Yujiro Asada

Summary

Affiliation: University of Miyazaki
Country: Japan

Publications

  1. doi request reprint Podoplanin expression in advanced atherosclerotic lesions of human aortas
    Kinta Hatakeyama
    Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692 Japan
    Thromb Res 129:e70-6. 2012
  2. ncbi request reprint Relation of CD39 to plaque instability and thrombus formation in directional atherectomy specimens from patients with stable and unstable angina pectoris
    Kinta Hatakeyama
    First Department of Pathology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    Am J Cardiol 95:632-5. 2005
  3. doi request reprint Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart
    Hiroyuki Masuyama
    Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Hypertens Res 32:597-603. 2009
  4. ncbi request reprint Antifibrotic effect of adrenomedullin on coronary adventitia in angiotensin II-induced hypertensive rats
    Toshihiro Tsuruda
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki 889 1692, Japan
    Cardiovasc Res 65:921-9. 2005
  5. doi request reprint Thrombin generation by intimal tissue factor contributes to thrombus formation on macrophage-rich neointima but not normal intima of hyperlipidemic rabbits
    Atsushi Yamashita
    Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Atherosclerosis 206:418-26. 2009
  6. doi request reprint Pharmacological stimulation of soluble guanylate cyclase modulates hypoxia-inducible factor-1alpha in rat heart
    Toshihiro Tsuruda
    Faculty of Medicine, Department of Internal Medicine, Circulatory and Body Fluid Regulation, University of Miyazaki, Miyazaki, Japan
    Am J Physiol Heart Circ Physiol 297:H1274-80. 2009
  7. ncbi request reprint Different inflammatory response and oxidative stress in neointimal hyperplasia after balloon angioplasty and stent implantation in cholesterol-fed rabbits
    Riichirou Kawamoto
    First Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692 Japan
    Pathol Res Pract 202:447-56. 2006
  8. ncbi request reprint Adrenomedullin administration immediately after myocardial infarction ameliorates progression of heart failure in rats
    Ryosai Nakamura
    First Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Miyazaki 889 1692, Japan
    Circulation 110:426-31. 2004
  9. ncbi request reprint Adrenomedullin in mast cells of abdominal aortic aneurysm
    Toshihiro Tsuruda
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan
    Cardiovasc Res 70:158-64. 2006
  10. ncbi request reprint Adenovirus-mediated transfer of human placental ectonucleoside triphosphate diphosphohydrolase to vascular smooth muscle cells suppresses platelet aggregation in vitro and arterial thrombus formation in vivo
    Eiji Furukoji
    Department of Radiology, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Circulation 111:808-15. 2005

Detail Information

Publications92

  1. doi request reprint Podoplanin expression in advanced atherosclerotic lesions of human aortas
    Kinta Hatakeyama
    Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692 Japan
    Thromb Res 129:e70-6. 2012
    ..These results suggest that podoplanin contributes to thrombotic property of advanced stages of atherosclerosis and that it might be a novel molecular target for an anti-thrombus drug...
  2. ncbi request reprint Relation of CD39 to plaque instability and thrombus formation in directional atherectomy specimens from patients with stable and unstable angina pectoris
    Kinta Hatakeyama
    First Department of Pathology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    Am J Cardiol 95:632-5. 2005
    ..These results suggest that CD39 expressed in atheromatous plaque plays an important role in preventing acute coronary syndromes...
  3. doi request reprint Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart
    Hiroyuki Masuyama
    Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Hypertens Res 32:597-603. 2009
    ..These results suggest that sGC stimulator BAY 41-2272 might be effective to reduce fibrosis in hypertensive heart disease by attenuating angiotensin II generation through myofibroblast transformation...
  4. ncbi request reprint Antifibrotic effect of adrenomedullin on coronary adventitia in angiotensin II-induced hypertensive rats
    Toshihiro Tsuruda
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki 889 1692, Japan
    Cardiovasc Res 65:921-9. 2005
    ..The purpose of this study was to examine the biological actions of AM against the profibrotic factor angiotensin II (Ang II) in coronary adventitia...
  5. doi request reprint Thrombin generation by intimal tissue factor contributes to thrombus formation on macrophage-rich neointima but not normal intima of hyperlipidemic rabbits
    Atsushi Yamashita
    Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Atherosclerosis 206:418-26. 2009
    ..The TF content in disrupted atherosclerotic plaques might play a more important role than hyperlipidemia in the development of atherothrombosis...
  6. doi request reprint Pharmacological stimulation of soluble guanylate cyclase modulates hypoxia-inducible factor-1alpha in rat heart
    Toshihiro Tsuruda
    Faculty of Medicine, Department of Internal Medicine, Circulatory and Body Fluid Regulation, University of Miyazaki, Miyazaki, Japan
    Am J Physiol Heart Circ Physiol 297:H1274-80. 2009
    ..01) induced by pressure overload. This study suggests that the pharmacological sGC-cGMP stimulation modulates the HIF-1alpha expression in response to hypoxia or mechanical load in the heart...
