Kenji J Tsuchiya

Summary

Country: Japan

Publications

  1. ncbi request reprint First-admission rates of schizophrenia in Denmark, 1980-1997: have they been increasing?
    Kenji J Tsuchiya
    Department of Psychiatric Demography, Institute of Basic Psychiatric Research, Aarhus University Psychiatric Hospital, Skovagervej 2, DK 8240, Risskov, Denmark
    Schizophr Res 54:187-91. 2002
  2. ncbi request reprint Risk factors in relation to an emergence of bipolar disorder: a systematic review
    Kenji J Tsuchiya
    National Centre for Register Based Research, University of Aarhus, Denmark
    Bipolar Disord 5:231-42. 2003
  3. ncbi request reprint Higher socio-economic status of parents may increase risk for bipolar disorder in the offspring
    Kenji J Tsuchiya
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Psychol Med 34:787-93. 2004
  4. ncbi request reprint Parental death and bipolar disorder: a robust association was found in early maternal suicide
    Kenji J Tsuchiya
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Handayama 1, Hamamatsu 4313192, Japan
    J Affect Disord 86:151-9. 2005
  5. doi request reprint Brain serotonin and dopamine transporter bindings in adults with high-functioning autism
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Arch Gen Psychiatry 67:59-68. 2010
  6. doi request reprint Replication study of Japanese cohorts supports the role of STX1A in autism susceptibility
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:454-8. 2011
  7. doi request reprint Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders
    Katsuaki Suzuki
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Japan
    Arch Gen Psychiatry 68:306-13. 2011
  8. doi request reprint Failure to confirm genetic association of the FXYD6 gene with schizophrenia: the Japanese population and meta-analysis
    Yasuhide Iwata
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:1221-7. 2010
  9. ncbi request reprint Decreased serum levels of hepatocyte growth factor in male adults with high-functioning autism
    Genichi Sugihara
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:412-5. 2007
  10. doi request reprint Reduced expression of apolipoprotein E receptor type 2 in peripheral blood lymphocytes from patients with major depressive disorder
    Katsuaki Suzuki
    Osaka Hamamatsu Joint Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:1007-10. 2010

