Research Topics
Genomes and Genes | Kunihiro SakumaSummaryAffiliation: Toyohasi University of Technology Location: Toyohashi, Japan URL: http://www.health.tut.ac.jp/sakuma/index.html Summary: I graduated from the doctoral program in University of Tsukuba, Japan 1996. From 1996 to 2000, I worked as researcher in Department of Physiology, Institute for Developmental Research of Aichi Human Service Center. At this time, I studied mainly the molecular mechanism of merosin-deficient congenital muscular dystrophy. From 2000 to 2005, I worked as assistant professor, Department of Legal Medicine, Kyoto Prefectural University of Medicine. In this place, my major concern was the functional role of calcineurin on muscle regeneration and hypertrophy. My research interests, now in the Research Center for Physical Fitness, Sports and Health, Toyohashi University of Technology, focus on molecular mechanism of sarcopenia and this attenuating strategy (nutrient, pharmaceutical, exercise, etc), and particularly on autophagy process in sarcopenia. I am author of about 50 papers published in international journals and invited book chapters. I participated in the member of Editorial Board of several journal (International Journal of Biomedical Science, World Journal of Neurology, etc). Grants: 2011 Research Grant-in-Aid for Scientific Research C (No. 23500578) 2008-2010 Research Grant-in-Aid for Scientific Research C (No. 20500575) 2005-2006 Research Grant-in-Aid for Young Scientists B (No. 17700500) 2003-2004 Research Grant-in-Aid for Young Scientists B (No. 15700423) 2001-2002 Research Grant-in-Aid for Encouraging Research A (No. 13780029) 1999-2000 Research Grant-in-Aid for Encouraging Research A (No. 11780059) from the Ministry of Education, Culture, Sports, Science and Technology of Japan Publications
| Collaborators
|
Detail Information
Publications
Molecular mechanisms in aging and current strategies to counteract sarcopeniaKunihiro Sakuma
Research Center for Physical Fitness, Sports and Health, Toyohashi University of Technology, Toyohashi, Japan
Curr Aging Sci 3:90-101. 2010..Resistance training in combination with amino acid-containing nutrition would be the best candidate to attenuate, prevent, or ultimately reverse age-related muscle wasting and weakness...
Cyclosporin A modulates cellular localization of MEF2C protein and blocks fiber hypertrophy in the overloaded soleus muscle of miceKunihiro Sakuma
Health Science Center, Toyohashi University of Technology, 1 1 Hibarigaoka, Tenpaku cho, Toyohashi 441 8580, Japan
Acta Neuropathol 115:663-74. 2008..Our results demonstrated that CsA treatment modulates the amount and cellular localization of MEF2C protein. The modulation of MEF2C by CsA treatment may inhibit the hypertrophic process in the soleus muscle after mechanical overloading...- Increased expression of neuregulin-1 in differentiating muscle satellite cells and in motoneurons during muscle regenerationMiyuki Hirata
Department of Orthopedics, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
Acta Neuropathol 113:451-9. 2007..Thus, NRG-1 may play an important role in the differentiation of satellite cells in muscle regeneration, while increased NRG-1 expression in motoneurons may enhance the remodeling of partially damaged axons... - The expression of IGF-I and myostatin mRNAs in skeletal muscle of hypophysectomized and underfed rats during postnatal growthA Yamaguchi
School of Dentistry, Health Sciences University of Hokkaido, Kanazawa, Ishikari Tobetsu, Hokkaido, Japan
Acta Physiol (Oxf) 186:291-300. 2006..To determine the roles of myostatin and insulin-like growth factor-I (IGF-I) during postnatal growth, we examined IGF-I and myostatin mRNA expression in the skeletal muscles of hypophysectomized and underfed rats during postnatal growth... - Normal distribution of presenilin-1 and nicastrin in skeletal muscle and the differential responses of these proteins after denervationKunihiro Sakuma
Health Science Center, Toyohashi University of Technology, 1 1, Hibarigaoka, Tenpaku cho, Toyohashi 441 8580, Japan
Biochim Biophys Acta 1760:980-7. 2006..These data suggest that enhanced presenilin-1 protein may play a role in the degeneration and regeneration of skeletal muscle... - Cyclosporin A treatment upregulates Id1 and Smad3 expression and delays skeletal muscle regenerationKunihiro Sakuma
Department of Legal Medicine, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, 602 8566 Kyoto, Japan
Acta Neuropathol 110:269-80. 2005..Our results demonstrated that CsA treatment upregulates Id1 and Smad3 expression and delays skeletal muscle regeneration in vivo... - Prolactin receptor knockdown in the rat paraventricular nucleus by a morpholino-antisense oligonucleotide causes hypocalcemia and stress gastric erosionTakahiko Fujikawa
Department of Biochemistry and Proteomics, Institute of Genomics and Regenerative Biology, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
Endocrinology 146:3471-80. 2005..These results suggest that PRL acting on the PRLR-L in the PVN is one of the critical pathways for regulating circulating Ca2+ levels under both acute stress and nonstress conditions... - Increase of Cardiotrophin-1 immunoreactivity in regenerating and overloaded but not denervated muscles of ratsJunji Nishikawa
