Shigeru Saito

Summary

Affiliation: Toyama Medical and Pharmaceutical University
Country: Japan

Publications

  1. pmc Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia
    S Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Clin Exp Immunol 117:550-5. 1999
  2. ncbi request reprint CD4(+)CD25high regulatory T cells in human pregnancy
    Shigeru Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
    J Reprod Immunol 65:111-20. 2005
  3. ncbi request reprint Mirimostim (macrophage colony-stimulating factor; M-CSF) improves chemotherapy-induced impaired natural killer cell activity, Th1/Th2 balance, and granulocyte function
    Takao Hidaka
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Sugitani, Toyoma shi, Toyama 930 0194, Japan
    Cancer Sci 94:814-20. 2003
  4. ncbi request reprint The preterm labor index and fetal fibronectin for prediction of preterm delivery with intact membranes
    Masatoshi Sakai
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Obstet Gynecol 101:123-8. 2003
  5. ncbi request reprint IX International Congress on Reproductive Immunology, 11-15 October 2004, Hakone, Japan
    Shigeru Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Reprod Immunol 68:121-6. 2005
  6. ncbi request reprint Prostaglandin D2 and reproduction
    Shigeru Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama shi, Japan
    Am J Reprod Immunol 47:295-302. 2002
  7. ncbi request reprint The incidence of pre-eclampsia among couples consisting of Japanese women and Caucasian men
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    J Reprod Immunol 70:93-8. 2006
  8. ncbi request reprint Th1/Th2 balance in preeclampsia
    Shigeru Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi, 930 0194 Toyama, Japan
    J Reprod Immunol 59:161-73. 2003
  9. ncbi request reprint Cytokine network at the feto-maternal interface
    S Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical Univertsity, Sugitani Toyama shi, Japan
    J Reprod Immunol 47:87-103. 2000
  10. ncbi request reprint Cytokine cross-talk between mother and the embryo/placenta
    S Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
    J Reprod Immunol 52:15-33. 2001

Detail Information

Publications109 found, 100 shown here

  1. pmc Quantitative analysis of peripheral blood Th0, Th1, Th2 and the Th1:Th2 cell ratio during normal human pregnancy and preeclampsia
    S Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Clin Exp Immunol 117:550-5. 1999
    ..These results demonstrated that Th2 cells were predominant in the second and third trimesters of normal pregnancy, but Th1 cells predominated in preeclamptic patients...
  2. ncbi request reprint CD4(+)CD25high regulatory T cells in human pregnancy
    Shigeru Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
    J Reprod Immunol 65:111-20. 2005
    ..Here, we review the differences between humans and mouse Treg cells and the role of CD4(+)CD25+Treg during pregnancy...
  3. ncbi request reprint Mirimostim (macrophage colony-stimulating factor; M-CSF) improves chemotherapy-induced impaired natural killer cell activity, Th1/Th2 balance, and granulocyte function
    Takao Hidaka
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Sugitani, Toyoma shi, Toyama 930 0194, Japan
    Cancer Sci 94:814-20. 2003
    ..These results indicate that chemotherapy markedly impaired the immunological functions, and that the administration of M-CSF significantly improved the impaired immunological functions...
  4. ncbi request reprint The preterm labor index and fetal fibronectin for prediction of preterm delivery with intact membranes
    Masatoshi Sakai
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Obstet Gynecol 101:123-8. 2003
    ..To compare the preterm labor index with the biochemical marker fetal fibronectin in predicting preterm delivery...
  5. ncbi request reprint IX International Congress on Reproductive Immunology, 11-15 October 2004, Hakone, Japan
    Shigeru Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Reprod Immunol 68:121-6. 2005
  6. ncbi request reprint Prostaglandin D2 and reproduction
    Shigeru Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama shi, Japan
    Am J Reprod Immunol 47:295-302. 2002
    ..PGD2 might appear to contribute to the maintenance of pregnancy by controlling the Th1/Th2 balance and antigen presentation by DCs through its dual receptor systems, CRTH2 and DP...
  7. ncbi request reprint The incidence of pre-eclampsia among couples consisting of Japanese women and Caucasian men
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    J Reprod Immunol 70:93-8. 2006
    ..Trowsdale, I., Moffett, A., 2004. Combinations of maternal KIR and fetal HLA-C genes influence the risk of pre-eclampsia and reproductive success. J. Exp. Med. 200, 957-965], although we did not check the haplotypes for HLA-C and KIR...
  8. ncbi request reprint Th1/Th2 balance in preeclampsia
    Shigeru Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi, 930 0194 Toyama, Japan
    J Reprod Immunol 59:161-73. 2003
    ..In this review, we discuss that Th1 predominant immunity is closely related to inflammation, endothelial dysfunction and poor placentation...
  9. ncbi request reprint Cytokine network at the feto-maternal interface
    S Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical Univertsity, Sugitani Toyama shi, Japan
    J Reprod Immunol 47:87-103. 2000
    ..Thus, Th2 type cytokines appear to contribute to the maintenance of pregnancy by controlling the immune and endocrine systems and promoting the function of the trophoblasts at the implantation site...
  10. ncbi request reprint Cytokine cross-talk between mother and the embryo/placenta
    S Saito
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
    J Reprod Immunol 52:15-33. 2001
    ..As a result of this closely related cross-talk, pregnancy is successfully maintained...
