihide Asano
    University of Tokyo, Tokyo, Japan
    Arthritis Rheum 52:1237-47. 2005
    ..To investigate the effects of FK-506 on the expression of the human alpha2(I) collagen gene and transforming growth factor beta (TGFbeta) signaling in normal and scleroderma fibroblasts...
  52. doi request reprint High calcium, ATP, and poly(I:C) augment the immune response to β-glucan in normal human epidermal keratinocytes
    Carren Sy Hau
    Department of Dermatology, University of Tokyo, Tokyo, Japan
    J Invest Dermatol 131:2255-62. 2011
    ..Thus, high calcium, ATP, and poly(I:C) augment the cytokine and chemokine production by β-glucan-stimulated NHEKs. Dectin-1 is present on NHEKs and may have an important role in cell response to β-glucan...
  53. ncbi request reprint Clinical correlation of brachial artery flow-mediated dilation in patients with systemic sclerosis
    Takehiro Takahashi
    Department of Dermatology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mod Rheumatol 24:106-11. 2014
    ..To investigate the clinical significance of flow-mediated dilation (FMD) in systemic sclerosis (SSc)...
  54. ncbi request reprint ICAM-1 deficiency exacerbates sarcoid-like granulomatosis induced by Propionibacterium acnes through impaired IL-10 production by regulatory T cells
    Masahiro Kamata
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Pathol 183:1731-9. 2013
    ..Our results indicate that ICAM-1 is imperative for inducing regulatory T cells to produce IL-10 in vivo, which would prevent granuloma formation...
  55. doi request reprint Clinical significance of serum soluble Tie1 levels in patients with systemic sclerosis
    Shinji Noda
    Department of Dermatology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo Bunkyo ku, Tokyo 113 8655, Japan
    Arch Dermatol Res 305:325-31. 2013
    ..The decrease in serum sTie1 levels may serve as a marker of proliferative vasculopathy in SSc with disease duration of >6 years...
  56. doi request reprint Increased circulating fibrinogen-like protein 2 in patients with systemic sclerosis
    Koichi Yanaba
    Department of Dermatology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Rheumatol 32:43-7. 2013
    ..The results show that the serum FGL2 level was increased in patients with SSc but not in patients with systemic lupus erythematosus or healthy individuals. Therefore, FGL2 possibly contribute to the development of SSc...
  57. doi request reprint Clinical significance of serum levels of secretory leukocyte protease inhibitor in patients with systemic sclerosis
    Naohiko Aozasa
    Department of Dermatology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Mod Rheumatol 22:576-83. 2012
    ..28, p < 0.05). Longitudinal study revealed the association of serum SLPI levels with the disease activity of SSc-ILD. SLPI serves as a useful serum marker for evaluating SSc-ILD...
  58. ncbi request reprint Adiponectin regulates cutaneous wound healing by promoting keratinocyte proliferation and migration via the ERK signaling pathway
    Sayaka Shibata
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Immunol 189:3231-41. 2012
    ..We propose that upregulation of systemic and/or local adiponectin levels is a potential and very promising therapeutic approach for dealing with diabetic wounds...
  59. ncbi request reprint Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins
    Manabu Fujimoto
    Department of Dermatology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan
    Arthritis Rheum 64:513-22. 2012
    ....
  60. doi request reprint Clinical significance of circulating platelet-activating factor acetylhydrolase levels in systemic sclerosis
    Koichi Yanaba
    Department of Dermatology, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Arch Dermatol Res 304:203-8. 2012
    ..PAF-AH could be a protective factor against the development of digital ulcers and arthritis/arthralgia in this disease and as such would be a useful serological marker for disease severity...
  61. ncbi request reprint Effects of hepatocyte growth factor on the expression of type I collagen and matrix metalloproteinase-1 in normal and scleroderma dermal fibroblasts
    Masatoshi Jinnin
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Invest Dermatol 124:324-30. 2005
    ..Thus, further investigation of the effects of HGF on collagen metabolism may contribute to the treatment of fibrosis in scleroderma...
  62. ncbi request reprint Epidermal growth factor induces fibronectin expression in human dermal fibroblasts via protein kinase C delta signaling pathway
    Yoshihiro Mimura
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Invest Dermatol 122:1390-8. 2004
    ..Rottlerin blocked the EGF-mediated reduction of mRNA degradation rate. These results indicate that EGF-mediated induction of fibronectin expression occurs at the post-transcriptional level and involves PKCdelta signaling pathway...
