Research Topics
| M ItoSummaryAffiliation: Toyo University Country: Japan Publications
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Publications
Mrp-dependent Na(+)/H(+) antiporters of Bacillus exhibit characteristics that are unanticipated for completely secondary active transportersM Ito
Faculty of Life Scienes, Toyo University, Gunma, Japan
FEBS Lett 496:117-20. 2001..coli (SBS2115); and in increasing non-fermentative growth of an NADH dehydrogenase-minus E. coli mutant (ANN0222). The results suggest the possibility that the Mrp systems may have both secondary and primary energization capacities...
Effects of nonpolar mutations in each of the seven Bacillus subtilis mrp genes suggest complex interactions among the gene products in support of Na(+) and alkali but not cholate resistanceM Ito
Faculty of Life Sciences, Toyo University, Oura gun, Gunma 374 0193, Japan
J Bacteriol 182:5663-70. 2000..Expression of an upstream gene, maeN, that encodes an Na(+)/malate symporter, was coordinately regulated with mrp, although it is not part of the operon...- Bacillus subtilis YqkI is a novel malic/Na+-lactate antiporter that enhances growth on malate at low protonmotive forceY Wei
Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
J Biol Chem 275:30287-92. 2000..Thus growth of B. subtilis to high density on a putatively nonfermentative dicarboxylic acid substrate depends on a malolactate exchange at suboptimal protonmotive force... - Contribution of the cell wall component teichuronopeptide to pH homeostasis and alkaliphily in the alkaliphile Bacillus lentus C-125R Aono
Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta 4259, Midori ku, Yokohama, 226 8501, Japan
J Bacteriol 181:6600-6. 1999..These results demonstrate that the acidic polymer TUP in the cell wall plays a role in pH homeostasis in this alkaliphile... - mrp, a multigene, multifunctional locus in Bacillus subtilis with roles in resistance to cholate and to Na+ and in pH homeostasisM Ito
Department of Biochemistry, Mount Sinai School of Medicine of the City University of New York, New York, New York 10029, USA
J Bacteriol 181:2394-402. 1999..Also, phenotypic differences among the mrp mutants suggest that functions in addition to Na+ and cholate resistance and pH homeostasis will be found among the remaining mrp genes... - Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidasesM Tani
Department of Bioscience and Biotechnology, Division of Bioresource and Bioenvironmental Sciences, Graduate School Kyushu University, 6 10 1, Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
J Biol Chem 275:11229-34. 2000..Interestingly, phylogenetic analysis of various ceramidases clearly indicated that neutral/alkaline ceramidases form a novel but highly conserved gene family that is evolutionarily different from lysosomal acid ceramidases... - JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathwayM Ito
Department of Biosciences, School of Science, Kitasato University, Kanagawa 228, Japan
Mol Cell Biol 19:7539-48. 1999..These results suggest that JSAP1 functions as a scaffold protein in the JNK3 cascade. We also discuss a scaffolding role for JSAP1 in the JNK1 and JNK2 cascades... - Purification and characterization of recombinant rat hepatic CYP4F1Y Kikuta
Department of Applied Biological Science, Fukuyama University, Hiroshima, Fukuyama, 7290292, Japan
Arch Biochem Biophys 369:193-6. 1999..In contrast, no activity was detected toward lipoxin B(4), laurate, palmitate, arachidonate, and benzphetamine. The results suggest that CYP4F1 participates in the hepatic inactivation of several bioactive eicosanoids... - A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1S Koyano
Department of Biosciences, School of Science, Kitasato University, 1 15 1 Kitasato, Kanagawa, Japan
FEBS Lett 457:385-8. 1999..In contrast, JNKBP1 had no or very little effect on the ERK signaling pathway. These results suggest that JNKBP1 functions to facilitate the specific and efficient activation of the JNK signaling pathways... - Identification of clp genes expressed in senescing Arabidopsis leavesK Nakabayashi
Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
Plant Cell Physiol 40:504-14. 1999..These observations suggest that chloroplast Clp protease is composed of very complicated combinations of subunits, and that ERD1, nClpP5 and pClpP have a role in the concerted degradation of protein in senescing chloroplasts... - Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activatorsM Ito
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021, USA