  11. pmc Granulysin produced by uterine natural killer cells induces apoptosis of extravillous trophoblasts in spontaneous abortion
    Akitoshi Nakashima
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, 930 0194, Japan
    Am J Pathol 173:653-64. 2008
    ..These data support a new apoptosis pathway for trophoblasts via uNK-derived granulysin, suggesting that granulysin is involved in spontaneous abortion...
  12. ncbi request reprint Macrophage colony-stimulating factor (M-CSF) prevents infectious death induced by chemotherapy in mice, while granulocyte-CSF does not
    Takao Hidaka
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Jpn J Cancer Res 93:426-35. 2002
    ..05). These results demonstrated that it is important not only to increase the granulocyte counts, but also to improve granulocyte functions for preventing infection under myelosuppression after chemotherapy...
  13. ncbi request reprint HER2 is frequently over-expressed in ovarian clear cell adenocarcinoma: possible novel treatment modality using recombinant monoclonal antibody against HER2, trastuzumab
    Masaki Fujimura
    Department of Obstetrics and Gynecology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama City
    Jpn J Cancer Res 93:1250-7. 2002
    ..The survival period of trastuzumab-treated mice was longer than that of the control group. From these findings, trastuzumab appears to be a candidate as a treatment modality for HER2 over-expressing ovarian CCA...
  14. doi request reprint A role for IL-17 in induction of an inflammation at the fetomaternal interface in preterm labour
    Mika Ito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama shi, Toyama, Japan
    J Reprod Immunol 84:75-85. 2010
    ..These results indicate that IL-17, produced by T cells, promotes inflammation at the fetomaternal interface in preterm delivery...
  15. doi request reprint Circulating and decidual Th17 cell levels in healthy pregnancy
    Akitoshi Nakashima
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    Am J Reprod Immunol 63:104-9. 2010
    ..However, the level of Th17 cells during pregnancy is still unclear. We investigated the level of peripheral Th17 cells in healthy pregnancy subjects...
  16. doi request reprint Ovarian squamous cell carcinoma which metastasized 8 years after cervical conization for early microinvasive cervical cancer: a case report
    Takao Hidaka
    Department of Obstetrics and Gynecology, University of Toyama, 2630, Sugitani, Toyama shi, Toyama 930 0194, Japan
    Jpn J Clin Oncol 41:807-10. 2011
    ....
  17. doi request reprint Accumulation of IL-17-positive cells in decidua of inevitable abortion cases
    Akitoshi Nakashima
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama, Japan
    Am J Reprod Immunol 64:4-11. 2010
    ..It is, however, still unknown how Th17 cells affect pregnancy outcome. We investigated the expression of IL-17-producing cells in human spontaneous abortion...
  18. ncbi request reprint Inadequate tolerance induction may induce pre-eclampsia
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama, Japan Center of Excellence COE 21st Program, Japan
    J Reprod Immunol 76:30-9. 2007
    ..In this process, CD4(+)CD25(+) regulatory T (Treg)-cells play central roles. In this review, we discuss the relationship between the risk of pre-eclampsia and tolerance induction...
  19. pmc Autophagy induced by HIF1α overexpression supports trophoblast invasion by supplying cellular energy
    Mikiko Yamanaka-Tatematsu
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama, Japan
    PLoS ONE 8:e76605. 2013
    ..These results suggest that autophagy plays a role in maintaining homeostasis by countervailing HIF1α-mediated cellular energy consumption in EVTs. ..
  20. ncbi request reprint Characterization of regulatory T cells in decidua of miscarriage cases with abnormal or normal fetal chromosomal content
    Kumiko Inada
    Department of Obstetrics and Gynecology, University of Toyama, Toyama 930 0194, Japan
    J Reprod Immunol 97:104-11. 2013
    ....
  21. ncbi request reprint Predominance of Th2-promoting dendritic cells in early human pregnancy decidua
    Satomi Miyazaki
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Japan
    J Leukoc Biol 74:514-22. 2003
    ..This finding was abolished by exogenous IL-12 administration with decidual myeloid DCs. Thus, the DCs in the decidua could regulate the Th1/Th2 balance to maintain a Th2-dominant state, leading to maintenance of pregnancy...
  22. pmc What is the role of regulatory T cells in the success of implantation and early pregnancy?
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama, 930 0194, Japan
    J Assist Reprod Genet 24:379-86. 2007
    ..CD4(+)CD25(+) regulatory T (Treg) cells and an enzyme called indoleamine-2, 3-dioxygenase (IDO) mediate maternal tolerance of the allogeneic fetus. Treg cells, therefore, may prevent early pregnancy loss due to maternal 'rejection.'..
  23. ncbi request reprint Accumulation of CRTH2-positive T-helper 2 and T-cytotoxic 2 cells at implantation sites of human decidua in a prostaglandin D(2)-mediated manner
    Toshihiko Michimata
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Sugitani, Toyama 930 0194, Japan
    Mol Hum Reprod 8:181-7. 2002
    ....