  63. ncbi request reprint Anti-p53 antibodies in patients with dermatomyositis/polymyositis
    Yoshihiro Mimura
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Clin Rheumatol 26:1328-31. 2007
    ..These results seemed to suggest that the presence of anti-p53 Abs in DM/PM patients is due to immunological abnormalities in this disease...
  64. ncbi request reprint Antagonistic effects of TNF-alpha on TGF-beta signaling through down-regulation of TGF-beta receptor type II in human dermal fibroblasts
    Kenichi Yamane
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 171:3855-62. 2003
    ..These results indicated that TNF-alpha impaired the response of the cells to TGF-beta by regulating the turnover of TbetaRII...
  65. pmc Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis: a multicentre, prospective, observational study
    Minoru Hasegawa
    Department of Dermatology, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan Department of Dermatology, School of Medicine, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University, Kanazawa, Japan
    PLoS ONE 9:e88150. 2014
    ..To assess the utility of circulating adhesion molecule levels as a prognostic indicator of disease progression in systemic sclerosis (SSc) patients with early onset disease...
  66. ncbi request reprint Successful experience of rituximab therapy for systemic sclerosis-associated interstitial lung disease with concomitant systemic lupus erythematosus
    Hayakazu Sumida
    Department of Dermatology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    J Dermatol 41:418-20. 2014
    ..Overall, the current report could pave the way to establish RTX as a disease-modifying drug for patients with SSc and/or SLE showing resistance to other already approved medications. ..
  67. ncbi request reprint Fli1 deficiency contributes to the suppression of endothelial CXCL5 expression in systemic sclerosis
    Yohei Ichimura
    Department of Dermatology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Arch Dermatol Res 306:331-8. 2014
    ..Since Fli1 deficiency is deeply related to aberrant angiogenesis in SSc, it is plausible that serum CXCL5 levels inversely reflect the severity of SSc vasculopathy. ..
  68. doi request reprint Serum levels of angiopoietin-2, but not angiopoietin-1, are elevated in patients with erythrodermic cutaneous T-cell lymphoma
    Makiko Kawaguchi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Acta Derm Venereol 94:9-13. 2014
    ..Moreover, the numbers of Ang-2+ cells in lesional skin of CTCL were significantly larger than those in normal skin. These results suggest that Ang-2 may have important roles in the development of CTCL. ..
  69. pmc Proteasome inhibitor bortezomib ameliorates intestinal injury in mice
    Koichi Yanaba
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    PLoS ONE 7:e34587. 2012
    ..In mice, the addition of dextran sulfate sodium (DSS) to drinking water leads to acute colitis that can serve as an experimental animal model for human ulcerative colitis...
  70. ncbi request reprint Clinical features of scleroderma patients with contracture of phalanges
    Ryuichi Ashida
    Department of Dermatology, Faculty of Medicine, University of Tokyo, and Mita Hospital, Tokyo, Japan
    Clin Rheumatol 26:1275-7. 2007
    ..Our study suggested that the presence of CP may be a marker of oesophageal involvement, pulmonary fibrosis and heart involvement...
  71. ncbi request reprint Constitutive phosphorylation of focal adhesion kinase is involved in the myofibroblast differentiation of scleroderma fibroblasts
    Yoshihiro Mimura
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Invest Dermatol 124:886-92. 2005
    ..These results indicate that the constitutive phosphorylation of FAK, which is possibly because of the autocrine TGF-beta signaling, may play an important role in alphaSMA expression in scleroderma fibroblasts...
  72. ncbi request reprint Rheumatoid factor isotypes in mixed connective tissue disease
    Yoshihiro Mimura
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Clin Rheumatol 25:572-4. 2006
    ..These results suggest that the presence of RF isotypes can be regarded as one of the various immunological abnormalities of MCTD...
  73. doi request reprint Serum-soluble Herpes Virus Entry Mediator Levels Reflect Disease Severity and Th2 Environment in Cutaneous T Cell Lymphoma
    Tomomitsu Miyagaki
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Acta Derm Venereol 93:465-7. 2013
    ..Abstract is missing (Letter). ..
  74. doi request reprint Decrease in circulating autotaxin by oral administration of prednisolone
    Hayakazu Sumida
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Clin Chim Acta 415:74-80. 2013
    ..ATX-LPA signaling is implicated in a wide range of physiological and pathophysiological processes including immune response...