  7. ncbi request reprint Different inflammatory response and oxidative stress in neointimal hyperplasia after balloon angioplasty and stent implantation in cholesterol-fed rabbits
    Riichirou Kawamoto
    First Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692 Japan
    Pathol Res Pract 202:447-56. 2006
    ....
  8. ncbi request reprint Adrenomedullin administration immediately after myocardial infarction ameliorates progression of heart failure in rats
    Ryosai Nakamura
    First Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Miyazaki 889 1692, Japan
    Circulation 110:426-31. 2004
    ..This study was performed to determine whether AM administration immediately after acute MI inhibits progression of heart failure in rats...
  9. ncbi request reprint Adrenomedullin in mast cells of abdominal aortic aneurysm
    Toshihiro Tsuruda
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan
    Cardiovasc Res 70:158-64. 2006
    ..The purpose of this study was to examine the pathophysiological role of AM in the development of human abdominal aortic aneurysm (AAA)...
  10. ncbi request reprint Adenovirus-mediated transfer of human placental ectonucleoside triphosphate diphosphohydrolase to vascular smooth muscle cells suppresses platelet aggregation in vitro and arterial thrombus formation in vivo
    Eiji Furukoji
    Department of Radiology, Miyazaki Medical College, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Circulation 111:808-15. 2005
    ..The present study examined whether these isoforms suppress platelet aggregation and thrombus formation after adenovirus-mediated gene transfer to vascular smooth muscle cells (SMCs)...
  11. doi request reprint MR signal change in venous thrombus relates organizing process and thrombolytic response in rabbit
    Yasuyoshi Kuroiwa
    Department of Radiological Technology, Koga General Hospital, Miyazaki, Japan
    Magn Reson Imaging 29:975-84. 2011
    ..Venous thrombosis can be reliably and noninvasively detected by MRI. Measurement of SI might support assessments of thrombus age and thrombolytic response...
  12. ncbi request reprint Increased vascular wall thrombogenicity combined with reduced blood flow promotes occlusive thrombus formation in rabbit femoral artery
    Atsushi Yamashita
    First Department of Pathology, Miyazaki Medical College, Miyazaki University, Kiyotake, Miyazaki, Japan
    Arterioscler Thromb Vasc Biol 24:2420-4. 2004
    ..Plaque disruption does not always result in complete thrombotic occlusion. The mechanism of arterial thrombus propagation remains unclear...
  13. doi request reprint Thioredoxin in coronary culprit lesions: possible relationship to oxidative stress and intraplaque hemorrhage
    Kensaku Nishihira
    Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan
    Atherosclerosis 201:360-7. 2008
    ....
  14. doi request reprint Usefulness of triple-phase thallium-201 SPECT in non-small-cell lung cancer (NSCLC): association with proliferative activity
    Seigo Fujita
    Department of Radiology, Miyazaki Medical College, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
    Ann Nucl Med 22:833-9. 2008
    ....
  15. ncbi request reprint Increased expression of interleukin-10 in unstable plaque obtained by directional coronary atherectomy
    Kensaku Nishihira
    First Department of Internal Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Eur Heart J 27:1685-9. 2006
    ..The present study investigates the expression and localization of interleukin (IL)-10, an important anti-inflammatory cytokine, in atherectomy specimens from patients with stable and unstable angina...
  16. ncbi request reprint Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits
    Jingyan Liang
    Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan
    Circulation 113:1993-2001. 2006
    ..However, the pathological roles of MMP-12 in the initiation and progression of atherosclerosis have not been defined...
  17. ncbi request reprint Expression of interleukin-18 in coronary plaque obtained by atherectomy from patients with stable and unstable angina
    Kensaku Nishihira
    Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Thromb Res 121:275-9. 2007
  18. ncbi request reprint Relation of C-reactive protein to restenosis after coronary stent implantation and to restenosis after coronary atherectomy
    Riichirou Kawamoto
    First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
    Am J Cardiol 94:104-7. 2004
    ..This suggests that the inflammatory response is more involved in the pathogenesis of in-stent restenosis than in restenosis after directional coronary atherectomy...
  19. ncbi request reprint Soluble guanylate cyclase stimulation on cardiovascular remodeling in angiotensin II-induced hypertensive rats
    Hiroyuki Masuyama
    Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki 889 1692, Japan
    Hypertension 48:972-8. 2006
    ....
  20. ncbi request reprint Critical role of von Willebrand factor and platelet interaction in venous thromboembolism
    Misaki Takahashi
    Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Histol Histopathol 24:1391-8. 2009
    ..These results suggest that VWF A1-platelet GPIb interaction plays a significant role in venous thrombus formation...
