Hiroshi Abe

Summary

Affiliation: University of Miyazaki
Country: Japan

Publications

  1. ncbi request reprint Prenatal psychological stress causes higher emotionality, depression-like behavior, and elevated activity in the hypothalamo-pituitary-adrenal axis
    Hiroshi Abe
    Division of Psychiatry, Department of Clinical Neuroscience, School of Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Neurosci Res 59:145-51. 2007
  2. ncbi request reprint Perirhinal N-methyl-D-aspartate and muscarinic systems participate in object recognition in rats
    Hiroshi Abe
    Department of Psychiatry, Miyazaki Medical College, University of Miyazaki, Miyazaki 889 1692, Japan
    Neurosci Lett 356:191-4. 2004
  3. doi request reprint Functional difference between rat perirhinal cortex and hippocampus in object and place discrimination tasks
    Hiroshi Abe
    Division of Psychiatry, Department of Clinical Neuroscience, School of Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Behav Brain Res 197:388-97. 2009
  4. doi request reprint Psychological prenatal stress reduced the number of BrdU immunopositive cells in the dorsal hippocampus without affecting the open field behavior of male and female rats at one month of age
    Kei Odagiri
    Division of Psychiatry, Department of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Neurosci Lett 446:25-9. 2008
  5. ncbi request reprint Changes in dopamine D2 receptors and 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine uptake in the brain of 6-hydroxydopamine-lesioned rats
    Yasushi Ishida
    Department of Psychiatry, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    Neurodegener Dis 1:109-12. 2004
  6. doi request reprint Differential expression of Fos and Zif268 in the nigrostriatal system after methamphetamine administration in a rat model of Parkinson's disease
    Yasushi Ishida
    Department of Psychiatry, Faculty of Medicine, University of Miyazaki, Kiyotake cho, Miyazaki gun, Miyazaki 889 1692, Japan
    Synapse 62:920-6. 2008
  7. doi request reprint Differential expression of FosB, c-Fos, and Zif268 in forebrain regions after acute or chronic L-DOPA treatment in a rat model of Parkinson's disease
    Kosuke Ebihara
    Department of Psychiatry, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
    Neurosci Lett 496:90-4. 2011
  8. doi request reprint Effects of intrathecal administration of newer antidepressants on mechanical allodynia in rat models of neuropathic pain
    Tetsuya Ikeda
    Division of Neurobiology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889 1692, Japan
    Neurosci Res 63:42-6. 2009
  9. doi request reprint Identification of venous sinus, tumor location, and pial supply during meningioma surgery by transdural indocyanine green videography
    Tetsuya Ueba
    Department of Neurosurgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    J Neurosurg 118:632-6. 2013
  10. doi request reprint Analgesic effect of milnacipran is associated with c-Fos expression in the anterior cingulate cortex in the rat neuropathic pain model
    Ryuichiro Takeda
    Department of Psychiatry, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki gun, Miyazaki 889 1692, Japan
    Neurosci Res 64:380-4. 2009

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Prenatal psychological stress causes higher emotionality, depression-like behavior, and elevated activity in the hypothalamo-pituitary-adrenal axis
    Hiroshi Abe
    Division of Psychiatry, Department of Clinical Neuroscience, School of Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Neurosci Res 59:145-51. 2007
    ..This is the first report that psychological prenatal stress in the communication box can cause changes in the neurobiology and behavior of offspring in rodents...
  2. ncbi request reprint Perirhinal N-methyl-D-aspartate and muscarinic systems participate in object recognition in rats
    Hiroshi Abe
    Department of Psychiatry, Miyazaki Medical College, University of Miyazaki, Miyazaki 889 1692, Japan
    Neurosci Lett 356:191-4. 2004
    ..These results suggest that activation of both NMDA and muscarinic receptors in the perirhinal cortex contributes to object recognition...
  3. doi request reprint Functional difference between rat perirhinal cortex and hippocampus in object and place discrimination tasks
    Hiroshi Abe
    Division of Psychiatry, Department of Clinical Neuroscience, School of Medicine, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Behav Brain Res 197:388-97. 2009
    ..They also suggest the possible involvement of the perirhinal cortex in spatial reference memory performance...
