T Hatanaka

Summary

Affiliation: Toyama Medical and Pharmaceutical University
Country: Japan

Publications

  1. ncbi Ion pair skin transport of a zwitterionic drug, cephalexin
    T Hatanaka
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama, Japan
    J Control Release 66:63-71. 2000
  2. ncbi Drug targeting efficacy to underlying muscle following topical application. I. Evaluation based on a physiological pharmacokinetic model
    T Hatanaka
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan
    Biol Pharm Bull 23:860-5. 2000
  3. ncbi Clinical pharmacokinetics of pravastatin: mechanisms of pharmacokinetic events
    T Hatanaka
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan
    Clin Pharmacokinet 39:397-412. 2000
  4. ncbi Stereoselective pharmacokinetics and pharmacodynamics of organic nitrates in rats
    T Hatanaka
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Pharmacol Exp Ther 298:346-53. 2001
  5. ncbi Age-related changes in skin permeability of hydrophilic and lipophilic compounds in rats
    T Ngawhirunpat
    Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Pharmazie 56:231-4. 2001
  6. ncbi Effect of pH on skin permeation enhancement of acidic drugs by l-menthol-ethanol system
    K Katayama
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Int J Pharm 226:69-80. 2001
  7. ncbi Age difference in simultaneous permeation and metabolism of ethyl nicotinate in rat skin
    T Ngawhirunpat
    Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Biol Pharm Bull 24:414-7. 2001

Collaborators

Detail Information

Publications7

  1. ncbi Ion pair skin transport of a zwitterionic drug, cephalexin
    T Hatanaka
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani 2630, Toyama, Japan
    J Control Release 66:63-71. 2000
    ..To obtain the maximum enhancement of skin transport of zwitterionic drugs via ion pair concept, one should select a counter ion having high lipophilicity and small volume, and a solvent with suitable pH and low dielectric constant...
  2. ncbi Drug targeting efficacy to underlying muscle following topical application. I. Evaluation based on a physiological pharmacokinetic model
    T Hatanaka
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan
    Biol Pharm Bull 23:860-5. 2000
    ....
  3. ncbi Clinical pharmacokinetics of pravastatin: mechanisms of pharmacokinetic events
    T Hatanaka
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan
    Clin Pharmacokinet 39:397-412. 2000
    ..Further mechanistic studies are required to establish the pharmacokinetic-pharmacodynamic relationships of pravastatin and to provide the optimal therapeutic efficacy for various types of patients with hypercholesterolaemia...
  4. ncbi Stereoselective pharmacokinetics and pharmacodynamics of organic nitrates in rats
    T Hatanaka
    Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Pharmacol Exp Ther 298:346-53. 2001
    ..This suggests that the stereostructure of organic nitrates controls the vasodilator potency and duration of action...
  5. ncbi Age-related changes in skin permeability of hydrophilic and lipophilic compounds in rats
    T Ngawhirunpat
    Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Pharmazie 56:231-4. 2001
    ..In addition, it is speculated that the thickness of skin is a large factor in the decrease of its permeability with age...
  6. ncbi Effect of pH on skin permeation enhancement of acidic drugs by l-menthol-ethanol system
    K Katayama
    Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Int J Pharm 226:69-80. 2001
    ..Whether the total flux increased with increase of pH was dependent on the lipophilicity of drug. These results suggest that the pH of l-menthol-ethanol system should be given attention to elicit the maximum permeation enhancement...
  7. ncbi Age difference in simultaneous permeation and metabolism of ethyl nicotinate in rat skin
    T Ngawhirunpat
    Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Biol Pharm Bull 24:414-7. 2001
    ..These findings indicated that the discrepancy in transdermal profiles of EN among the ages tested was dominantly due to the difference in the development of esterase in the growth process...