  21. ncbi request reprint Adrenomedullin induces matrix metalloproteinase-2 activity in rat aortic adventitial fibroblasts
    Toshihiro Tsuruda
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan
    Biochem Biophys Res Commun 325:80-4. 2004
    ..In the present study, we examined the effect of the bioactive peptide adrenomedullin (AM) on activity and expression of matrix metalloproteinases (MMPs) in cultured aortic adventitial fibroblasts...
  22. ncbi request reprint Different distribution of pentraxin 3 and C-reactive protein in coronary atherosclerotic plaques
    Yunosuke Matsuura
    Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan
    J Atheroscler Thromb 19:837-45. 2012
    ..To understand the differences between histopathological characteristics related to PTX3 (pentraxin 3) and CRP (C-reactive protein) in coronary atherosclerotic plaques...
  23. doi request reprint Usefulness of carotid intima-media thickness measurement as an indicator of generalized atherosclerosis: findings from autopsy analysis
    Takashi Iwakiri
    Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Atherosclerosis 225:359-62. 2012
    ..Ultrasound-determined carotid intima-media thickness (IMT) is widely used as an indicator of generalized atherosclerotic burden, but there are limited autopsy findings in support of the association, directly...
  24. doi request reprint Inhibition of development of abdominal aortic aneurysm by glycolysis restriction
    Toshihiro Tsuruda
    Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki 889 1692, Japan
    Arterioscler Thromb Vasc Biol 32:1410-7. 2012
    ..The mechanisms underlying abdominal aortic aneurysm development remain unknown. We hypothesized that acceleration of glucose metabolism with the upregulation of glucose transporters is associated with abdominal aortic aneurysm development...
  25. ncbi request reprint Overexpression of proadrenomedullin N-terminal 20 peptide blunts blood pressure rise and attenuates myocardial hypertrophy and fibrosis in hypertensive rats
    Yuan Ning Cao
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Kiyotake, 5200 Kihara, Miyazaki 889 1692, Japan
    FEBS Lett 579:4997-5001. 2005
    ..These results suggest that in addition to reducing blood pressure, PAMP suppresses cardiac hypertrophy through negative regulation of the local cardiac RAS...
  26. ncbi request reprint Detection of von Willebrand factor and tissue factor in platelets-fibrin rich coronary thrombi in acute myocardial infarction
    Atsushi Yamashita
    Department of Pathology, University of Miyazaki Faculty of Medicine, Miyazaki, Japan
    Am J Cardiol 97:26-8. 2006
    ..vWF and/or TF may contribute to occlusive thrombus formation and be novel therapeutic candidates for treating patients with coronary thrombosis...
  27. doi request reprint Factor VIII contributes to platelet-fibrin thrombus formation via thrombin generation under low shear conditions
    Chihiro Sugita
    Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Thromb Res 124:601-7. 2009
    ..Increased plasma levels and activities of coagulation factor VIII (FVIII) comprise risk factors for DVT and pulmonary thromboembolism...
  28. ncbi request reprint Adrenomedullin alleviates not only neointimal formation but also perivascular hyperplasia following arterial injury in rats
    Toshihiro Tsuruda
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Japan
    Eur J Pharmacol 508:201-4. 2005
    ....
  29. doi request reprint Presence of older thrombus in patients with late and very late drug-eluting stent thrombosis
    Kensaku Nishihira
    Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    J Cardiol 59:57-63. 2012
    ..We morphologically investigated the age of DES thrombi aspirated during percutaneous coronary intervention (PCI) from patients with either late or very late ST that resulted in acute myocardial infarction (AMI)...
  30. doi request reprint Adventitial mast cells contribute to pathogenesis in the progression of abdominal aortic aneurysm
    Toshihiro Tsuruda
    Department of Internal Medicine, Circulatory and Body Fluid Regulation, Faculty of Medicine, University of Miyazaki 5200 Kihara Kiyotake, Miyazaki 889 1692, Japan
    Circ Res 102:1368-77. 2008
    ..Collectively, these data suggest that adventitial mast cells play a critical role in the progression of AAA...
  31. doi request reprint Atherosclerotic lesions rich in macrophages or smooth muscle cells discriminated in rabbit iliac arteries based on T1 relaxation time and lipid content
    Yasuyoshi Kuroiwa
    Department of Radiological Technology, Koga General Hospital, Miyazaki, Japan
    Acad Radiol 17:230-8. 2010
    ..We therefore investigated whether MRI provides valuable information about the characteristics of atherosclerotic vessels using rabbit models of macrophage-rich or SMC-rich atherosclerotic arteries...
  32. ncbi request reprint Possible contribution of C-reactive protein within coronary plaque to increasing its own plasma levels across coronary circulation
    Tetsunori Ishikawa
    First Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Miyazaki, Japan
    Am J Cardiol 93:611-4. 2004
    ..Thus, CRP within coronary plaque might contribute to increased plasma CRP levels across coronary circulation, particularly among patients with unstable angina pectoris...
