Michio Suzuki

Summary

Affiliation: Toyama Medical and Pharmaceutical University
Country: Japan

Publications

  1. ncbi request reprint Anomalous cerebral asymmetry in patients with schizophrenia demonstrated by voxel-based morphometry
    Yasuhiro Kawasaki
    Department of Neuropsychiatry, University of Toyama School of Medicine, Toyama, Japan
    Biol Psychiatry 63:793-800. 2008
  2. ncbi request reprint Regional changes in brain gray and white matter in patients with schizophrenia demonstrated with voxel-based analysis of MRI
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 55:41-54. 2002
  3. ncbi request reprint Male-specific volume expansion of the human hippocampus during adolescence
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Cereb Cortex 15:187-93. 2005
  4. ncbi request reprint Prefrontal abnormalities in patients with simple schizophrenia: structural and functional brain-imaging studies in five cases
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 140:157-71. 2005
  5. ncbi request reprint Volume reduction of the right anterior limb of the internal capsule in patients with schizotypal disorder
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 130:213-25. 2004
  6. ncbi request reprint Differential contributions of prefrontal and temporolimbic pathology to mechanisms of psychosis
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Brain 128:2109-22. 2005
  7. ncbi request reprint Morphological brain changes associated with Schneider's first-rank symptoms in schizophrenia: a MRI study
    M Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Psychol Med 35:549-60. 2005
  8. doi request reprint Association between absence of the adhesio interthalamica and amygdala volume in schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 162:101-11. 2008
  9. doi request reprint The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 172:128-35. 2009
  10. doi request reprint The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesio interthalamica and medial temporal lobe structures
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1236-42. 2008

Collaborators

Detail Information

Publications75

  1. ncbi request reprint Anomalous cerebral asymmetry in patients with schizophrenia demonstrated by voxel-based morphometry
    Yasuhiro Kawasaki
    Department of Neuropsychiatry, University of Toyama School of Medicine, Toyama, Japan
    Biol Psychiatry 63:793-800. 2008
    ..We sought to clarify in which brain regions of the patient the normal cerebral asymmetry is disrupted and the extent of disruption...
  2. ncbi request reprint Regional changes in brain gray and white matter in patients with schizophrenia demonstrated with voxel-based analysis of MRI
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 55:41-54. 2002
    ..Reduced white matter in the connecting bundles, which was first found in this study, may imply morphological substrates for abnormalities in the fronto-thalamic and fronto-temporolimbic connectivity in schizophrenia...
  3. ncbi request reprint Male-specific volume expansion of the human hippocampus during adolescence
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Cereb Cortex 15:187-93. 2005
    ..The possible relevance of these findings to progress in myelination and implications in psychiatric disorders were discussed...
  4. ncbi request reprint Prefrontal abnormalities in patients with simple schizophrenia: structural and functional brain-imaging studies in five cases
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 140:157-71. 2005
    ..It is also suggested that simple schizophrenia may occupy an extreme position of the schizophrenic continuum where the prefrontal deficits and negative symptoms are most purely manifested...
  5. ncbi request reprint Volume reduction of the right anterior limb of the internal capsule in patients with schizotypal disorder
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 130:213-25. 2004
    ..Volume deficit confined to the right ALIC suggests that limited involvement of the fronto-thalamic connectivity may have some relevance to the sparing of schizotypal patients from the development of overt psychosis...
  6. ncbi request reprint Differential contributions of prefrontal and temporolimbic pathology to mechanisms of psychosis
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Brain 128:2109-22. 2005
    ....
  7. ncbi request reprint Morphological brain changes associated with Schneider's first-rank symptoms in schizophrenia: a MRI study
    M Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Psychol Med 35:549-60. 2005
    ..To clarify the brain morphological basis for the production of these symptoms, volumes of the frontal and medial temporal regions and their clinical correlates were examined in patients with schizophrenia...
  8. doi request reprint Association between absence of the adhesio interthalamica and amygdala volume in schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 162:101-11. 2008
    ....
  9. doi request reprint The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 172:128-35. 2009
    ..Our findings also suggest that the DISC1 genotype variation might have some relevance to the medication effect on brain morphology in schizophrenia...
  10. doi request reprint The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesio interthalamica and medial temporal lobe structures
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1236-42. 2008
    ....
