M Ito

Summary

Affiliation: Toyo University
Country: Japan

Publications

  1. pmc Properties of motility in Bacillus subtilis powered by the H+-coupled MotAB flagellar stator, Na+-coupled MotPS or hybrid stators MotAS or MotPB
    Masahiro Ito
    Graduate School of Life Sciences, Toyo University, Oura gun, Gunma 374 0193, Japan
    J Mol Biol 352:396-408. 2005
  2. ncbi request reprint Improvement of the electro-transformation efficiency of facultatively alkaliphilic Bacillus pseudofirmus OF4 by high osmolarity and glycine treatment
    M Ito
    Faculty of Life Sciences, Toyo University, Oura gun, Gunma, Japan
    Biosci Biotechnol Biochem 65:2773-5. 2001
  3. pmc Effects of nonpolar mutations in each of the seven Bacillus subtilis mrp genes suggest complex interactions among the gene products in support of Na(+) and alkali but not cholate resistance
    M Ito
    Faculty of Life Sciences, Toyo University, Oura gun, Gunma 374 0193, Japan
    J Bacteriol 182:5663-70. 2000
  4. ncbi request reprint Mrp-dependent Na(+)/H(+) antiporters of Bacillus exhibit characteristics that are unanticipated for completely secondary active transporters
    M Ito
    Faculty of Life Scienes, Toyo University, Gunma, Japan
    FEBS Lett 496:117-20. 2001
  5. pmc Contribution of the cell wall component teichuronopeptide to pH homeostasis and alkaliphily in the alkaliphile Bacillus lentus C-125
    R Aono
    Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta 4259, Midori ku, Yokohama, 226 8501, Japan
    J Bacteriol 181:6600-6. 1999
  6. pmc mrp, a multigene, multifunctional locus in Bacillus subtilis with roles in resistance to cholate and to Na+ and in pH homeostasis
    M Ito
    Department of Biochemistry, Mount Sinai School of Medicine of the City University of New York, New York, New York 10029, USA
    J Bacteriol 181:2394-402. 1999
  7. ncbi request reprint Bacillus subtilis YqkI is a novel malic/Na+-lactate antiporter that enhances growth on malate at low protonmotive force
    Y Wei
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 275:30287-92. 2000
  8. ncbi request reprint Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases
    M Tani
    Department of Bioscience and Biotechnology, Division of Bioresource and Bioenvironmental Sciences, Graduate School Kyushu University, 6 10 1, Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Biol Chem 275:11229-34. 2000
  9. ncbi request reprint Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family
    B Pierrat
    Novartis Pharma Inc, Basle, Switzerland
    Eur J Biochem 267:2680-7. 2000
  10. ncbi request reprint Helicobacter pylori-associated gastritis is related to babA2 expression without heterogeneity of the 3' region of the cagA genotype in gastric biopsy specimens
    X F Xie
    Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
    Pathobiology 74:309-16. 2007

Collaborators

Detail Information

Publications64

  1. pmc Properties of motility in Bacillus subtilis powered by the H+-coupled MotAB flagellar stator, Na+-coupled MotPS or hybrid stators MotAS or MotPB
    Masahiro Ito
    Graduate School of Life Sciences, Toyo University, Oura gun, Gunma 374 0193, Japan
    J Mol Biol 352:396-408. 2005
    ..Finally, optimal function at elevated viscosity was found only in MotPS and MotPB and is therefore conferred by MotP...
  2. ncbi request reprint Improvement of the electro-transformation efficiency of facultatively alkaliphilic Bacillus pseudofirmus OF4 by high osmolarity and glycine treatment
    M Ito
    Faculty of Life Sciences, Toyo University, Oura gun, Gunma, Japan
    Biosci Biotechnol Biochem 65:2773-5. 2001
    ..Transformation efficiency improved 110-fold in glycine-treated cells compared to non-glycine-treated cells. Under optimum conditions, the transformation efficiency was 1.69 x 10(6) transformants per microg of pUB110...