  75. ncbi request reprint Serum matrix metalloproteinase-3 in systemic sclerosis
    Masatoshi Jinnin
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655 Tokyo, Japan
    Arch Dermatol Res 296:25-9. 2004
    ..These results suggest that increased serum MMP-3 is a marker for developing RA in SSc patients. SSc patients with increased serum MMP-3 levels need to be followed up carefully because of the risk of developing overlapping RA...
  76. ncbi request reprint Anti-agalactosyl immunoglobulin G antibodies in localized scleroderma
    Yoshihiro Mimra
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Int J Dermatol 44:817-20. 2005
    ..Anti-agalactosyl immunoglobulin G (IgG) antibodies (anti-AG IgG) have been reported to be detected and correlated with disease activity in some collagen diseases...
  77. doi request reprint CCL11-CCR3 interactions promote survival of anaplastic large cell lymphoma cells via ERK1/2 activation
    Tomomitsu Miyagaki
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan
    Cancer Res 71:2056-65. 2011
    ..Thus, our findings prompt a novel therapeutic approach to treat relapses of an aggressive form of lymphoma based on the discovery that a cell surface marker of disease functions as a critical autocrine growth receptor...
  78. doi request reprint Significant attenuation of macrovascular involvement by bosentan in a patient with diffuse cutaneous systemic sclerosis with multiple digital ulcers and gangrene
    Yohei Ichimura
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Mod Rheumatol 21:548-52. 2011
    ..Stenosis of the ulnar artery, evaluated by magnetic resonance angiography, was attenuated by the bosentan treatment, suggesting that bosentan exerts a reverse remodeling effect against the pathological organic changes of arteries in SSc...
  79. doi request reprint Improvement of endothelial function in parallel with the amelioration of dry cough and dyspnea due to interstitial pneumonia by intravenous cyclophosphamide pulse therapy in patients with systemic sclerosis: a preliminary report of two cases
    Takehiro Takahashi
    Department of Dermatology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Mod Rheumatol 22:598-601. 2012
    ..We herein report the details of these cases and discuss the potential of FMD to predict and evaluate the effect of IVCY on SSc-ILD...
  80. doi request reprint Investigation of prognostic factors for skin sclerosis and lung function in Japanese patients with early systemic sclerosis: a multicentre prospective observational study
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Rheumatology (Oxford) 51:129-33. 2012
    ..It is well known that ethnic variations exist in the clinical features and severity of SSc. However, neither the clinical course nor prognostic factors have been thoroughly investigated in the Japanese population...
  81. doi request reprint Serum IL-33 levels are raised in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis
    Koichi Yanaba
    Department of Dermatology, The Jikei University School of Medicine, Minato, Tokyo, Japan
    Clin Rheumatol 30:825-30. 2011
    ..IL-33 levels were increased in SSc patients and correlated with the extent of skin sclerosis and the severity of pulmonary fibrosis. Therefore, IL-33 possibly plays a role in cutaneous and pulmonary fibrosis in SSc patients...
  82. doi request reprint A possible contribution of elevated serum clusterin levels to the inhibition of digital ulcers and pulmonary arterial hypertension in systemic sclerosis
    Koichi Yanaba
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Japan
    Arch Dermatol Res 304:459-63. 2012
    ..Clusterin could be a protective factor against the development of digital ulcers and pulmonary arterial hypertension in this disease and as such would be a possible therapeutic target...
  83. ncbi request reprint Increased serum soluble CD147 levels in patients with systemic sclerosis: association with scleroderma renal crisis
    Koichi Yanaba
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Rheumatol 31:835-9. 2012
    ..These results suggest that sCD147 may have a role in the development of renal crisis in SSc. Measurement of serum sCD147 may be useful for risk stratification for renal crisis in SSc...
  84. doi request reprint Serum interleukin 9 levels are increased in patients with systemic sclerosis: association with lower frequency and severity of pulmonary fibrosis
    Koichi Yanaba
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Rheumatol 38:2193-7. 2011
    ..To determine serum interleukin 9 (IL-9) levels and their clinical associations in patients with systemic sclerosis (SSc)...
  85. ncbi request reprint Clinical and laboratory features of scleroderma patients developing skeletal myopathy
    Yoshihiro Mimura
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, 113 Bunkyo ku, Tokyo, Japan
    Clin Rheumatol 24:99-102. 2005
    ....
  86. ncbi request reprint Serum levels of manganese superoxide dismutase in patients with localized scleroderma
    Masatoshi Jinnin
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Exp Dermatol 13:357-60. 2004
    ..These results suggested that the serum levels of this enzyme may be a serological marker for the disease activity and the extent of skin involvement in this disease...