Mol Cell 3:361-70. 1999..Identification of the TRAP230 subunit as a previously predicted gene product also suggests a coactivator-related transcription defect in certain disease states... - Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cellsS Endo
Laboratory for Learning and Memory, RIKEN, Brain Science Institute, Hirosawa 2 1, Wako, 351 0198, Japan
Proc Natl Acad Sci U S A 96:2467-72. 1999..However, purified G-substrate phosphorylated by cGMP-dependent protein kinase inhibited protein phosphatase 2A more effectively than protein phosphatase 1, suggesting a distinct role as a protein phosphatase inhibitor... - A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulationW Gu
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021, USA
Mol Cell 3:97-108. 1999..These findings demonstrate both positive and negative functional capabilities for the human complex, emphasize novel (CTD-independent) regulatory mechanisms, and link the complex to other human coactivator complexes... - The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashionC X Yuan
Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
Proc Natl Acad Sci U S A 95:7939-44. 1998.... - Enantioselective transesterification using lipase-displaying yeast whole-cell biocatalystT Matsumoto
Division of Molecular Science, Graduate School of Science and Technology, Kobe University, 1-1 Rokkodaicho, Nada-ku, 657-8501 Kobe, Japan
Appl Microbiol Biotechnol 64:481-5. 2004..The results obtained in this study demonstrate the applicability of the lipase-displaying yeast whole cell biocatalyst to bioconversion processes in non-aqueous organic solvents... - Identification and characterization of a novel protein inhibitor of type 1 protein phosphataseH Shirato
Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
Biochemistry 39:13848-55. 2000..These results strongly suggest a multiple-point interaction between I-4 and PP1C, which is thought to cause the inhibition of I-4 which is stronger than the inhibition of I-2... - Isolation and RNA gel blot analysis of genes that could serve as potential molecular markers for leaf senescence in Arabidopsis thalianaS Yoshida
Department of Biological Sciences, Graduated School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033 Japan
Plant Cell Physiol 42:170-8. 2001..These expression characteristics of YLS genes will be useful as potential molecular markers, which will enhance our understanding of natural and artificial senescence processes... - Overexpression of Bax inhibitor suppresses the fungal elicitor-induced cell death in rice (Oryza sativa L) cellsH Matsumura
Iwate Biotechnology Research Center, Kitakami, Iwate 024 0003, Japan
Plant J 33:425-34. 2003..grisea elicitor. Thus, the plant Bax inhibitor plays a functional role in regulating cell death in the rice cell culture system... - Recognition of ADP-ribosylation factor 4-like by HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes from patients with brain tumorsY Nonaka
Department of Immunology, Kurume University School of Medicine, Fukuoka, Japan
Tissue Antigens 60:319-27. 2002..These results indicate that these two ARF4L peptides could be targets for immunotherapy of HLA-A2+ patients with brain tumors... - UDP-Gal: betaGlcNAc beta1, 3-galactosyltransferase, polypeptide 3 (GALT3) is a tumour antigen recognised by HLA-A2-restricted cytotoxic T lymphocytes from patients with brain tumourN Tsuda
Department of Immunology, Kurume University School of Medicine, 67 Asohi machi, Kurume, Fukuoka 830 0011, Japan
Br J Cancer 87:1006-12. 2002..These peptides may be useful in the peptide-based specific immunotherapy for patients with malignant brain tumours... - A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse developmentM Nakashima
Department of Clinical Oral Molecular Biology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
Mech Dev 119:21-34. 2002.... - Molecular cloning, functional expression and characterization of (E)-beta farnesene synthase from Citrus junosT Maruyama
Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
Biol Pharm Bull 24:1171-5. 2001..A possible reaction mechanism for terpene biosynthesis is also discussed on the basis of sequence comparison of CJFS with known sesquiterpene synthase genes... - Molecular events involved in up-regulating human Na+-independent neutral amino acid transporter LAT1 during T-cell activationT Nii
Department of Clinical Nutrition, School of Medicine, Tokushima University, Kuramoto Cho 3, Tokushima City 770 8503, Japan
Biochem J 358:693-704. 2001..These findings indicated that a removal of the block to mRNA elongation stimulates the induction of system-L amino acid transporter gene transcripts (LAT1 and 4F2hc) in activated T-cells... - Purification and properties of the cell-associated beta-xylosidase from AureobasidiumS Hayashi
