I Saiki

Summary

Affiliation: Toyama Medical and Pharmaceutical University
Country: Japan

Publications

  1. ncbi request reprint A Kampo medicine "Juzen-taiho-to"--prevention of malignant progression and metastasis of tumor cells and the mechanism of action
    I Saiki
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Biol Pharm Bull 23:677-88. 2000
  2. ncbi request reprint 4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) inhibits the intrahepatic spread of hepatocellular carcinoma and prolongs the life-span of tumor-bearing animals
    K Murakami
    Department of Pathogenic Biochemistry, Research Institute for Wakan Yaku, Toyama Medical and Pharmaceutical University, Japan
    Clin Exp Metastasis 16:633-43. 1998
  3. ncbi request reprint TAC-101 (4-[3,5-bis(trimethylsilyl)benzamido]benzoic acid) inhibits spontaneous mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma
    K Murakami
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
    Jpn J Cancer Res 90:1254-61. 1999
  4. ncbi request reprint Inhibition of angiogenesis and intrahepatic growth of colon cancer by TAC-101
    K Murakami
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan
    Clin Cancer Res 5:2304-10. 1999
  5. pmc Mediastinal lymph node metastasis model by orthotopic intrapulmonary implantation of Lewis lung carcinoma cells in mice
    Y Doki
    Department of Pathogenic Biochemistry, Research Institute for Wakan Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Br J Cancer 79:1121-6. 1999
  6. ncbi request reprint A Kampo formulation: Byakko-ka-ninjin-to (Bai-Hu-Jia-Ren-Sheng-Tang) inhibits IgE-mediated triphasic skin reaction in mice: the role of its constituents in expression of the efficacy
    T Tatsumi
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Department of Japanese Oriental (Kampo) Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani
    Biol Pharm Bull 24:284-90. 2001
  7. ncbi request reprint Intrahepatic metastasis by orthotopic implantation of a fragment of murine hepatoma and its related molecules
    S Sawada
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Tumour Biol 22:154-61. 2001
  8. ncbi request reprint Anti-invasive activity of synthetic serine protease inhibitors and its combined effect with a matrix metalloproteinase inhibitor
    T Ikeda
    Department of Pathogenic Biochemistry, Toyama Medical and Pharmaceutical University, Japan
    Anticancer Res 18:4259-65. 1998
  9. ncbi request reprint Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma
    N Mitani
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan
    Cancer Lett 165:35-42. 2001
  10. ncbi request reprint Involvement of insulin-like growth factor binding protein-3 in the retinoic acid receptor-alpha-mediated inhibition of hepatocellular carcinoma cell proliferation
    K Murakami
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan
    Cancer Lett 151:63-70. 2000