  11. ncbi request reprint Volume reduction of the left planum temporale gray matter associated with long duration of untreated psychosis in schizophrenia: a preliminary report
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 154:209-19. 2007
    ....
  12. ncbi request reprint Parietal lobe volume deficits in schizophrenia spectrum disorders
    Shi Yu Zhou
    Department of Neuropsychiatry, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 89:35-48. 2007
    ..The additional volume alterations in schizophrenia may support the notion that a deficit in the posterior parietal region is critical for the manifestation of overt psychotic symptoms...
  13. ncbi request reprint Morphologic alterations of the parcellated superior temporal gyrus in schizophrenia spectrum
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 83:131-43. 2006
    ....
  14. ncbi request reprint Bilateral volume reduction of the insular cortex in patients with schizophrenia: a volumetric MRI study
    Tsutomu Takahashi
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 131:185-94. 2004
    ..The findings of this study suggest that there is a possible progressive loss of the gray matter volume of the bilateral insular cortices subsequent to the onset of schizophrenia...
  15. ncbi request reprint Lack of normal gender differences of the perigenual cingulate gyrus in schizophrenia spectrum disorders. A magnetic resonance imaging study
    Tsutomu Takahashi
    Dept of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Eur Arch Psychiatry Clin Neurosci 254:273-80. 2004
    ..These results suggest that both schizotypal and schizophrenia patients may share the same disruption of the normal pattern of gender differences of the perigenual cingulate gyrus...
  16. doi request reprint A follow-up MRI study of the superior temporal subregions in schizotypal disorder and first-episode schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 119:65-74. 2010
    ....
  17. doi request reprint Longitudinal MRI study of the pituitary volume in chronic schizophrenia: a preliminary report
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan
    Psychiatry Res 202:84-7. 2012
    ....
  18. ncbi request reprint Volumetric magnetic resonance imaging study of the anterior cingulate gyrus in schizotypal disorder
    Tsutomu Takahashi
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Eur Arch Psychiatry Clin Neurosci 252:268-77. 2002
    ..These results suggest that both schizotypal and schizophrenic subjects share, at least in part, the same cerebral asymmetry abnormalities...
  19. doi request reprint Neonatal exposure to MK-801, an N-methyl-D-aspartate receptor antagonist, enhances methamphetamine-induced locomotion and disrupts sensorimotor gating in pre- and postpubertal rats
    Takashi Uehara
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Sugitani, Toyama, Japan
    Brain Res 1352:223-30. 2010
    ..These findings suggest that transient exposure to MK-801 in the neonatal stage causes exaggerated dopamine transmission and cognitive deficits, particularly in the post-puberty stage...
  20. doi request reprint Volume reduction and altered sulco-gyral pattern of the orbitofrontal cortex in first-episode schizophrenia
    Yoichiro Takayanagi
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 121:55-65. 2010
    ..In addition, it remains elusive whether the OFC morphology in first-episode patients is related to their clinical features...
  21. doi request reprint The relationship between prefrontal brain volume and characteristics of memory strategy in schizophrenia spectrum disorders
    Mie Matsui
    Department of Neuropsychology, Graduate School of Medicine, University of Toyama, Toyama, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1854-62. 2008
    ..The findings for schizotypal patients suggest a compensation mechanism to remember the words using a serial processing strategy is at work when the inferior frontal gyrus cannot mediate semantic processing...
  22. doi request reprint Effect of perospirone on P300 electrophysiological activity and social cognition in schizophrenia: a three-dimensional analysis with sloreta
    Tomiki Sumiyoshi
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan
    Psychiatry Res 172:180-3. 2009
    ..The distinct cognition-enhancing profile of perospirone in patients with schizophrenia may be related to its actions on 5-HT(1A) receptors...
  23. ncbi request reprint Prevalence of large cavum septi pellucidi and its relation to the medial temporal lobe structures in schizophrenia spectrum
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:1235-41. 2007
    ..These findings might reflect neurodevelopmental abnormalities in midline and associated limbic structures of the brain in schizophrenia spectrum...
  24. doi request reprint Change in the expression of myelination/oligodendrocyte-related genes during puberty in the rat brain
    Tadasu Matsuoka
    Department of Neuropsychiatry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Neural Transm 117:1265-8. 2010
    ..As these genes have been reported to be diminished in the brain of patients with schizophrenia, the results of this study suggest an exaggerated maturation process may contribute to the pathogenesis of psychotic disorders...