  33. doi request reprint Inhibition of factor XI reduces thrombus formation in rabbit jugular vein under endothelial denudation and/or blood stasis
    Misaki Takahashi
    Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Thromb Res 125:464-70. 2010
    ..The aim of this study is to understand the role of FXI in venous thrombus formation under conditions of endothelial denudation and/or blood stasis...
  34. ncbi request reprint Involvement of C-reactive protein obtained by directional coronary atherectomy in plaque instability and developing restenosis in patients with stable or unstable angina pectoris
    Tetsunori Ishikawa
    First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
    Am J Cardiol 91:287-92. 2003
    ..These findings suggest that CRP in atheromatous plaque plays an important role in the pathogenesis of unstable angina and restenosis after coronary intervention...
  35. pmc Nuclear expression of thioredoxin-1 in the invasion front is associated with outcome in patients with gallbladder carcinoma
    Motoaki Nagano
    Department of Surgical Oncology and Regulation of Organ Function, Miyazaki University School of Medicine, Kiyotake, Miyazaki, Japan
    HPB (Oxford) 14:573-82. 2012
    ..The aim of the present study was to examine the distribution of TRX-1 and TRX-R expressions in gallbladder carcinoma (GBC) to clarify their usefulness as prognostic factors after surgical resection...
  36. pmc C-reactive protein in atherosclerotic lesions: its origin and pathophysiological significance
    Huijun Sun
    Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305 8575, Japan
    Am J Pathol 167:1139-48. 2005
    ..These results suggest that there is a link between plasma CRP and the degree of atherosclerosis and that inhibition of plasma CRP may represent a therapeutic modality for the treatment of cardiovascular disease...
  37. ncbi request reprint Repeated sirolimus-eluting stent implantation to treat sirolimus-eluting stent and bare-metal stent restenosis
    Kensaku Nishihira
    Department of Cardiology, Miyazaki Medical Association Hospital, Miyazaki, Japan
    Circ J 74:2329-33. 2010
    ..The present study compares the clinical and angiographic outcomes of using sirolimus-eluting stents (SES) for re-intervention against ISR that was originally treated with sirolimus-eluting or bare-metal (BMS) stents...
  38. doi request reprint Associations of plasma pentraxin 3 and monocyte chemoattractant protein-1 concentrations with cardiovascular disease in patients with chronic kidney disease
    Keiko Nishi
    Division of Circulatory and Body Fluid Regulation, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Ren Fail 33:398-404. 2011
    ..Additionally, PTX3 might be a more sensitive marker for the association of CVD than hsCRP and TNF╬▒ in patients with advanced CKD...
  39. doi request reprint Elevated plasma factor VIII enhances venous thrombus formation in rabbits: contribution of factor XI, von Willebrand factor and tissue factor
    Chihiro Sugita
    Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Thromb Haemost 110:62-75. 2013
    ..In conclusion, elevated plasma FVIII levels enhance venous thrombus formation and propagation. Excess thrombin generation by FXI and VWF-mediated FVIII recruitment appear to contribute to the growth of FVIII-driven venous thrombus. ..
  40. doi request reprint Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus
    Atsushi Yamashita
    Department of Pathology Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Atherosclerosis 224:511-4. 2012
    ..The paucity of CD34-positive cells and the high levels of HMGB-1 expression in acute coronary thrombi from patients with type 2 DM could facilitate thrombus formation...
  41. doi request reprint Loss of cellular viability in areas of ground-glass opacity on computed tomography images immediately after pulmonary radiofrequency ablation in rabbits
    Masaomi Kuroki
    Department of Radiology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Jpn J Radiol 30:323-30. 2012
    ..To determine cellular viability of lung parenchyma and neoplastic cells in areas of ground-glass opacity (GGO) on computed tomography (CT) images immediately after pulmonary radiofrequency ablation (RFA) in rabbits...
  42. ncbi request reprint [Localization and possible function of adrenomedullin in human tissues]
    Kinta Hatakeyama
    First Department of Pathology, Miyazaki Medical College, University of Miyazaki
    Nihon Rinsho 62:211-5. 2004
  43. ncbi request reprint Quantitative analysis of vessels with smooth muscle layer in astrocytic tumors: correlation with histological grade and prognostic significance
    Shinya Sato
    Pathology Division, University of Miyazaki Hospital, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Histol Histopathol 26:497-504. 2011
    ....
