I Abe

Summary

Affiliation: University of Shizuoka
Country: Japan

Publications

  1. ncbi Site-directed mutagenesis of benzalacetone synthase. The role of the Phe215 in plant type III polyketide synthases
    Ikuro Abe
    School of Pharmaceutical Sciences and the 21st Century COE Program, University of Shizuoka, 52 1 Yada, Japan
    J Biol Chem 278:25218-26. 2003
  2. ncbi Green tea polyphenols: novel and potent inhibitors of squalene epoxidase
    I Abe
    University of Shizuoka, School of Pharmaceutical Sciences, 52 1 Yada, Shizuoka, 422 8526, Japan
    Biochem Biophys Res Commun 268:767-71. 2000
  3. ncbi Enzymatic formation of quinolone alkaloids by a plant type III polyketide synthase
    Ikuro Abe
    School of Pharmaceutical Sciences and the COE 21 Program, University of Shizuoka, Shizuoka 422 8526, Japan
    Org Lett 8:6063-5. 2006
  4. ncbi Site-directed mutagenesis of conserved aromatic residues in rat squalene epoxidase
    Ikuro Abe
    School of Pharmaceutical Sciences, The 21st Century COE Program, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Biochem Biophys Res Commun 352:259-63. 2007
  5. ncbi Enzymatic formation of unnatural cytokinin analogs by adenylate isopentenyltransferase from mulberry
    Ikuro Abe
    School of Pharmaceutical Sciences, The COE 21 Program, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Biochem Biophys Res Commun 355:795-800. 2007
  6. ncbi Mechanism and stereochemistry of enzymatic cyclization of 24,30-Bisnor-2,3-oxidosqualene by recombinant beta-amyrin synthase
    Ikuro Abe
    School of Pharmaceutical Sciences and the COE 21 Program, University of Shizuoka, Shizuoka 422 8526, Japan
    J Am Chem Soc 126:6880-1. 2004
  7. ncbi Enzymatic synthesis of cyclic triterpenes
    Ikuro Abe
    School of Pharmaceutical Sciences, University of Shizuoka, and PRESTO, Japan Science and Technology Agency, 52 1 Yada, Shizuoka, 422 8526, Japan
    Nat Prod Rep 24:1311-31. 2007
  8. ncbi Enzymatic formation of long-chain polyketide pyrones by plant type III polyketide synthases
    Ikuro Abe
    School of Pharmaceutical Sciences and the 21st Century COE Program, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Phytochemistry 65:2447-53. 2004
  9. ncbi A plant type III polyketide synthase that produces pentaketide chromone
    Ikuro Abe
    School of Pharmaceutical Sciences and the COE 21 Program, University of Shizuoka, Shizuoka 422 8526, Japan
    J Am Chem Soc 127:1362-3. 2005
  10. ncbi Engineered biosynthesis of plant polyketides: chain length control in an octaketide-producing plant type III polyketide synthase
    Ikuro Abe
    School of Pharmaceutical Sciences and the COE21 Program, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Am Chem Soc 127:12709-16. 2005

Collaborators

Detail Information

Publications51

  1. ncbi Site-directed mutagenesis of benzalacetone synthase. The role of the Phe215 in plant type III polyketide synthases
    Ikuro Abe
    School of Pharmaceutical Sciences and the 21st Century COE Program, University of Shizuoka, 52 1 Yada, Japan
    J Biol Chem 278:25218-26. 2003
    ..These results confirmed the critical role of Phe-215 in the polyketide formation reactions and provided structural basis for understanding the structure-function relationship of the plant type III PKSs...
  2. ncbi Green tea polyphenols: novel and potent inhibitors of squalene epoxidase
    I Abe
    University of Shizuoka, School of Pharmaceutical Sciences, 52 1 Yada, Shizuoka, 422 8526, Japan
    Biochem Biophys Res Commun 268:767-71. 2000
    ..74 microM), and non-time-dependent manner. The potent enzyme inhibition would be caused by specific binding to the enzyme, and by scavenging reactive oxygen species required for the monooxygenase reaction...
