H Ogawa

Summary

Affiliation: Toyama Medical and Pharmaceutical University
Country: Japan

Publications

  1. ncbi request reprint Mammalian glycine N-methyltransferases. Comparative kinetic and structural properties of the enzymes from human, rat, rabbit and pig livers
    H Ogawa
    Department of Biochemistry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan
    Comp Biochem Physiol B 106:601-11. 1993
  2. ncbi request reprint Catalytic mechanism of glycine N-methyltransferase
    Yoshimi Takata
    Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, Kansas 66045 7534, USA
    Biochemistry 42:8394-402. 2003
  3. ncbi request reprint Serine hydroxymethyltransferase and threonine aldolase: are they identical?
    H Ogawa
    Department of Biochemistry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan
    Int J Biochem Cell Biol 32:289-301. 2000
  4. ncbi request reprint Rat liver 4S-benzo[a]pyrene-binding protein is distinct from glycine N-methyltransferase
    H Ogawa
    Department of Biochemistry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan
    Biochem Biophys Res Commun 233:300-4. 1997
  5. ncbi request reprint Evidence for a dimeric structure of rat liver serine dehydratase
    Hirofumi Ogawa
    Faculty of Medicine, Department of Biochemistry, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Int J Biochem Cell Biol 34:533-43. 2002
  6. ncbi request reprint Enzymatic and biochemical properties of a novel human serine dehydratase isoform
    Hirofumi Ogawa
    Department of Biochemistry, Toyama Medical and Pharmaceutical University Faculty of Medicine, Toyama 930 0194, Japan
    Biochim Biophys Acta 1764:961-71. 2006
  7. ncbi request reprint Rat liver serine dehydratase. Bacterial expression and two folding domains as revealed by limited proteolysis
    H Ogawa
    Department of Biochemistry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    J Biol Chem 274:12855-60. 1999
  8. ncbi request reprint Human liver serine dehydratase. cDNA cloning and sequence homology with hydroxyamino acid dehydratases from other sources
    H Ogawa
    Department of Biochemistry, Toyama Medical and Pharmaceutical University, Faculty of Medicine, Japan
    J Biol Chem 264:15818-23. 1989
  9. pmc Molecular cloning, sequence analysis, and expression in Escherichia coli of the cDNA for guanidinoacetate methyltransferase from rat liver
    H Ogawa
    Department of Biochemistry, Toyama Medical and Pharmaceutical University, Faculty of Medicine, Japan
    Proc Natl Acad Sci U S A 85:694-8. 1988
  10. ncbi request reprint Rat glycine methyltransferase. Complete amino acid sequence deduced from a cDNA clone and characterization of the genomic DNA
    H Ogawa
    Department of Biochemistry, Toyama Medical and Pharmaceutical University Faculty of Medicine, Japan
    Eur J Biochem 168:141-51. 1987

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Mammalian glycine N-methyltransferases. Comparative kinetic and structural properties of the enzymes from human, rat, rabbit and pig livers
    H Ogawa
    Department of Biochemistry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan
    Comp Biochem Physiol B 106:601-11. 1993
    ..Except for this difference, however, all enzymes show a high degree of sequence homology...
  2. ncbi request reprint Catalytic mechanism of glycine N-methyltransferase
    Yoshimi Takata
    Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, Kansas 66045 7534, USA
    Biochemistry 42:8394-402. 2003
    ..Thermal motion of the enzyme leads to a collision of the N and C(E) so that a S(N)2 methyltransfer reaction occurs. The proposed mechanism is supported by mutagenesis studies...
  3. ncbi request reprint Serine hydroxymethyltransferase and threonine aldolase: are they identical?
    H Ogawa
    Department of Biochemistry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan
    Int J Biochem Cell Biol 32:289-301. 2000
    ..Thus, although serine hydroxymethyltransferase from some mammalian livers exhibits a low threonine aldolase activity, the two enzymes are distinct from each other and mammals lack the "genuine" threonine aldolase...