  87. ncbi request reprint The prevalence and clinical significance of anti-U1 RNA antibodies in patients with systemic sclerosis
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan
    J Invest Dermatol 120:204-10. 2003
    ..05). These results indicate that anti-U1 RNA antibodies may be a serologic indicator for pulmonary fibrosis in systemic sclerosis patients with anti-U1 RNP antibodies...
  88. doi request reprint Disseminated cutaneous and visceral Kaposi's sarcoma in a patient with rheumatoid arthritis receiving corticosteroids and tacrolimus
    Takashi Taniguchi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Mod Rheumatol 21:309-12. 2011
    ..We herein report the details of the clinical course and discuss the possible contribution of corticosteroids and tacrolimus to the development of aggressive KS in the present case...
  89. doi request reprint Semaphorin 7A on keratinocytes induces interleukin-8 production by monocytes
    Masahiro Kamata
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Dermatol Sci 62:176-82. 2011
    ..Semaphorin 7A (Sema7A) expressed on activated T cells stimulates cytokine production in monocytes through its receptor, α1β1 integrin...
  90. doi request reprint A case of dermatomyositis with "liver disease associated with rheumatoid diseases" positive for anti-liver-kidney microsome-1 antibody
    Shinji Noda
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Rheumatol 29:941-3. 2010
    ....
  91. doi request reprint CCR10 and CCL27 are overexpressed in cutaneous squamous cell carcinoma
    Hiromichi Kai
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Pathol Res Pract 207:43-8. 2011
    ..These results suggest that CCR10 and CCL27 overexpression in SCC is related to the progression of SCC and is useful for the diagnosis of SCC...
  92. doi request reprint Serum CCL23 levels are increased in patients with systemic sclerosis
    Koichi Yanaba
    Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan
    Arch Dermatol Res 303:29-34. 2011
    ..05). The results show that serum CCL23 level was increased in the early phase of SSc. CCL23 could be associated with induction of SSc and as such would be a serologically useful marker for disease activity...
  93. ncbi request reprint The development of Th1-mediated sarcoidosis improves the clinical course of Th2-mediated atopic dermatitis
    Tomomitsu Miyagaki
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Mod Rheumatol 21:406-9. 2011
    ..We herein describe the details of his clinical course and discuss the impact of negative cross-regulation between Th1 and Th2 immune responses...
  94. doi request reprint Ultraviolet light-induced Köbner phenomenon contributes to the development of skin eruptions in multicentric reticulohistiocytosis
    Takashi Taniguchi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Acta Derm Venereol 91:160-3. 2011
    ..This is the first known report demonstrating the contribution of UV-light-induced Köbner phenomenon for the development of skin eruptions in patients with multicentric reticulo-histiocytosis...
  95. pmc IL-10-producing regulatory B10 cells inhibit intestinal injury in a mouse model
    Koichi Yanaba
    Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan
    Am J Pathol 178:735-43. 2011
    ..These results demonstrate that IL-10 production from regulatory B10 cells regulates DSS-induced intestinal injury. These findings may provide new insights and therapeutic approaches for treating ulcerative colitis...
  96. ncbi request reprint Prevalence of 52-kd and 60-kd Ro/SS-A autoantibodies in Japanese patients with polymyositis/dermatomyositis
    Masahide Kubo
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Am Acad Dermatol 47:148-51. 2002
    ....
  97. ncbi request reprint High-dose intravenous immunoglobulin infusion in polyarteritis nodosa: report on one case and review of the literature
    Yoshihide Asano
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Rheumatol 25:396-8. 2006
    ..We review related articles and discuss its effectiveness in PN...
  98. doi request reprint Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study
    Yasuhito Hamaguchi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Arch Dermatol 147:391-8. 2011
    ..To clarify the association of clinical and prognostic features with dermatomyositis (DM)-specific autoantibodies (Abs) in adult Japanese patients with DM...
  99. doi request reprint Development of Behçet's disease in a Caucasian with human leukocyte antigen B51 after immigration to Japan
    Takayuki Kimura
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Dermatol 38:581-4. 2011
    ....
  100. ncbi request reprint IL-4 up-regulates the expression of tissue inhibitor of metalloproteinase-2 in dermal fibroblasts via the p38 mitogen-activated protein kinase dependent pathway
    Hironobu Ihn
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 168:1895-902. 2002
    ..The expression of the dominant-negative mutant p38 MAPK represses the IL-4-induced TIMP-2 expression in human dermal fibroblasts. Thus, IL-4 can potentially alter the dermal matrix metabolism by regulating TIMP-2...