Tsugunobu Andoh

Summary

Affiliation: Toyama Medical and Pharmaceutical University
Country: Japan

Publications

  1. ncbi request reprint Preconditioning-mediated neuroprotection: role of nitric oxide, cGMP, and new protein expression
    Tsugunobu Andoh
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Japan
    Ann N Y Acad Sci 962:1-7. 2002
  2. ncbi request reprint Mechanical allodynia induced by paclitaxel, oxaliplatin and vincristine: different effectiveness of gabapentin and different expression of voltage-dependent calcium channel alpha(2)delta-1 subunit
    Punam Gauchan
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    Biol Pharm Bull 32:732-4. 2009
  3. doi request reprint Leukotriene B(4) mediates sphingosylphosphorylcholine-induced itch-associated responses in mouse skin
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930 1094, Japan
    J Invest Dermatol 129:2854-60. 2009
  4. ncbi request reprint Roles of kinin B1 and B2 receptors in skin cancer pain produced by orthotopic melanoma inoculation in mice
    Masahide Fujita
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Eur J Pain 14:588-94. 2010
  5. ncbi request reprint Inhibitory effects of the methanol extract of Ganoderma lucidum on mosquito allergy-induced itch-associated responses in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    J Pharmacol Sci 114:292-7. 2010
  6. doi request reprint Morphine inhibits herpetic allodynia through mu-opioid receptors induced in Abeta-fiber neurons
    Atsushi Sasaki
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Neuroreport 19:975-9. 2008
  7. ncbi request reprint Intracisternal, but not intrathecal, injection of naloxone inhibits cutaneous itch-related response in mice
    Yasushi Kuraishi
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Biol Pharm Bull 31:2143-5. 2008
  8. ncbi request reprint Pharmacological evaluation of morphine and non-opioid analgesic adjuvants in a mouse model of skin cancer pain
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 31:520-2. 2008
  9. ncbi request reprint Inhibitory effect of methanol extract of Ganoderma lucidum on acute itch-associated responses in mice
    Qun Zhang
    Department of Applied Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0914, Japan
    Biol Pharm Bull 33:909-11. 2010
  10. ncbi request reprint Involvement of peripheral adenosine 5'-triphosphate and P2X purinoceptor in pain-related behavior produced by orthotopic melanoma inoculation in mice
    Masahide Fujita
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan
    Eur J Neurosci 31:1629-36. 2010