Collaborators

Detail Information

Publications19

  1. ncbi request reprint A Kampo medicine "Juzen-taiho-to"--prevention of malignant progression and metastasis of tumor cells and the mechanism of action
    I Saiki
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Biol Pharm Bull 23:677-88. 2000
    ..We also discuss the mechanism of the inhibitory action and the importance of the formulation and the constituent drugs in determining the efficacy...
  2. ncbi request reprint 4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) inhibits the intrahepatic spread of hepatocellular carcinoma and prolongs the life-span of tumor-bearing animals
    K Murakami
    Department of Pathogenic Biochemistry, Research Institute for Wakan Yaku, Toyama Medical and Pharmaceutical University, Japan
    Clin Exp Metastasis 16:633-43. 1998
    ..In summary, these results suggest that TAC-101 would be useful for a new class of therapeutic agents and that it may improve the prognosis of patients with liver-tumors including metastasizing tumor and HCC...
  3. ncbi request reprint TAC-101 (4-[3,5-bis(trimethylsilyl)benzamido]benzoic acid) inhibits spontaneous mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma
    K Murakami
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
    Jpn J Cancer Res 90:1254-61. 1999
    ..These findings suggest that TAC-101 is a novel anti-cancer agent that may improve the therapeutic modalities for lung cancer patients with metastatic disease...
  4. ncbi request reprint Inhibition of angiogenesis and intrahepatic growth of colon cancer by TAC-101
    K Murakami
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan
    Clin Cancer Res 5:2304-10. 1999
    ..007 and 0.015, respectively). These findings indicate that TAC-101 inhibits tumor angiogenesis and suggest that it may be effective against hepatic metastasis of colon cancer...
  5. pmc Mediastinal lymph node metastasis model by orthotopic intrapulmonary implantation of Lewis lung carcinoma cells in mice
    Y Doki
    Department of Pathogenic Biochemistry, Research Institute for Wakan Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Br J Cancer 79:1121-6. 1999
    ..Thus, a solitary pulmonary tumour nodule model with lymph node metastasis approximates clinical lung cancer and may provide a useful basis for lung cancer research...
  6. ncbi request reprint A Kampo formulation: Byakko-ka-ninjin-to (Bai-Hu-Jia-Ren-Sheng-Tang) inhibits IgE-mediated triphasic skin reaction in mice: the role of its constituents in expression of the efficacy
    T Tatsumi
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Department of Japanese Oriental (Kampo) Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani
    Biol Pharm Bull 24:284-90. 2001
    ..These findings suggest that the effect of Byakko-ka-ninjin-to formulation on cutaneous inflammatory disease can differ from the sum of the effect of the individual constituents...
  7. ncbi request reprint Intrahepatic metastasis by orthotopic implantation of a fragment of murine hepatoma and its related molecules
    S Sawada
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Tumour Biol 22:154-61. 2001
    ..Thus, intrahepatic metastasis of CBO140C12 tumor might be involved in the enhancement of the invasiveness of tumor cells via marked expression of MMP-9 and MT1-MMP...
  8. ncbi request reprint Anti-invasive activity of synthetic serine protease inhibitors and its combined effect with a matrix metalloproteinase inhibitor
    T Ikeda
    Department of Pathogenic Biochemistry, Toyama Medical and Pharmaceutical University, Japan
    Anticancer Res 18:4259-65. 1998
    ..In conclusion, FOY-305 inhibited the invasion of tumor cells through interference with the u-PA activity of tumor cells, and this inhibitory activity was augmented by the combination with a MMP inhibitor...
  9. ncbi request reprint Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinoma
    N Mitani
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan
    Cancer Lett 165:35-42. 2001
    ....
  10. ncbi request reprint Involvement of insulin-like growth factor binding protein-3 in the retinoic acid receptor-alpha-mediated inhibition of hepatocellular carcinoma cell proliferation
    K Murakami
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan
    Cancer Lett 151:63-70. 2000
    ..The RAR-alpha expression closely related to the upregulation of IGFBP-3 as compared with RAR-beta or RAR-alpha expressions. RAR-alpha agonist would be beneficial to inhibit the growth of HCC...
  11. ncbi request reprint Accumulation of extracellular matrix in the liver induces high metastatic potential of hepatocellular carcinoma to the lung
    S Sawada
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama, Japan
    Int J Oncol 19:65-70. 2001
    ..This is the first report showing that increase of MMP-2 in the fibrotic liver can influence the metastatic potential of HCC cells...
  12. ncbi request reprint Effect of prostatic neuropeptides on migration of prostate cancer cell lines
    O Nagakawa
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Int J Urol 8:65-70. 2001
    ....
  13. ncbi request reprint Induction of autocrine factor inhibiting cell motility from murine B16-BL6 melanoma cells by alpha-melanocyte stimulating hormone
    J Murata
    Department of Pathogenic Biochemistry, Research Institute for Wakan Yaku, Toyama Medical and Pharmaceutical University, Japan
    Int J Cancer 80:889-95. 1999
    ..The treatment of tumor cells with cycloheximide reduced the activity in alpha-MSH-stimulated CM. Our results suggest that alpha-MSH inhibited the motility of B16-BL6 cells through induction of autocrine factor(s)...
  14. ncbi request reprint Social isolation stress impairs the resistance of mice to experimental liver metastasis of murine colon 26-L5 carcinoma cells
    W Wu
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan
    Biol Pharm Bull 24:772-6. 2001
    ..These findings suggested that social isolation stress could significantly impair the resistance of mice to the development of metastasis...
  15. ncbi request reprint Effect of Shimotsu-to (a Kampo medicine, Si-Wu-Tang) and its constituents on triphasic skin reaction in passively sensitized mice
    E Tahara
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    J Ethnopharmacol 68:219-28. 1999
    ..These findings indicate that the Shimotsu-to formulation is useful for the inhibition of cutaneous inflammatory diseases...
  16. ncbi request reprint Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide
    Y Hayakawa
    Department of Pathogenic Biochemistry, Research Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Eur J Immunol 31:1720-7. 2001
    ....
  17. ncbi request reprint Effect of a matrix metalloproteinase inhibitor (ONO-4817) on lung metastasis of murine renal cell carcinoma
    Y Muraishi
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Anticancer Res 21:3845-52. 2001
    ..These results suggest that use of the MMP inhibitor (MMPI) ONO-481 7 may provide a therapeutic basis for preventing lung recurrence and metastasis of renal cell carcinoma...
  18. ncbi request reprint Antiproliferative activity of diarylheptanoids from the seeds of Alpinia blepharocalyx
    M S Ali
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Biol Pharm Bull 24:525-8. 2001
    ..Moreover, the conjugated double bond of the chalcone moiety and the phenolic hydroxyl group potentiate the antiproliferative activity of the compounds...
  19. pmc Selective inhibition of TNF-alpha-induced activation of mitogen-activated protein kinases and metastatic activities by gefitinib
    Y Ueno
    Division of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Br J Cancer 92:1690-5. 2005
    ..These results suggest that the TNF-alpha signalling pathway is a possible target of gefitinib in suppressing the intrahepatic metastasis of hepatocellular carcinoma...