Miho Aoshima

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Novel [2Fe-2S]-type redox center C in SdhC of archaeal respiratory complex II from Sulfolobus tokodaii strain 7
    Toshio Iwasaki
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    J Biol Chem 277:39642-8. 2002
  2. ncbi Metabolic characteristics of an isocitrate dehydrogenase defective derivative of escherichia coli BL21(DE3)
    Miho Aoshima
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Biotechnol Bioeng 84:732-7. 2003
  3. pmc Nondecarboxylating and decarboxylating isocitrate dehydrogenases: oxalosuccinate reductase as an ancestral form of isocitrate dehydrogenase
    Miho Aoshima
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8567, Japan
    J Bacteriol 190:2050-5. 2008
  4. ncbi A novel biotin protein required for reductive carboxylation of 2-oxoglutarate by isocitrate dehydrogenase in Hydrogenobacter thermophilus TK-6
    Miho Aoshima
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Mol Microbiol 51:791-8. 2004
  5. ncbi A novel enzyme, citryl-CoA synthetase, catalysing the first step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6
    Miho Aoshima
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Mol Microbiol 52:751-61. 2004
  6. ncbi A novel oxalosuccinate-forming enzyme involved in the reductive carboxylation of 2-oxoglutarate in Hydrogenobacter thermophilus TK-6
    Miho Aoshima
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8567, Japan
    Mol Microbiol 62:748-59. 2006
  7. ncbi Novel enzyme reactions related to the tricarboxylic acid cycle: phylogenetic/functional implications and biotechnological applications
    Miho Aoshima
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo, 113 8657, Japan
    Appl Microbiol Biotechnol 75:249-55. 2007
  8. ncbi A novel enzyme, citryl-CoA lyase, catalysing the second step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6
    Miho Aoshima
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Mol Microbiol 52:763-70. 2004

Detail Information

Publications8

  1. ncbi Novel [2Fe-2S]-type redox center C in SdhC of archaeal respiratory complex II from Sulfolobus tokodaii strain 7
    Toshio Iwasaki
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    J Biol Chem 277:39642-8. 2002
    ..tokodaii respiratory complex II, as compared with those in mitochondrial and some mesophilic bacterial enzymes, indicate modular evolution of this ubiquitous electron entry site in the respiratory chains of aerobic organisms...
  2. ncbi Metabolic characteristics of an isocitrate dehydrogenase defective derivative of escherichia coli BL21(DE3)
    Miho Aoshima
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Biotechnol Bioeng 84:732-7. 2003
    ..In addition, isocitrate lyase was not highly induced at the stationary phase. MA1935 was shown to be a good host strain for ICDH gene expression...
  3. pmc Nondecarboxylating and decarboxylating isocitrate dehydrogenases: oxalosuccinate reductase as an ancestral form of isocitrate dehydrogenase
    Miho Aoshima
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8567, Japan
    J Bacteriol 190:2050-5. 2008
    ..Oxalosuccinate-reducing enzyme may be the ancestral form of ICDH, which evolved to the extant isocitrate oxidative decarboxylating enzyme by acquiring higher substrate affinities...
  4. ncbi A novel biotin protein required for reductive carboxylation of 2-oxoglutarate by isocitrate dehydrogenase in Hydrogenobacter thermophilus TK-6
    Miho Aoshima
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Mol Microbiol 51:791-8. 2004
    ..These observations indicate that the novel biotin protein is an ATP-dependent factor, which is involved in the reverse (carboxylating) reaction of isocitrate dehydrogenase...
  5. ncbi A novel enzyme, citryl-CoA synthetase, catalysing the first step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6
    Miho Aoshima
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Mol Microbiol 52:751-61. 2004
    ..The deduced amino acid sequences of the CCS subunits show similarity to part of the ACL sequence. The evolutionary relationship between CCS, SCS and ACL is discussed...
  6. ncbi A novel oxalosuccinate-forming enzyme involved in the reductive carboxylation of 2-oxoglutarate in Hydrogenobacter thermophilus TK-6
    Miho Aoshima
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8567, Japan
    Mol Microbiol 62:748-59. 2006
    ..The CFI-ICDH system may also be present in mammals, where it could play a significant role in modulating central metabolism...
  7. ncbi Novel enzyme reactions related to the tricarboxylic acid cycle: phylogenetic/functional implications and biotechnological applications
    Miho Aoshima
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo, 113 8657, Japan
    Appl Microbiol Biotechnol 75:249-55. 2007
    ..In contrast, the key enzyme in the reductive carboxylation of 2-oxoglutarate appears to be more widely distributed in extant organisms. The four newly discovered enzymes have a number of potential biotechnological applications...
  8. ncbi A novel enzyme, citryl-CoA lyase, catalysing the second step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6
    Miho Aoshima
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 8657, Japan
    Mol Microbiol 52:763-70. 2004
    ..By further sequence comparisons, the phylogenetic relationship between CCS, CCL, ACL and CS was investigated...