Masaki Kamakura

Summary

Affiliation: Toyama Prefectural University
Country: Japan

Publications

  1. ncbi Inhibition of specific degradation of 57-kDa protein in royal jelly during storage by citrate buffer
    Masaki Kamakura
    Biotechnology Research Center, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Kosugi, Toyama 939 0398, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:207-10. 2005
  2. doi Royalactin induces queen differentiation in honeybees
    Masaki Kamakura
    Biotechnology Research Center, Toyama Prefectural University, Imizu, Toyama 939 0398, Japan
    Nature 473:478-83. 2011
  3. ncbi Influence of royal jelly on mouse hepatic gene expression and safety assessment with a DNA microarray
    Masaki Kamakura
    Biotechnology Research Center, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Kosugi, Toyama 939 0398, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:148-55. 2005
  4. ncbi Increase of AMPA receptor glutamate receptor 1 subunit and B-cell receptor-associated protein 31 gene expression in hippocampus of fatigued mice
    Masaki Kamakura
    Biotechnology Research Center, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Kosugi, Toyama 939 0398, Japan
    Neurosci Lett 387:1-4. 2005
  5. ncbi A hypopharyngeal gland protein of the worker honeybee Apis mellifera L. enhances proliferation of primary-cultured rat hepatocytes and suppresses apoptosis in the absence of serum
    Masaki Kamakura
    Biotechnology Research Center, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Kosugi, Toyama 939 0398, Japan
    Protein Expr Purif 45:307-14. 2006
  6. ncbi Changes in hepatic gene expression associated with the hypocholesterolaemic activity of royal jelly
    Masaki Kamakura
    Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939 0398, Japan
    J Pharm Pharmacol 58:1683-9. 2006
  7. doi Comparison of metabolism of sesamin and episesamin by drug-metabolizing enzymes in human liver
    Kaori Yasuda
    Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan
    Drug Metab Dispos 40:1917-26. 2012
  8. doi Human cytochrome P450-dependent differential metabolism among three 2α-substituted-1α,25-dihydroxyvitamin D(3) analogs
    Kaori Yasuda
    Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939 0398, Japan
    J Steroid Biochem Mol Biol 133:84-92. 2013
  9. doi Sequential metabolism of sesamin by cytochrome P450 and UDP-glucuronosyltransferase in human liver
    Kaori Yasuda
    Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939 0398, Japan
    Drug Metab Dispos 39:1538-45. 2011
  10. doi Three-step hydroxylation of vitamin D3 by a genetically engineered CYP105A1: enzymes and catalysis
    Keiko Hayashi
    Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Kurokawa, Imizu, Toyama, Japan
    FEBS J 277:3999-4009. 2010