Department of Legal Medicine, Kyoto Prefectural University of Medicine, Japan
Neuropathology 25:54-65. 2005..We therefore believe that CT-1 plays a key role in regeneration and hypertrophy in the skeletal muscle of rats... - Changes in PKB/Akt and calcineurin signaling during recovery in atrophied soleus muscle induced by unloadingTakao Sugiura
Department of Exercise and Health Sciences, Faculty of Education, Yamaguchi University, Japan
Am J Physiol Regul Integr Comp Physiol 288:R1273-8. 2005..Our data support the concept that CaN is involved in muscle remodeling during the later phases of recovery from disuse muscle atrophy... - Expression of mRNA for specific fibroblast growth factors associates with that of the myogenic markers MyoD and proliferating cell nuclear antigen in regenerating and overloaded rat plantaris muscleY Tanaka
Laboratory of Human Performance and Fitness, Graduate School of Education, Hokkaido University, Sapporo, Hokkaido, Japan
Acta Physiol (Oxf) 194:149-59. 2008.... - Age-related reductions in expression of serum response factor and myocardin-related transcription factor A in mouse skeletal musclesKunihiro Sakuma
Health Science Center, Toyohashi University of Technology, 1 1 Hibarigaoka, Tenpaku cho, Toyohashi 441 8580, Japan
Biochim Biophys Acta 1782:453-61. 2008..Senescent mice possessed significantly higher levels of MyoD protein in the cytosol and nucleus. Decreased SRF and MRTF expression may induce the atrophy of skeletal muscle with aging... 
The recent understanding of the neurotrophin's role in skeletal muscle adaptationKunihiro Sakuma
Research Center for Physical Fitness, Sports and Health, Toyohashi University of Technology, 1 1 Hibarigaoka, Tenpaku cho, Toyohashi 441 8580, Japan
J Biomed Biotechnol 2011:201696. 2011..This paper provides a basis for a better understanding of the role of these factors under such pathological conditions and for treatment of human neuromuscular disease...- Oxidative stress and skeletal muscle dysfunction with agingWataru Aoi
Laboratory of Health Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan
Curr Aging Sci 4:101-9. 2011..This article describes the influence of oxidative stress on the progress of age-related muscle dysfunction and reviews the effect of countermeasures such as exercise and diet... - Muscle contractile activity regulates Sirt3 protein expression in rat skeletal musclesFumi Hokari
Dept of Health and Nutrition, Niigata Univ of Health and Welfare, Niigata, 1398 Shimami cho, Niigata City, Niigata 950 3198, Japan
J Appl Physiol 109:332-40. 2010.... - The functional role of calcineurin in hypertrophy, regeneration, and disorders of skeletal muscleKunihiro Sakuma
Research Center for Physical Fitness, Sports and Health, Toyohashi University of Technology, 1 1 Hibarigaoka, Tenpaku cho, Toyohashi 441 8580, Japan
J Biomed Biotechnol 2010:721219. 2010..Activation of calcineurin produces muscular hypertrophy of the slow-twitch soleus muscle but not fast-twitch muscles... - Expression profile of Notch-1 in mechanically overloaded plantaris muscle of miceMai Akiho
Research Center for Physical Fitness, Sports and Health, Toyohashi, University of Technology, 1 1 Hibarigaoka, Tenpaku cho, Toyohashi, 441 8580, Japan
Life Sci 86:59-65. 2010..We investigated the expression pattern of Notch-1 in normal and hypertrophied plantaris muscle of mice... - The adaptive responses in several mediators linked with hypertrophy and atrophy of skeletal muscle after lower limb unloading in humansK Sakuma
Research Center for Physical Fitness, Sports and Health, Toyohashi University of Technology, Toyohashi, Japan
Acta Physiol (Oxf) 197:151-9. 2009.... - The expression pattern of PKCtheta in satellite cells of normal and regenerating muscle in the ratSeiji Tokugawa
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medcicine, Kamigyo ku, Kyoto
Neuropathology 29:211-8. 2009..After 4 and 6 days, the localization of PKCtheta coincided with those of Pax7 and TGF-beta. Thus, PKCtheta may play an important role in inhibiting differentiation and maintaining the quiescent satellite cells in muscle regeneration... - Interleukin-8 expression in the esophageal mucosa of patients with gastroesophageal reflux diseaseN Yoshida
Molecular Gastroenterology and Hepatology, Department of Legal Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Scand J Gastroenterol 39:816-22. 2004..CONCLUSION: These results suggest that IL-8 in the esophageal mucosa may be involved in the pathogenesis of esophageal inflammation, including non-erosive GERD... - Oxidative stress and delayed-onset muscle damage after exerciseWataru Aoi
Department of Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, 602 8566, Japan
Free Radic Biol Med 37:480-7. 2004.... - Pathological changes in levels of three small stress proteins, alphaB crystallin, HSP 27 and p20, in the hindlimb muscles of dy mouseK Sakuma
Department of Physiology, Institute for Developmental Research, Aichi Human Service Center, Kamiya cho, Kasugai, Aichi 480 0392, Japan
Biochim Biophys Acta 1406:162-8. 1998.... - Differential adaptations of insulin-like growth factor-I, basic fibroblast growth factor, and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading: an immunohistochemical studyK Sakuma