  3. pmc Effects of nonpolar mutations in each of the seven Bacillus subtilis mrp genes suggest complex interactions among the gene products in support of Na(+) and alkali but not cholate resistance
    M Ito
    Faculty of Life Sciences, Toyo University, Oura gun, Gunma 374 0193, Japan
    J Bacteriol 182:5663-70. 2000
    ..Expression of an upstream gene, maeN, that encodes an Na(+)/malate symporter, was coordinately regulated with mrp, although it is not part of the operon...
  4. ncbi request reprint Mrp-dependent Na(+)/H(+) antiporters of Bacillus exhibit characteristics that are unanticipated for completely secondary active transporters
    M Ito
    Faculty of Life Scienes, Toyo University, Gunma, Japan
    FEBS Lett 496:117-20. 2001
    ..coli (SBS2115); and in increasing non-fermentative growth of an NADH dehydrogenase-minus E. coli mutant (ANN0222). The results suggest the possibility that the Mrp systems may have both secondary and primary energization capacities...
  5. pmc Contribution of the cell wall component teichuronopeptide to pH homeostasis and alkaliphily in the alkaliphile Bacillus lentus C-125
    R Aono
    Department of Biological Information, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta 4259, Midori ku, Yokohama, 226 8501, Japan
    J Bacteriol 181:6600-6. 1999
    ..These results demonstrate that the acidic polymer TUP in the cell wall plays a role in pH homeostasis in this alkaliphile...
  6. pmc mrp, a multigene, multifunctional locus in Bacillus subtilis with roles in resistance to cholate and to Na+ and in pH homeostasis
    M Ito
    Department of Biochemistry, Mount Sinai School of Medicine of the City University of New York, New York, New York 10029, USA
    J Bacteriol 181:2394-402. 1999
    ..Also, phenotypic differences among the mrp mutants suggest that functions in addition to Na+ and cholate resistance and pH homeostasis will be found among the remaining mrp genes...
  7. ncbi request reprint Bacillus subtilis YqkI is a novel malic/Na+-lactate antiporter that enhances growth on malate at low protonmotive force
    Y Wei
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 275:30287-92. 2000
    ..Thus growth of B. subtilis to high density on a putatively nonfermentative dicarboxylic acid substrate depends on a malolactate exchange at suboptimal protonmotive force...
  8. ncbi request reprint Molecular cloning of the full-length cDNA encoding mouse neutral ceramidase. A novel but highly conserved gene family of neutral/alkaline ceramidases
    M Tani
    Department of Bioscience and Biotechnology, Division of Bioresource and Bioenvironmental Sciences, Graduate School Kyushu University, 6 10 1, Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Biol Chem 275:11229-34. 2000
    ..Interestingly, phylogenetic analysis of various ceramidases clearly indicated that neutral/alkaline ceramidases form a novel but highly conserved gene family that is evolutionarily different from lysosomal acid ceramidases...
  9. ncbi request reprint Uncoupling proteins 2 and 3 interact with members of the 14.3.3 family
    B Pierrat
    Novartis Pharma Inc, Basle, Switzerland
    Eur J Biochem 267:2680-7. 2000
    ..3.3 proteins potentiated the inhibitory effect of UCP3 overexpression on cell growth. These findings suggest that 14.3.3 proteins could be involved in the targeting of UCPs to the mitochondria...
  10. ncbi request reprint Helicobacter pylori-associated gastritis is related to babA2 expression without heterogeneity of the 3' region of the cagA genotype in gastric biopsy specimens
    X F Xie
    Department of Medicine and Molecular Science, Hiroshima University, Hiroshima, Japan
    Pathobiology 74:309-16. 2007
    ..Blood group antigen binding adhesin (BabA) helps the strains adhere to the epithelial cell layer and is the most important adhesin of H. pylori...
  11. ncbi request reprint Localization of the gene coding for myosin phosphatase, target subunit 1 (MYPT1) to human chromosome 12q15-q21
    N Takahashi
    Central Laboratories for Key Technology, Kirin Brewery Co Ltd, Kanagawa, Japan
    Genomics 44:150-2. 1997
    ..2. Radiation hybrid mapping has shown that the human MYPT1 gene is located very near the highly polymorphic marker CHLC.GATA65A12, which lies between D12S350 and D12S106...
