Hiroshi Tsuneki

Summary

Affiliation: Toyama Medical and Pharmaceutical University
Country: Japan

Publications

  1. ncbi request reprint Antiangiogenic activity of beta-eudesmol in vitro and in vivo
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Eur J Pharmacol 512:105-15. 2005
  2. ncbi request reprint Alkaloids indolizidine 235B', quinolizidine 1-epi-207I, and the tricyclic 205B are potent and selective noncompetitive inhibitors of nicotinic acetylcholine receptors
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930 0194, Japan
    Mol Pharmacol 66:1061-9. 2004
  3. ncbi request reprint Nicotinic enhancement of proliferation in bovine and porcine cerebral microvascular endothelial cells
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Biol Pharm Bull 27:1951-6. 2004
  4. ncbi request reprint Marine alkaloids (-)-pictamine and (-)-lepadin B block neuronal nicotinic acetylcholine receptors
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, Japan
    Biol Pharm Bull 28:611-4. 2005
  5. pmc Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    BMC Pharmacol 4:18. 2004
  6. doi request reprint The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 172:128-35. 2009
  7. ncbi request reprint The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesio interthalamica and medial temporal lobe structures
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1236-42. 2008
  8. doi request reprint Cilostazol ameliorates systemic insulin resistance in diabetic db/db mice by suppressing chronic inflammation in adipose tissue via modulation of both adipocyte and macrophage functions
    Tsutomu Wada
    Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Eur J Pharmacol 707:120-9. 2013
  9. doi request reprint Central versus peripheral impact of estradiol on the impaired glucose metabolism in ovariectomized mice on a high-fat diet
    Rika Yonezawa
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    Am J Physiol Endocrinol Metab 303:E445-56. 2012
  10. doi request reprint Impact of lipid phosphatases SHIP2 and PTEN on the time- and Akt-isoform-specific amelioration of TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes
    Mariko Ikubo
    Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Am J Physiol Endocrinol Metab 296:E157-64. 2009