Department of Physiology, Aichi Human Service Center, Japan
Acta Neuropathol 95:123-30. 1998..Furthermore, bFGF appears not to be related to the compensatory hypertrophy produced by overloading... - The adaptive response of MyoD family proteins in overloaded, regenerating and denervated rat musclesK Sakuma
Department of Physiology, Institute for Developmental Research, Aichi Human Service Center, Kamiya cho, Kasugai, Aichi 480 0392, Japan
Biochim Biophys Acta 1428:284-92. 1999..These results indicate that the fast-type-specific gene expression in muscle is modulated by MyoD and Myf-5 proteins and suggest that myogenin protein plays an important role in the reconstruction of damaged neuromuscular connections... - Postnatal profiles of myogenic regulatory factors and the receptors of TGF-beta 2, LIF and IGF-I in the gastrocnemius and rectus femoris muscles of dy mouseK Sakuma
Department of Physiology, Aichi Human Service Center, Japan
Acta Neuropathol 99:169-76. 2000..Therefore, unlike the situation in mdx mice, the milieu of regeneration following repetitive damage seems to be degraded in the muscles of dy mice... - Marked reduction of focal adhesion kinase, serum response factor and myocyte enhancer factor 2C, but increase in RhoA and myostatin in the hindlimb dy mouse musclesKunihiro Sakuma
Department of Legal Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, 602 8566 Kyoto, Japan
Acta Neuropathol 108:241-9. 2004..Enhancing myostatin protein would result in further atrophy and degeneration of muscle fiber in dy mice... - Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in miceWataru Aoi
Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, 602 0841, Japan
Antioxid Redox Signal 5:139-44. 2003..Astaxanthin can attenuate exercise-induced damage in mouse skeletal muscle and heart, including an associated neutrophil infiltration that induces further damage... - Serum response factor plays an important role in the mechanically overloaded plantaris muscle of ratsKunihiro Sakuma
Department of Legal Medicine, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Japan
Histochem Cell Biol 119:149-60. 2003..These results suggest that the signaling pathway through RhoA-FAK-SRF is important to the differentiation of satellite cells by interacting MyoD and myogenin in the hypertrophied muscle of rats... - Calcineurin is a potent regulator for skeletal muscle regeneration by association with NFATc1 and GATA-2Kunihiro Sakuma
Department of Legal Medicine, Kyoto Prefectural University of Medicine, 456 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Japan
Acta Neuropathol 105:271-80. 2003..Thus, calcineurin may have an important role in muscle regeneration in association with NFATc1 and GATA-2... - The reciprocal change of neurotrophin-4 and glial cell line-derived neurotrophic factor protein in the muscles, spinal cord and cerebellum of the dy mouseKunihiro Sakuma
Department of Legal Medicine, Kyoto Prefectural University of Medicine, 456 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
Acta Neuropathol 104:482-92. 2002..Furthermore, dy mice include neurogenic abnormalities in the cerebellum and spinal cord along with myogenic disorder of muscle fibers... - A possible role for BDNF, NT-4 and TrkB in the spinal cord and muscle of rat subjected to mechanical overload, bupivacaine injection and axotomyK Sakuma
Department of Legal Medicine, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, 602 8566, Kyoto, Japan
Brain Res 907:1-19. 2001..Furthermore, by interacting with BDNF and NT-4, the TrkB in the spinal cord may be important for the survival of motoneurons and outgrowth of injured peripheral axons following muscle damage... - Differential adaptation of growth and differentiation factor 8/myostatin, fibroblast growth factor 6 and leukemia inhibitory factor in overloaded, regenerating and denervated rat musclesK Sakuma
Department of Physiology, Institute for Developmental Research, Aichi Human Service Center, Kamiya cho, Kasugai, Aichi, Japan
Biochim Biophys Acta 1497:77-88. 2000..The marked reduction of FGF6 in the hypertrophied and regenerating muscle would imply that FGF6 regulates muscle differentiation but not proliferation of satellite cells and/or myoblasts... - The adaptive response of transforming growth factor-beta 2 and -beta RII in the overloaded, regenerating and denervated muscles of ratsK Sakuma
Department of Physiology, Aichi Human Service Center, Japan
Acta Neuropathol 99:177-85. 2000..These results indicate that TGF-beta RII is preferentially distributed in fast-type muscles. Furthermore, TGF-beta 2 may play an important role in muscle hypertrophy and regeneration by the usage of TGF-beta RII... - Sarcopenia and cachexia: the adaptations of negative regulators of skeletal muscle massKunihiro Sakuma
Research Center for Physical Fitness, Sports and Health, Toyohashi University of Technology, 1 1 Hibarigaoka, Tenpaku cho, Toyohashi, 441 8580, Japan
J Cachexia Sarcopenia Muscle 3:77-94. 2012..This review provides an overview of the adaptive changes in negative regulators of muscle mass in both sarcopenia and cachexia...