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Preconditioning-mediated neuroprotection: role of nitric oxide, cGMP, and new protein expression
    Tsugunobu Andoh
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama, Japan
    Ann N Y Acad Sci 962:1-7. 2002
    ..These results suggest that *NO-cGMP-PKG signaling pathway plays an important role in the preconditioning-induced neuroprotection, and perhaps cardioprotection, against oxidative stress...
  2. ncbi request reprint Mechanical allodynia induced by paclitaxel, oxaliplatin and vincristine: different effectiveness of gabapentin and different expression of voltage-dependent calcium channel alpha(2)delta-1 subunit
    Punam Gauchan
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    Biol Pharm Bull 32:732-4. 2009
    ..It may be partly due to the distinct effects of chemotherapy agents on the expression of alpha(2)delta-1 subunit of voltage-dependent calcium channel...
  3. doi request reprint Leukotriene B(4) mediates sphingosylphosphorylcholine-induced itch-associated responses in mouse skin
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930 1094, Japan
    J Invest Dermatol 129:2854-60. 2009
    ..Sphingomyelin deacylase and SPC receptors may be previously unreported targets for antipruritic drugs...
  4. ncbi request reprint Roles of kinin B1 and B2 receptors in skin cancer pain produced by orthotopic melanoma inoculation in mice
    Masahide Fujita
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Eur J Pain 14:588-94. 2010
    ..Although bradykinin is a potent algogenic peptide, the roles of this peptide and kinin receptors in cancer pain are unclear...
  5. ncbi request reprint Inhibitory effects of the methanol extract of Ganoderma lucidum on mosquito allergy-induced itch-associated responses in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    J Pharmacol Sci 114:292-7. 2010
    ..lucidum extract relieves allergic itch through a peripheral action. The results support the idea that mast cells and H₁ histamine receptors are not the primary sites of the antipruritic action of G. lucidum extract...
  6. doi request reprint Morphine inhibits herpetic allodynia through mu-opioid receptors induced in Abeta-fiber neurons
    Atsushi Sasaki
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Neuroreport 19:975-9. 2008
    ..Viral propagation in the sensory ganglion may induce mu-opioid receptor expression in Abeta fibers, which may be responsible for the inhibitory action of local opioids on mechanical allodynia in mice with herpetic pain...
  7. ncbi request reprint Intracisternal, but not intrathecal, injection of naloxone inhibits cutaneous itch-related response in mice
    Yasushi Kuraishi
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Biol Pharm Bull 31:2143-5. 2008
    ..These results suggest that mu-opioid receptor in the lower brainstem, but not spinal cord, is a site of central pruritogenic action of opioids and is involved in the facilitatory regulation of itch signaling...
  8. ncbi request reprint Pharmacological evaluation of morphine and non-opioid analgesic adjuvants in a mouse model of skin cancer pain
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 31:520-2. 2008
    ..This mouse model of skin cancer may be useful for the pharmacological evaluation of the effects of opioids and analgesic adjuvants on mixed nociceptive-neuropathic pain of advanced cancer...
  9. ncbi request reprint Inhibitory effect of methanol extract of Ganoderma lucidum on acute itch-associated responses in mice
    Qun Zhang
    Department of Applied Pharmacology, University of Toyama, 2630 Sugitani, Toyama 930 0914, Japan
    Biol Pharm Bull 33:909-11. 2010
    ..These results raise the possibility that MEGL is effective against pruritus mediated by proteinases and 5-HT and that primary afferents expressing PAR(2) and 5-HT(2A) receptors are the sites of its action...
  10. ncbi request reprint Involvement of peripheral adenosine 5'-triphosphate and P2X purinoceptor in pain-related behavior produced by orthotopic melanoma inoculation in mice
    Masahide Fujita
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan
    Eur J Neurosci 31:1629-36. 2010
    ..These results suggest that ATP and P2X, especially P2X(3), receptors are involved in skin cancer pain, due to the increased release of ATP and increased expression of P2X(3) receptors in the sensory neurons...
  11. doi request reprint Modality-specific hyperexcitability of dorsal horn neurons to mechanical stimuli in herpetic mice
    Yukitoshi Nishikawa
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Neuroreport 20:1077-80. 2009
    ..These results suggest that dynamic allodynia in the affected dermatome is because of the increased excitability of wide-dynamic range neurons, but not primary afferents, to brush stimulation...
  12. ncbi request reprint Pharmacological differences between static and dynamic allodynia in mice with herpetic or postherpetic pain
    Atsushi Sasaki
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan
    J Pharmacol Sci 108:266-73. 2008
    ..This murine model may be useful for the study of the mechanisms of dynamic allodynia of herpetic pain or postherpetic neuralgia and the development of new analgesics effective against the dynamic allodynia...
  13. doi request reprint Different roles of capsaicin-sensitive and H1 histamine receptor-expressing sensory neurones in itch of mosquito allergy in mice
    Tasuku Nakano
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Acta Derm Venereol 88:449-54. 2008
    ..The results suggest that capsaicin-sensitive sensory neurones that lack H1 histamine receptors play a key role in signalling of allergic itch...
  14. ncbi request reprint Activation of proteinase-activated receptors induces itch-associated response through histamine-dependent and -independent pathways in mice
    Kenichiro Tsujii
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    J Pharmacol Sci 108:385-8. 2008
    ..These results suggest that PAR1, PAR2, and PAR4 are involved in itch and that histamine is a cause of itch related to PAR1 and PAR4, but not PAR2...
  15. ncbi request reprint Evidence for separate involvement of different mu-opioid receptor subtypes in itch and analgesia induced by supraspinal action of opioids
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan
    J Pharmacol Sci 106:667-70. 2008
    ..The results suggest that different subtype and/or splice variants of mu-OR are separately involved in pruritus and antinociception of opioids...
  16. ncbi request reprint A mouse model of sural nerve injury-induced neuropathy: gabapentin inhibits pain-related behaviors and the hyperactivity of wide-dynamic range neurons in the dorsal horn
    Yu Omori
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan
    J Pharmacol Sci 109:532-9. 2009