  4. ncbi request reprint Rat liver 4S-benzo[a]pyrene-binding protein is distinct from glycine N-methyltransferase
    H Ogawa
    Department of Biochemistry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan
    Biochem Biophys Res Commun 233:300-4. 1997
    ..The lung, in which no GNMT mRNA occurred, had the 4 S BAP. Extracts of Escherichia coli and COS-7 cells expressing large amounts of GNMT showed no 4 S BAP. These findings suggest that the 4 S BAP is distinct from the subunit of GNMT...
  5. ncbi request reprint Evidence for a dimeric structure of rat liver serine dehydratase
    Hirofumi Ogawa
    Faculty of Medicine, Department of Biochemistry, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Int J Biochem Cell Biol 34:533-43. 2002
    ..The present results clearly confirm that rat SDH is a dimer, and suggest that sheep SDH is similar to rat SDH immunologically, but with a molecular weight 7500 smaller than reported previously...
  6. ncbi request reprint Enzymatic and biochemical properties of a novel human serine dehydratase isoform
    Hirofumi Ogawa
    Department of Biochemistry, Toyama Medical and Pharmaceutical University Faculty of Medicine, Toyama 930 0194, Japan
    Biochim Biophys Acta 1764:961-71. 2006
    ..The poor expression of the isoform could be explained by the more stable secondary structure of the mRNA than that of the hepatic SDH mRNA. The present findings may provide a clue as to why the protein level in cultured cells is low...
  7. ncbi request reprint Rat liver serine dehydratase. Bacterial expression and two folding domains as revealed by limited proteolysis
    H Ogawa
    Department of Biochemistry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    J Biol Chem 274:12855-60. 1999
    ..Upon the removal of urea, both fragments spontaneously refolded. These results suggest that serine dehydratase consists of two folding domains connected by a region that is very susceptible to proteases...
  8. ncbi request reprint Human liver serine dehydratase. cDNA cloning and sequence homology with hydroxyamino acid dehydratases from other sources
    H Ogawa
    Department of Biochemistry, Toyama Medical and Pharmaceutical University, Faculty of Medicine, Japan
    J Biol Chem 264:15818-23. 1989
    ....
  9. pmc Molecular cloning, sequence analysis, and expression in Escherichia coli of the cDNA for guanidinoacetate methyltransferase from rat liver
    H Ogawa
    Department of Biochemistry, Toyama Medical and Pharmaceutical University, Faculty of Medicine, Japan
    Proc Natl Acad Sci U S A 85:694-8. 1988
    ..Also, the enzyme showed kinetic properties indistinguishable from those of the liver enzyme...
  10. ncbi request reprint Rat glycine methyltransferase. Complete amino acid sequence deduced from a cDNA clone and characterization of the genomic DNA
    H Ogawa
    Department of Biochemistry, Toyama Medical and Pharmaceutical University Faculty of Medicine, Japan
    Eur J Biochem 168:141-51. 1987
    ..TATA, CAAT and GC sequences, and the complementary sequence to the enhancer core element, were located upstream of the transcription initiation site...
  11. ncbi request reprint Diurnal variation of the serine dehydratase mRNA level in rat liver
    H Ogawa
    Department of Biochemistry, Toyama Medical and Pharmaceutical University Faculty of Medicine, Japan
    Arch Biochem Biophys 308:285-91. 1994
    ..These results indicate that the rhythmic expression of serine dehydratase gene is controlled by both meal-responsive and photoresponsive regulators...