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Antiangiogenic activity of beta-eudesmol in vitro and in vivo
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Eur J Pharmacol 512:105-15. 2005
    ..These results indicate that beta-eudesmol inhibits angiogenesis, at least in part, through the blockade of the ERK signaling pathway. We considered that beta-eudesmol may aid the development of drugs to treat angiogenic diseases...
  2. ncbi request reprint Alkaloids indolizidine 235B', quinolizidine 1-epi-207I, and the tricyclic 205B are potent and selective noncompetitive inhibitors of nicotinic acetylcholine receptors
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930 0194, Japan
    Mol Pharmacol 66:1061-9. 2004
    ....
  3. ncbi request reprint Nicotinic enhancement of proliferation in bovine and porcine cerebral microvascular endothelial cells
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Biol Pharm Bull 27:1951-6. 2004
    ..These results demonstrate that nicotinic stimulation promotes the proliferation of bovine and porcine cerebral microvascular endothelial cells, at least in part, through the MAP kinase activation...
  4. ncbi request reprint Marine alkaloids (-)-pictamine and (-)-lepadin B block neuronal nicotinic acetylcholine receptors
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, Japan
    Biol Pharm Bull 28:611-4. 2005
    ....
  5. pmc Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    BMC Pharmacol 4:18. 2004
    ..The present study was aimed at providing evidence of improvement in glucose metabolism in diabetic mice and healthy humans upon green tea consumption...
  6. doi request reprint The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 172:128-35. 2009
    ..Our findings also suggest that the DISC1 genotype variation might have some relevance to the medication effect on brain morphology in schizophrenia...
  7. ncbi request reprint The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesio interthalamica and medial temporal lobe structures
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1236-42. 2008
    ....
  8. doi request reprint Cilostazol ameliorates systemic insulin resistance in diabetic db/db mice by suppressing chronic inflammation in adipose tissue via modulation of both adipocyte and macrophage functions
    Tsutomu Wada
    Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Eur J Pharmacol 707:120-9. 2013
    ..Thus, the present study reveals an additional benefit in the use of cilostazol in the treatment of patients with type 2 diabetes...
  9. doi request reprint Central versus peripheral impact of estradiol on the impaired glucose metabolism in ovariectomized mice on a high-fat diet
    Rika Yonezawa
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    Am J Physiol Endocrinol Metab 303:E445-56. 2012
    ....
  10. doi request reprint Impact of lipid phosphatases SHIP2 and PTEN on the time- and Akt-isoform-specific amelioration of TNF-alpha-induced insulin resistance in 3T3-L1 adipocytes
    Mariko Ikubo
    Department of Internal Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Am J Physiol Endocrinol Metab 296:E157-64. 2009
    ....
  11. doi request reprint Hypothalamic orexin prevents hepatic insulin resistance induced by social defeat stress in mice
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama, Japan
    Neuropeptides 47:213-9. 2013
    ....
  12. ncbi request reprint Role of orexin in the central regulation of glucose and energy homeostasis
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, University of Toyama, Toyama 930 0194, Japan
    Endocr J 59:365-74. 2012
    ..Taken together, hypothalamic orexin system may manage multiple tasks to coordinate the interconnection among the arousal, feeding, circadian, and glucose homeostasis pathways...
  13. doi request reprint Both type I and II IFN induce insulin resistance by inducing different isoforms of SOCS expression in 3T3-L1 adipocytes
    Tsutomu Wada
    Department of Clinical Pharmacology, University of Toyama, Sugitani, Toyama, Japan
    Am J Physiol Endocrinol Metab 300:E1112-23. 2011
    ....
  14. doi request reprint Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose diet
    Tsutomu Wada
    Department of Clinical Pharmacology, University of Toyama, Toyama 930 0194, Japan
    Endocrinology 151:2040-9. 2010
    ..These results indicate that inhibition of mineralocorticoid receptor might be a beneficial therapeutic approach for diet-induced phenotypes of metabolic syndrome and fatty liver...
  15. ncbi request reprint Impact of transgenic overexpression of SH2-containing inositol 5'-phosphatase 2 on glucose metabolism and insulin signaling in mice
    Syota Kagawa
    Department of Clinical Pharmacology, University of Toyama, Toyama, Japan
    Endocrinology 149:642-50. 2008
    ....
  16. doi request reprint Protective effects of coenzyme Q10 against angiotensin II-induced oxidative stress in human umbilical vein endothelial cells
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, University of Toyama, Toyama, Japan
    Eur J Pharmacol 701:218-27. 2013
    ....
  17. ncbi request reprint Coenzyme Q10 prevents high glucose-induced oxidative stress in human umbilical vein endothelial cells
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Eur J Pharmacol 566:1-10. 2007
    ..Thus, we provide the first evidence that coenzyme Q10 has a beneficial effect in protecting against the endothelial dysfunction by high glucose-induced oxidative stress in vitro...
  18. ncbi request reprint Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors
    Naoki Toyooka
    Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama 930 0194, Japan
    Bioorg Med Chem Lett 17:5872-5. 2007
    ..Thus, based on these studies, it would appear that C4 substituents greater in length than the allyl of 1-epi-207I reduce alpha7-potency without affecting alpha4beta2-potency...
  19. pmc Flexible synthesis of poison-frog alkaloids of the 5,8-disubstituted indolizidine-class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B", (-)-221I, and an epimer of 193E and pharmacological effects at neuronal nicotinic acetylcholine recepto
    Soushi Kobayashi
    Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama, 930 0194, Japan
    Beilstein J Org Chem 3:30. 2007
    ....
  20. doi request reprint The inositol phosphatase SHIP2 negatively regulates insulin/IGF-I actions implicated in neuroprotection and memory function in mouse brain