  24. ncbi request reprint Evaluation of effectiveness of prophylactic cerclage of a short cervix according to interleukin-8 in cervical mucus
    Masatoshi Sakai
    Department of Obstetrics, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Am J Obstet Gynecol 194:14-9. 2006
    ..This study was undertaken to compare rates of preterm delivery according to cervical mucus interleukin-8 (IL-8) among women who underwent cerclage because of a short cervix...
  25. ncbi request reprint Interleukin-8 and glucose in amniotic fluid, fetal fibronectin in vaginal secretions and preterm labor index based on clinical variables are optimal predictive markers for preterm delivery in patients with intact membranes
    Satoshi Yoneda
    Department of Obstetrics and Gynecology, Toyama University, Toyama, Japan
    J Obstet Gynaecol Res 33:38-44. 2007
    ..Various predictive markers for preterm delivery have been proposed in previous studies. We investigated which marker is most reliable...
  26. pmc Establishment and characterization of immortalized human amniotic epithelial cells
    Kaixuan Zhou
    Department of Regenerative Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    Cell Reprogram 15:55-67. 2013
    ..In conclusion, the immortalization of HAEs with the characteristics of stem cells has been established, allowing these iHAEs to become useful for cell therapy and regenerative medicine...
  27. ncbi request reprint The ratio of interleukin (IL)-18 to IL-12 secreted by peripheral blood mononuclear cells is increased in normal pregnant subjects and decreased in pre-eclamptic patients
    Masatoshi Sakai
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama shi Toyama 930 0194, Japan
    J Reprod Immunol 61:133-43. 2004
    ....
  28. ncbi request reprint Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice
    Tomoko Shima
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
    J Reprod Immunol 85:121-9. 2010
    ....
  29. ncbi request reprint The role of the immune system in preeclampsia
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Mol Aspects Med 28:192-209. 2007
    ..Furthermore, the immunoregulatory system is down-regulated in preeclampsia and persistent inflammation reduces regulatory T cell function. Therefore, systematical immunoactivation may be one cause of preeclampsia...
  30. doi request reprint Th1/Th2/Th17 and regulatory T-cell paradigm in pregnancy
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    Am J Reprod Immunol 63:601-10. 2010
    ..Here, we will review the immunological environment in normal pregnancy and complicated pregnancy, such as implantation failure, abortion, preterm labor, and preeclampsia from the viewpoint of the new Th1/Th2/Th17 and Treg paradigms...
  31. doi request reprint Prediction of exact delivery time in patients with preterm labor and intact membranes at admission by amniotic fluid interleukin-8 level and preterm labor index
    Satoshi Yoneda
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    J Obstet Gynaecol Res 37:861-6. 2011
    ..To examine whether delivery time for preterm labor can be predicted by clinical and biochemical markers at admission...
  32. pmc Impaired autophagy by soluble endoglin, under physiological hypoxia in early pregnant period, is involved in poor placentation in preeclampsia
    Akitoshi Nakashima
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama, Japan
    Autophagy 9:303-16. 2013
    ..This is the first report showing that impaired autophagy in EVT contributes to the pathophysiology of preeclampsia...
  33. ncbi request reprint IDO expression on decidual and peripheral blood dendritic cells and monocytes/macrophages after treatment with CTLA-4 or interferon-gamma increase in normal pregnancy but decrease in spontaneous abortion
    Naoko Miwa
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Mol Hum Reprod 11:865-70. 2005
    ..These data suggest that CTLA-4 on Treg cells up-regulates IDO expression on decidual and peripheral blood DC and monocytes by the induction of IFN-gamma production...
  34. ncbi request reprint Regulatory T cells and regulatory natural killer (NK) cells play important roles in feto-maternal tolerance
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Semin Immunopathol 29:115-22. 2007
    ..Not only Treg cells but also regulatory NK cells may inhibit maternal T cell or NK cell fetal attack...
  35. ncbi request reprint Expression of indoleamine 2, 3-dioxygenase and the recruitment of Foxp3-expressing regulatory T cells in the development and progression of uterine cervical cancer
    Takafumi Nakamura
    Department of Obstetrics and Gynecology, University of Toyama, Toyama 930 0194, Japan
    Cancer Sci 98:874-81. 2007
    ..IDO expression at the invasive front of cancer cells and APC, and the localization of Foxp3(+) Treg cells in front of cancer tissues, may create a network between IDO and Treg for the induction of immune escape...
  36. ncbi request reprint A Th2 chemokine, TARC, produced by trophoblasts and endometrial gland cells, regulates the infiltration of CCR4+ T lymphocytes into human decidua at early pregnancy
    Hiroshi Tsuda
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Sugitani Toyama, Japan
    Am J Reprod Immunol 48:1-8. 2002
    ..We examined the distribution of CCR4 expressing CD4+ and CD8+-T cells in human decidua at early pregnancy, and localized TARC in the decidual tissue and chorionic tissue...
  37. ncbi request reprint Macrophage colony-stimulating factor restored chemotherapy-induced granulocyte dysfunctions: role of IL-8 production by monocytes
    Akiko Teranishi
    Department of Obstetrics and Gynecology, Nara Medical University, Japan
    Int Immunopharmacol 2:83-94. 2002
    ..These observations suggest that M-CSF enhances the production of IL-8 from monocytes in vivo, thereby improving chemotherapy-induced granulocyte dysfunction...