  3. ncbi Enzymatic formation of quinolone alkaloids by a plant type III polyketide synthase
    Ikuro Abe
    School of Pharmaceutical Sciences and the COE 21 Program, University of Shizuoka, Shizuoka 422 8526, Japan
    Org Lett 8:6063-5. 2006
    ..Manipulation of the functionally divergent type III PKSs by a nonphysiological substrate thus provides an efficient method for production of pharmaceutically important quinolone alkaloids...
  4. ncbi Site-directed mutagenesis of conserved aromatic residues in rat squalene epoxidase
    Ikuro Abe
    School of Pharmaceutical Sciences, The 21st Century COE Program, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Biochem Biophys Res Commun 352:259-63. 2007
    ..These aromatic residues are likely to be located at the substrate-binding domain of the active-site, and control the stereochemical course of the enzyme reaction...
  5. ncbi Enzymatic formation of unnatural cytokinin analogs by adenylate isopentenyltransferase from mulberry
    Ikuro Abe
    School of Pharmaceutical Sciences, The COE 21 Program, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Biochem Biophys Res Commun 355:795-800. 2007
    ....
  6. ncbi Mechanism and stereochemistry of enzymatic cyclization of 24,30-Bisnor-2,3-oxidosqualene by recombinant beta-amyrin synthase
    Ikuro Abe
    School of Pharmaceutical Sciences and the COE 21 Program, University of Shizuoka, Shizuoka 422 8526, Japan
    J Am Chem Soc 126:6880-1. 2004
    ....
  7. ncbi Enzymatic synthesis of cyclic triterpenes
    Ikuro Abe
    School of Pharmaceutical Sciences, University of Shizuoka, and PRESTO, Japan Science and Technology Agency, 52 1 Yada, Shizuoka, 422 8526, Japan
    Nat Prod Rep 24:1311-31. 2007
    ..126 References are cited...
  8. ncbi Enzymatic formation of long-chain polyketide pyrones by plant type III polyketide synthases
    Ikuro Abe
    School of Pharmaceutical Sciences and the 21st Century COE Program, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Phytochemistry 65:2447-53. 2004
    ....
  9. ncbi A plant type III polyketide synthase that produces pentaketide chromone
    Ikuro Abe
    School of Pharmaceutical Sciences and the COE 21 Program, University of Shizuoka, Shizuoka 422 8526, Japan
    J Am Chem Soc 127:1362-3. 2005
    ..This provided new insights into the catalytic functions and specificities of the CHS-superfamily type III PKS enzymes...
  10. ncbi Engineered biosynthesis of plant polyketides: chain length control in an octaketide-producing plant type III polyketide synthase
    Ikuro Abe
    School of Pharmaceutical Sciences and the COE21 Program, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Am Chem Soc 127:12709-16. 2005
    ..This provided novel strategies for the engineered biosynthesis of pharmaceutically important plant polyketides...
  11. ncbi [Engineered biosynthesis of plant polyketides]
    Ikuro Abe
    Tanpakushitsu Kakusan Koso 52:996-1002. 2007
  12. ncbi Active site residues governing substrate selectivity and polyketide chain length in aloesone synthase
    Ikuro Abe
    School of Pharmaceutical Sciences, and the COE21 Program, University of Shizuoka, Japan
    FEBS J 273:208-18. 2006
    ..Finally, Ser338 in proximity of the catalytic Cys164 guides the linear polyketide intermediate to extend into the pocket, thus leading to formation of the hepataketide in Rheum palmatum ALS...
  13. ncbi Engineered biosynthesis of plant polyketides: manipulation of chalcone synthase
    Ikuro Abe
    School of Pharmaceutical Sciences and the COE 21 Program, University of Shizuoka, Shizuoka 422 8526, Japan
    Org Lett 8:499-502. 2006
    ..The functional conversion is based on the simple steric modulation of a chemically inert residue lining the active-site cavity...