  25. ncbi request reprint Volume reduction of the amygdala in patients with schizophrenia: a magnetic resonance imaging study
    Lisha Niu
    Department of Psychology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 132:41-51. 2004
    ..The results may be important for understanding the role of the amygdala in the pathophysiology of schizophrenia and the anatomical substrates of gender difference in the expressions of the illness...
  26. doi request reprint Long-term effects of neonatal MK-801 treatment on prepulse inhibition in young adult rats
    Takashi Uehara
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama, Japan
    Psychopharmacology (Berl) 206:623-30. 2009
    ..Neonatal treatment of rats with non-competitive NMDA antagonists has been shown to induce behavioral abnormality in a later period...
  27. doi request reprint Volume reductions in frontopolar and left perisylvian cortices in methamphetamine induced psychosis
    Yuta Aoki
    Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 147:355-61. 2013
    ....
  28. doi request reprint Longitudinal MRI study of the midline brain regions in first-episode schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
    Psychiatry Res 212:150-3. 2013
    ..The CSP showed no group difference. These results suggest a role for the AI as a possible neurodevelopmental marker of schizophrenia...
  29. ncbi request reprint Temporal lobe gray matter in schizophrenia spectrum: a volumetric MRI study of the fusiform gyrus, parahippocampal gyrus, and middle and inferior temporal gyri
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 87:116-26. 2006
    ....
  30. doi request reprint Reduced amygdala and hippocampal volumes in patients with methamphetamine psychosis
    Lina Orikabe
    Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Schizophr Res 132:183-9. 2011
    ....
  31. ncbi request reprint Volumetric analysis of sulci/gyri-defined in vivo frontal lobe regions in schizophrenia: Precentral gyrus, cingulate gyrus, and prefrontal region
    Shi Yu Zhou
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 139:127-39. 2005
    ....
  32. ncbi request reprint Proton magnetic resonance spectroscopy of the inferior frontal gyrus and thalamus and its relationship to verbal learning task performance in patients with schizophrenia: a preliminary report
    Hirofumi Hagino
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    Psychiatry Clin Neurosci 56:499-507. 2002
    ..These results support the notion of metabolic abnormalities in the left inferior frontal region related to verbal memory deficits in patients with schizophrenia...
  33. doi request reprint Longitudinal volume changes of the pituitary gland in patients with schizotypal disorder and first-episode schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:177-83. 2011
    ..These findings suggest that the pituitary gland exhibits ongoing volume changes during the early course of the schizophrenia spectrum as a possible marker of state-related impairments...
  34. ncbi request reprint Decreased volume and increased asymmetry of the anterior limb of the internal capsule in patients with schizophrenia
    Shi Yu Zhou
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Biol Psychiatry 54:427-36. 2003
    ..The purpose of this study was to detect the volumetric changes in the ALIC in view of the putative abnormal frontothalamic connectivity in schizophrenia...
  35. ncbi request reprint Bilateral volume reduction of the insular cortex in patients with schizophrenia: a volumetric MRI Study
    Tsutomu Takahashi
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Psychiatry Res 132:187-96. 2004
    ..The findings of this study suggest that there is a possible progressive loss of the gray matter volume of the bilateral insular cortices subsequent to the onset of schizophrenia...
  36. ncbi request reprint Structural brain differences in patients with schizophrenia and schizotypal disorder demonstrated by voxel-based morphometry
    Yasuhiro Kawasaki
    Dept of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Eur Arch Psychiatry Clin Neurosci 254:406-14. 2004
    ....
  37. ncbi request reprint Volumetric MRI study of the short and long insular cortices in schizophrenia spectrum disorders
    Tsutomu Takahashi
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 138:209-20. 2005
    ..These results suggest that the volume reduction of the insular cortex may be specific to overt schizophrenia without topographically specific localization...
  38. doi request reprint Serotonin-1A receptor gene polymorphism and the ability of antipsychotic drugs to improve attention in schizophrenia
    Tomiki Sumiyoshi
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama 930 0194, Japan
    Adv Ther 27:307-13. 2010
    ....