  38. ncbi request reprint Interleukin 2 receptor gamma chain (gamma(c)) knockout mice show less regularity in estrous cycle but achieve normal pregnancy without fetal compromise
    Satomi Miyazaki
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Japan
    Am J Reprod Immunol 47:222-30. 2002
    ....
  39. doi request reprint Comparison of risk factors for major obstetric complications between Western countries and Japan: a case-cohort study
    Arihiro Shiozaki
    Department of Obstetrics and Gynecology, University of Toyama, Sugitani, Toyama
    J Obstet Gynaecol Res 37:1447-54. 2011
    ..The aim of this study was to demonstrate the differences in risk factors for obstetrical complications between Japan and Western countries...
  40. doi request reprint Stemness of human Wharton's jelly mesenchymal cells is maintained by floating cultivation
    Osamu Higuchi
    Department of Regenerative Medicine, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan
    Cell Reprogram 14:448-55. 2012
    ....
  41. doi request reprint Stage I ovarian cancer cases during early, mid and late pregnancy periods: three case reports and review of the literature
    Toru Hasegawa
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama, Japan
    J Obstet Gynaecol Res 37:650-5. 2011
    ..Even with stage Ia ovarian cancer, restaging laparotomy at cesarean section or post-delivery may be important to determine the treatment plan because staging during pregnancy is rarely complete...
  42. doi request reprint Outcomes of infants exposed to oseltamivir or zanamivir in utero during pandemic (H1N1) 2009
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    Am J Obstet Gynecol 209:130.e1-9. 2013
    ..To assess adverse fetal outcomes and short-term prognoses of infants exposed to oseltamivir or zanamivir in utero during pandemic (H1N1) 2009 in Japan...
  43. doi request reprint Which types of regulatory T cells play important roles in implantation and pregnancy maintenance?
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    Am J Reprod Immunol 69:340-5. 2013
    ..Therefore, we should evaluate the true Treg level and clarify which types of Treg cells play important roles in implantation and pregnancy maintenance in mice and humans...
  44. doi request reprint Anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian immature teratoma
    Azusa Sameshima
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    J Obstet Gynaecol Res 37:1883-6. 2011
    ..We present a case of anti-NMDAR encephalitis associated with ovarian immature teratoma. The symptoms were dramatically relieved by tumor resection and immunotherapy...
  45. ncbi request reprint Paclitaxel/carboplatin versus cyclophosphamide/adriamycin/cisplatin as postoperative adjuvant chemotherapy for advanced endometrial adenocarcinoma
    Takao Hidaka
    Department of Obstetrics and Gynecology, Toyama University School of Medicine, Toyama, Japan
    J Obstet Gynaecol Res 32:330-7. 2006
    ..However, since October 1999 a paclitaxel/carboplatin regimen has been substituted for CAP. To evaluate the antitumor activity and toxic effects of those regimens, we retrospectively reviewed cases that were treated in our hospital...
  46. ncbi request reprint The balance between cytotoxic NK cells and regulatory NK cells in human pregnancy
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    J Reprod Immunol 77:14-22. 2008
    ..We summarize the progress in studying NK reg cells and focus on how NK reg cells and cytotoxic NK cells affect the reproductive immune response...
  47. doi request reprint Herbal medicine Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice
    Takao Hidaka
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, 2630, Sugitani, Toyama shi, Toyama 930 0194, Japan
    Eur J Pain 13:22-7. 2009
    ..To ascertain the effectiveness of Shakuyaku-kanzo-to on paclitaxel-induced pain, we investigated the effects of Shakuyaku-kanzo-to and its constituent herbal medicines in a mouse model...
  48. ncbi request reprint Selective inhibition of the epidermal growth factor receptor by ZD1839 decreases the growth and invasion of ovarian clear cell adenocarcinoma cells
    Masaki Fujimura
    Department of Obstetrics and Gynecology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Clin Cancer Res 8:2448-54. 2002
    ..Severe combined immunodeficient mice bearing RMG-1 xenografts treated with ZD1839 survived for longer than the untreated control group. From these findings, we conclude that ZD1839 may offer a new and effective treatment for ovarian CCA...
  49. doi request reprint Endometrioid adenocarcinoma of the vagina with a microglandular pattern arising from endometriosis after hysterectomy
    Kazuhiro Nomoto
    Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, Toyama, University of Toyama, Toyama City, Toyama 930 0194, Japan
    Pathol Int 60:636-41. 2010
    ..Pathologists are encouraged to be aware of the occurrence of endometrioid adenocarcinoma associated with endometriosis in the vaginal stump after hysterectomy, and microglandular morphology which might be a source of misinterpretation...
  50. ncbi request reprint Carcinomatous meningitis associated with ovarian cancer complicated by SIADH
    Toru Hasegawa
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Japan
    Gan To Kagaku Ryoho 37:739-42. 2010
    ..Clinicians should consider carcinomatous meningitis when there are findings of SIADH...
  51. ncbi request reprint Relationship between cervical mucus interleukin-8 concentrations and vaginal bacteria in pregnancy
    Masatoshi Sakai
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyoma, Japan
    Am J Reprod Immunol 52:106-12. 2004
    ..High interleukin (IL)-8 concentration in cervical mucus in the second trimester is a risk factor for premature birth. We investigated the relationship between vaginal pathogens and IL-8 in cervical mucus...