  4. doi request reprint Psychological prenatal stress reduced the number of BrdU immunopositive cells in the dorsal hippocampus without affecting the open field behavior of male and female rats at one month of age
    Kei Odagiri
    Division of Psychiatry, Department of Clinical Neuroscience, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    Neurosci Lett 446:25-9. 2008
    ....
  5. ncbi request reprint Changes in dopamine D2 receptors and 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine uptake in the brain of 6-hydroxydopamine-lesioned rats
    Yasushi Ishida
    Department of Psychiatry, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    Neurodegener Dis 1:109-12. 2004
    ..Therefore, the combination of a D2 antagonist and FDOPA may provide a potentially useful method for assessing the effects of dopamine depletion in Parkinson's disease...
  6. doi request reprint Differential expression of Fos and Zif268 in the nigrostriatal system after methamphetamine administration in a rat model of Parkinson's disease
    Yasushi Ishida
    Department of Psychiatry, Faculty of Medicine, University of Miyazaki, Kiyotake cho, Miyazaki gun, Miyazaki 889 1692, Japan
    Synapse 62:920-6. 2008
    ..This may suggest that Fos and Zif268 therefore possess gene-specific and region-specific functions in the basal ganglia nuclei...
  7. doi request reprint Differential expression of FosB, c-Fos, and Zif268 in forebrain regions after acute or chronic L-DOPA treatment in a rat model of Parkinson's disease
    Kosuke Ebihara
    Department of Psychiatry, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake cho, Miyazaki 889 1692, Japan
    Neurosci Lett 496:90-4. 2011
    ..In summary, differential expression of three IEG proteins was observed in the forebrain regions during a course of chronic L-DOPA treatment of 6-OHDA-treated hemiparkinsonian rats...
  8. doi request reprint Effects of intrathecal administration of newer antidepressants on mechanical allodynia in rat models of neuropathic pain
    Tetsuya Ikeda
    Division of Neurobiology, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki 889 1692, Japan
    Neurosci Res 63:42-6. 2009
    ....
  9. doi request reprint Identification of venous sinus, tumor location, and pial supply during meningioma surgery by transdural indocyanine green videography
    Tetsuya Ueba
    Department of Neurosurgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    J Neurosurg 118:632-6. 2013
    ..The aim of this study was to evaluate a new intraoperative imaging modality by performing transdural ICG videography during surgery for meningiomas...
  10. doi request reprint Analgesic effect of milnacipran is associated with c-Fos expression in the anterior cingulate cortex in the rat neuropathic pain model
    Ryuichiro Takeda
    Department of Psychiatry, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki gun, Miyazaki 889 1692, Japan
    Neurosci Res 64:380-4. 2009
    ....
  11. doi request reprint Involvement of vasopressin V1b receptor in anti-anxiety action of SSRI and SNRI in mice
    Yuta Ishizuka
    Department of Psychiatry, Faculty of Medicine, University of Miyazaki, Miyazaki gun, Miyazaki, Japan
    Neurosci Res 66:233-7. 2010
    ..These results suggest that the anti-anxiety action of 5-HT reuptake inhibitors might partly involve V1bR regulating the anxiety behaviors...
  12. doi request reprint Safety and feasibility of combined coiling and neuroendoscopy for better outcomes in the treatment of severe subarachnoid hemorrhage accompanied by massive intraventricular hemorrhage
    Mitsutoshi Iwaasa
    Department of Neurosurgery, Faculty of Medicine, Fukuoka University, 7 45 1 Nanakuma, Jounan Ku, Fukuoka City, Fukuoka 814 0180, Japan
    J Clin Neurosci 20:1264-8. 2013
    ..Neuroendoscopically removing the IVH from all of the ventricles between the lateral and the fourth ventricle and coiling the ruptured aneurysm is a safe, feasible approach for treating severe SAH with massive IVH. ..
  13. doi request reprint Effect of blonanserin on methamphetamine-induced disruption of latent inhibition and c-Fos expression in rats
    Aki Kuramashi
    Department of Psychiatry, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki City, Miyazaki 889 1692, Japan Electronic address
    Neurosci Lett 549:97-102. 2013
    ....
  14. doi request reprint Quantitative evaluation using the plaque/muscle ratio index panels predicts plaque type and risk of embolism in patients undergoing carotid artery stenting
    Koichiro Takemoto
    Department of Neurosurgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Clin Neurol Neurosurg 115:1298-303. 2013
    ..We sought to use a magnetic resonance (MR) plaque imaging technique to establish the plaque/muscle ratio (PMR) index panel to identify vulnerable plaques in subjects undergoing carotid artery stenting (CAS)...