Faculty of Engineering, Department of Applied Chemistry, Miyazaki University, Miyazaki 889-2192, Japan
J Ind Microbiol Biotechnol 26:276-9. 2001..The Michaelis constant (K(m)) and maximum velocity (V(max)) toward p-nitrophenyl-beta-D-xyloside were 2.0 mmol l(-1) and 0.94 mmol min(-1) mg(-1) protein, respectively. The enzyme was inhibited strongly by mercury, lead, and copper ions... - Identification of human CPI-17, an inhibitory phosphoprotein for myosin phosphataseK Yamawaki
First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, 514 8507, Japan
Biochem Biophys Res Commun 285:1040-5. 2001..The cloned human CPI-17 gene indicated 4 coding exons and CPI-17beta was an alternative splice variant due to deletion of the second exon. FISH analysis located the human CPI-17 gene on chromosome 19q13.1... - Molecular cloning and analysis of the 5'-flanking region of the human MYPT1 geneH Machida
First Department of Internal Medicine, University School of Medicine, Tsu, Mie, Japan
Biochim Biophys Acta 1517:424-9. 2001..Luciferase reporter assays showed the presence of two regions for positive elements and one for a negative element... - Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidneyS Mitsutake
Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
J Biol Chem 276:26249-59. 2001..Interestingly, the kidney ceramidase was found to be enriched in the raft microdomains with cholesterol and GM1 ganglioside... - Molecular cloning, functional expression and characterization of d-limonene synthase from Schizonepeta tenuifoliaT Maruyama
Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Japan
Biol Pharm Bull 24:373-7. 2001..Here, we report on the cloning of dLMS, and the putative stereochemical regulation mechanism is discussed based on the comparison of the deduced amino acid sequence of dLMS with those of known l-limonene synthases... - Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoterK Hamada
Department of Obstetrics and Gynecology, School of Medicine, Ehime University, Shitsukawa, Shigenobu, Osen gun, Ehime 791 0295, Japan
Biochim Biophys Acta 1518:124-31. 2001.... - Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNAN Ohkura
Institute of Biomedical Science, TERUMO R and D Center, Kanagawa 258 0000, Japan
Gene 211:79-85. 1998.... - A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mappingM Fujioka
First Department of Internal Medicine, Mie University School of Medicine, Japan
Genomics 49:59-68. 1998..1, compared to the chromosomal location 12q15-q21-2 for MYPT1. It is suggested that the products of the two gene families of myosin phosphatase target subunit may be localized differently among various tissues... - Interaction of the ribosomal protein, L5, with protein phosphatase type 1K Hirano
Muscle Biology Group, University of Arizona, Tucson 85721, USA
J Biol Chem 270:19786-90. 1995..These data indicate that L5 binds to the catalytic subunit of the type 1 protein phosphatase and may act as a target molecule for phosphatase in ribosomal function or other cell mechanisms... - Identification of the site of interaction of the 14-3-3 protein with phosphorylated tryptophan hydroxylaseT Ichimura
Department of Biochemistry, Faculty of Science, Niigata University, Japan
J Biol Chem 270:28515-8. 1995..The result is consistent with the recently published crystal structure of this protein family, which suggests the importance of the negatively charged groove-like structure in the ligand binding... - Isolation of cDNA clones coding for rat isovaleryl-CoA dehydrogenase and assignment of the gene to human chromosome 15J P Kraus
Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510
Genomics 1:264-9. 1987..This location differs from that of the gene for medium-chain acyl-CoA dehydrogenase, a closely related enzyme, which has been previously assigned to chromosome 1... - Nucleotide sequence of cDNA and predicted amino acid sequence of rat liver uricaseM Ito
Division of Molecular Genetics, Fujita Gakuen Health University, Aichi, Japan
Eur J Biochem 173:459-63. 1988..The complete amino acid sequence predicted for rat liver uricase was compared with that of soybean nodulin uricase and nine highly homologous regions of the two enzymes were found... - Molecular cloning and nucleotide sequence of cDNAs encoding the alpha-subunit of human electron transfer flavoproteinG Finocchiaro
Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510