  52. doi request reprint Blocking on the CXCR4/mTOR signalling pathway induces the anti-metastatic properties and autophagic cell death in peritoneal disseminated gastric cancer cells
    Isaya Hashimoto
    Department of Surgery II, Faculty of Medicine, University of Toyama, Toyama, Japan
    Eur J Cancer 44:1022-9. 2008
    ..Therefore, blocking on the CXCR4/mTOR signalling pathway may be useful for the future development of a more effective therapeutic strategy for gastric cancer involved in peritoneal dissemination...
  53. doi request reprint Clinical implication of recent advances in our understanding of IL-17 and reproductive immunology
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
    Expert Rev Clin Immunol 7:649-57. 2011
    ..Recent data show the reciprocal development of pathways between Th1/Th17 subsets and between Th17/Treg subsets, and the imbalance of Th17/Treg development has been reported in recurrent pregnancy loss and preeclampsia...
  54. doi request reprint Comparison of risk factors for gestational hypertension and preeclampsia in Japanese singleton pregnancies
    Arihiro Shiozaki
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    J Obstet Gynaecol Res 39:492-9. 2013
    ..To demonstrate the difference between risk factors for gestational hypertension (GH) and preeclampsia (PE)...
  55. doi request reprint Central versus peripheral impact of estradiol on the impaired glucose metabolism in ovariectomized mice on a high-fat diet
    Rika Yonezawa
    Department of Obstetrics and Gynecology, University of Toyama, Toyama, Japan
    Am J Physiol Endocrinol Metab 303:E445-56. 2012
    ....
  56. ncbi request reprint Cytokine profile of natural killer cells in early human pregnancy
    Subaru Higuma-Myojo
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Am J Reprod Immunol 54:21-9. 2005
    ..To examine whether the NK1/NK2/NK3/NKr1 paradigm can be adapted in natural killer (NK) cells...
  57. ncbi request reprint Interleukin-12 secretion by peripheral blood mononuclear cells is decreased in normal pregnant subjects and increased in preeclamptic patients
    Masatoshi Sakai
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Sugitani Toyama shi, Toyama, Japan
    Am J Reprod Immunol 47:91-7. 2002
    ..Peripheral blood mononuclear cell (PBMC) production of interleukin (IL)-12, which induce Th1 responses, has not been compared between these clinical states...
  58. ncbi request reprint Elevated interleukin-8 in cervical mucus as an indicator for treatment to prevent premature birth and preterm, pre-labor rupture of membranes: a prospective study
    Masatoshi Sakai
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Am J Reprod Immunol 51:220-5. 2004
    ..We investigated whether cervical shortening and high interleukin (IL)-8 in cervical mucus were valuable indications for treatment to prevent premature birth and preterm, pre-labor rupture of membranes (pPROM)...
  59. doi request reprint Alpha 1 antitrypsin activity is decreased in human amnion in premature rupture of the fetal membranes
    Noriko Izumi-Yoneda
    Department of Regenerative Medicine, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan
    Mol Hum Reprod 15:49-57. 2009
    ....
  60. doi request reprint Effect of the Fukushima nuclear power plant accident on radioiodine (¹³¹ I) content in human breast milk
    Nobuya Unno
    Department of Obstetrics and Gynecology, Kitasato University, School of Medicine, Sagamihara, Japan
    J Obstet Gynaecol Res 38:772-9. 2012
    ..Whether environmental pollution with (131) I can contaminate human breast milk has not been documented...
  61. doi request reprint The balance of the immune system between T cells and NK cells in miscarriage
    Akitoshi Nakashima
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Japan
    Am J Reprod Immunol 67:304-10. 2012
    ..This paper aimed at finding a cause of RPL by analyzing the balance of the immune system between T cells and NK cells in an early-stage miscarriage...
  62. doi request reprint Massive postpartum hemorrhage after chemotherapy in a patient with acute promyelocytic leukemia
    Aiko Aoki
    Department of Obstetrics and Gynecology Third Department of Internal Medicine, University of Toyama, Toyama, Japan
    J Obstet Gynaecol Res 37:1759-63. 2011
    ..As administration of cytotoxic agents may induce disseminated intravascular coagulation, we should take care to avoid uterine bleeding after chemotherapy in acute promyelocytic leukemia cases treated soon after delivery...
  63. pmc Systemic lymphadenectomy cannot be recommended for low-risk corpus cancer
    Takao Hidaka
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama 930 0194, Japan
    Obstet Gynecol Int 2010:490219. 2010
    ..Conclusion. Omission of lymphadenectomy did not worsen the DFS or OS. The present findings suggest that systemic lymphadenectomy could be omitted in low-risk endometrial carcinoma...
  64. ncbi request reprint A free radical initiator, 2,2'-azobis (2-aminopropane) dihydrochloride enhances hyperthermia-induced apoptosis in human uterine cervical cancer cell lines
    Hiroyoshi Yuki
    Department of Obstetrics and Gynecology, Yukiguniyamato General Hospital, 4415 Urasa, Yamato machi, Niigata 949 7302, Japan
    Free Radic Res 37:631-43. 2003
    ..Since it is known that cancer cells are generally resistant to physical and chemical stress-induced apoptosis, free radical generators like AAPH appear to be a useful thermosensitizer for hyperthermic cancer therapy...