  39. doi request reprint Prevalence and length of the adhesio interthalamica in schizophrenia spectrum disorders
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
    Psychiatry Res 164:90-4. 2008
    ..The AI was more often absent and shorter in both disorders than in controls, possibly reflecting common neurodevelopmental abnormalities in the schizophrenia spectrum...
  40. doi request reprint The effects of cognitive rehabilitation on social knowledge in patients with schizophrenia
    Mie Matsui
    Department of Neuropsychology, Graduate School of Medicine, University of Toyama, Toyama 930 0194, Japan
    Appl Neuropsychol 16:158-64. 2009
    ..Improvements in social cognitive functioning were durable at three-month follow-up. Cognitive rehabilitation can clearly benefit schizophrenic patients, at least when combined with atypical antipsychotic medication...
  41. doi request reprint Calcineurin A gamma and B gene expressions in the whole blood in Japanese patients with schizophrenia
    Masahiko Murata
    Department of Psychiatry, National Hokuriku Hospital, 5963 Nobusue, Nanto, Toyama, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1000-4. 2008
    ..The results of this study suggest that the CaN A gamma gene may be an effective predictor of the progression of psychosis. The effect of medications on expression of CaN genes requires further study...
  42. ncbi request reprint Lack of self-control as assessed by a personality inventory is related to reduced volume of supplementary motor area
    Mie Matsui
    Department of Psychology, School of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Psychiatry Res 116:53-61. 2002
    ..These results provide important clues to the neural basis for the disturbance of self commonly observed in schizophrenia spectrum disorders...
  43. doi request reprint Membrane fatty acid levels as a predictor of treatment response in chronic schizophrenia
    Tomiki Sumiyoshi
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan
    Psychiatry Res 186:23-7. 2011
    ..The results of this study suggest composition of phospholipids in the erythrocyte membrane provide a feasible marker to predict treatment response in patients with schizophrenia...
  44. ncbi request reprint Lack of normal structural asymmetry of the anterior cingulate gyrus in female patients with schizophrenia: a volumetric magnetic resonance imaging study
    Tsutomu Takahashi
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 55:69-81. 2002
    ..These results suggest that gender may play an important role in the structural asymmetry anomalies in schizophrenia...
  45. pmc Mismatch negativity and cognitive performance for the prediction of psychosis in subjects with at-risk mental state
    Yuko Higuchi
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Science, Toyama, Japan
    PLoS ONE 8:e54080. 2013
    ..The main interest was to determine if these neurocognitive measures predict progression to overt schizophrenia in ARMS subjects...
  46. doi request reprint Altered depth of the olfactory sulcus in first-episode schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 40:167-72. 2013
    ..These findings suggest that the olfactory sulcus depth, but not length, may be a static vulnerability marker of schizophrenia that reflects early neurodevelopmental abnormality...
  47. doi request reprint T-817MA, a novel neurotrophic agent, ameliorates loss of GABAergic parvalbumin-positive neurons and sensorimotor gating deficits in rats transiently exposed to MK-801 in the neonatal period
    Takashi Uehara
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan
    J Psychiatr Res 46:622-9. 2012
    ..These results indicate that T-817MA may provide a novel therapeutic approach for the treatment of cognitive deficits of schizophrenia...
  48. pmc Classification of first-episode schizophrenia patients and healthy subjects by automated MRI measures of regional brain volume and cortical thickness
    Yoichiro Takayanagi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan
    PLoS ONE 6:e21047. 2011
    ....
  49. ncbi request reprint Perigenual cingulate gyrus volume in patients with schizophrenia: a magnetic resonance imaging study
    Tsutomu Takahashi
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Biol Psychiatry 53:593-600. 2003
    ..Anterior cingulate gyrus abnormalities have been suggested to be involved in the pathophysiology of schizophrenia; however, little is known about morphologic changes in the perigenual cingulate gyrus in schizophrenia patients...
  50. ncbi request reprint Multiple structural brain measures obtained by three-dimensional magnetic resonance imaging to distinguish between schizophrenia patients and normal subjects
    Kazue Nakamura
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Bull 30:393-404. 2004
    ..These findings support the view that schizophrenia patients have structural deviations in multiple brain areas and that a combination of structural brain measures can distinguish between patients and controls...