Collaborators

Detail Information

Publications48

  1. ncbi request reprint First-admission rates of schizophrenia in Denmark, 1980-1997: have they been increasing?
    Kenji J Tsuchiya
    Department of Psychiatric Demography, Institute of Basic Psychiatric Research, Aarhus University Psychiatric Hospital, Skovagervej 2, DK 8240, Risskov, Denmark
    Schizophr Res 54:187-91. 2002
    ..Apparently, the shift of diagnostic classification system in 1994 from ICD-8 to ICD-10 did not explain the increase as a whole, nor did the changing number of psychiatric beds during the decades...
  2. ncbi request reprint Risk factors in relation to an emergence of bipolar disorder: a systematic review
    Kenji J Tsuchiya
    National Centre for Register Based Research, University of Aarhus, Denmark
    Bipolar Disord 5:231-42. 2003
    ..Our aim was to review the literature on such risk factors - risk factors other than family history of affective disorders - as predictors for the initial onset of BPD...
  3. ncbi request reprint Higher socio-economic status of parents may increase risk for bipolar disorder in the offspring
    Kenji J Tsuchiya
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Psychol Med 34:787-93. 2004
    ..The aim of the present study was to explore the association between the socio-economic status of an individual or the parent and the risk for bipolar disorder...
  4. ncbi request reprint Parental death and bipolar disorder: a robust association was found in early maternal suicide
    Kenji J Tsuchiya
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Handayama 1, Hamamatsu 4313192, Japan
    J Affect Disord 86:151-9. 2005
    ....
  5. doi request reprint Brain serotonin and dopamine transporter bindings in adults with high-functioning autism
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Arch Gen Psychiatry 67:59-68. 2010
    ..Although its neurobiological underpinnings are postulated to lie in abnormalities of the serotoninergic and dopaminergic systems, the details remain unknown...
  6. doi request reprint Replication study of Japanese cohorts supports the role of STX1A in autism susceptibility
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:454-8. 2011
    ..In the anterior cingulate gyrus region, STX1A expression in the autism group was found to be significantly lower than that of the control group. Thus, we suggest a possible role of STX1A in the pathogenesis of autism...
  7. doi request reprint Reduced acetylcholinesterase activity in the fusiform gyrus in adults with autism spectrum disorders
    Katsuaki Suzuki
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Japan
    Arch Gen Psychiatry 68:306-13. 2011
    ..The fusiform gyrus has been regarded as the key structure in face perception. The cholinergic system is known to regulate the function of the visual pathway, including the fusiform gyrus...
  8. doi request reprint Failure to confirm genetic association of the FXYD6 gene with schizophrenia: the Japanese population and meta-analysis
    Yasuhide Iwata
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:1221-7. 2010
    ..We conclude that the FXYD6 gene does not have a major influence on susceptibility to schizophrenia across populations...
  9. ncbi request reprint Decreased serum levels of hepatocyte growth factor in male adults with high-functioning autism
    Genichi Sugihara
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:412-5. 2007
    ..In this study, we studied whether serum HGF levels are altered in subjects with high-functioning autism...
  10. doi request reprint Reduced expression of apolipoprotein E receptor type 2 in peripheral blood lymphocytes from patients with major depressive disorder
    Katsuaki Suzuki
    Osaka Hamamatsu Joint Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:1007-10. 2010
    ..Results from this preliminary study suggest that the expression of ApoER2 may serve as a trait marker for major depressive disorder...
  11. doi request reprint Serum levels of platelet-derived growth factor BB homodimers are increased in male children with autism
    Masanobu Kajizuka
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:154-8. 2010
    ..In this study, we screened serum levels of these growth factors in young male subjects with autism...
  12. ncbi request reprint Decreased serum levels of epidermal growth factor in adult subjects with high-functioning autism
    Katsuaki Suzuki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Biol Psychiatry 62:267-9. 2007
    ..In this study, we examined whether serum levels of EGF are altered in adult subjects with high-functioning autism...
  13. ncbi request reprint Decreased serum levels of platelet-endothelial adhesion molecule (PECAM-1) in subjects with high-functioning autism: a negative correlation with head circumference at birth
    Kenji J Tsuchiya
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Biol Psychiatry 62:1056-8. 2007
    ..This study was undertaken to determine whether serum levels of the adhesion molecules in subjects with high-functioning autism are altered as compared with those of normal controls...
  14. ncbi request reprint Disruption of reelin signaling attenuates methamphetamine-induced hyperlocomotion
    Hideo Matsuzaki
    Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Eur J Neurosci 25:3376-84. 2007
    ..These results indicate that reelin signaling plays a pivotal role in the dopaminergic system in adult mice, especially in postsynaptic levels...
  15. ncbi request reprint Increased levels of serum soluble L-selectin in unmedicated patients with schizophrenia
    Yasuhide Iwata
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Schizophr Res 89:154-60. 2007
    ..For specificity, we also investigated selectin levels in patients with major depression...
  16. doi request reprint Decreased serum levels of adiponectin in subjects with autism
    Azusa Fujita-Shimizu
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:455-8. 2010