  65. doi request reprint Future directions of studies for recurrent miscarriage associated with immune etiologies
    Shigeru Saito
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Reprod Immunol 90:91-5. 2011
    ..Careful examination of the immune system at the decidua basalis in an early-stage abortion in RPL cases with normal fetal chromosome may reveal useful information...
  66. doi request reprint Impact of fetal sex in pregnancy-induced hypertension and preeclampsia in Japan
    Arihiro Shiozaki
    Department of Obstetrics and Gynecology, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Reprod Immunol 89:133-9. 2011
    ..The male antigen and the increased number of MHC mismatches in DD twin pregnancies were not a risk factor for PIH and preeclampsia. Female fetal sex was a risk factor for PIH and preeclampsia...
  67. ncbi request reprint Cisplatin enhances the p53-independent apoptosis induced by a topoisomerase I inhibitor (CPT-11) in the lens epithelial tumors in transgenic mice
    Takafumi Nakamura
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Oncol Rep 12:253-8. 2004
    ..Apoptosis in the p53-wild-type alphaT3 tumors was observed in a Cisplatin dose-dependent manner. In addition, it was found that Cisplatin augmented CPT-11-induced p53-independent apoptosis in p53-deficient alphaT3 mice...
  68. ncbi request reprint Low adjusted serum ionized calcium concentration shortly after birth predicts poor outcome in neonatal hypoxic-ischemic encephalopathy
    Satoshi Yoneda
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Obstet Gynaecol Res 31:57-64. 2005
    ..The aim of this study was to investigate whether or not the serum ionized calcium concentration in neonates with hypoxic-ischemic encephalopathy (HIE) could be used to predict their outcome...
  69. ncbi request reprint Characterization of ventricular myocardial performance in the fetus by tissue Doppler imaging
    Sayaka Watanabe
    Department of Pediatrics, School of Medicine, University of Toyama, Toyama, Japan
    Circ J 73:943-7. 2009
    ..Clinically useful indices of fetal cardiac function have not been fully delineated for tissue Doppler imaging (TDI)...
  70. ncbi request reprint Interleukin (IL)-17A stimulates IL-8 secretion, cyclooxygensase-2 expression, and cell proliferation of endometriotic stromal cells
    Tetsuya Hirata
    Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Endocrinology 149:1260-7. 2008
    ..IL-17A also enhanced the expression of cyclooxygensase-2 mRNA and proliferation of ESCs. IL-17A may play a role in the development of endometriosis by stimulating inflammatory responses and proliferation of ESCs...
  71. ncbi request reprint Treatment for patients with postmenopausal osteoporosis who have been placed on HRT and show a decrease in bone mineral density: effects of concomitant administration of vitamin K(2)
    Takao Hidaka
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Bone Miner Metab 20:235-9. 2002
    ..Therefore, as a supplementary drug for postmenopausal osteoporosis, vitamin K(2) is a good therapeutic option for patients who are placed on HRT...
  72. doi request reprint Comparison of risk factors for placental abruption and placenta previa: case-cohort study
    Yoshio Matsuda
    Department of Obstetrics and Gynecology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    J Obstet Gynaecol Res 37:538-46. 2011
    ..A case-cohort study was performed to clarify and compare the risk factors for placental abruption and placenta previa...
  73. ncbi request reprint Maternal total parenteral nutrition and fetal subdural hematoma
    Masatoshi Sakai
    Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Obstet Gynecol 101:1142-4. 2003
    ..Fetal subdural hematoma is rare, and no case resulting from vitamin K deficiency secondary to maternal total parenteral nutrition has been reported...
  74. ncbi request reprint Immature NK cells suppress dendritic cell functions during the development of leukemia in a mouse model
    Kazumi Ebata
    The Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Japan
    J Immunol 176:4113-24. 2006
    ..In conclusion, we identified circulating immature NK cells with immunosuppressive activities. These cells may be important for understanding the involvement of the host immune system during the development of leukemia...
  75. ncbi request reprint Lymphoid enhancer-binding factor-1 binds and activates the recombination-activating gene-2 promoter together with c-Myb and Pax-5 in immature B cells
    Zhe Xiong Jin
    Department of Immunology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    J Immunol 169:3783-92. 2002
    ..The link between LEF-1/beta-catenin and Wnt signaling in B lineage cells will be discussed...
  76. ncbi request reprint Characterization of chromatin structure and enhancer elements for murine recombination activating gene-2
    Xing Cheng Wei
    Department of Immunology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    J Immunol 169:873-81. 2002
    ..These results show that the tissue- and stage-specific expression of murine RAG-2 is regulated by alteration of the chromatin structure as well as cis-regulatory enhancer elements...
  77. doi request reprint Subsequent pregnancy outcomes in recurrent miscarriage patients with a paternal or maternal carrier of a structural chromosome rearrangement
    Mayumi Sugiura-Ogasawara
    Department of Obstetrics and Gynecology, Nagoya City University Medical School, Mizuho ku, Nagoya, 467, Japan
    J Hum Genet 53:622-8. 2008
    ..Explanation of the success rate with natural conception should be provided before the subsequent pregnancy after ascertainment of carrier status...