  44. ncbi request reprint Ecto-nucleoside triphosphate diphosphohydrolase inhibits ATP- and ADP-induced vasoconstriction
    Eiji Furukoji
    Department of Radiology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Thromb Res 121:583-5. 2008
  45. doi request reprint ADAMTS-13 attenuates thrombus formation on type I collagen surface and disrupted plaques under flow conditions
    Sayaka Moriguchi-Goto
    Department of Pathology, University of Miyazaki, Kiyotake, Japan
    Atherosclerosis 203:409-16. 2009
    ..WH2-22-1A significantly augmented thrombus formation on injured neointima. These results suggest that the disintegrin-like domain of ADAMTS-13 functions in attenuating thrombus growth on diseased arteries exposed to a high shear rate...
  46. ncbi request reprint Cardiac rupture in acute myocardial infarction: post-mortem MR imaging
    Yasuyoshi Kuroiwa
    Department of Radiological Technology, Koga General Hospital, Miyazaki, Japan
    Magn Reson Med Sci 10:255-8. 2011
    ..A rupture site rich in erythrocytes after AMI might affect SI on T(1) and T(2)WI in cardiac MR imaging...
  47. ncbi request reprint Role of thrombogenic factors in the development of atherosclerosis
    Kousuke Marutsuka
    Pathology Division, Miyazaki Medical College Hospital, University of Miyazaki, Miyazaki, Japan
    J Atheroscler Thromb 12:1-8. 2005
    ..Thus TF, in addition to factors downstream of the coagulation cascade and the protease-activated receptor 2 activation system, would be a multifactorial regulator of atherogenesis...
  48. ncbi request reprint Immunohistological localization and possible functions of adrenomedullin
    Kousuke Marutsuka
    First Department of Pathology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Hypertens Res 26:S33-40. 2003
    ..In addition, AM is also present in the auditory system. These lines of evidence suggest that AM and its related peptides not only play a role in vasodilatation, but also exhibit multiple biological activities in mammals...
  49. ncbi request reprint Adrenomedullin augments the release and production of tissue factor pathway inhibitor in human aortic endothelial cells
    Kousuke Marutsuka
    First Department of Pathology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, Japan
    Cardiovasc Res 57:232-7. 2003
    ..The aim of this study was to elucidate the effects of AM on release and production of TFPI in ECs...
  50. doi request reprint Incidence of asymptomatic coronary thrombosis and plaque disruption: comparison of non-cardiac and cardiac deaths among autopsy cases
    Yuichiro Sato
    Department of Pathology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Thromb Res 124:19-23. 2009
    ..However, the incidence of thrombus formation and plaque disruption in patients with non-cardiac death (NCD) remains unclear...
  51. doi request reprint Hypereosinophilic syndrome associated with occlusive coronary thrombosis and right ventricular thrombus
    Yuichiro Sato
    Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Pathol Int 58:138-41. 2008
    ..The findings suggest a causal relationship between coronary thrombosis and eosinophilia. To the authors' knowledge this is the first report to document the clinical and histological findings of coronary thrombosis in a patient with HES...
  52. ncbi request reprint Granulomatous amoebic encephalitis caused by Balamuthia mandrillaris
    Kouji Yamasaki
    Department of Neurosurgery, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Neurol Med Chir (Tokyo) 51:667-70. 2011
    ..GAE is usually fatal, and is difficult to diagnose except at autopsy. Therefore, awareness of this disease is important, and earlier diagnosis and the development of a better therapeutic strategy will improve clinical outcome...
  53. doi request reprint Morning blood pressure surge, morning platelet aggregation, and silent cerebral infarction in older Japanese hypertensive patients
    Kazuomi Kario
    Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan
    J Hypertens 29:2433-9. 2011
    ....
  54. ncbi request reprint Large cell neuroendocrine carcinoma of the uterine cervix: a clinicopathological study of six cases
    Yuichiro Sato
    Department of Pathology, Miyazaki Prefectural Hospital, Miyazaki, Japan
    Int J Gynecol Pathol 22:226-30. 2003
    ..The results of this study confirm the aggressive nature of cervical LCNECs. The recognition of LCNECs is necessary to establish the most effective treatment for these aggressive tumors...
  55. ncbi request reprint Stromal cell biology--a way to understand the evolution of cardiovascular diseases
    Toshihiro Tsuruda
    Department of Internal Medicine, Circulatory and Body Fluid Regulation, University of Miyazaki, Miyazaki, Japan
    Circ J 74:1042-50. 2010
    ....
  56. ncbi request reprint Renal biopsy in elderly patients: a clinicopathological analysis
    Shigehiro Uezono
    First Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    Ren Fail 28:549-55. 2006
    ..Percutaneous renal biopsy provides clinically useful information about the elderly because clinical presentation and the predicted diagnosis sometimes vary...
  57. ncbi request reprint Two cases of pheochromocytoma associated with tetralogy of Fallot
    Toshihiro Kita
    First Department of Internal Medicine, Miyazaki Medical College, Miyazaki, Japan
    Hypertens Res 26:433-7. 2003
    ..Differential diagnosis of pheochromocytoma could be paramount in congenital heart disease patients who show unexpected or unusual symptoms...