  14. ncbi [Engineered biosynthesis of plant polyketides]
    Ikuro Abe
    Tanpakushitsu Kakusan Koso 48:2275-85. 2003
  15. ncbi Structure-based engineering of a plant type III polyketide synthase: formation of an unnatural nonaketide naphthopyrone
    Ikuro Abe
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    J Am Chem Soc 129:5976-80. 2007
    ..A homology model predicted that the active-site cavity volume of the triple mutant is increased to 4 times that of the wild-type PCS...
  16. ncbi Green tea polyphenols as potent enhancers of glucocorticoid-induced mouse mammary tumor virus gene expression
    I Abe
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, 422 8526, Japan
    Biochem Biophys Res Commun 281:122-5. 2001
    ..The regulation of the level of the glucocorticoid-induced gene expression by the antioxidative gallates is of great interest from a therapeutic point of view...
  17. ncbi Inhibition of vertebrate squalene epoxidase by isoprenyl gallates and phenylalkyl gallates
    I Abe
    University of Shizuoka, School of Pharmaceutical Sciences, Yida, Japan
    Bioorg Med Chem Lett 10:2525-8. 2000
    ..Isoprenyl gallates (4-6) showed good inhibition (IC50 = 1.5 5.1 microM), as potent as previously reported substrate analogues, while phenylalkyl gallates (7-10) were moderate inhibitors of the enzyme (IC50 = 12-61 microM)...
  18. ncbi Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase
    I Abe
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    J Nat Prod 64:1010-4. 2001
    ..83 microM) showed potent enzyme inhibition at the submicromolar concentration range, while esters with shorter chain lengths (C(1)-C(4)) and a C(18) ester exhibited moderate inhibition (IC(50) = 8-47 microM)...
  19. ncbi Molecular cloning, expression, and site-directed mutations of oxidosqualene cyclase from Cephalosporium caerulens
    I Abe
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526, Shizuoka, Japan
    Biochim Biophys Acta 1522:67-73. 2001
    ..cerevisiae OSLC), were chosen for site-directed mutagenesis experiments; H234E, H234Y, H234F, D456E, D456N, and D456H mutants were inactive, while H234W and H234K mutants retained lanosterol-forming activity...
  20. ncbi Antioxidative galloyl esters as enzyme inhibitors of p-hydroxybenzoate hydroxylase
    I Abe
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    FEBS Lett 483:131-4. 2000
    ..Molecular modeling predicted that EGCG binds to the enzyme in the proximity of the FAD binding site via formation of three hydrogen bonds...
  21. ncbi Enzymatic formation of an unnatural C(6)-C(5) aromatic polyketide by plant type III polyketide synthases
    Ikuro Abe
    University of Shizuoka, School of Pharmaceutical Sciences, 52 1 Yada, Shizuoka 422 8526, Japan
    Org Lett 4:3623-6. 2002
    ..In contrast, succinyl-CoA was not accepted as a substrate by the enzymes...
  22. ncbi Potent and selective inhibition of squalene epoxidase by synthetic galloyl esters
    I Abe
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, 422 8526, Japan
    Biochem Biophys Res Commun 270:137-40. 2000
    ..033 microM) and no-time-dependent manner. The potent inhibition of the flavin monooxygenase would be caused by specific binding to the enzyme, and by scavenging reactive oxygen species required for the epoxidation reaction...
  23. ncbi Enzymatic formation of an unnatural hexacyclic C35 polyprenoid by bacterial squalene cyclase
    Ikuro Abe
    University of Shizuoka, School of Pharmaceutical Sciences, 52 1 Yada, Shizuoka 422 8526, Japan
    J Am Chem Soc 124:14514-5. 2002
    ..The substrate should be folded in chair-chair-chair-chair-boat-boat conformation to achieve the stereochemistry of the cyclization product...