    Yoshiyuki Soeda
    Department of Clinical Pharmacology, University of Toyama, Toyama, Japan
    Mol Endocrinol 24:1965-77. 2010
    ..These results suggest that SHIP2 is a potent negative regulator of insulin/IGF-I actions in the brain, and excess amounts of SHIP2 may be related, at least in part, to brain dysfunction in insulin resistance with type 2 diabetes...
  21. ncbi request reprint Impact of SRC homology 2-containing inositol 5'-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signaling
    Syota Kagawa
    Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Clin Endocrinol Metab 90:2911-9. 2005
    ..These results indicate that the polymorphisms of SHIP2 are implicated, at least in part, in type 2 diabetes, possibly by affecting the metabolic and/or mitogenic insulin signaling in the Japanese population...
  22. ncbi request reprint Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cells
    Tsutomu Wada
    Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Endocrinology 148:790-9. 2007
    ....
  23. doi request reprint Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes
    Tsutomu Wada
    Department of Clinical Pharmacology, University of Toyama, Sugitani, Toyama, Japan
    Endocrinology 150:1662-9. 2009
    ..Thus, aldosterone appears to be a novel key factor in the development of insulin resistance in visceral obesity...
  24. ncbi request reprint Comparative study on the combined effects of bunazosin and nipradilol or timolol on intraocular pressure in normotensive rabbits
    Masahiro Orihashi
    Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Jpn J Ophthalmol 49:523-6. 2005
    ..To compare the ocular hypotensive effect of nipradilol and timolol in combination with bunazosin in rabbits...
  25. ncbi request reprint Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity
    Toshiyasu Sasaoka
    Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Pharmacol Ther 112:799-809. 2006
    ..Inhibition of PTEN in the tissues specifically targeted, including skeletal muscle and fat, may result in an amelioration of insulin resistance in type 2 diabetes, although caution against the formation of tumors is needed...
  26. ncbi request reprint Novel G423S mutation of human alpha7 nicotinic receptor promotes agonist-induced desensitization by a protein kinase C-dependent mechanism
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Mol Pharmacol 71:777-86. 2007
    ..Thus, we provide the first evidence that a variant in the human CHRNA7 gene alters the function of alpha7 nicotinic receptors...
  27. ncbi request reprint Characteristics of signalling properties mediated by long-acting insulin analogue glargine and detemir in target cells of insulin
    Tsutomu Wada
    Department of Clinical Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Diabetes Res Clin Pract 81:269-77. 2008
    ..In contrast, detemir-induced metabolic signaling is less potent in all cell types studied, and is reduced further by increasing concentrations of albumin...
  28. doi request reprint Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2)
    Yoshinori Ichihara
    Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930 0194, Japan
    Eur J Med Chem 62:649-60. 2013
    ..CPDA was found to enhance in vitro insulin signaling through the Akt pathway more efficiently than the previously reported SHIP2 inhibitor AS1949490, and ameliorated abnormal glucose metabolism in diabetic (db/db) mice...
  29. doi request reprint Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Neurosci Lett 435:34-9. 2008
    ....
  30. ncbi request reprint Altered subcellular distribution of estrogen receptor alpha is implicated in estradiol-induced dual regulation of insulin signaling in 3T3-L1 adipocytes
    Kiyofumi Nagira
    Department of Clinical Pharmacology, University of Toyama, Japan
    Endocrinology 147:1020-8. 2006
    ....
  31. ncbi request reprint Type II pyrethroid deltamethrin produces antidepressant-like effects in mice
    Ichiro Takasaki
    Department of Pharmacology, Graduate School of Science and Engineering, University of Toyama, 3190 Gofuku, Toyama 930 8555, Japan Molecular Genetic Research, Life Science Research Center, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan Electronic address
    Behav Brain Res 257:182-8. 2013
    ..The results of the present study suggest that DM possesses antidepressant-like properties, and may be a possible source for the development of drugs to treat neurodegenerative and psychiatric disorders including depression. ..
  32. ncbi request reprint Inhibitory effect of nifedipine on tumor necrosis factor alpha-induced neovascularization in cultured choroidal explants of streptozotocin-diabetic rat
    Shinjiro Kobayashi
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Hokuriku University, 3 Ho Kanagawa Machi, Kanazawa 920 1181, Japan
    Biol Pharm Bull 28:242-6. 2005
    ..Nifedipine inhibited the action of TNF alpha probably by blocking voltage-dependent Ca2+ channels in the endothelial progenitor cells of the diabetic choroid...
  33. ncbi request reprint [Modulation of excitability in midbrain dopaminergic neurons and skeletal muscles by neuronal nicotinic receptors: perspectives from knockout mice]
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Nihon Yakurigaku Zasshi 122:18P-21P. 2003
    ..Thus, the approach based on natural products can still provide a great advantage for producing novel therapeutics...
  34. ncbi request reprint Reduction of blood glucose level by orexins in fasting normal and streptozotocin-diabetic mice
    Hiroshi Tsuneki
    Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Eur J Pharmacol 448:245-52. 2002
    ..These results demonstrate that orexins lower the blood glucose levels exclusively in the fasting state. The orexins may stimulate some neural and hormonal network and thereby promote blood glucose utilization...
  35. ncbi request reprint Robust stimulation of TrkB induces delayed increases in BDNF and Arc mRNA expressions in cultured rat cortical neurons via distinct mechanisms
    Makoto Yasuda
    Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan
    J Neurochem 103:626-36. 2007
    ....
  36. ncbi request reprint Potent reduction of intraocular pressure by nipradilol plus latanoprost in ocular hypertensive rabbits
    Masahiro Orihashi
    Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Biol Pharm Bull 28:65-8. 2005
    ....