    ..This study suggests that decreased levels of serum adiponectin might be implicated in the pathophysiology of autism...
  17. ncbi request reprint Decreased expression of reelin receptor VLDLR in peripheral lymphocytes of drug-naive schizophrenic patients
    Katsuaki Suzuki
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Schizophr Res 98:148-56. 2008
    ..Our findings suggest that peripheral VLDLR mRNA levels may serve as a reliable peripheral biological marker of schizophrenia, and that the reelin-VLDLR/ApoER2 signaling pathway plays a role in the pathophysiology of schizophrenia...
  18. doi request reprint Age-specific 3-month cumulative incidence of postpartum depression: the Hamamatsu Birth Cohort (HBC) Study
    Kaori Matsumoto
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    J Affect Disord 133:607-10. 2011
    ..To address this, we estimated the age-specific 3-month cumulative incidence of PPD using the Hamamatsu Birth Cohort for Mothers and Children (HBC)...
  19. doi request reprint Microglial activation in young adults with autism spectrum disorder
    Katsuaki Suzuki
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    JAMA Psychiatry 70:49-58. 2013
    ..However, to our knowledge, no information is available on the patterns of distribution of microglial activation in the brain in ASD...
  20. pmc Alteration of plasma glutamate and glutamine levels in children with high-functioning autism
    Chie Shimmura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    PLoS ONE 6:e25340. 2011
    ....
  21. doi request reprint Paternal age at birth and high-functioning autistic-spectrum disorder in offspring
    Kenji J Tsuchiya
    Osaka Hamamatsu Joint Research Center for Child Mental Development OHJRC CMD, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Br J Psychiatry 193:316-21. 2008
    ..Previous studies have reported the association between advanced paternal age at birth and the risk of autistic-spectrum disorder in offspring, including offspring with intellectual disability...
  22. pmc Perinatal asphyxia reduces dentate granule cells and exacerbates methamphetamine-induced hyperlocomotion in adulthood
    Tomoyasu Wakuda
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
    PLoS ONE 3:e3648. 2008
    ..Hippocampus is one of the brain regions implicated in the late-onset dopaminergic dysfunction associated with hypoxic obstetric complications...
  23. pmc Brain region-specific altered expression and association of mitochondria-related genes in autism
    Ayyappan Anitha
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, 431 3192, Japan
    Mol Autism 3:12. 2012
    ..abstract:..
  24. doi request reprint Further evidence for the role of MET in autism susceptibility
    Ismail Thanseem
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Higashi ku, Hamamatsu, Shizuoka 431 3192, Japan
    Neurosci Res 68:137-41. 2010
    ..4 kb. Our results provide further evidence for a possible role of MET in the pathogenesis of ASD...
  25. doi request reprint Jiko-shisen-kyofu (fear of one's own glance), but not taijin-kyofusho (fear of interpersonal relations), is an east Asian culture-related specific syndrome
    Yasuhide Iwata
    Osaka Hamamatsu Joint Research Centre for Child Mental Development, Hamamatsu University School of Medicine, Handayama, Shizuoka, Japan
    Aust N Z J Psychiatry 45:148-52. 2011
    ..The aim of the study was to introduce clinical features of phobia of one's own glance to western psychiatrists...
  26. pmc Investigation of the serum levels of anterior pituitary hormones in male children with autism
    Keiko Iwata
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Mol Autism 2:16. 2011
    ..abstract:..
  27. pmc Enzymes in the glutamate-glutamine cycle in the anterior cingulate cortex in postmortem brain of subjects with autism
    Chie Shimmura
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Mol Autism 4:6. 2013
    ..We hypothesized that alterations in the glutamate-glutamine cycle in the ACC might play a role in the pathophysiology of autism...
  28. pmc Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders
    Katsuaki Suzuki
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    PLoS ONE 6:e20470. 2011
    ..The aim of the study was to explore immunological markers in peripheral plasma samples from non-medicated subjects with high-functioning ASD...
  29. pmc Seasonal variations of neuromotor development by 14 months of age: Hamamatsu Birth Cohort for mothers and children (HBC Study)
    Kenji J Tsuchiya
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    PLoS ONE 7:e52057. 2012
    ..Neuromotor development showed cyclic seasonality during the first year of life. The effects brought about by month of birth disappeared around 1 year of age, and warmer months seemed to accelerate the neuromotor development...
  30. doi request reprint Psychosocial risk factors for postpartum depression and their relation to timing of onset: the Hamamatsu Birth Cohort (HBC) Study
    Tsuruko Mori
    Department of Child Development, United Graduate School of Child Development, Osaka University, Hamamatsu, Japan
    J Affect Disord 135:341-6. 2011
    ..To address potential difference in PPD in relation to onset of the illness, we investigated risk factors for early- and late-onset PPD using a representative birth cohort in Japan...
  31. doi request reprint Metabolite alterations in the hippocampus of high-functioning adult subjects with autism
    Katsuaki Suzuki
    Osaka Hamamatsu Joint Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Int J Neuropsychopharmacol 13:529-34. 2010
    ..Results suggest that high-functioning adult subjects with autism have abnormal metabolite concentrations in the hippocampal formation, which may in part account for their aggression...
  32. ncbi request reprint Decreased serum levels of transforming growth factor-beta1 in patients with autism
    Kyoko Okada
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:187-90. 2007
    ..In this study, we studied whether serum levels of TGF-beta1 are altered in patients with autism...