  24. ncbi Enzymatic formation of unnatural novel polyketides from alternate starter and nonphysiological extension substrate by chalcone synthase
    Ikuro Abe
    University of Shizuoka, School of Pharmaceutical Sciences, and The 21st Century COE Program, 52 1 Yada, Shizuoka 422 8526, Japan
    Org Lett 5:1277-80. 2003
    ..On the other hand, the enzyme also accepted hexanoyl-CoA and methylmalonyl-CoA as substrates to produce an unnatural novel triketide, 4-hydroxy-3,5-dimethyl-6-pentyl-pyran-2-one...
  25. ncbi Benzalacetone synthase. A novel polyketide synthase that plays a crucial role in the biosynthesis of phenylbutanones in Rheum palmatum
    I Abe
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Eur J Biochem 268:3354-9. 2001
    ..Finally, besides the phenylbutanones in rhubarb, BAS has been proposed to play a crucial role for the construction of the C6-C4 moiety of a variety of natural products such as medicinally important gingerols in ginger plant...
  26. ncbi Novel polyketides synthesized with a higher plant stilbene synthase
    H Morita
    University of Shizuoka, School of Pharmaceutical Sciences, Yada, Japan
    Eur J Biochem 268:3759-66. 2001
    ..Manipulation of the biosynthesis of polyketides by synthetic analogs could lead to the development of a chemical library of pharmaceutically interesting novel polyketides...
  27. ncbi Probing biosynthesis of plant polyketides with synthetic N-acetylcysteamine thioesters
    Satoshi Oguro
    School of Pharmaceutical Sciences, and The 21st Century COE Program, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Biochem Biophys Res Commun 325:561-7. 2004
    ..Furthermore, by co-action of the CHS and the PKR, the NAC-thioesters were converted to 6'-deoxychalcone in the presence of NADPH and malonyl-CoA...
  28. ncbi Structure function analysis of benzalacetone synthase from Rheum palmatum
    Tsuyoshi Abe
    School of Pharmaceutical Sciences, The COE21 Program, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Bioorg Med Chem Lett 17:3161-6. 2007
    ..Instead, homology modeling suggested a possibility that, unlike the case of CHS, BAS utilizes an alternative pocket to lock the coumaroyl moiety for the diketide formation reaction...
  29. ncbi The first plant type III polyketide synthase that catalyzes formation of aromatic heptaketide
    Ikuro Abe
    School of Pharmaceutical Sciences, and The 21st Century COE Program, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    FEBS Lett 562:171-6. 2004
    ..This provides new insights into the catalytic functions of type III PKSs, and suggests further involvement in the biosynthesis of plant polyketides...
  30. ncbi Novel type III polyketide synthases from Aloe arborescens
    Yuusuke Mizuuchi
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    FEBS J 276:2391-401. 2009
    ..Site-directed mutagenesis demonstrated that the A207G mutant dominantly produced the octaketides SEK4/SEK4b, whereas the A207M mutant yielded a pentaketide 5,7-dihydroxy-2-methylchromone...
  31. ncbi An acridone-producing novel multifunctional type III polyketide synthase from Huperzia serrata
    Kiyofumi Wanibuchi
    School of Pharmaceutical Sciences and the COE 21 Program, University of Shizuoka, Japan
    FEBS J 274:1073-82. 2007
    ..Interestingly, Hu. serrata polyketide synthase 1 lacks most of the consensus active site sequences with acridone synthase from Ruta graveolens (Rutaceae)...
  32. doi Enzymatic formation of unnatural novel chalcone, stilbene, and benzophenone scaffolds by plant type III polyketide synthase
    She Po Shi
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Org Lett 11:551-4. 2009
    ..The findings suggested further strategies for production of unnatural polyketides by combination of the precursor-directed biosynthesis and the structure-guided engineering of type III PKS...
  33. ncbi [Engineering of squalene cyclizing enzymes]
    Ikuro Abe
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Yakugaku Zasshi 128:1109-18. 2008
    ....