  51. ncbi request reprint Relationship between exploratory eye movements and brain morphology in schizophrenia spectrum patients: voxel-based morphometry of three-dimensional magnetic resonance imaging
    Masahiko Tsunoda
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930 0194, Japan
    Eur Arch Psychiatry Clin Neurosci 255:104-10. 2005
    ....
  52. doi request reprint Increased pituitary volume in subjects at risk for psychosis and patients with first-episode schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
    Psychiatry Clin Neurosci 67:540-8. 2013
    ..Enlarged pituitary gland has been reported in schizophrenia, possibly reflecting hypothalamic-pituitary-adrenal hyperactivity. The aim of the present study was to examine whether individuals at risk of psychosis also have similar changes...
  53. pmc LORETA current source density for duration mismatch negativity and neuropsychological assessment in early schizophrenia
    Tomohiro Miyanishi
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan
    PLoS ONE 8:e61152. 2013
    ..We investigated the current source density of duration mismatch negativity (dMMN), by using low-resolution brain electromagnetic tomography (LORETA), and neuropsychological performance in subjects with early schizophrenia...
  54. doi request reprint Reduced white matter fractional anisotropy and clinical symptoms in schizophrenia: a voxel-based diffusion tensor imaging study
    Kazue Nakamura
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 202:233-8. 2012
    ..These findings suggest widespread disruption of white matter integrity in schizophrenia, which could partly explain the severity of negative symptomatology...
  55. ncbi request reprint Multivariate voxel-based morphometry successfully differentiates schizophrenia patients from healthy controls
    Yasuhiro Kawasaki
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Neuroimage 34:235-42. 2007
    ..These findings suggest that the characteristic distribution of gray matter changes may be of diagnostic value for schizophrenia...
  56. doi request reprint A follow-up MRI study of the fusiform gyrus and middle and inferior temporal gyri in schizophrenia spectrum
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1957-64. 2011
    ..Our findings suggest regional specificity of the progressive gray matter reduction in the temporal lobe structures, which might be specific to overt schizophrenia within the schizophrenia spectrum...
  57. pmc Developmental trajectories of amygdala and hippocampus from infancy to early adulthood in healthy individuals
    Akiko Uematsu
    Department of Psychology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    PLoS ONE 7:e46970. 2012
    ..The sex differences and laterality during development of these two regions suggest that sex-related factors such as sex hormones and functional laterality might affect brain development...
  58. ncbi request reprint Quantification of lateral ventricular subdivisions in schizophrenia by high-resolution three-dimensional magnetic resonance imaging
    Takashi Yotsutsuji
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 122:1-12. 2003
    ..Thus, the schizophrenia patients showed ventricular enlargement, particularly in the left temporal horn, being more severely affected in the male than in the female...
  59. ncbi request reprint Effect of MK-801 on gene expressions in the amygdala of rats
    Tadasu Matsuoka
    Department of Neuropsychiatry, University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan
    Synapse 62:1-7. 2008
    ..The results of this study provide an insight into the neural substrates responsible for the generation of psychotic symptoms...
  60. doi request reprint Differentiation of first-episode schizophrenia patients from healthy controls using ROI-based multiple structural brain variables
    Yoichiro Takayanagi
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930 0194, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:10-7. 2010
    ..Brain morphometric measures from magnetic resonance imaging (MRI) have not been used to discriminate between first-episode patients with schizophrenia and healthy subjects...
  61. doi request reprint Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Neurosci Lett 435:34-9. 2008
    ....
  62. pmc Gray matter changes in subjects at high risk for developing psychosis and first-episode schizophrenia: a voxel-based structural MRI study
    Kazue Nakamura
    Department of Neuropsychiatry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama Toyama, Japan
    Front Psychiatry 4:16. 2013
    ..Further studies with a larger ARMS subjects would be required to examine the potential role of neuroimaging methods in the prediction of future transition into psychosis...
  63. ncbi request reprint Subchronic phencyclidine administration alters central vasopressin receptor binding and social interaction in the rat
    Kodai Tanaka
    Department of Neuropsychiatry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630, Sugitani, Toyama 930 0194, Japan
    Brain Res 992:239-45. 2003
    ..13 mg/kg/day, 14 days, i.p.) impaired social interactions in rats, as has been previously reported. These results suggest that NMDA antagonists have modulatory effects on the central vasopressinergic system and social interaction...