Collaborators

Detail Information

Publications28

  1. ncbi Inhibition of specific degradation of 57-kDa protein in royal jelly during storage by citrate buffer
    Masaki Kamakura
    Biotechnology Research Center, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Kosugi, Toyama 939 0398, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:207-10. 2005
    ..0) effectively inhibited the decrease of 57-kDa protein concentration in RJ during storage. These results suggest that citrate buffer (pH 4.0) could be available as a new preservative agent to maintain the quality of RJ...
  2. doi Royalactin induces queen differentiation in honeybees
    Masaki Kamakura
    Biotechnology Research Center, Toyama Prefectural University, Imizu, Toyama 939 0398, Japan
    Nature 473:478-83. 2011
    ..These findings indicate that a specific factor in royal jelly, royalactin, drives queen development through an Egfr-mediated signalling pathway...
  3. ncbi Influence of royal jelly on mouse hepatic gene expression and safety assessment with a DNA microarray
    Masaki Kamakura
    Biotechnology Research Center, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Kosugi, Toyama 939 0398, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:148-55. 2005
    ..We suggest that application of DNA microarray technology to the biochemical evaluation of food safety may be effective for rapid and precise quality control...
  4. ncbi Increase of AMPA receptor glutamate receptor 1 subunit and B-cell receptor-associated protein 31 gene expression in hippocampus of fatigued mice
    Masaki Kamakura
    Biotechnology Research Center, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Kosugi, Toyama 939 0398, Japan
    Neurosci Lett 387:1-4. 2005
    ..These results suggest that a compositional change of AMPA receptor (increase of GluR1) and upregulation of the Bap31 gene may be implicated in fatigue in mice...
  5. ncbi A hypopharyngeal gland protein of the worker honeybee Apis mellifera L. enhances proliferation of primary-cultured rat hepatocytes and suppresses apoptosis in the absence of serum
    Masaki Kamakura
    Biotechnology Research Center, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Kosugi, Toyama 939 0398, Japan
    Protein Expr Purif 45:307-14. 2006
    ..It also activated mitogen-activated protein kinase, as well as protein kinase B, which is a key regulator of cell survival. These findings suggest that p56kP-4 has a growth factor-like action on primary-cultured rat hepatocytes...
  6. ncbi Changes in hepatic gene expression associated with the hypocholesterolaemic activity of royal jelly
    Masaki Kamakura
    Biotechnology Research Center, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939 0398, Japan
    J Pharm Pharmacol 58:1683-9. 2006
    ..Thus, the hypocholesterolaemic action of RJ appears to be associated with a decrease of SQLE and an increase of LDLR in mice...
  7. doi Comparison of metabolism of sesamin and episesamin by drug-metabolizing enzymes in human liver
    Kaori Yasuda
    Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Imizu, Toyama, Japan
    Drug Metab Dispos 40:1917-26. 2012
    ..In this study, we have revealed significantly different metabolism by P450, UDP-glucuronosyltransferase, and catechol-O-methyltransferase for sesamin and episesamin, resulting in different biological effects...
  8. doi Human cytochrome P450-dependent differential metabolism among three 2α-substituted-1α,25-dihydroxyvitamin D(3) analogs
    Kaori Yasuda
    Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939 0398, Japan
    J Steroid Biochem Mol Biol 133:84-92. 2013
    ..These results suggest that modification at C-2α position and C-19 demethylenation markedly change metabolic profiles and biological activities of vitamin D analogs...
  9. doi Sequential metabolism of sesamin by cytochrome P450 and UDP-glucuronosyltransferase in human liver
    Kaori Yasuda
    Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939 0398, Japan
    Drug Metab Dispos 39:1538-45. 2011
    ..On the basis of these results, we concluded that CYP2C9, UGT2B7, and COMT played essential roles in the metabolism of sesamin in the human liver...
  10. doi Three-step hydroxylation of vitamin D3 by a genetically engineered CYP105A1: enzymes and catalysis
    Keiko Hayashi
    Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Kurokawa, Imizu, Toyama, Japan
    FEBS J 277:3999-4009. 2010
    ..In conclusion, we have demonstrated that R73V/R84A can catalyze hydroxylations at C25, C1 and C26 (C27) positions of vitamin D(3) to produce biologically useful compounds...
  11. doi Anti-proliferative activity of 25-hydroxyvitamin D3 in human prostate cells
    Eiji Munetsuna
    Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939 0398, Japan Department of Biochemistry, Fujita Health University for Medical Science, Toyoake 470 1192, Japan
    Mol Cell Endocrinol 382:960-70. 2014
    ..DNA microarray and real-time RT-PCR analyses suggest that semaphorin 3B, cystatin E/M, and cystatin D may be involved in the antiproliferative effect of 25(OH)D3. ..
  12. doi Mechanism of the anti-proliferative action of 25-hydroxy-19-nor-vitamin D(3) in human prostate cells
    Eiji Munetsuna
    Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939 0398, Japan
    J Mol Endocrinol 47:209-18. 2011
    ....
  13. doi UV-dependent production of 25-hydroxyvitamin D2 in the recombinant yeast cells expressing human CYP2R1
    Kaori Yasuda
    Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939 0398, Japan
    Biochem Biophys Res Commun 434:311-5. 2013
    ..This novel method for producing 25-hydroxyvitamin D2 without a substrate could be useful for practical purposes...
  14. doi Bioconversion of vitamin D to its active form by bacterial or mammalian cytochrome P450
    Toshiyuki Sakaki
    Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939 0398, Japan
    Biochim Biophys Acta 1814:249-56. 2011