  34. ncbi Structure function analysis of novel type III polyketide synthases from Arabidopsis thaliana
    Yuusuke Mizuuchi
    School of Pharmaceutical Sciences, University of Shizuoka, Yada, Japan
    Biol Pharm Bull 31:2205-10. 2008
    ..Interestingly, despite the low sequence identity, homology modeling revealed that the active-site architecture of PKS-A and PKS-B showed similarity to that of a bacterial type III PKS from Mycobacterium tuberculosis...
  35. ncbi Engineering of plant polyketide biosynthesis
    Ikuro Abe
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Chem Pharm Bull (Tokyo) 56:1505-14. 2008
    ..Structure-based engineering of the type III PKS superfamily enzymes would thus lead to further production of chemically and structurally divergent unnatural novel polyketides...
  36. ncbi 1-methylidenesqualene and 25-methylidenesqualene as active-site probes for bacterial squalene:hopene cyclase
    Hideya Tanaka
    University of Shizuoka, School of Pharmaceutical Sciences, 2 1 Yada, Shizuoka 422 8526, Japan
    Org Lett 6:803-6. 2004
    ..reaction: see text]..
  37. ncbi Enzymatic cyclization of 22,23-dihydro-2,3-oxidosqualene into euph-7-en-3beta-ol and bacchar-12-en-3beta-ol by recombinant beta-amyrin synthase
    Ikuro Abe
    School of Pharmaceutical Sciences and the COE 21 Program, University of Shizuoka, Shizuoka 422 8526, Japan
    J Am Chem Soc 126:3426-7. 2004
    ..It is remarkable that the formation of the anti-Markovnikov six-membered D-ring did not depend on the participation of the terminal pi-electrons...
  38. ncbi Enzymatic formation of indole-containing unnatural cyclic polyprenoids by bacterial squalene:hopene cyclase
    Hideya Tanaka
    School of Pharmaceutical Sciences and the COE 21 Program, University of Shizuoka, Shizuoka 422 8526, Japan
    Org Lett 7:5873-6. 2005
    ..Interestingly, 3-(geranylgeranyl)indole was not a substrate for the bacterial squalene cyclase, while 3-(farnesyldimethylallyl)indole was efficiently converted to a 2:1 mixture of unnatural novel products...
  39. ncbi Molecular cloning, expression, and characterization of adenylate isopentenyltransferase from hop (Humulus lupulus L.)
    Yuichi Sakano
    School of Pharmaceutical Sciences and the 21st Century COE Program, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Phytochemistry 65:2439-46. 2004
    ..Site-directed mutagenesis of a conserved Asp62, located right after the ATP/GTP binding motif, with Ala resulted in complete loss of enzyme activity...
  40. ncbi The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics
    Junko Sugatani
    Department of Pharmaco Biochemistry and COE 21, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Biochem Pharmacol 67:989-1000. 2004
    ..Taken together, the results indicate that UGT1A1 was induced in response to flavonoids and xenobiotics through the transactivation of the 290-bp reporter gene, that was a multi-component enhancer containing CAR, PXR and AhR motifs...
  41. ncbi Structural insight into chain-length control and product specificity of pentaketide chromone synthase from Aloe arborescens
    Hiroyuki Morita
    Mitsubishi Kagaku Institute of Life Sciences MITILS, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
    Chem Biol 14:359-69. 2007
    ..These findings not only provided insight into the polyketide formation reaction, but they also suggested strategies for the engineered biosynthesis of polyketides...
  42. pmc Crystallization and preliminary crystallographic analysis of a plant type III polyketide synthase that produces benzalacetone
    Hiroyuki Morita
    Mitsubishi Kagaku Institute of Life Sciences MITILS, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:304-6. 2008
    ..6, b = 89.6, c = 81.1 A, alpha = gamma = 90.0, beta = 100.5 degrees . Diffraction data were collected to 1.8 A resolution using synchrotron radiation at BL24XU of SPring-8...
  43. ncbi Cloning and functional analysis of a novel aldo-keto reductase from Aloe arborescens
    Hiroyuki Morita
    Mitsubishi Kagaku Institute of Life Sciences MITILS
    Biol Pharm Bull 30:2262-7. 2007
    ..Finally, a homology model on the basis of the crystal structure of Hordeum vulgare AKR predicted the active-site architecture of the enzyme...
