Research Topics
Genomes and Genes | Hiroshi TsunekiSummaryAffiliation: Toyama Medical and Pharmaceutical University Country: Japan Publications
| Collaborators
|
Detail Information
Publications
Marine alkaloids (-)-pictamine and (-)-lepadin B block neuronal nicotinic acetylcholine receptorsHiroshi Tsuneki
Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, Japan
Biol Pharm Bull 28:611-4. 2005....- Alkaloids indolizidine 235B', quinolizidine 1-epi-207I, and the tricyclic 205B are potent and selective noncompetitive inhibitors of nicotinic acetylcholine receptorsHiroshi Tsuneki
Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930 0194, Japan
Mol Pharmacol 66:1061-9. 2004.... - Nicotinic enhancement of proliferation in bovine and porcine cerebral microvascular endothelial cellsHiroshi Tsuneki
Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, Toyama, Japan
Biol Pharm Bull 27:1951-6. 2004..These results demonstrate that nicotinic stimulation promotes the proliferation of bovine and porcine cerebral microvascular endothelial cells, at least in part, through the MAP kinase activation... - Antiangiogenic activity of beta-eudesmol in vitro and in vivoHiroshi Tsuneki
Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
Eur J Pharmacol 512:105-15. 2005..These results indicate that beta-eudesmol inhibits angiogenesis, at least in part, through the blockade of the ERK signaling pathway. We considered that beta-eudesmol may aid the development of drugs to treat angiogenic diseases... 
Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humansHiroshi Tsuneki
Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
BMC Pharmacol 4:18. 2004..The present study was aimed at providing evidence of improvement in glucose metabolism in diabetic mice and healthy humans upon green tea consumption...
The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesio interthalamica and medial temporal lobe structuresTsutomu Takahashi
Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
Prog Neuropsychopharmacol Biol Psychiatry 32:1236-42. 2008....- The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophreniaTsutomu Takahashi
Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
Psychiatry Res 172:128-35. 2009..Our findings also suggest that the DISC1 genotype variation might have some relevance to the medication effect on brain morphology in schizophrenia... - Central versus peripheral impact of estradiol on the impaired glucose metabolism in ovariectomized mice on a high-fat dietRika Yonezawa
Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
Am J Physiol Endocrinol Metab 303:E445-56. 2012.... - Impact of lipid phosphatases SHIP2 and PTEN on the time- and Akt-isoform-specific amelioration of TNF-alpha-induced insulin resistance in 3T3-L1 adipocytesMariko Ikubo
Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
Am J Physiol Endocrinol Metab 296:E157-64. 2009.... - Role of orexin in the central regulation of glucose and energy homeostasisHiroshi Tsuneki
Department of Clinical Pharmacology, University of Toyama, Toyama 930 0194, Japan
Endocr J 59:365-74. 2012..Taken together, hypothalamic orexin system may manage multiple tasks to coordinate the interconnection among the arousal, feeding, circadian, and glucose homeostasis pathways... - Both type I and II IFN induce insulin resistance by inducing different isoforms of SOCS expression in 3T3-L1 adipocytesTsutomu Wada
Department of Clinical Pharmacology, University of Toyama, Sugitani, Toyama, Japan
Am J Physiol Endocrinol Metab 300:E1112-23. 2011.... - Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose dietTsutomu Wada
Department of Clinical Pharmacology, University of Toyama, Toyama 930 0194, Japan
Endocrinology 151:2040-9. 2010..These results indicate that inhibition of mineralocorticoid receptor might be a beneficial therapeutic approach for diet-induced phenotypes of metabolic syndrome and fatty liver... - Impact of transgenic overexpression of SH2-containing inositol 5'-phosphatase 2 on glucose metabolism and insulin signaling in miceSyota Kagawa
Department of Clinical Pharmacology, University of Toyama, Toyama, Japan
Endocrinology 149:642-50. 2008.... - The inositol phosphatase SHIP2 negatively regulates insulin/IGF-I actions implicated in neuroprotection and memory function in mouse brainYoshiyuki Soeda
Department of Clinical Pharmacology, University of Toyama, Toyama, Japan
Mol Endocrinol 24:1965-77. 2010..These results suggest that SHIP2 is a potent negative regulator of insulin/IGF-I actions in the brain, and excess amounts of SHIP2 may be related, at least in part, to brain dysfunction in insulin resistance with type 2 diabetes... - Flexible synthesis of poison-frog alkaloids of the 5,8-disubstituted indolizidine-class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B", (-)-221I, and an epimer of 193E and pharmacological effects at neuronal nicotinic acetylcholine receptoSoushi Kobayashi
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama, 930 0194, Japan
Beilstein J Org Chem 3:30. 2007.... - Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptorsNaoki Toyooka
Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama 930 0194, Japan
Bioorg Med Chem Lett 17:5872-5. 2007..Thus, based on these studies, it would appear that C4 substituents greater in length than the allyl of 1-epi-207I reduce alpha7-potency without affecting alpha4beta2-potency... - Coenzyme Q10 prevents high glucose-induced oxidative stress in human umbilical vein endothelial cellsHiroshi Tsuneki
Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
Eur J Pharmacol 566:1-10. 2007..Thus, we provide the first evidence that coenzyme Q10 has a beneficial effect in protecting against the endothelial dysfunction by high glucose-induced oxidative stress in vitro... - Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cellsTsutomu Wada
Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
Endocrinology 148:790-9. 2007.... - Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytesTsutomu Wada
Department of Clinical Pharmacology, University of Toyama, Sugitani, Toyama, Japan
Endocrinology 150:1662-9. 2009..Thus, aldosterone appears to be a novel key factor in the development of insulin resistance in visceral obesity... - Comparative study on the combined effects of bunazosin and nipradilol or timolol on intraocular pressure in normotensive rabbitsMasahiro Orihashi
Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan
Jpn J Ophthalmol 49:523-6. 2005.... - Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesityToshiyasu Sasaoka
Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
Pharmacol Ther 112:799-809. 2006..Inhibition of PTEN in the tissues specifically targeted, including skeletal muscle and fat, may result in an amelioration of insulin resistance in type 2 diabetes, although caution against the formation of tumors is needed... - Impact of SRC homology 2-containing inositol 5'-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signalingSyota Kagawa
Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
J Clin Endocrinol Metab 90:2911-9. 2005..These results indicate that the polymorphisms of SHIP2 are implicated, at least in part, in type 2 diabetes, possibly by affecting the metabolic and/or mitogenic insulin signaling in the Japanese population... - Novel G423S mutation of human alpha7 nicotinic receptor promotes agonist-induced desensitization by a protein kinase C-dependent mechanismHiroshi Tsuneki
Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
Mol Pharmacol 71:777-86. 2007..Thus, we provide the first evidence that a variant in the human CHRNA7 gene alters the function of alpha7 nicotinic receptors... - Characteristics of signalling properties mediated by long-acting insulin analogue glargine and detemir in target cells of insulinTsutomu Wada
Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
Diabetes Res Clin Pract 81:269-77. 2008..In contrast, detemir-induced metabolic signaling is less potent in all cell types studied, and is reduced further by increasing concentrations of albumin... - Altered subcellular distribution of estrogen receptor alpha is implicated in estradiol-induced dual regulation of insulin signaling in 3T3-L1 adipocytesKiyofumi Nagira
Department of Clinical Pharmacology, University of Toyama, Japan
Endocrinology 147:1020-8. 2006.... - Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisonsTsutomu Takahashi
Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
Neurosci Lett 435:34-9. 2008.... - [Modulation of excitability in midbrain dopaminergic neurons and skeletal muscles by neuronal nicotinic receptors: perspectives from knockout mice]Hiroshi Tsuneki
Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
Nippon Yakurigaku Zasshi 122:18P-21P. 2003..Thus, the approach based on natural products can still provide a great advantage for producing novel therapeutics... - Inhibitory effect of nifedipine on tumor necrosis factor alpha-induced neovascularization in cultured choroidal explants of streptozotocin-diabetic ratShinjiro Kobayashi
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University, 3 Ho Kanagawa Machi, Kanazawa 920 1181, Japan
Biol Pharm Bull 28:242-6. 2005..Nifedipine inhibited the action of TNF alpha probably by blocking voltage-dependent Ca2+ channels in the endothelial progenitor cells of the diabetic choroid... - Reduction of blood glucose level by orexins in fasting normal and streptozotocin-diabetic miceHiroshi Tsuneki
Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
Eur J Pharmacol 448:245-52. 2002..These results demonstrate that orexins lower the blood glucose levels exclusively in the fasting state. The orexins may stimulate some neural and hormonal network and thereby promote blood glucose utilization... - Robust stimulation of TrkB induces delayed increases in BDNF and Arc mRNA expressions in cultured rat cortical neurons via distinct mechanismsMakoto Yasuda
Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan
J Neurochem 103:626-36. 2007.... - Potent reduction of intraocular pressure by nipradilol plus latanoprost in ocular hypertensive rabbitsMasahiro Orihashi
Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani, Japan
Biol Pharm Bull 28:65-8. 2005....