  15. ncbi request reprint Different response between production of free radicals induced by central and peripheral administration of interleukin-1beta in conscious rats
    Yuta Ishizuka
    Department of Psychiatry, Faculty of Medicine, University of Miyazaki, 5200 Kihara, Miyazaki 889 1692, Japan
    Neurosci Res 60:10-4. 2008
    ..This finding should be useful for our understanding of the response of NO and free radicals such as *OH and O(2)(-) in the mPFC after central and peripheral administration of IL-1beta...
  16. ncbi request reprint Alteration of striatal [11C]raclopride and 6-[18F]fluoro-L-3,4-dihydroxyphenylalanine uptake precedes development of methamphetamine-induced rotation following unilateral 6-hydroxydopamine lesions of medial forebrain bundle in rats
    Yasushi Ishida
    Department of Psychiatry, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Miyazaki gun, Miyazaki 889 1692, Japan
    Neurosci Lett 389:30-4. 2005
    ....
  17. ncbi request reprint Unilateral lesions of mesostriatal dopaminergic pathway alters the withdrawal response of the rat hindpaw to mechanical stimulation
    Ryuichiro Takeda
    Department of Psychiatry, Miyazaki Medical College, University of Miyazaki, Miyazaki 889 1692, Japan
    Neurosci Res 52:31-6. 2005
    ....
  18. doi request reprint Transdural imaging of meningiomas by indocyanine green videography: the eclipse sign
    Tetsuya Ueba
    Department of Neurosurgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    J Neurol Surg A Cent Eur Neurosurg 74:51-3. 2013
    ..To establish a new intraoperative imaging modality, we performed transdural indocyanine green videography during the surgery of meningiomas...
  19. doi request reprint Refractory chronic immune thrombocytopenic purpura in a child with acute lymphoblastic leukemia
    Satoshi Horino
    Department of Pediatrics, School of Medicine, Tohoku University Hospital, Tohoku University, 1 1 Seiryo cho, Aoba ku, Sendai, Miyagi, Japan
    Int J Hematol 90:483-5. 2009
    ..To our knowledge, this is the first child case of chronic ITP during chemotherapy for ALL and splenectomy was effective in this patient...
  20. doi request reprint Exposure of the wide interior of the fourth ventricle without splitting the vermis: importance of cutting procedures for the tela choroidea
    Toshio Matsushima
    Department of Neurosurgery, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga shi, Saga, 849 8501, Japan
    Neurosurg Rev 35:563-71; discussion 571-2. 2012
    ..In this article, we employ detailed illustrations to precisely demonstrate the operative procedures and techniques for fourth ventricular surgeries...
  21. ncbi request reprint Eye movement during facial affect recognition by patients with schizophrenia, using Japanese pictures of facial affect
    Yuko Shiraishi
    Department of Community Psychiatric Nursing, School of Nursing, Faculty of Medicine, University of Miyazaki, Japan
    Percept Mot Skills 113:409-20. 2011
    ..Some expected facial affect recognition disorder was seen in schizophrenic patients responding to the Japanese version of affect pictures, but there was no correlation between facial affect recognition disorder and aberrant eye movement...
  22. ncbi request reprint Thyrotropin-releasing hormone-stimulated thyrotropin expression involves islet-brain-1/c-Jun N-terminal kinase interacting protein-1
    Hiroshi Abe
    First Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Endocrinology 145:5623-8. 2004
    ..This effect is not found in the presence of a mutated nonfunctional (IB1S59N) IB1/JIP-1 protein. Together, these facts point to a central role of the IB1/JIP-1 protein in the control of TRH-mediated TSH-beta stimulation...
  23. ncbi request reprint Medial prefrontal cell activity signaling prediction errors of action values
    Madoka Matsumoto
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Nat Neurosci 10:647-56. 2007
    ..Therefore, these responses in medial prefrontal cells may signal the direction and amount of error in prediction of values of executed actions to specify the adjustment in subsequent action selections...
  24. ncbi request reprint Circadian rhythms in behavior and clock gene expressions in the brain of mice lacking histidine decarboxylase
    Hiroshi Abe
    Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Brain Res Mol Brain Res 124:178-87. 2004
    ....