  58. ncbi request reprint Contribution of von Willebrand factor to thrombus formation on neointima of rabbit stenotic iliac artery under high blood-flow velocity
    Atsushi Yamashita
    First Department of Pathology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Arterioscler Thromb Vasc Biol 23:1105-10. 2003
    ..We examined the contribution of vWF to thrombus formation and subsequent intimal growth by using a repeated balloon-injury model in rabbits...
  59. ncbi request reprint Atheroembolic renal disease: clinical findings of 11 cases
    Seiichiro Hara
    First Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Miyazaki, Japan
    J Atheroscler Thromb 9:288-91. 2002
    ..Since the population at risk for AERD is growing, we should recognize this disease as a cause of acute renal failure...
  60. doi request reprint Both 5-hydroxytryptamine 5-HT2A and 5-HT1B receptors are involved in the vasoconstrictor response to 5-HT in the human isolated internal thoracic artery
    Naoko Tanaka
    First Department of Pharmacology, School of Pharmacological Sciences, Kyushu University of Health and Welfare, Nobeoka, Miyazaki, Japan
    Clin Exp Pharmacol Physiol 35:836-40. 2008
    ..Thus, when the human ITA is used as an arterial graft, a combination of 5-HT(2A) and 5-HT(1B) receptor antagonists would appear to be most useful to prevent 5-HT-induced vasospasm...
  61. ncbi request reprint Neuroendocrine carcinoma of the posterior mediastinum arising from a foregut cyst
    Atsushi Yamashita
    First Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Pathol Int 55:285-9. 2005
    ..Malignant change within a foregut cyst is very uncommon. This is the first report of a neuroendocrine carcinoma of the posterior mediastinum arising from a foregut cyst...
  62. ncbi request reprint Relationship between cancer cell proliferation, tumour angiogenesis and 201Tl uptake in non-small cell lung cancer
    Seigo Fujita
    Department of Radiology, Miyazaki Medical College, Japan
    Nucl Med Commun 27:989-97. 2006
    ..To investigate whether 201Tl uptake is associated with cell proliferation and angiogenesis in non-small-cell lung carcinoma (NSCLC)...
  63. ncbi request reprint Atypical extraventricular neurocytoma
    Sayaka Moriguchi
    Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Pathol Int 56:25-9. 2006
    ..High proliferative activity without accumulation of p53 suggests that other factors are involved in oncogenesis of atypical EVN...
  64. doi request reprint Hemangioma of the umbilical cord with pseudocyst
    Shuntaro Matsuda
    Department of Pathology, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Fetal Pediatr Pathol 30:16-21. 2011
    ..A total of 33 umbilical cord hemangioma cases have been reported in detail, and only seven cases had a pseudocystic degeneration. The associated pathologic findings of umbilical cord hemangioma are reviewed...
  65. doi request reprint So-called 'adenosarcoma' of the kidney a novel adult renal tumor with a cystic appearance
    Naoki Sameshima
    Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Pathol Int 61:313-8. 2011
    ..Because these findings did not coincide with established descriptions of cystic renal neoplasms, we preferred the term, 'adenosarcoma'. This could become a new classification for adult cystic renal tumors...
  66. pmc Therapeutic efficacy of intra-articular adrenomedullin injection in antigen-induced arthritis in rabbits
    Toshiyuki Okura
    Department of Medicine of Sensory and Motor Organs, Division of Orthopedic Surgery, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Arthritis Res Ther 10:R133. 2008
    ..The purpose of the present study was to evaluate the therapeutic effects of adrenomedullin in rabbits with antigen-induced arthritis, an experimental model of rheumatoid arthritis...
  67. ncbi request reprint Intraneural synovial sarcoma originating from the median nerve
    Hisao Uehara
    Division of Neurosurgery, Department of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Neurol Med Chir (Tokyo) 48:77-82. 2008
    ..Total removal of the recurrent tumor was performed. Synovial sarcoma was finally diagnosed by the identification of SYT-SSX1 fusion gene transcripts using reverse transcriptase-polymerase chain reaction with a frozen tumor tissue sample...
  68. ncbi request reprint Expression of hepatocyte growth factor activator inhibitor type 1 in endothelial cells
    Yutaka Akiyama
    Section of Oncopathology and Regenerative Biology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan
    Hum Cell 19:91-7. 2006
    ....
  69. pmc A rabbit model of thrombosis on atherosclerotic lesions
    Atsushi Yamashita
    Department of Pathology, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    J Biomed Biotechnol 2011:424929. 2011
    ..Emerging transgenic and stem cell technologies should also provide an invaluable rabbit experimental model in the near future...
  70. ncbi request reprint [An autopsy case of polymyositis with exacerbation of chronic myocarditis]
    Yasuji Arimura
    Division of Neurology, Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    No To Shinkei 55:599-604. 2003
    ..When a patient with mild polymyositis complains of general fatigue, myocarditis should be carefully evaluated because of the high risk of death...