  78. ncbi request reprint Cooperative binding of c-Myb and Pax-5 activates the RAG-2 promoter in immature B cells
    Hiroyuki Kishi
    Department of Immunology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    Blood 99:576-83. 2002
    ..These results suggest that cooperative binding of c-Myb and Pax-5 to the RAG-2 promoter is one of the mechanisms to direct the restricted expression of the RAG-2 in immature B cells...
  79. ncbi request reprint [Apoptosis as a measure of chemosensitivity to anti-cancer drugs in gynecological cancer]
    Hiroshi Fushiki
    Dept of Obstetrics and Gynecology, Tonami General Hospital
    Gan To Kagaku Ryoho 29:215-9. 2002
    ..To examine apoptosis as a measure of chemosensitivity to anti-cancer drugs in gynecological cancer xenografted into nude mice...
  80. ncbi request reprint TSLP-induced placental DC activation and IL-10(+) NK cell expansion: comparative study based on BALB/c x C57BL/6 and NOD/SCID x C57BL/6 pregnant models
    Yi Lin
    Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou, China
    Clin Immunol 126:104-17. 2008
    ..TSLP-DC and NK cell contact appears necessary for IL-10(+)CD49b(+) cell expansion. Placental NK cells from NOD/SCIDxC57BL/6 mice appear less sensitive to TSLP-DC induction...
  81. ncbi request reprint Expansion of alpha-galactosylceramide-stimulated Valpha24+ NKT cells cultured in the absence of animal materials
    Yukie Harada
    Hematopoietic Stem Cell Transplant Immunotherapy Unit, National Cancer Center Hospital, Tokyo 104 0045, Japan
    J Immunother 28:314-21. 2005
    ..Valpha24+ NKT cells can be efficiently expanded from G-CSF-mobilized peripheral blood MNCs in non-FBS culture conditions with alpha-GalCer and IL-2...
  82. ncbi request reprint Complex angioplasty up to chronic total occlusion
    Milan A Nedeljkovic
    Department of Cardiology, Institute for Cardiovascular Diseases, Clinical Center of Serbia, Belgrade, Serbia and Montenegro
    Herz 31:156-64. 2006
  83. ncbi request reprint Successful coronary intervention for chronic total occlusion in an anomalous right coronary artery using the retrograde approach via a collateral vessel
    Hideaki Kaneda
    Cardiology Laboratory, Shonan Kamakura General Hospital, 1202 1 Yamazaki, Kamakura 247 8533, Japan
    J Invasive Cardiol 19:E1-4. 2007
    ....
  84. ncbi request reprint Angioplasty for chronic total occlusion by using tapered-tip guidewires
    Shigeru Saito
    Division of Cardiology and Catheterization Laboratories, Heart Center of ShonanKamakura General Hospital, Kamakura City, Japan
    Catheter Cardiovasc Interv 59:305-11. 2003
    ..TRI can achieve a high success rate even in CTO lesions provided that the case selection is adequate...
  85. ncbi request reprint Comparison of effects of rapid colloid loading before and after spinal anesthesia on maternal hemodynamics and neonatal outcomes in cesarean section
    Koichi Nishikawa
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi City 371 8511, Japan
    J Clin Monit Comput 21:125-9. 2007
    ..This study tested the hypothesis that colloid loading after spinal blockade can reduce hypotension compared with preloading, and affect neonatal outcomes...
  86. ncbi request reprint Localization of the induced metallothionein and DNA damage in rat kidney after gold injection
    Shigeru Saito
    Department of Preventive Medicine, St Marianna University School of Medicine, Kawasaki, Japan
    J Histochem Cytochem 50:1263-71. 2002
    ..These findings suggest that the DNA damage in the kidneys of rats injected with Au may be associated with Cu-binding proteins but not with Cu-MT...
  87. ncbi request reprint Impairment of hepatosplanchnic oxygenation and increase of serum hyaluronate during normothermic and mild hypothermic cardiopulmonary bypass
    Nobuhiro Okano
    Department of Anesthesiology, Saitama Cardiovascular and Pulmonary Center, Saitama, Japan
    Anesth Analg 95:278-86, table of contents. 2002
    ..The failure of the liver to increase HA extraction to a great degree suggests that a functional impairment of the SEC may contribute to the observed increase of serum HA...
  88. pmc ASIAN: a web server for inferring a regulatory network framework from gene expression profiles
    Sachiyo Aburatani
    Laboratory of Biostatistics, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    Nucleic Acids Res 33:W659-64. 2005
    ..Thus, the ASIAN (Automatic System for Inferring A Network) web server provides an initial basis for inferring regulatory relationships, in that the clustering serves as the first step toward identifying the gene function...
  89. ncbi request reprint Induction of apoptosis mediated by fas receptor and activation of caspase-3 in MRL-+/+ or MRL-lpr/lpr murine oocytes
    Maowu Guo
    Department of Immunology, Institute of Medical Science, University of Tokyo, Japan
    Zygote 10:17-22. 2002
    ....
  90. ncbi request reprint Protective effect of taurine against renal interstitial fibrosis of rats induced by cisplatin
    Shin Sato
    Department of Food and Nutrition, Hakodate Junior College, Hakodate 042 0955, Japan
    Naunyn Schmiedebergs Arch Pharmacol 365:277-83. 2002
    ..These results suggested that taurine suppressed the increase of infiltrating macrophages, and led to the attenuation of renal interstitial fibrosis ( P<0.05)...