  12. pmc JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway
    M Ito
    Department of Biosciences, School of Science, Kitasato University, Kanagawa 228, Japan
    Mol Cell Biol 19:7539-48. 1999
    ..These results suggest that JSAP1 functions as a scaffold protein in the JNK3 cascade. We also discuss a scaffolding role for JSAP1 in the JNK1 and JNK2 cascades...
  13. ncbi request reprint Purification and characterization of recombinant rat hepatic CYP4F1
    Y Kikuta
    Department of Applied Biological Science, Fukuyama University, Hiroshima, Fukuyama, 7290292, Japan
    Arch Biochem Biophys 369:193-6. 1999
    ..In contrast, no activity was detected toward lipoxin B(4), laurate, palmitate, arachidonate, and benzphetamine. The results suggest that CYP4F1 participates in the hepatic inactivation of several bioactive eicosanoids...
  14. ncbi request reprint A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1
    S Koyano
    Department of Biosciences, School of Science, Kitasato University, 1 15 1 Kitasato, Kanagawa, Japan
    FEBS Lett 457:385-8. 1999
    ..In contrast, JNKBP1 had no or very little effect on the ERK signaling pathway. These results suggest that JNKBP1 functions to facilitate the specific and efficient activation of the JNK signaling pathways...
  15. ncbi request reprint Identification of clp genes expressed in senescing Arabidopsis leaves
    K Nakabayashi
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Japan
    Plant Cell Physiol 40:504-14. 1999
    ..These observations suggest that chloroplast Clp protease is composed of very complicated combinations of subunits, and that ERD1, nClpP5 and pClpP have a role in the concerted degradation of protein in senescing chloroplasts...
  16. ncbi request reprint Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators
    M Ito
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021, USA
    Mol Cell 3:361-70. 1999
    ..Identification of the TRAP230 subunit as a previously predicted gene product also suggests a coactivator-related transcription defect in certain disease states...
  17. ncbi request reprint Identification and characterization of a novel protein inhibitor of type 1 protein phosphatase
    H Shirato
    Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    Biochemistry 39:13848-55. 2000
    ..These results strongly suggest a multiple-point interaction between I-4 and PP1C, which is thought to cause the inhibition of I-4 which is stronger than the inhibition of I-2...
  18. ncbi request reprint Isolation and RNA gel blot analysis of genes that could serve as potential molecular markers for leaf senescence in Arabidopsis thaliana
    S Yoshida
    Department of Biological Sciences, Graduated School of Science, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033 Japan
    Plant Cell Physiol 42:170-8. 2001
    ..These expression characteristics of YLS genes will be useful as potential molecular markers, which will enhance our understanding of natural and artificial senescence processes...
  19. ncbi request reprint Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter
    K Hamada
    Department of Obstetrics and Gynecology, School of Medicine, Ehime University, Shitsukawa, Shigenobu, Osen gun, Ehime 791 0295, Japan
    Biochim Biophys Acta 1518:124-31. 2001
    ....
  20. ncbi request reprint Enantioselective transesterification using lipase-displaying yeast whole-cell biocatalyst
    T Matsumoto
    Division of Molecular Science, Graduate School of Science and Technology, Kobe University, 1 1 Rokkodaicho, Nada Ku, 657 8501 Kobe, Japan
    Appl Microbiol Biotechnol 64:481-5. 2004
    ..The results obtained in this study demonstrate the applicability of the lipase-displaying yeast whole cell biocatalyst to bioconversion processes in non-aqueous organic solvents...
  21. ncbi request reprint Overexpression of Bax inhibitor suppresses the fungal elicitor-induced cell death in rice (Oryza sativa L) cells
    H Matsumura
    Iwate Biotechnology Research Center, Kitakami, Iwate 024 0003, Japan
    Plant J 33:425-34. 2003
    ..grisea elicitor. Thus, the plant Bax inhibitor plays a functional role in regulating cell death in the rice cell culture system...
  22. ncbi request reprint Recognition of ADP-ribosylation factor 4-like by HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes from patients with brain tumors
    Y Nonaka
    Department of Immunology, Kurume University School of Medicine, Fukuoka, Japan
    Tissue Antigens 60:319-27. 2002
    ..These results indicate that these two ARF4L peptides could be targets for immunotherapy of HLA-A2+ patients with brain tumors...
