Research Topics
| I SaikiSummaryAffiliation: Toyama Medical and Pharmaceutical University Country: Japan Publications
| Collaborators
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Detail Information
Publications
A Kampo medicine "Juzen-taiho-to"--prevention of malignant progression and metastasis of tumor cells and the mechanism of actionI Saiki
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
Biol Pharm Bull 23:677-88. 2000..We also discuss the mechanism of the inhibitory action and the importance of the formulation and the constituent drugs in determining the efficacy...- 4-[3,5-Bis(trimethylsilyl)benzamido] benzoic acid (TAC-101) inhibits the intrahepatic spread of hepatocellular carcinoma and prolongs the life-span of tumor-bearing animalsK Murakami
Department of Pathogenic Biochemistry, Research Institute for Wakan Yaku, Toyama Medical and Pharmaceutical University, Japan
Clin Exp Metastasis 16:633-43. 1998..In summary, these results suggest that TAC-101 would be useful for a new class of therapeutic agents and that it may improve the prognosis of patients with liver-tumors including metastasizing tumor and HCC... - TAC-101 (4-[3,5-bis(trimethylsilyl)benzamido]benzoic acid) inhibits spontaneous mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinomaK Murakami
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
Jpn J Cancer Res 90:1254-61. 1999..These findings suggest that TAC-101 is a novel anti-cancer agent that may improve the therapeutic modalities for lung cancer patients with metastatic disease... - Inhibition of angiogenesis and intrahepatic growth of colon cancer by TAC-101K Murakami
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan
Clin Cancer Res 5:2304-10. 1999..007 and 0.015, respectively). These findings indicate that TAC-101 inhibits tumor angiogenesis and suggest that it may be effective against hepatic metastasis of colon cancer... 
Mediastinal lymph node metastasis model by orthotopic intrapulmonary implantation of Lewis lung carcinoma cells in miceY Doki
Department of Pathogenic Biochemistry, Research Institute for Wakan Yaku, Toyama Medical and Pharmaceutical University, Sugitani, Japan
Br J Cancer 79:1121-6. 1999..Thus, a solitary pulmonary tumour nodule model with lymph node metastasis approximates clinical lung cancer and may provide a useful basis for lung cancer research...- A Kampo formulation: Byakko-ka-ninjin-to (Bai-Hu-Jia-Ren-Sheng-Tang) inhibits IgE-mediated triphasic skin reaction in mice: the role of its constituents in expression of the efficacyT Tatsumi
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Department of Japanese Oriental (Kampo) Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani
Biol Pharm Bull 24:284-90. 2001..These findings suggest that the effect of Byakko-ka-ninjin-to formulation on cutaneous inflammatory disease can differ from the sum of the effect of the individual constituents... - Intrahepatic metastasis by orthotopic implantation of a fragment of murine hepatoma and its related moleculesS Sawada
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
Tumour Biol 22:154-61. 2001..Thus, intrahepatic metastasis of CBO140C12 tumor might be involved in the enhancement of the invasiveness of tumor cells via marked expression of MMP-9 and MT1-MMP... - Anti-invasive activity of synthetic serine protease inhibitors and its combined effect with a matrix metalloproteinase inhibitorT Ikeda
Department of Pathogenic Biochemistry, Toyama Medical and Pharmaceutical University, Japan
Anticancer Res 18:4259-65. 1998..In conclusion, FOY-305 inhibited the invasion of tumor cells through interference with the u-PA activity of tumor cells, and this inhibitory activity was augmented by the combination with a MMP inhibitor... - Inhibitory effect of berberine on the mediastinal lymph node metastasis produced by orthotopic implantation of Lewis lung carcinomaN Mitani
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, 930-0194, Toyama, Japan
Cancer Lett 165:35-42. 2001.... - Involvement of insulin-like growth factor binding protein-3 in the retinoic acid receptor-alpha-mediated inhibition of hepatocellular carcinoma cell proliferationK Murakami
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan
Cancer Lett 151:63-70. 2000..The RAR-alpha expression closely related to the upregulation of IGFBP-3 as compared with RAR-beta or RAR-alpha expressions. RAR-alpha agonist would be beneficial to inhibit the growth of HCC... - Accumulation of extracellular matrix in the liver induces high metastatic potential of hepatocellular carcinoma to the lungS Sawada
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama, Japan
Int J Oncol 19:65-70. 2001..This is the first report showing that increase of MMP-2 in the fibrotic liver can influence the metastatic potential of HCC cells... - Effect of prostatic neuropeptides on migration of prostate cancer cell linesO Nagakawa
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
Int J Urol 8:65-70. 2001.... - Induction of autocrine factor inhibiting cell motility from murine B16-BL6 melanoma cells by alpha-melanocyte stimulating hormoneJ Murata
Department of Pathogenic Biochemistry, Research Institute for Wakan Yaku, Toyama Medical and Pharmaceutical University, Japan
Int J Cancer 80:889-95. 1999..The treatment of tumor cells with cycloheximide reduced the activity in alpha-MSH-stimulated CM. Our results suggest that alpha-MSH inhibited the motility of B16-BL6 cells through induction of autocrine factor(s)... - Social isolation stress impairs the resistance of mice to experimental liver metastasis of murine colon 26-L5 carcinoma cellsW Wu
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Japan
Biol Pharm Bull 24:772-6. 2001..These findings suggested that social isolation stress could significantly impair the resistance of mice to the development of metastasis... - Effect of Shimotsu-to (a Kampo medicine, Si-Wu-Tang) and its constituents on triphasic skin reaction in passively sensitized miceE Tahara
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
J Ethnopharmacol 68:219-28. 1999..These findings indicate that the Shimotsu-to formulation is useful for the inhibition of cutaneous inflammatory diseases... - Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramideY Hayakawa
Department of Pathogenic Biochemistry, Research Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
Eur J Immunol 31:1720-7. 2001.... - Effect of a matrix metalloproteinase inhibitor (ONO-4817) on lung metastasis of murine renal cell carcinomaY Muraishi
Department of Pathogenic Biochemistry, Institute of Natural Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
Anticancer Res 21:3845-52. 2001..These results suggest that use of the MMP inhibitor (MMPI) ONO-481 7 may provide a therapeutic basis for preventing lung recurrence and metastasis of renal cell carcinoma... - Antiproliferative activity of diarylheptanoids from the seeds of Alpinia blepharocalyxM S Ali
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
Biol Pharm Bull 24:525-8. 2001..Moreover, the conjugated double bond of the chalcone moiety and the phenolic hydroxyl group potentiate the antiproliferative activity of the compounds... - Selective inhibition of TNF-alpha-induced activation of mitogen-activated protein kinases and metastatic activities by gefitinibY Ueno
Division of Pathogenic Biochemistry, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
Br J Cancer 92:1690-5. 2005..These results suggest that the TNF-alpha signalling pathway is a possible target of gefitinib in suppressing the intrahepatic metastasis of hepatocellular carcinoma...