  12. pmc Sequence of the rat serine dehydratase gene
    H Ogawa
    Department of Biochemistry, Toyama Medical and Pharmaceutical University Faculty of Medicine, Japan
    Nucleic Acids Res 16:10921-3. 1988
  13. ncbi request reprint Mutation of histidine 373 to leucine in cytochrome P450c17 causes 17 alpha-hydroxylase deficiency
    S Monno
    Department of Internal Medicine, Toyama Medical and Pharmaceutical University Faculty of Medicine, Japan
    J Biol Chem 268:25811-7. 1993
    ..coli cells expressing the wild-type enzyme. These results show that the His373-->Leu mutant does not incorporate the heme prosthetic group properly and suggest a critical role of His373 in heme binding...
  14. ncbi request reprint The peptide sequences near the bound pyridoxal phosphate are conserved in serine dehydratase from rat liver, and threonine dehydratases from yeast and Escherichia coli
    H Ogawa
    Department of Biochemistry, Toyama Medical and Pharmaceutical University, Faculty of Medicine, Japan
    Biochim Biophys Acta 996:139-41. 1989
    ..The sequence of seven amino acids around the bound pyridoxal phosphate is highly conserved in serine dehydratase from rat liver, and threonine dehydratases from yeast and Escherichia coli...
  15. ncbi request reprint Microheterogeneity and intrahepatic localization of human and rat liver cytosolic alanine aminotransferase
    T Matsuzawa
    Department of Biochemistry, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan
    Biochim Biophys Acta 1340:115-22. 1997
    ..In human hepatocytes the plasma membrane was intensely stained, implicating an intracellular localization near the plasma membrane...
  16. ncbi request reprint Rat serine dehydratase gene codes for two species of mRNA of which only one is translated into serine dehydratase
    H Ogawa
    Department of Biochemistry, Toyama Medical and Pharmaceutical University Faculty of Medicine, Japan
    J Biol Chem 265:14407-13. 1990
    ....
  17. pmc Nucleotide sequence of the rat guanidinoacetate methyltransferase gene
    H Ogawa
    Department of Biochemistry, Toyama Medical and Pharmaceutical University, Faculty of Medicine, Japan
    Nucleic Acids Res 16:8715-6. 1988
  18. ncbi request reprint GTP-binding-protein-coupled receptor kinase 2 (GRK2) binds and phosphorylates tubulin
    K Haga
    Department of Neurochemistry, Faculty of Medicine, University of Tokyo, Japan
    Eur J Biochem 255:363-8. 1998
    ..The phosphorylation of tubulin was stimulated by betagamma subunits and agonist-bound muscarinic receptors. Phosphorylated tubulin could be polymerized into microtubules, and polymerized tubulin was also phosphorylated by GRK2...
  19. pmc A single amino acid substitution within the mature sequence of ornithine aminotransferase obstructs mitochondrial entry of the precursor
    T Kobayashi
    Department of Biochemistry, School of Medicine, Fujita Health University, Aichi, Japan
    Am J Hum Genet 57:284-91. 1995
    ..These findings suggest that not only the signal sequence but a critical part of the mature sequence plays an essential role in mitochondrial entry of the OAT precursor protein...
  20. ncbi request reprint Evaluation of the effects of peptide antibiotics human beta-defensins-1/-2 and LL-37 on histamine release and prostaglandin D(2) production from mast cells
    F Niyonsaba
    Department of Biochemistry, Juntendo University, School of Medicine, Tokyo, Japan
    Eur J Immunol 31:1066-75. 2001
    ..Thus, hBD-2 and LL-37 may have modulatory effects on inflammatory reactions...
  21. ncbi request reprint Long-term interleukin-1alpha treatment inhibits insulin signaling via IL-6 production and SOCS3 expression in 3T3-L1 adipocytes
    T Uno
    First Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan
    Horm Metab Res 40:8-12. 2008
    ..These results suggest that the IL-1alpha-mediated deterioration of insulin signaling is largely due to the IL-6 production and SOCS3 induction in 3T3-L1 adipocytes...