J Biol Chem 263:15773-80. 1988..The molecular sizes of the precursor and mature alpha-ETF have been estimated to be 35 and 32 kDa, respectively, by sodium dodecyl sulfate-polyacrylamide gel electrophoresis... - Thermosensitive omsA mutation of Escherichia coli that causes thermoregulated release of periplasmic proteinsT Tsuruoka
Central Research Laboratories, Meiji Seika, Ltd, Yokohama, Japan
J Bacteriol 170:5229-35. 1988..The omsA mutant may be useful for production of periplasmic proteins, which it releases into the culture medium on shift up of temperature... - Determinations of the DNA sequence of the mreB gene and of the gene products of the mre region that function in formation of the rod shape of Escherichia coli cellsM Doi
Institute of Applied Microbiology, University of Tokyo, Japan
J Bacteriol 170:4619-24. 1988..The mreB protein and some of these three proteins may function together in determination of cell shape... - The alpha subunit of type II Ca2+/calmodulin-dependent protein kinase is highly conserved in DrosophilaK O Cho
Division of Biology, California Institute of Technology, Pasadena 91125
Neuron 7:439-50. 1991..The protein product of this gene is expressed at much higher levels in the fly head than in the body. Thus, both the amino acid sequence and the tissue specificity of the mammalian kinase are highly conserved in Drosophila... - Structural analysis of the gene encoding rat uricaseM Ito
Division of Molecular Genetics, School of Medicine, Fujita Health University, Aichi, Japan
Genomics 11:905-13. 1991..The palindromic sequence is located 158 to 151 nucleotides upstream from the transcription initiation site, surrounded by a direct repeat (TCAGCAA)... - A unique mutation in the vitamin D receptor gene in three Japanese patients with vitamin D-dependent rickets type II: utility of single-strand conformation polymorphism analysis for heterozygous carrier detectionT Saijo
Department of Pediatrics, University of Tokushima School of Medicine, Japan
Am J Hum Genet 49:668-73. 1991..Single-strand conformation polymorphism analysis of amplified DNA confirmed that all patients were homozygous and that parents from one family were heterozygous carriers for this mutation... - [1H and 31P magnetic resonance spectroscopy study of a case of phosphoglycerate kinase deficiency]M Ito
Department of Pediatrics, Hamamatsu University School of Medicine
No To Hattatsu 24:244-9. 1992..The reason of the reduction of alanine levels was uncertain. A compensatory mechanism for energy supply to the muscle tissue was considered... - Molecular cloning of chick liver HMG 2a cDNA and developmental expression of HMG 2a mRNAT Oka
Department of Nutritional Chemistry, School of Medicine, University of Tokushima, Japan
Biochim Biophys Acta 1130:224-6. 1992..2.0 kb and 1.2 kb mRNAs were found in newly hatched chick liver and decreased during postnatal development of chicks... - Identification of an amino acid residue involved in the substrate-binding site of rat liver uricase by site-directed mutagenesisM Ito
Division of Molecular Genetics, Fujita Health University, School of Medicine, Aichi, Japan
Biochem Biophys Res Commun 187:101-7. 1992..These findings suggest that this amino acid is involved in the substrate-binding site of the enzyme... - A gene that is related to SRY and is expressed in the testes encodes a leucine zipper-containing proteinN Takamatsu
Department of Biosciences, School of Science, Kitasato University, Kanagawa, Japan
Mol Cell Biol 15:3759-66. 1995..Thus, the repressed transactivation of the intact SOX-LZ in CHO cells was primarily attributable to the low level of DNA binding of SOX-LZ homodimers... - Cloning of tropomodulin cDNA and localization of gene transcripts during mouse embryogenesisM Ito
Institute for Genetic Medicine, University of Southern California School of Medicine, Los Angeles 90033
Dev Biol 167:317-28. 1995.... - cDNA cloning of a novel rainbow trout SRY-type HMG box protein, rtSox23, and its functional analysisA Yamashita
Department of Biosciences, School of Science, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228, Japan
Gene 209:193-200. 1998..The rainbow trout p62 mRNA was also prominent in ovary and brain. Taken together, these results suggest that the rainbow trout p62 associates with rtSox23 in vivo and modulates the function of rtSox23... - cDNA cloning of a new member of the FTZ-F1 subfamily from a rainbow troutM Ito
Department of Biosciences, School of Science, Kitasato University, Kanagawa, Japan
Biochim Biophys Acta 1395:271-4. 1998..On the other hand, the overall homology between tFZR1 and zebrafish FTZ-F1 is low (33.0%). The results indicate that tFZR1 is a new member of fushitarazu factor 1 (FTZ-F1) subfamily... - Rainbow trout SOX9: cDNA cloning, gene structure and expressionN Takamatsu