  23. pmc UDP-Gal: betaGlcNAc beta1, 3-galactosyltransferase, polypeptide 3 (GALT3) is a tumour antigen recognised by HLA-A2-restricted cytotoxic T lymphocytes from patients with brain tumour
    N Tsuda
    Department of Immunology, Kurume University School of Medicine, 67 Asohi machi, Kurume, Fukuoka 830 0011, Japan
    Br J Cancer 87:1006-12. 2002
    ..These peptides may be useful in the peptide-based specific immunotherapy for patients with malignant brain tumours...
  24. ncbi request reprint A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development
    M Nakashima
    Department of Clinical Oral Molecular Biology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka 812 8582, Japan
    Mech Dev 119:21-34. 2002
    ....
  25. ncbi request reprint Molecular cloning, functional expression and characterization of (E)-beta farnesene synthase from Citrus junos
    T Maruyama
    Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University, Japan
    Biol Pharm Bull 24:1171-5. 2001
    ..A possible reaction mechanism for terpene biosynthesis is also discussed on the basis of sequence comparison of CJFS with known sesquiterpene synthase genes...
  26. pmc Molecular events involved in up-regulating human Na+-independent neutral amino acid transporter LAT1 during T-cell activation
    T Nii
    Department of Clinical Nutrition, School of Medicine, Tokushima University, Kuramoto Cho 3, Tokushima City 770 8503, Japan
    Biochem J 358:693-704. 2001
    ..These findings indicated that a removal of the block to mRNA elongation stimulates the induction of system-L amino acid transporter gene transcripts (LAT1 and 4F2hc) in activated T-cells...
  27. ncbi request reprint Purification and properties of the cell-associated beta-xylosidase from Aureobasidium
    S Hayashi
    Faculty of Engineering, Department of Applied Chemistry, Miyazaki University, Miyazaki 889-2192, Japan
    J Ind Microbiol Biotechnol 26:276-9. 2001
    ..The Michaelis constant (K(m)) and maximum velocity (V(max)) toward p-nitrophenyl-beta-D-xyloside were 2.0 mmol l(-1) and 0.94 mmol min(-1) mg(-1) protein, respectively. The enzyme was inhibited strongly by mercury, lead, and copper ions...
  28. ncbi request reprint Identification of human CPI-17, an inhibitory phosphoprotein for myosin phosphatase
    K Yamawaki
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, 514 8507, Japan
    Biochem Biophys Res Commun 285:1040-5. 2001
    ..The cloned human CPI-17 gene indicated 4 coding exons and CPI-17beta was an alternative splice variant due to deletion of the second exon. FISH analysis located the human CPI-17 gene on chromosome 19q13.1...
  29. ncbi request reprint Molecular cloning and analysis of the 5'-flanking region of the human MYPT1 gene
    H Machida
    First Department of Internal Medicine, University School of Medicine, Tsu, Mie, Japan
    Biochim Biophys Acta 1517:424-9. 2001
    ..Luciferase reporter assays showed the presence of two regions for positive elements and one for a negative element...
  30. ncbi request reprint Purification, characterization, molecular cloning, and subcellular distribution of neutral ceramidase of rat kidney
    S Mitsutake
    Department of Bioscience and Biotechnology, Graduate School of Bioresource and Bioenvironmental Sciences, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Biol Chem 276:26249-59. 2001
    ..Interestingly, the kidney ceramidase was found to be enriched in the raft microdomains with cholesterol and GM1 ganglioside...
  31. ncbi request reprint Molecular cloning, functional expression and characterization of d-limonene synthase from Schizonepeta tenuifolia
    T Maruyama
    Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo, Japan
    Biol Pharm Bull 24:373-7. 2001
    ..Here, we report on the cloning of dLMS, and the putative stereochemical regulation mechanism is discussed based on the comparison of the deduced amino acid sequence of dLMS with those of known l-limonene synthases...
  32. pmc Molecular identification of human G-substrate, a possible downstream component of the cGMP-dependent protein kinase cascade in cerebellar Purkinje cells
    S Endo
    Laboratory for Learning and Memory, RIKEN, Brain Science Institute, Hirosawa 2 1, Wako, 351 0198, Japan
    Proc Natl Acad Sci U S A 96:2467-72. 1999
    ..However, purified G-substrate phosphorylated by cGMP-dependent protein kinase inhibited protein phosphatase 2A more effectively than protein phosphatase 1, suggesting a distinct role as a protein phosphatase inhibitor...