  71. ncbi request reprint Segmentectomy for reactive lymphoid hyperplasia of the liver: Report of a case
    Naoki Maehara
    Department of Surgery 1, University of Miyazaki, School of Medicine, 5200 Kihara, Kiyotake, Miyazaki, 889 1692, Japan
    Surg Today 36:1019-23. 2006
    ..Immunohistochemical study revealed polyclonality, confirming a pathological diagnosis of RLH of the liver. We discuss the clinicopathologic characteristics of this unusual disease...
  72. ncbi request reprint Hemoglobin stimulates the expression of matrix metalloproteinases, MMP-2 and MMP-9 by synovial cells: a possible cause of joint damage after intra-articular hemorrhage
    Takuya Tajima
    Department of Physiology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
    J Orthop Res 23:891-8. 2005
    ..These findings suggest that hemoglobin stimulates the secretion of uPA, MMP-2 and MMP-9 by synovial tissues, and raise a possible role of hemoglobin in joint damage after intra-articular bleeding...
  73. ncbi request reprint Intravascular ultrasound imaging in the assessment of atherosclerotic plaques in rabbit abdominal aorta: comparison with histologic findings
    Reiji Ochiai
    Department of Radiology, Miyazaki Medical College, Kiyotake, Japan
    Invest Radiol 37:309-13. 2002
    ..To examine the correlation between the echogenicity and the components of atherosclerotic plaques in rabbit...
  74. ncbi request reprint Newly established clear cell sarcoma (malignant melanoma of soft parts) cell line expressing melanoma-associated Melan-A antigen and overexpressing C-MYC oncogene
    Hiroshi Moritake
    Department of Pediatrics, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, Japan
    Cancer Genet Cytogenet 135:48-56. 2002
    ..The availability of this MP-CCS-SY cell line will help to understand the molecular biology of this malignancy and should be useful as a tool for developing an immunotherapy...
  75. ncbi request reprint Protease-activated receptor 2 (PAR2) mediates vascular smooth muscle cell migration induced by tissue factor/factor VIIa complex
    Kousuke Marutsuka
    First Department of Pathology, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Thromb Res 107:271-6. 2002
    ..The migratory response was dependent on a catalytic activity of FVIIa, and did not involve factor Xa and thrombin generation. In this study, we examined TF/FVIIa-induced SMC migration...
  76. doi request reprint Reciprocal contribution of pentraxin 3 and C-reactive protein to obesity and metabolic syndrome
    Tsuneo Ogawa
    Department of Nutrition Management, Minami Kyushu University, Miyazaki, Japan
    Obesity (Silver Spring) 18:1871-4. 2010
    ..In conclusion, PTX3 and CRP antagonistically participate in the development of obesity or MetS...
  77. ncbi request reprint Beneficial effects of adrenomedullin on left ventricular remodeling after myocardial infarction in rats
    Ryosai Nakamura
    First Department of Internal Medicine, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki, Japan
    Cardiovasc Res 56:373-80. 2002
    ..The aim of this study was to examine the effects of long-term administration of AM on left ventricular (LV) remodeling, hemodynamic and hormonal parameters in a rat model of MI...
  78. ncbi request reprint Two Japanese cases of lichen planus pigmentosus-inversus
    Aki Kashima
    Department of Dermatology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan
    Int J Dermatol 46:740-2. 2007
    ..2B). Both the epidermis and the upper dermis contained CD1a(+) cells (Fig. 2C). The keratinocytes focally and weakly expressed HLA-DR (Fig. 2D). These findings were identical in samples from both patients...
  79. ncbi request reprint Expression and immunohistochemical localization of adrenomedullin in the mouse cochlea
    Tetsuya Tono
    Department of Otolaryngology, Miyazaki Medical College, Miyazaki, Japan
    ORL J Otorhinolaryngol Relat Spec 64:169-72. 2002
    ..These results suggest that AM may play a role in the regulation not only of cochlear hemodynamics but also of cochlear fluid dynamics...
  80. doi request reprint Down-regulation of TCF8 is involved in the leukemogenesis of adult T-cell leukemia/lymphoma
    Tomonori Hidaka
    Division of Tumor and Cellular Biochemistry, Department of Medical Sciences, University of Miyazaki, Miyazaki, Japan
    Blood 112:383-93. 2008
    ..These findings indicate that TCF8 has a tumor suppressor role in ATLL...
  81. ncbi request reprint Local expression of platelet-activating factor-acetylhydrolase reduces accumulation of oxidized lipoproteins and inhibits inflammation, shear stress-induced thrombosis, and neointima formation in balloon-injured carotid arteries in nonhyperlipidemic rabbi
    Hideki Arakawa
    Department of Biochemistry and Molecular Pathophysiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    Circulation 111:3302-9. 2005
    ..However, this was markedly reduced in the AdPAF-AH-treated arteries. No differences in the titers of autoantibodies to OxLDL or total cholesterol in blood were found between controls and AdPAF-AH-treated rabbits...