Department of Biosciences, School of Science, Kitasato University, Sagamihara, Kanagawa, Japan
Gene 202:167-70. 1997..The rainbow trout and human SOX9 genes show a similar gene structure, and the two introns in the coding region are located at conserved positions. In rainbow trout, the SOX9 mRNA was prominent in testis and brain... - Isolation and characterization of mouse high-glycine/tyrosine proteinsN Aoki
Department of Dermatology, Niigata University School of Medicine, Niigata, Japan
J Biol Chem 272:30512-8. 1997..The novel findings that each gene is activated transcriptionally with a distinct expression pattern spatially and temporally suggest that there is a remarkable difference in the distribution of these proteins in hair... - Localization of the gene coding for myosin phosphatase, target subunit 1 (MYPT1) to human chromosome 12q15-q21N Takahashi
Central Laboratories for Key Technology, Kirin Brewery Co Ltd, Kanagawa, Japan
Genomics 44:150-2. 1997..2. Radiation hybrid mapping has shown that the human MYPT1 gene is located very near the highly polymorphic marker CHLC.GATA65A12, which lies between D12S350 and D12S106... - Interaction of smooth muscle myosin phosphatase with phospholipidsM Ito
First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
Biochemistry 36:7607-14. 1997..This mechanism could be important in localization of myosin phosphatase and in targeting substrates at different loci... - Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B familyN Ohkura
Institute of Biomedical Science, TERUMO R and D Center, Kanagawa, Japan
Biochim Biophys Acta 1308:205-14. 1996..This suggests that the Nur77/NGFI-B family has evolved from a common ancestral gene. Fluorescence in situ hybridization (FISH) revealed that the gene is located on chromosome 9q... - Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein RhoT Matsui
Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma, Japan
EMBO J 15:2208-16. 1996..Thus it is likely that Rho-kinase is a putative target serine/threonine kinase for Rho and serves as a mediator of the Rho-dependent signaling pathway... - The substrate-binding site in Escherichia coli cyclophilin A preferably recognizes a cis-proline isomer or a highly distorted form of the trans isomerM Konno
Department of Chemistry, Faculty of Science Ochanomizu University, Tokyo, Japan
J Mol Biol 256:897-908. 1996..coli CyPA forming a complex with CsA. Thus, the extra amino acid residue of E. coli CyPA, polar Gln89, lies along the pathway to the hydrophobic pocket of CyPA and seems to prevent the access hydrophobic part of CsA to the cleft of CyPA... - Possible involvement of inefficient cleavage of preprovasopressin by signal peptidase as a cause for familial central diabetes insipidusM Ito
First Department of Internal Medicine, Nagoya University School of Medicine, Aichi, Japan
J Clin Invest 91:2565-71. 1993..These data suggest that inefficient processing of preproVP produced by the mutant allele is possibly involved in the pathogenesis of diabetes insipidus in the affected individuals... - Molecular cloning of a cDNA encoding a novel fatty acid-binding protein from rat skinR Watanabe
Department of Biochemistry, Niigata University School of Medicine, Japan
Biochem Biophys Res Commun 200:253-9. 1994..1 kDa and exhibits around 50% identity to myelin P2 protein, adipocyte FABP and heart FABP. Our results propose that C-FABP is a new member of the FABP family... - Evidence for the role of human immunodeficiency virus type 1 Nef protein as a growth inhibitor to CD4+ T lymphocytes and for the blocking of the Nef function by anti-Nef antibodiesY Fujii
Institute for Laboratory Animal Research, Nagoya University School of Medicine, Japan
Vaccine 11:837-47. 1993.... - Characterization of the myosin-binding subunit of smooth muscle myosin phosphataseH Shimizu
First Department of Internal Medicine, Mie University School of Medicine, Japan
J Biol Chem 269:30407-11. 1994..Myosin binding and binding to the catalytic subunit are properties of a 58,000-Da fragment that represents the N-terminal part of the molecule... - Mutation of E1 alpha gene in a female patient with pyruvate dehydrogenase deficiency due to rapid degradation of E1 proteinM Ito
Department of Pediatrics School of Medicine, University of Tokushima, Japan
J Inherit Metab Dis 15:848-56. 1992..The mutant alpha subunit protein failed to form a stable structure of pyruvate dehydrogenase, so that both alpha and beta subunit proteins were degraded rapidly...