  64. doi request reprint LORETA analysis of three-dimensional distribution of δ band activity in schizophrenia: relation to negative symptoms
    Toru Itoh
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan
    Neurosci Res 70:442-8. 2011
    ..The results of this study suggest the role for electrophysiological changes in some of the brain regions, e.g. prefrontal cortex, in the manifestation of negative symptoms...
  65. doi request reprint Effects of direct cedrol inhalation into the lower airway on brain hemodynamics in totally laryngectomized subjects
    Etsuro Hori
    System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    Auton Neurosci 168:88-92. 2012
    ..These results provide the first evidence that an odorant in the lower airway modulates autonomic activity via the central nervous system...
  66. ncbi request reprint Improvement of occipital alpha activity by repetitive hyperbaric oxygen therapy in patients with carbon monoxide poisoning: a possible indicator for treatment efficacy
    Masahiko Murata
    Department of Neuropsychiatry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    J Neurol Sci 235:69-74. 2005
    ....
  67. doi request reprint Clinical and social determinants of a longer duration of untreated psychosis of schizophrenia in a Japanese population
    Herbert Nishii
    Department of Neuropsychiatry, Toho University School of Medicine, Omori Nishi, Ota ku, Tokyo, Japan
    Early Interv Psychiatry 4:182-8. 2010
    ..To measure the duration of untreated psychosis (DUP) among patients with schizophrenia in a Japanese population and to investigate clinical and social determinants of the DUP...
  68. ncbi request reprint N-methyl-D-aspartate-R1 receptor antisense oligodeoxynucleotide modulates pre- and postsynaptic expression of D2 dopamine receptors in the rat
    Masahiko Murata
    Department of Neuropsychiatry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Neurosci Lett 335:9-12. 2002
    ..These results suggest that specific inhibition of NMDA receptor expression modulates pre- and post-synaptic expression of DRD(2), possibly via reduced nigrostriatal dopaminergic activity...
  69. doi request reprint Clinical practice and research activities for early psychiatric intervention at Japanese leading centres
    Masafumi Mizuno
    Il Bosco, Toho University Omori Medical Center, Department of Neuropsychiatry, Toho University School of Medicine, 6 11 1 Omori Nishi, Ota ku, Tokyo, Japan
    Early Interv Psychiatry 3:5-9. 2009
    ..To describe clinical practice and research activities for early psychiatric intervention in Japan, a country with a huge number of psychiatric beds and a history of long-stay, hospital-based psychiatry...
  70. ncbi request reprint [Morphological study on brains of patients with schizophrenia--its application to the objective diagnosis]
    Michio Suzuki
    Seishin Shinkeigaku Zasshi 108:654-60. 2006
  71. ncbi request reprint [Generation of physiopathology of schizophrenia--a hypothesis of temporal-frontal lobe 2-step development]
    Masayoshi Kurachi
    Seishin Shinkeigaku Zasshi 106:1180-5. 2004
  72. ncbi request reprint [Study on disease susceptibility to schizophrenia using brain MRI imaging]
    Michio Suzuki
    Seishin Shinkeigaku Zasshi 109:339-45. 2007
  73. ncbi request reprint [Pathological change of brain and premorbid vulnerability to stress in patients with schizophrenia]
    Michio Suzuki
    Seishin Shinkeigaku Zasshi 109:765-700. 2007
  74. ncbi request reprint Stress sensitization in schizophrenia
    Kunio Yuii
    Research Institute of Asperger Disorder, Ahiya University Graduate School of Education Rokurokuso Machi 13 22, Ashiya, 659 8511 Hyogo, Japan
    Ann N Y Acad Sci 1113:276-90. 2007
    ..Suzuki)...
  75. doi request reprint Five-day oral cefditoren pivoxil versus 10-day oral amoxicillin for pediatric group A streptococcal pharyngotonsillitis
    Takao Ozaki
    Department of Pediatrics, Konan Kosci Hospital, 137 Ohmatsubara, Takaya cho, Konan, Aichi 483 8704, Japan
    J Infect Chemother 14:213-8. 2008
    ..Because the efficacy for pediatric group A streptococcus pharyngotonsillitis was similar between oral cefditoren-pivoxil for 5 days and amoxicillin for 10 days, the shorter treatment period may make the former regimen preferable...