  44. pmc Crystallization and preliminary crystallographic analysis of an octaketide-producing plant type III polyketide synthase
    Hiroyuki Morita
    Mitsubishi Kagaku Institute of Life Sciences MITILS, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
    Acta Crystallogr Sect F Struct Biol Cryst Commun 63:947-9. 2007
    ..The crystals belonged to space group I422, with unit-cell parameters a = b = 110.2, c = 281.4 A, alpha = beta = gamma = 90.0 degrees . Diffraction data were collected to 2.6 A resolution using synchrotron radiation at BL24XU of SPring-8...
  45. pmc Crystallization and preliminary crystallographic analysis of an acridone-producing novel multifunctional type III polyketide synthase from Huperzia serrata
    Hiroyuki Morita
    Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
    Acta Crystallogr Sect F Struct Biol Cryst Commun 63:576-8. 2007
    ..3, b = 85.0, c = 137.7 A, alpha = beta = gamma = 90.0 degrees. Diffraction data were collected to 2.0 A resolution using synchrotron radiation at BL24XU of SPring-8...
  46. pmc Crystallization and preliminary crystallographic analysis of a novel plant type III polyketide synthase that produces pentaketide chromone
    Hiroyuki Morita
    Mitsubishi Kagaku Institute of Life Sciences MITILS, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
    Acta Crystallogr Sect F Struct Biol Cryst Commun 62:899-901. 2006
    ..2, b = 88.4, c = 70.0 A, alpha = gamma = 90.0, beta = 95.6 degrees . Diffraction data were collected to 1.6 A resolution using synchrotron radiation at BL24XU of SPring-8...
  47. pmc Characteristic comparison of triglyceride-rich remnant lipoprotein measurement between a new homogenous assay (RemL-C) and a conventional immunoseparation method (RLP-C)
    Hiroshi Yoshida
    Department of Laboratory Medicine, Jikei University Kashiwa Hospital, Japan
    Lipids Health Dis 7:18. 2008
    ....
  48. ncbi Enzymatic reactions by five chalcone synthase homologs from hop (Humulus lupulus L.)
    Yukio Okada
    Bioresources Research and Development Laboratories, Sapporo Breweries, Ltd, Gunma, Japan
    Biosci Biotechnol Biochem 68:1142-5. 2004
    ..Narigenin-chalcone production by VPS was much lower than by CHS_H1. Therefore, it is highly possible that flavonoid depends mainly on CHS_H1, while bitter acid biosynthesis depends mainly on VPS and CHS_H1...
  49. pmc Lanosterol synthase mutations cause cholesterol deficiency-associated cataracts in the Shumiya cataract rat
    Masayuki Mori
    Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    J Clin Invest 116:395-404. 2006
    ..These findings may have some relevance to other types of cataracts, inborn defects of cholesterol synthesis, and the effects of cholesterol-lowering medication...
  50. ncbi Analysis of agaritine in mushrooms and in agaritine-administered mice using liquid chromatography-tandem mass spectrometry
    Kazunari Kondo
    National Institute of Health Sciences, Division of Foods, Kamiyoga 1 18 1, Setagaya, Tokyo 158 8501, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 834:55-61. 2006
    ..These results indicate that this analytical method for quantifying agaritine could help to evaluate the risk of mushroom hydrazines to humans...
  51. ncbi Determination of genotoxic phenylhydrazine agaritine in mushrooms using liquid chromatography-electrospray ionization tandem mass spectrometry
    Kazunari Kondo
    National Institute of Health Sciences, Division of Foods, Kamiyoga 1 18 1, Setagaya, Tokyo 158 8501, Japan
    Food Addit Contam 23:1179-86. 2006
    ..The results indicate that this specific and sensitive analytical method for detecting and quantifying agaritine and its derivatives could help evaluate the risk of mushroom hydrazines to humans...