  25. ncbi request reprint Effects of nursing mothers on rPer1 and rPer2 circadian expressions in the neonatal rat suprachiasmatic nuclei vary with developmental stage
    Hidenobu Ohta
    Department of Physiology, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Eur J Neurosci 15:1953-60. 2002
    ..It is concluded that the ability of nursing mothers to entrain pup circadian oscillation depends on the developmental stage...
  26. ncbi request reprint Periodic absence of nursing mothers phase-shifts circadian rhythms of clock genes in the suprachiasmatic nucleus of rat pups
    Hidenobu Ohta
    Department of Physiology, Hokkaido University Graduate School of Medicine, North 15, West 7, Kita ku, Sapporo 060 8638, Japan
    Eur J Neurosci 17:1628-34. 2003
    ..These findings indicate that periodic absence of the nursing mother in the first week of life produces a resetting effect on the neonatal circadian clock and induces stress responses in the hypothalamus-pituitary-adrenal axis...
  27. ncbi request reprint Gene expression of neuropeptide Y in the nucleus of the solitary tract is activated in rats under restricted daily feeding but not under 48-h food deprivation
    Kouji Ishizaki
    Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Eur J Neurosci 17:2097-105. 2003
    ..These findings indicate that the NPY neurons from the NST are specifically activated by RF, whereas those from the ARC are generally stimulated by an increased food demand...
  28. ncbi request reprint Calcium-induced mitochondrial swelling and cytochrome c release in the brain: its biochemical characteristics and implication in ischemic neuronal injury
    Tohru Kobayashi
    Department of Neurosurgery, University of Hokkaido Graduate School of Medicine, North 15 West 7, Kita ku, Sapporo 060 8638, Japan
    Brain Res 960:62-70. 2003
    ..Cytochrome c is released from brain mitochondria through an mPT-independent mechanism. CsA potentially ameliorates delayed neuronal injury in the hippocampus due to transient forebrain ischemia...
  29. ncbi request reprint Ischemic depolarization monitoring: evaluation of protein synthesis in the hippocampal CA1 after brief unilateral ischemia in a gerbil model
    Takatoshi Sorimachi
    Department of Neurosurgery, Brain Research Institute, Niigata University, Japan
    J Neurosurg 97:104-11. 2002
    ..The authors investigate whether depolarization monitoring is an accurate index of ischemic damage in a gerbil model of unilateral ischemia and assess the effects of brief cerebral ischemia on protein synthesis in this model...
  30. ncbi request reprint Fluorescein uptake by a monocarboxylic acid transporter in human intestinal Caco-2 cells
    Kenji Kuwayama
    Laboratory of Biophysical Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, 060 0812, Sapporo, Japan
    Biochem Pharmacol 63:81-8. 2002
    ..The transporter has a wide spectrum of substrate recognition and seems likely to be different from MCT1...
  31. ncbi request reprint Localization of pore-forming subunit of the ATP-sensitive K(+)-channel, Kir6.2, in rat brain neurons and glial cells
    Ming Zhou
    Department of Anatomy, Akita University School of Medicine, Hondo 1 1 1 Akita 010 8543, Japan
    Brain Res Mol Brain Res 101:23-32. 2002
    ..2. Under the electron microscope, we showed in vivo for the first time that the immunoreactive products were localized in the endoplasmic reticulum and Golgi apparatus as well as the plasma membranes of neurons and glial cells...
  32. pmc Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins
    Yukio Kimata
    Research and Education Center for Genetic Information, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Japan
    Mol Biol Cell 14:2559-69. 2003
    ..We speculate that recognition of unfolded proteins is based on their competition with Ire1 for binding with BiP/Kar2...
  33. ncbi request reprint A study on the conformation-anomeric effect-stereoselectivity relationship in anomeric radical reactions, using conformationally restricted glucose derivatives as substrates
    Hiroshi Abe
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    J Org Chem 68:7439-47. 2003
    ....
  34. ncbi request reprint Construction of a cis-cyclopropane via reductive radical decarboxylation. Enantioselective synthesis of cis- and trans-1-arylpiperazyl-2-phenylcyclopropanes designed as antidopaminergic agents
    Kazuya Yamaguchi
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    J Org Chem 68:9255-62. 2003
    ....