  33. ncbi request reprint A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation
    W Gu
    Laboratory of Biochemistry and Molecular Biology, Rockefeller University, New York, New York 10021, USA
    Mol Cell 3:97-108. 1999
    ..These findings demonstrate both positive and negative functional capabilities for the human complex, emphasize novel (CTD-independent) regulatory mechanisms, and link the complex to other human coactivator complexes...
  34. pmc The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion
    C X Yuan
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 95:7939-44. 1998
    ....
  35. pmc A gene that is related to SRY and is expressed in the testes encodes a leucine zipper-containing protein
    N Takamatsu
    Department of Biosciences, School of Science, Kitasato University, Kanagawa, Japan
    Mol Cell Biol 15:3759-66. 1995
    ..Thus, the repressed transactivation of the intact SOX-LZ in CHO cells was primarily attributable to the low level of DNA binding of SOX-LZ homodimers...
  36. ncbi request reprint Interaction of the ribosomal protein, L5, with protein phosphatase type 1
    K Hirano
    Muscle Biology Group, University of Arizona, Tucson 85721, USA
    J Biol Chem 270:19786-90. 1995
    ..These data indicate that L5 binds to the catalytic subunit of the type 1 protein phosphatase and may act as a target molecule for phosphatase in ribosomal function or other cell mechanisms...
  37. ncbi request reprint Identification of the site of interaction of the 14-3-3 protein with phosphorylated tryptophan hydroxylase
    T Ichimura
    Department of Biochemistry, Faculty of Science, Niigata University, Japan
    J Biol Chem 270:28515-8. 1995
    ..The result is consistent with the recently published crystal structure of this protein family, which suggests the importance of the negatively charged groove-like structure in the ligand binding...
  38. ncbi request reprint Isolation of cDNA clones coding for rat isovaleryl-CoA dehydrogenase and assignment of the gene to human chromosome 15
    J P Kraus
    Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510
    Genomics 1:264-9. 1987
    ..This location differs from that of the gene for medium-chain acyl-CoA dehydrogenase, a closely related enzyme, which has been previously assigned to chromosome 1...
  39. ncbi request reprint Nucleotide sequence of cDNA and predicted amino acid sequence of rat liver uricase
    M Ito
    Division of Molecular Genetics, Fujita Gakuen Health University, Aichi, Japan
    Eur J Biochem 173:459-63. 1988
    ..The complete amino acid sequence predicted for rat liver uricase was compared with that of soybean nodulin uricase and nine highly homologous regions of the two enzymes were found...
  40. ncbi request reprint Molecular cloning and nucleotide sequence of cDNAs encoding the alpha-subunit of human electron transfer flavoprotein
    G Finocchiaro
    Department of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06510
    J Biol Chem 263:15773-80. 1988
    ..The molecular sizes of the precursor and mature alpha-ETF have been estimated to be 35 and 32 kDa, respectively, by sodium dodecyl sulfate-polyacrylamide gel electrophoresis...
  41. pmc Thermosensitive omsA mutation of Escherichia coli that causes thermoregulated release of periplasmic proteins
    T Tsuruoka
    Central Research Laboratories, Meiji Seika, Ltd, Yokohama, Japan
    J Bacteriol 170:5229-35. 1988
    ..The omsA mutant may be useful for production of periplasmic proteins, which it releases into the culture medium on shift up of temperature...
  42. pmc Determinations of the DNA sequence of the mreB gene and of the gene products of the mre region that function in formation of the rod shape of Escherichia coli cells
    M Doi
    Institute of Applied Microbiology, University of Tokyo, Japan
    J Bacteriol 170:4619-24. 1988
    ..The mreB protein and some of these three proteins may function together in determination of cell shape...
  43. ncbi request reprint Structural analysis of the gene encoding rat uricase
    M Ito
    Division of Molecular Genetics, School of Medicine, Fujita Health University, Aichi, Japan
    Genomics 11:905-13. 1991
    ..The palindromic sequence is located 158 to 151 nucleotides upstream from the transcription initiation site, surrounded by a direct repeat (TCAGCAA)...