  82. ncbi request reprint Local expression of C-type natriuretic peptide suppresses inflammation, eliminates shear stress-induced thrombosis, and prevents neointima formation through enhanced nitric oxide production in rabbit injured carotid arteries
    Jian Yong Qian
    Department of Biochemistry and Molecular Pathophysiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    Circ Res 91:1063-9. 2002
    ..Our study demonstrates that overexpression of CNP shows antithrombotic and antiinflammatory effects and reduces neointima formation mainly through enhanced NO production...
  83. ncbi request reprint Impact of body mass index on in-hospital outcomes after percutaneous coronary intervention for ST segment elevation acute myocardial infarction
    Masami Kosuge
    Division of Cardiology, Yokohama City University Medical Center, Japan
    Circ J 72:521-5. 2008
    ..The impact of body mass index (BMI) on outcomes after primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) remains unclear...
  84. ncbi request reprint Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome
    Masafumi Myoishi
    Department of Cardiovascular Medicine, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    Circulation 116:1226-33. 2007
    ..Although apoptosis is considered to be essential for the progression and rupture of atherosclerotic plaques, the influence of ER stress and apoptosis on rupture of unstable coronary plaques remains unclear...
  85. ncbi request reprint [Inflammatory and immune responses in arterial thrombus formation]
    Yujiro Asada
    Rinsho Ketsueki 46:83-90. 2005
  86. ncbi request reprint Impairment of endothelium-dependent relaxation of aortas and pulmonary arteries from spontaneously hyperlipidemic mice (Apodemus sylvaticus)
    Kaoru M Ito
    Department of Nutrition Management, Faculty of Health and Nutrition, Minami Kyushu University, 880 0032 Miyazaki, Japan
    Vascul Pharmacol 47:166-73. 2007
    ..Thus, AHL mice are valuable as a new experimental model to study the relation of hyperlipidemia to vascular disease since the endothelial function is impaired in these mild hyperlipidemic animals...
  87. ncbi request reprint Beneficial effect of preinfarction angina on in-hospital outcome is preserved in elderly patients undergoing coronary intervention for anterior acute myocardial infarction
    Masami Kosuge
    Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan
    Circ J 69:630-5. 2005
    ..However, it remains unclear whether preinfarction angina has a beneficial effect on clinical outcome in elderly patients undergoing percutaneous coronary intervention (PCI)...
  88. ncbi request reprint Sex differences in early mortality of patients undergoing primary stenting for acute myocardial infarction
    Masami Kosuge
    Division of Cardiology, Yokohama City University Medical Center, Japan
    Circ J 70:217-21. 2006
    ..Limited information exists regarding the impact of gender on in-hospital outcome after primary stenting for acute myocardial infarction (AMI)...
  89. ncbi request reprint Effects of preinfarction angina pectoris on infarct size and in-hospital mortality after coronary intervention for acute myocardial infarction
    Masami Kosuge
    Division of Cardiology, Yokohama City University Medical Center, Yokohama, Japan
    Am J Cardiol 92:840-3. 2003
    ..Beneficial effects of preinfarction angina on infarct size and in-hospital outcome are evident in patients with anterior infarction, but not in those with nonanterior infarction...
  90. ncbi request reprint Disruption of autosomal recessive hypercholesterolemia gene shows different phenotype in vitro and in vivo
    Mariko Harada-Shiba
    Department of Bioscience, National Cardiovascular Center Research Institute, Fujishiro dai, Suita, Osaka 565 8565, Japan
    Circ Res 95:945-52. 2004
    ..These findings were consistent with the observations with the ARH homozygous patients and suggested that certain cellular environmental factors modulate the requirement of ARH for the LDLR function...
  91. ncbi request reprint Tissue factor pathway inhibitor is highly susceptible to chymase-mediated proteolysis
    Tsutomu Hamuro
    Therapeutic Protein Products Research Department, The Chemo Sero Therapeutic Research Institute, Kaketsuken, Japan
    FEBS J 274:3065-77. 2007
    ..These data indicate that TFPI is a novel and highly susceptible substrate of chymase. We propose that chymase-mediated proteolysis of TFPI may induce a thrombosis-prone state at inflammatory sites...
  92. ncbi request reprint Ultrasound accelerates thrombolysis of acutely induced platelet-rich thrombi similar to those in acute myocardial infarction
    Hiroyuki Kawata
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara 634 8522, Japan
    Circ J 71:1643-8. 2007
    ..The effects of adding ultrasound (US) to pharmacological lysis of platelet-rich thrombi was examined in a rabbit model of femoral artery occlusion...