  35. ncbi request reprint A systematic study of C-glucoside trisphosphates as myo-inositol trisphosphate receptor ligands. Synthesis of beta-C-glucoside trisphosphates based on the conformational restriction strategy
    Masaru Terauchi
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    J Med Chem 49:1900-9. 2006
    ....
  36. ncbi request reprint Design and synthesis of 5'-deoxy-5'-phenyladenophostin A, a highly potent IP3 receptor ligand
    Tetsuya Mochizuki
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    Org Lett 8:1455-8. 2006
    ..This compound proved to be a highly potent IP(3) receptor agonist...
  37. ncbi request reprint Goal-based action selection and utility-based action bias
    Kenji Matsumoto
    Cognitive Brain Mapping Laboratory, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama, Japan
    Neural Netw 19:1315-20. 2006
    ..This transition of dominance between the two decision systems may be enhanced by a reference-point shift based on the goal-setting process during goal-based action selection...
  38. ncbi request reprint Daily restricted feeding resets the circadian clock in the suprachiasmatic nucleus of CS mice
    Hiroshi Abe
    Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Am J Physiol Regul Integr Comp Physiol 292:R607-15. 2007
    ..These results indicate that the SCN circadian pacemaker of CS mice is entrainable to RF under DD and suggest that CS mice have a circadian clock system that can be reset by a signal associated with feeding time...
  39. ncbi request reprint Isolated necrotizing arteritis (localized polyarteritis nodosa): examination of the histological process and disease entity based on the histological classification of stage and histological differences from polyarteritis nodosa
    Toshiharu Matsumoto
    First Department of Pathology, Juntendo University, Tokyo 113 8421, Japan
    Cardiovasc Pathol 16:92-7. 2007
    ..Therefore, we examined the disease entity of INA based on the histological comparison of both diseases. In addition, a histological classification of INA, in which the histological process of INA is included, was described...
  40. ncbi request reprint Localization of sulfonylurea receptor subunits, SUR2A and SUR2B, in rat heart
    Ming Zhou
    Department of Anatomy, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    J Histochem Cytochem 55:795-804. 2007
    ..Thus, SUR2A and SUR2B are not only the regulatory subunits of sarcolemmal K(ATP) channels but may also function as regulatory subunits in mitochondrial K(ATP) channels and play important roles in cardioprotection...
  41. ncbi request reprint Synthesis of adenophostin A analogues conjugating an aromatic group at the 5'-position as potent IP3 receptor ligands
    Tetsuya Mochizuki
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    J Med Chem 49:5750-8. 2006
    ..This biological activity of 5a-c can be rationalized by molecular modeling using the ligand binding domain of the IP(3) receptor...
  42. ncbi request reprint Detection of specific noncovalent interaction of peptide with DNA by MALDI-TOF
    Shi Zhong Luo
    The Key Laboratory for Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, China
    J Am Soc Mass Spectrom 15:28-31. 2004
    ..This specific interaction depends on the matrix. It was only observed in the ATT matrix and not in the other two matrixes (CHCA and DHBA)...
  43. ncbi request reprint Localization of the sulphonylurea receptor subunits, SUR2A and SUR2B, in rat renal tubular epithelium
    Ming Zhou
    Department of Anatomy, Akita University School of Medicine
    Tohoku J Exp Med 214:247-56. 2008
    ..In conclusion, the regulatory subunits of the K(ATP) channel in the rat kidney are SUR2A and SUR2B; they also are candidate regulatory subunits for the mitochondrial K(ATP) channel...
  44. ncbi request reprint Induced hippocampal neuron protection in an optimized gerbil ischemia model: insult thresholds for tolerance induction and altered gene expression defined by ischemic depolarization
    Hiroshi Abe
    Department of Neurology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Cereb Blood Flow Metab 24:84-97. 2004
    ....
  45. ncbi request reprint ATP-sensitive K+-channel subunits on the mitochondria and endoplasmic reticulum of rat cardiomyocytes
    Ming Zhou
    Department of Anatomy, Akita University School of Medicine, Japan
    J Histochem Cytochem 53:1491-500. 2005
    ..The data obtained in this study will be useful for analyzing the composition of K(ATP) channels of cardiomyocytes and help to understanding the cardioprotective role of K(ATP) channels during heart ischemia...