  44. pmc A unique mutation in the vitamin D receptor gene in three Japanese patients with vitamin D-dependent rickets type II: utility of single-strand conformation polymorphism analysis for heterozygous carrier detection
    T Saijo
    Department of Pediatrics, University of Tokushima School of Medicine, Japan
    Am J Hum Genet 49:668-73. 1991
    ..Single-strand conformation polymorphism analysis of amplified DNA confirmed that all patients were homozygous and that parents from one family were heterozygous carriers for this mutation...
  45. ncbi request reprint [1H and 31P magnetic resonance spectroscopy study of a case of phosphoglycerate kinase deficiency]
    M Ito
    Department of Pediatrics, Hamamatsu University School of Medicine
    No To Hattatsu 24:244-9. 1992
    ..The reason of the reduction of alanine levels was uncertain. A compensatory mechanism for energy supply to the muscle tissue was considered...
  46. ncbi request reprint Molecular cloning of chick liver HMG 2a cDNA and developmental expression of HMG 2a mRNA
    T Oka
    Department of Nutritional Chemistry, School of Medicine, University of Tokushima, Japan
    Biochim Biophys Acta 1130:224-6. 1992
    ..2.0 kb and 1.2 kb mRNAs were found in newly hatched chick liver and decreased during postnatal development of chicks...
  47. ncbi request reprint Identification of an amino acid residue involved in the substrate-binding site of rat liver uricase by site-directed mutagenesis
    M Ito
    Division of Molecular Genetics, Fujita Health University, School of Medicine, Aichi, Japan
    Biochem Biophys Res Commun 187:101-7. 1992
    ..These findings suggest that this amino acid is involved in the substrate-binding site of the enzyme...
  48. ncbi request reprint Cloning of tropomodulin cDNA and localization of gene transcripts during mouse embryogenesis
    M Ito
    Institute for Genetic Medicine, University of Southern California School of Medicine, Los Angeles 90033
    Dev Biol 167:317-28. 1995
    ....
  49. ncbi request reprint Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase
    H Shimizu
    First Department of Internal Medicine, Mie University School of Medicine, Japan
    J Biol Chem 269:30407-11. 1994
    ..Myosin binding and binding to the catalytic subunit are properties of a 58,000-Da fragment that represents the N-terminal part of the molecule...
  50. ncbi request reprint Evidence for the role of human immunodeficiency virus type 1 Nef protein as a growth inhibitor to CD4+ T lymphocytes and for the blocking of the Nef function by anti-Nef antibodies
    Y Fujii
    Institute for Laboratory Animal Research, Nagoya University School of Medicine, Japan
    Vaccine 11:837-47. 1993
    ....
  51. ncbi request reprint Alternative splicing generates isoforms of human neuron-derived orphan receptor-1 (NOR-1) mRNA
    N Ohkura
    Institute of Biomedical Science, TERUMO R and D Center, Kanagawa 258 0000, Japan
    Gene 211:79-85. 1998
    ....
  52. ncbi request reprint A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping
    M Fujioka
    First Department of Internal Medicine, Mie University School of Medicine, Japan
    Genomics 49:59-68. 1998
    ..1, compared to the chromosomal location 12q15-q21-2 for MYPT1. It is suggested that the products of the two gene families of myosin phosphatase target subunit may be localized differently among various tissues...
  53. ncbi request reprint cDNA cloning of a novel rainbow trout SRY-type HMG box protein, rtSox23, and its functional analysis
    A Yamashita
    Department of Biosciences, School of Science, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228, Japan
    Gene 209:193-200. 1998
    ..The rainbow trout p62 mRNA was also prominent in ovary and brain. Taken together, these results suggest that the rainbow trout p62 associates with rtSox23 in vivo and modulates the function of rtSox23...
  54. ncbi request reprint cDNA cloning of a new member of the FTZ-F1 subfamily from a rainbow trout
    M Ito
    Department of Biosciences, School of Science, Kitasato University, Kanagawa, Japan
    Biochim Biophys Acta 1395:271-4. 1998
    ..On the other hand, the overall homology between tFZR1 and zebrafish FTZ-F1 is low (33.0%). The results indicate that tFZR1 is a new member of fushitarazu factor 1 (FTZ-F1) subfamily...