  33. doi request reprint Reliability and validity of autism diagnostic interview-revised, Japanese version
    Kenji J Tsuchiya
    Department of Child Development, United Graduate School of Child Development at Hamamatsu, Handayama 1 Higashiku, Hamamatsu, 431 3192, Japan
    J Autism Dev Disord 43:643-62. 2013
    ....
  34. doi request reprint In vivo changes in microglial activation and amyloid deposits in brain regions with hypometabolism in Alzheimer's disease
    Masamichi Yokokura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Eur J Nucl Med Mol Imaging 38:343-51. 2011
    ..The purpose of the present study was to clarify the in vivo relationship between Aβ accumulation and neuroinflammation in those specific brain regions in early AD...
  35. doi request reprint Genetic and expression analyses reveal elevated expression of syntaxin 1A ( STX1A) in high functioning autism
    Kazuhiko Nakamura
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Int J Neuropsychopharmacol 11:1073-84. 2008
    ....
  36. ncbi request reprint Increased serum levels of glutamate in adult patients with autism
    Atsuko Shinohe
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka 431 3192, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1472-7. 2006
    ..In this study, we studied whether amino acids (glutamate, glutamine, glycine, D-serine, and L-serine) related to glutamatergic neurotransmission are altered in serum of adult patients with autism...
  37. pmc Irradiation in adulthood as a new model of schizophrenia
    Yasuhide Iwata
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
    PLoS ONE 3:e2283. 2008
    ..Epidemiological studies suggest that radiation exposure may be a potential risk factor for schizophrenia in adult humans. Here, we investigated whether adult irradiation in rats caused behavioral abnormalities relevant to schizophrenia...
  38. ncbi request reprint Brain serotonin transporter density and aggression in abstinent methamphetamine abusers
    Yoshimoto Sekine
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
    Arch Gen Psychiatry 63:90-100. 2006
    ..It remains unknown whether methamphetamine damages serotonin neurons in humans...
  39. ncbi request reprint Poor mental health associated with job dissatisfaction among school teachers in Japan
    Michiko Nagai
    Department of Psychiatric Nursing, Hamamatsu University School of Medicine, Shizuoka, Japan
    J Occup Health 49:515-22. 2007
    ..Poor mental health of Japanese school teachers, female teachers in particular, was found to be associated with job dissatisfaction...
  40. ncbi request reprint [Recent progress of epidemiological research in search of the aetiology of autism]
    Kenji J Tsuchiya
    Research Center for Child Mental Development, Hamamatsu University School of Medicine, Handayama 1 20 1 Higashiku, Hamamatsu, 431 3192 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 31:29-34. 2011
    ..The HBC is expected to enroll 1,200 dyads of mother and child and to follow them until the child becomes 4 years of age...
  41. ncbi request reprint Advanced paternal age associated with an elevated risk for schizophrenia in offspring in a Japanese population
    Kenji J Tsuchiya
    Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Schizophr Res 76:337-42. 2005
    ..To address this question, we conducted a case-control study of a Japanese population...
  42. pmc Methamphetamine causes microglial activation in the brains of human abusers
    Yoshimoto Sekine
    Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
    J Neurosci 28:5756-61. 2008
    ..These results suggest that chronic self-administration of methamphetamine can cause reactive microgliosis in the brains of human methamphetamine abusers, a level of activation that appears to subside over longer periods of abstinence...
  43. ncbi request reprint A promoter haplotype of the inositol monophosphatase 2 gene (IMPA2) at 18p11.2 confers a possible risk for bipolar disorder by enhancing transcription
    Tetsuo Ohnishi
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan
    Neuropsychopharmacology 32:1727-37. 2007
    ..In conclusion, the present study suggests that a promoter haplotype of IMPA2 possibly contributes to risk for bipolar disorder by elevating IMPA2 levels in the brain, albeit the genetic effect varies among populations...
  44. ncbi request reprint Linkage disequilibrium analysis of the CHRNA7 gene and its partially duplicated region in schizophrenia
    Yasuhide Iwata
    Division of Psychological Medicine, Institute of Psychiatry, 1 Windsor Walk, Denmark Hill, London, UK
    Neurosci Res 57:194-202. 2007
    ..However, we could not exclude the possibility of a weak genetic effect due to the small sample size. Analyses of larger samples and higher-density markers, particularly around SNP9 (IVS4-1912), are still needed...
  45. ncbi request reprint Effective adjunctive use of pergolide with quetiapine for cognitive impairment and negative symptoms in schizophrenia
    Yoshimoto Sekine
    J Clin Psychopharmacol 25:281-3. 2005
  46. ncbi request reprint Increased rate of birth complications and small head size at birth in winter-born male patients with schizophrenia
    Shu Takagai
    Schizophr Res 83:303-5. 2006
  47. pmc Association and synergistic interaction between promoter variants of the DRD4 gene in Japanese schizophrenics
    Mizuho Nakajima
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako City, Saitama, 351 0198, Japan
    J Hum Genet 52:86-91. 2007
    ..These results suggest that the upstream variants have a primary functional effect in the etiology of schizophrenia in the Japanese population...
  48. ncbi request reprint Genetic examination of the PLXNA2 gene in Japanese and Chinese people with schizophrenia
    Mizuho Takeshita
    Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    Schizophr Res 99:359-64. 2008
    ..These findings suggest that PLXNA2 confers a varying genetic risk for schizophrenia among different populations...