  22. ncbi request reprint Some biochemical and histochemical properties of human liver serine dehydratase
    Tatsuhiko Kashii
    Department of Medicine, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Int J Biochem Cell Biol 37:574-89. 2005
    ..These findings provide an additional support to the previous notion suggested by physiological experiments that contribution of serine dehydratase to gluconeogenesis is negligible or little in human liver...
  23. ncbi request reprint Crystal structure of serine dehydratase from rat liver
    Taro Yamada
    Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, Kansas 66045 7534, USA
    Biochemistry 42:12854-65. 2003
    ..A possible catalytic mechanism involves the phosphate group, surrounded by the characteristic sequence, acting as a general acid to donate a proton to the leaving hydroxyl group of serine...
  24. doi request reprint A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies
    Taro Yamada
    Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045 7534, USA
    Biochim Biophys Acta 1780:809-18. 2008
    ..Consequently, the proton transfer rate from S(G) of C309 to N1 of the bound PLP is decreased, which determines the rate of catalytic reaction...
  25. ncbi request reprint Crystal structure of guanidinoacetate methyltransferase from rat liver: a model structure of protein arginine methyltransferase
    Junichi Komoto
    Department of Molecular Biosciences, The University of Kansas, 1200 Sunnyside Avenue, 2034 Howorth Hall, Lawrence, KS 66045 7534, USA
    J Mol Biol 320:223-35. 2002
    ..Therefore, this structure provides insight into the structure and catalysis of protein arginine methyltransferases...
  26. ncbi request reprint Localization and hormonal control of serine dehydratase during metabolic acidosis differ markedly from those of phosphoenolpyruvate carboxykinase in rat kidney
    Tohru Masuda
    Department of Biochemistry, Faculty of Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Japan
    Int J Biochem Cell Biol 35:1234-47. 2003
    ..The present findings clearly indicate that the localization of SDH and its hormonal regulation during acidosis are strikingly different from those of PEPCK...
  27. ncbi request reprint Serine dehydratase expression decreases in rat livers injured by chronic thioacetamide ingestion
    Inmaculada López-Flores
    Biochemistry and Molecular Biology Section, Department of Experimental Biology, University of Jaen, Campus Las Lagunillas, Jaen, Spain
    Mol Cell Biochem 268:33-43. 2005
    ..These results enhance our understanding about the biochemical mechanisms implied in the control and integration of serine catabolism during liver injury in rat...
  28. ncbi request reprint Catalytic mechanism of S-adenosylhomocysteine hydrolase: roles of His 54, Asp130, Glu155, Lys185, and Aspl89
    Taro Yamada
    Department of Molecular Biosciences, 3004 Haworth Hall, University of Kansas, Lawrence, KS 66045 7534, USA
    Int J Biochem Cell Biol 37:2417-35. 2005
    ....
  29. ncbi request reprint Catalytic mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190
    Yoshimi Takata
    Department of Molecular Biosciences, University of Kansas, Lawrence, Kansas 66045 7534, USA
    J Biol Chem 277:22670-6. 2002
    ..His-54 and His-300 hold and polarize a water molecule, which nucleophilically attacks the C5'- of 3'-keto-4',5'-dehydroadenosine to produce 3'-keto-Ado...
  30. ncbi request reprint Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine
    Yafei Huang
    Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045 7534, USA
    J Biol Chem 277:7477-82. 2002
    ..C4 interaction. DEA has been believed to be an inactivator of AdoHcyase, but this study indicates that DEA is a reversible inhibitor. On the basis of the complexed structure, selective inhibitors of AdoHcyase have been designed...
  31. ncbi request reprint Monoclinic guanidinoacetate methyltransferase and gadolinium ion-binding characteristics
    Junichi Komoto
    Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045 7534, USA
    Acta Crystallogr D Biol Crystallogr 59:1589-96. 2003
    ..Gd ions can bind to proteins without changing the native protein structures and Gd atoms produce strong anomalous dispersion signals from Cu Kalpha radiation; however, Gd-ion binding to protein requires a relatively specific geometry...