Tsugunobu Andoh


Affiliation: University of Toyama
Country: Japan


  1. Li S, Andoh T, Zhang Q, Uta D, Kuraishi Y. β2-Microglobulin, interleukin-31, and arachidonic acid metabolites (leukotriene B4 and thromboxane A2) are involved in chronic renal failure-associated itch-associated responses in mice. Eur J Pharmacol. 2019;: pubmed publisher
    ..In addition to LTB4 and TXA2, it is also suggested that β2-microglobulin and interleukin-31 are involved in itching associated with CRF-induced pruritus. ..
  2. Akiyama T, Andoh T, Ohtsuka E, Nojima H, Ouchi H, Takahata H, et al. Peripheral gabapentin regulates mosquito allergy-induced itch in mice. Eur J Pharmacol. 2018;833:44-49 pubmed publisher
    ..These results suggest that gabapentin regulates allergic itch by acting on the calcium channel α2δ-1 subunit in peripheral TRPV1-positive neurons. ..
  3. Shinohara A, Andoh T, Saiki I, Kuraishi Y. Analgesic effects of systemic fentanyl on cancer pain are mediated by not only central but also peripheral opioid receptors in mice. Eur J Pharmacol. 2018;833:275-282 pubmed publisher
    ..These results suggest that the analgesic effect of systemic fentanyl is produced via central and peripheral µ- opioid receptors in cancer pain, and cancer cells are a key site of peripheral action. ..
  4. Mizoguchi S, Andoh T, Yakura T, Kuraishi Y. Involvement of c-Myc-mediated transient receptor potential melastatin 8 expression in oxaliplatin-induced cold allodynia in mice. Pharmacol Rep. 2016;68:645-8 pubmed publisher
    ..These results suggest that oxaliplatin induces cold allodynia through the increase of c-Myc-mediated TRPM8 expression in primary sensory neurons. ..
  5. Andoh T, Asakawa Y, Kuraishi Y. Non-myelinated C-fibers, but not myelinated A-fibers, elongate into the epidermis in dry skin with itch. Neurosci Lett. 2018;672:84-89 pubmed publisher
    ..These results suggest that the elongated epidermal peripheral nerve fibers comprise SP/CGRP-containing C-fibers but not A-fibers. Thus, these fibers may be involved in the induction of dry skin pruritus. ..
  6. Andoh T, Li S, Uta D. Involvement of thromboxane A2 in interleukin-31-induced itch-associated response in mice. Pharmacol Rep. 2018;70:251-257 pubmed publisher
    ..IL-31 increased the concentration of intracellular Ca2+ ions in mouse keratinocytes. It is suggested that IL-31 elicits itch-associated responses through TXA2 produced from keratinocytes. ..
  7. Sakamoto A, Andoh T, Kuraishi Y. Involvement of mast cells and proteinase-activated receptor 2 in oxaliplatin-induced mechanical allodynia in mice. Pharmacol Res. 2016;105:84-92 pubmed publisher
    ..Therefore, oxaliplatin may indirectly affect the functions of mast cells through its action on capsaicin-sensitive primary afferents. ..
  8. Kagaya K, Sasaki A, Kino Y, Taniguchi H, Kuraishi Y, Andoh T. Involvement of oxidative stress in increased peripheral nerve firing during spontaneous dysesthesia in a mouse model of ischemia-reperfusion. Neurosci Lett. 2016;631:109-14 pubmed publisher
    ..These results suggest that an increase in peripheral nerve activity related to oxidative stress may be involved in the spontaneous dysesthesia induced by transient ischemia-reperfusion. ..
  9. Andoh T, Sakamoto A, Kuraishi Y. 5-HT1A receptor agonists, xaliproden and tandospirone, inhibit the increase in the number of cutaneous mast cells involved in the exacerbation of mechanical allodynia in oxaliplatin-treated mice. J Pharmacol Sci. 2016;131:284-7 pubmed publisher
    ..These results suggest that the prophylactic repetitive administration of 5-HT1A receptor agonists attenuates oxaliplatin-induced mechanical allodynia by inhibiting the cutaneous mast cell migration. ..

More Information


  1. Andoh T, Shinohara A, Kuraishi Y. Inhibitory effect of fentanyl citrate on the release of endothlin-1 induced by bradykinin in melanoma cells. Pharmacol Rep. 2017;69:139-142 pubmed publisher
    ..These results suggest that fentanyl citrate regulates bradykinin-induced endothelin-1 secretion through ?-opioid receptors in melanoma cells. ..
  2. Andoh T, Kobayashi N, Uta D, Kuraishi Y. Prophylactic topical paeoniflorin prevents mechanical allodynia caused by paclitaxel in mice through adenosine A1 receptors. Phytomedicine. 2017;25:1-7 pubmed publisher
    ..These results suggest that prophylactic topical application of PF is effective in alleviating PTX-induced mechanical allodynia by protecting sensory nerves from demyelination via activation of the A1R. ..
  3. Andoh T, Yamamoto A, Haza S, Yuhki K, Ushikubi F, Narumiya S, et al. Thromboxane A2 is Involved in Itch-associated Responses in Mice with Atopic Dermatitis-like Skin Lesions. Acta Derm Venereol. 2016;96:899-904 pubmed publisher
    ..Taken together, these results suggest that epidermal TXA2, which may be produced via PAR2 activation, is involved in itching in atopic dermatitis. ..
  4. Andoh T, Maki T, Li S, Uta D. β2-Microglobulin elicits itch-related responses in mice through the direct activation of primary afferent neurons expressing transient receptor potential vanilloid 1. Eur J Pharmacol. 2017;810:134-140 pubmed publisher
    ..These results suggest that β2-MG is a pruritogen and elicits itch-related responses, at least in part, through TRPV1-expressing primary sensory neurons. ..
  5. Andoh T, Harada A, Kuraishi Y. Involvement of Leukotriene B4 Released from Keratinocytes in Itch-associated Response to Intradermal Interleukin-31 in Mice. Acta Derm Venereol. 2017;97:922-927 pubmed publisher
    ..IL-31 increased the production of LTB4 in mouse keratinocytes. These results suggest that IL-31 elicits itch not only through direct action on primary sensory neurones, but also by inducing LTB4 production in keratinocytes. ..