  55. ncbi request reprint Rainbow trout SOX9: cDNA cloning, gene structure and expression
    N Takamatsu
    Department of Biosciences, School of Science, Kitasato University, Sagamihara, Kanagawa, Japan
    Gene 202:167-70. 1997
    ..The rainbow trout and human SOX9 genes show a similar gene structure, and the two introns in the coding region are located at conserved positions. In rainbow trout, the SOX9 mRNA was prominent in testis and brain...
  56. ncbi request reprint Isolation and characterization of mouse high-glycine/tyrosine proteins
    N Aoki
    Department of Dermatology, Niigata University School of Medicine, Niigata, Japan
    J Biol Chem 272:30512-8. 1997
    ..The novel findings that each gene is activated transcriptionally with a distinct expression pattern spatially and temporally suggest that there is a remarkable difference in the distribution of these proteins in hair...
  57. ncbi request reprint Interaction of smooth muscle myosin phosphatase with phospholipids
    M Ito
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    Biochemistry 36:7607-14. 1997
    ..This mechanism could be important in localization of myosin phosphatase and in targeting substrates at different loci...
  58. ncbi request reprint Structure, mapping and expression of a human NOR-1 gene, the third member of the Nur77/NGFI-B family
    N Ohkura
    Institute of Biomedical Science, TERUMO R and D Center, Kanagawa, Japan
    Biochim Biophys Acta 1308:205-14. 1996
    ..This suggests that the Nur77/NGFI-B family has evolved from a common ancestral gene. Fluorescence in situ hybridization (FISH) revealed that the gene is located on chromosome 9q...
  59. pmc Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho
    T Matsui
    Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma, Japan
    EMBO J 15:2208-16. 1996
    ..Thus it is likely that Rho-kinase is a putative target serine/threonine kinase for Rho and serves as a mediator of the Rho-dependent signaling pathway...
  60. ncbi request reprint The substrate-binding site in Escherichia coli cyclophilin A preferably recognizes a cis-proline isomer or a highly distorted form of the trans isomer
    M Konno
    Department of Chemistry, Faculty of Science Ochanomizu University, Tokyo, Japan
    J Mol Biol 256:897-908. 1996
    ..coli CyPA forming a complex with CsA. Thus, the extra amino acid residue of E. coli CyPA, polar Gln89, lies along the pathway to the hydrophobic pocket of CyPA and seems to prevent the access hydrophobic part of CsA to the cleft of CyPA...
  61. ncbi request reprint Immunological and physical characterization of the brain G protein-gated muscarinic potassium channel
    A Inanobe
    Department of Cell Biology and Signaling, Yamagata University School of Medicine, Japan
    Biochem Biophys Res Commun 217:1238-44. 1995
    ..These results suggest that the KG channel is most likely a tetrameric macroprotein composed of GIRK1 and co-immunoprecipitated proteins in the forebrain...
  62. pmc Possible involvement of inefficient cleavage of preprovasopressin by signal peptidase as a cause for familial central diabetes insipidus
    M Ito
    First Department of Internal Medicine, Nagoya University School of Medicine, Aichi, Japan
    J Clin Invest 91:2565-71. 1993
    ..These data suggest that inefficient processing of preproVP produced by the mutant allele is possibly involved in the pathogenesis of diabetes insipidus in the affected individuals...
  63. ncbi request reprint Molecular cloning of a cDNA encoding a novel fatty acid-binding protein from rat skin
    R Watanabe
    Department of Biochemistry, Niigata University School of Medicine, Japan
    Biochem Biophys Res Commun 200:253-9. 1994
    ..1 kDa and exhibits around 50% identity to myelin P2 protein, adipocyte FABP and heart FABP. Our results propose that C-FABP is a new member of the FABP family...
  64. ncbi request reprint Mutation of E1 alpha gene in a female patient with pyruvate dehydrogenase deficiency due to rapid degradation of E1 protein
    M Ito
    Department of Pediatrics School of Medicine, University of Tokushima, Japan
    J Inherit Metab Dis 15:848-56. 1992
    ..The mutant alpha subunit protein failed to form a stable structure of pyruvate dehydrogenase, so that both alpha and beta subunit proteins were degraded rapidly...