  91. ncbi request reprint The molarless condition in aged SAMP8 mice attenuates hippocampal Fos induction linked to water maze performance
    Kazuko Watanabe
    Department of Physiology, Gifu University School of Medicine, Gifu 500 8705, Japan
    Behav Brain Res 128:19-25. 2002
    ..Gerontol. 2001; 36:283-95], the present results suggest the detrimental effects of a reduction in chewing on hippocampal processing in aged SAMP8 mice that would be linked with stress induced by the molarless condition...
  92. ncbi request reprint 2,3,7,8-Tetrachlorodibenzo-p-dioxin in maternal breast milk and newborn head circumference
    Muneko Nishijo
    Department of Public Health, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    J Expo Sci Environ Epidemiol 18:246-51. 2008
    ..These facts suggested that fetal brain development might be influenced by maternal exposure to TCDD in the environment...
  93. ncbi request reprint Freeze-thawing procedures have no influence on the phenotypic and functional development of dendritic cells generated from peripheral blood CD14+ monocytes
    Shin Ichi Hori
    Hematopoietic Stem Cell Transplant Immunotherapy Unit, National Cancer Center Hospital, Tokyo, Japan
    J Immunother 27:27-35. 2004
    ..Although this study design was limited with the use of fetal bovine serum, the observation still suggests that freeze-thawing does not affect viability, phenotype, subsequent maturation, or functions of DCs at any stage of maturation...
  94. ncbi request reprint High-resolution SNP and haplotype maps of the human gamma-glutamyl carboxylase gene (GGCX) and association study between polymorphisms in GGCX and the warfarin maintenance dose requirement of the Japanese population
    Pei Chieng Cha
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Hum Genet 52:856-64. 2007
    ..We found no significant association between the polymorphisms in GGCX and the dose requirement...
  95. ncbi request reprint Survival of parvovirus B19-infected cells by cellular autophagy
    Akitoshi Nakashima
    Department of Microbiology and Immunology, Tohoku University Graduate School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Virology 349:254-63. 2006
    ..Moreover, inhibition of autophagy by 3-MA significantly facilitated B19-infection-mediated cell death. These results suggest a novel mechanism by which B19-infected cells survive by cellular autophagy...
  96. ncbi request reprint Liver-targeted and peripheral blood alterations of regulatory T cells in primary biliary cirrhosis
    Ruth Y Lan
    Division of Rheumatology, Allergy, and Clinical Immunology, University of California Davis, Davis, CA 95616, USA
    Hepatology 43:729-37. 2006
    ..001) and early-stage AIH (P < .001). In conclusion, these data provide support for a genetic modulation of Treg frequency and illustrate the role Tregs play in the loss of tolerance in PBC...
  97. doi request reprint p75 Neurotrophin receptor is a marker for precursors of stellate cells and portal fibroblasts in mouse fetal liver
    Kaori Suzuki
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan
    Gastroenterology 135:270-281.e3. 2008
    ..HSCs and PFs play pivotal roles in liver regeneration and fibrosis. However, the roles of mesenchymal cells in fetal liver remain poorly understood. In this study, we aimed to characterize mesenchymal cells in mouse fetal liver...
  98. ncbi request reprint Association of VKORC1 and CYP2C9 polymorphisms with warfarin dose requirements in Japanese patients
    Taisei Mushiroda
    Laboratory for Pharmacogenetics, SNP Research Center, The Institute of Physical and Chemical Research RIKEN, Tokyo, Japan
    J Hum Genet 51:249-53. 2006
    ..5 mg/day for index 2 group; P = 4.4 x 10(-13)). Thus, analysis of the combination of VKORC1 and CYP2C9 genotypes should identify warfarin-sensitive patients who require a lower dose of drug, allowing personalized warfarin treatment...
  99. ncbi request reprint Landiolol and esmolol prevent tachycardia without altering cerebral blood flow
    Shigeru Saito
    Department of Anesthesiology, Gunma University Graduate School of Medicine, 3 39 22, Showamachi, Maebashi 371 8511, Japan
    Can J Anaesth 52:1027-34. 2005
    ..The effects of two ultra-short acting ss-adrenergic-blocking drugs, esmolol and landiolol, on systemic and cerebral circulation were studied during ECT...
  100. ncbi request reprint Relationship between newborn size and mother's blood cadmium levels, Toyama, Japan
    Muneko Nishijo
    Department of Public Health, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Arch Environ Health 59:22-5. 2004
    ..Newborn size might be influenced by maternal blood Cd levels to which infants may be exposed during gestation...
  101. ncbi request reprint Human umbilical cord blood-derived cells differentiate into hepatocyte-like cells in the Fas-mediated liver injury model
    Kazunobu Nonome
    Laboratory of Transplantation Immunology, National Research Institute for Child Health and Development, Setagaya Ku, Tokyo 157 8535, Japan
    Am J Physiol Gastrointest Liver Physiol 289:G1091-9. 2005
    ..HUCB cells differentiated into hepatocyte-like cells in the mouse liver, and liver injury was essential during this process. The differences between CD34(+) and CD34(-) cells were not observed in human hepatocyte-specific expression...