    ..Therefore, we believe that the bioconversion of vitamin D and its analogs is one of the most promising P450 reactions in terms of practical application...
  15. doi Metabolism of sesamin by cytochrome P450 in human liver microsomes
    Kaori Yasuda
    Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939 0398, Japan
    Drug Metab Dispos 38:2117-23. 2010
    ..Our findings strongly suggest that further studies are needed to reveal the interaction between sesamin and therapeutic drugs mainly metabolized by CYP2C9...
  16. doi Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1
    Keiko Hayashi
    Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, 5180 Kurokawa, Imizu, Toyama 939 0398, Japan
    Biochemistry 47:11964-72. 2008
    ....
  17. doi Upregulation of Myo6 expression after traumatic stress in mouse hippocampus
    Keisuke Tamaki
    Laboratories of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kakuma machi, Kanazawa, Ishikawa 920 1192, Japan
    Neurosci Lett 433:183-7. 2008
    ..These results suggest that Myo6 may be selectively and rapidly upregulated to play a hitherto unidentified role in the maintenance of the integrity and functionality in the hippocampus after traumatic stress...
  18. ncbi Inhibition of specific degradation of 57-kDa protein in royal jelly during storage by ethylenediaminetetraacetic acid
    Masaki Kamakura
    POLA R and D Laboratories, POLA Corporation, Yokohama, Japan
    Biosci Biotechnol Biochem 66:175-8. 2002
    ..These results suggest that EDTA inhibits a specific proteinase activity in RJ, thereby suppressing the degradation of 57-kDa protein during storage at high temperature...
  19. ncbi Signal transduction mechanism leading to enhanced proliferation of primary cultured adult rat hepatocytes treated with royal jelly 57-kDa protein
    Masaki Kamakura
    POLA R and D Laboratories, POLA Corporation, Kashio cho, Totuka ku, Yokohama 244 0812, Japan
    J Biochem 132:911-9. 2002
    ..These results suggest that, like growth factors, the 57-kDa protein activates several important intracellular signaling factors involved in the stimulation of hepatocyte DNA synthesis and the protection of cells from apoptosis...
  20. ncbi Enzymatic properties of human CYP2W1 expressed in Escherichia coli
    Hidenori Yoshioka
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Biochem Biophys Res Commun 345:169-74. 2006
    ..Further analysis using an E. coli expression system will reveal substrate specificity of CYP2W1 and why this P450 isoform is universally conserved in vertebrates...
  21. doi Crystal structure of CYP105A1 (P450SU-1) in complex with 1alpha,25-dihydroxyvitamin D3
    Hiroshi Sugimoto
    RIKEN SPring 8 Center, Harima Institute, Sayo, Hyogo 679 5148, Japan
    Biochemistry 47:4017-27. 2008
    ..These results provide the structural basis for understanding the mechanism of the two-step hydroxylation that activates VD 3...
  22. ncbi Purification and characterization of mouse CYP27B1 overproduced by an Escherichia coli system coexpressing molecular chaperonins GroEL/ES
    Eriko Uchida
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Oiwake cho, Sakyo ku, Kyoto 606 8502, Japan
    Biochem Biophys Res Commun 323:505-11. 2004
    ..Based on these results and the fact that human CYP27A1 and Streptomyces CYP105A1 also convert vitamin D3 to 1alpha,25(OH)D3, 1alpha-hydroxylation, and 25-hydroxylation of vitamin D3 appear to be closely linked together...
  23. ncbi Metabolism of vitamin D by human microsomal CYP2R1
    Raku Shinkyo
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Oiwake cho, Sakyo ku, Kyoto 606 8502, Japan
    Biochem Biophys Res Commun 324:451-7. 2004
    ..97min(-1), respectively. The k(cat)/K(m) value of CYP2R1 was 26-fold higher than that of CYP27A1. These results strongly suggest that CYP2R1 plays a physiologically important role in the vitamin D 25-hydroxylation in humans...
  24. ncbi Metabolism of 2 alpha-propoxy-1 alpha,25-dihydroxyvitamin D3 and 2 alpha-(3-hydroxypropoxy)-1 alpha,25-dihydroxyvitamin D3 by human CYP27A1 and CYP24A1
    Daisuke Abe
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    Drug Metab Dispos 33:778-84. 2005
    ..These results and a high calcium effect of C3O1 and O2C3 in animal experiments using rats suggest that C3O1 and O2C3 are promising for clinical treatment of osteoporosis...
  25. ncbi Identification of the amino acid residue of CYP27B1 responsible for binding of 25-hydroxyvitamin D3 whose mutation causes vitamin D-dependent rickets type 1
    Keiko Yamamoto
    Institute of Biomaterials and Bioengineering and School of Biomedical Sciences, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo 101 0062, Japan
    J Biol Chem 280:30511-6. 2005
    ..This is the first report that shows a critical amino acid residue recognizing the 25-hydroxyl group of the vitamin D3...
  26. ncbi Biodegradation of dioxins by recombinant Escherichia coli expressing rat CYP1A1 or its mutant
    Raku Shinkyo
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Kyoto 606 8502, Japan
    Appl Microbiol Biotechnol 72:584-90. 2006
    ..These results indicate the possible application of prokaryotic cells expressing DeltaF240A to the bioremediation of PCDD-contaminated soil...
  27. ncbi Role of Gln 85 of human CYP27A1 in 25-hydroxyvitamin D(3)-binding and protein folding
    Natsumi Sawada
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Biochem Biophys Res Commun 355:211-6. 2007
    ..Based on these results, it is possible that Gln 85 plays essential roles in both substrate-binding and protein folding...
  28. ncbi Kinetic studies of 25-hydroxy-19-nor-vitamin D3 and 1 alpha,25-dihydroxy-19-nor-vitamin D3 hydroxylation by CYP27B1 and CYP24A1
    Naoko Urushino
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Oiwake cho, Sakyo ku, Kyoto, Japan
    Drug Metab Dispos 35:1482-8. 2007
    ..Thus, the results suggest that 25(OH)-19-nor-D(3) has potential as an attractive agent for prostate cancer therapy...