    ..Sural nerve ligation provides a new mouse model of neuropathic pain, which is easy to prepare and sensitive to gabapentin...
  17. doi request reprint Cathepsin E induces itch-related response through the production of endothelin-1 in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, Japan
    Eur J Pharmacol 686:16-21. 2012
    ..These results suggest that cathepsin E is an endogenous itch inducer, and that its action is mediated at least in part by the production of endothelin-1 in the epidermis...
  18. doi request reprint Involvement of leukotriene B4 in itching in a mouse model of ocular allergy
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Exp Eye Res 98:97-103. 2012
    ..H(1) receptor antagonists with an inhibitory effect on the action and/or production of LTB(4) may have more potent anti-pruritic activity than selective H(1) antagonists...
  19. doi request reprint Contribution of spinal galectin-3 to acute herpetic allodynia in mice
    Ichiro Takasaki
    University of Toyama, Toyama, Japan
    Pain 153:585-92. 2012
    ..Galectin-3 may be a new therapeutic target for the treatment of herpes zoster-associated pain...
  20. ncbi request reprint Possible involvement of 5-lipoxygenase metabolite in itch-associated response of mosquito allergy in mice
    Yasushi Kuraishi
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    J Pharmacol Sci 105:41-7. 2007
    ..The results suggest that 5-lipoxygenase metabolite(s) other than leukotriene B(4) and cysteinyl leukotrienes are involved in mosquito allergy-associated itching...
  21. ncbi request reprint Involvement of Tryptase and Proteinase-Activated Receptor-2 in Spontaneous Itch-Associated Response in Mice With Atopy-like Dermatitis
    Kenichiro Tsujii
    Department of Applied Pharmacology, Graduate School of Medical and Pharmaceutical Science, University of Toyama, Japan
    J Pharmacol Sci 109:388-95. 2009
    ..PAR(2)-immunoreactivity was observed in the epidermal keratinocytes in healthy and dermatitis mice. These results suggest that PAR(2) and serine proteinase(s), mainly tryptase, are involved in the itch of chronic dermatitis...
  22. doi request reprint Topical surfactant-induced pruritus: involvement of histamine released from epidermal keratinocytes
    Yoshihiro Inami
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 1094, Japan
    J Pharmacol Exp Ther 344:459-66. 2013
    ..The present results suggest that sodium laurate induced delayed scratching at an alkaline pH through the increased production of histamine in keratinocytes, which may be due to enhanced processing of 74-kDa to 53-kDa HDC...
  23. ncbi request reprint Effects of topical application of tacrolimus on acute itch-associated responses in mice
    Tasuku Nakano
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 31:752-4. 2008
    ..Though precise mechanisms remain unclear, the action on sensory neurons expressing protease-activated receptor-2 and transient receptor potential vanilloid-1 capsaicin receptor may be involved in the inhibitory effects of tacrolimus...
  24. ncbi request reprint Suppression by bepotastine besilate of substance P-induced itch-associated responses through the inhibition of the leukotriene B4 action in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Eur J Pharmacol 547:59-64. 2006
    ..The results suggest that the inhibition of the actions of leukotriene B(4) as well as histamine is involved in the anti-pruritic effect of bepotastine besilate...
  25. ncbi request reprint Itch-related responses of dorsal horn neurons to cutaneous allergic stimulation in mice
    Yu Omori
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Japan
    Neuroreport 20:478-81. 2009
    ..The results suggest that a small minority of neurons in the superficial dorsal horn are involved in allergic itch signals...
  26. ncbi request reprint [Surfactant-induced itching and the involvement of histamine released from keratinocytes]
    Yoshihiro Inami
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Yakugaku Zasshi 132:1225-30. 2012
    ..The increase in histamine release may be attributable to the activation of HDC in epidermal keratinocytes...
  27. doi request reprint Different dorsal horn neurons responding to histamine and allergic itch stimuli
    Tasuku Nakano
    Department of Applied Pharmacology, University of Toyama, Toyama, Japan
    Neuroreport 19:723-6. 2008
    ....
  28. ncbi request reprint Tonic inhibition of allergic itch signaling by the descending noradrenergic system in mice
    Yoshikazu Gotoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    J Pharmacol Sci 115:417-20. 2011
    ..The serotonergic system may not be involved...
  29. ncbi request reprint Effects of the prostaglandin E1 analog limaprost on mechanical allodynia caused by chemotherapeutic agents in mice
    Punam Gauchan
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    J Pharmacol Sci 109:469-72. 2009
    ..These results suggest that limaprost is effective against mechanical allodynia induced by paclitaxel and oxaliplatin, which may be due to inhibition of the decrease in peripheral blood flow...
  30. ncbi request reprint Involvement of endothelin and ET(A) endothelin receptor in mechanical allodynia in mice given orthotopic melanoma inoculation
    Masahide Fujita
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Japan
    J Pharmacol Sci 106:257-63. 2008
    ..These results suggest that ET-1 and ET(A) receptor are at least partly involved in the induction of pain induced by melanoma cell inoculation...
  31. ncbi request reprint Effects of loperamide on mechanical allodynia induced by herpes simplex virus type-1 in mice
    Atsushi Sasaki
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Pharmacol Sci 104:218-24. 2007
    ..The non-narcotic micro-opioid receptor agonist loperamide may relieve acute herpetic pain in patients with herpes zoster...
  32. ncbi request reprint Repeated treatment with the traditional medicine Unsei-in inhibits substance P-induced itch-associated responses through downregulation of the expression of nitric oxide synthase 1 in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan
    J Pharmacol Sci 94:207-10. 2004
    ..Repeated administration of Unsei-in (300 mg/kg) reduced the cutaneous NOS1 level. The results suggest that the inhibition of cutaneous NOS1 expression and NO production participates in the antipruritic action of Unsei-in...
  33. ncbi request reprint Inhibitory effect of the repeated treatment with Unsei-in on substance P-induced itch-associated responses through the downregulation of the expression of NK(1) tachykinin receptor in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 26:896-8. 2003
    ..These results suggest that Unsei-in inhibits substance P-associated itching and that the inhibition is at least partly due to the suppression of the expression of NK(1) tachykinin receptors in the skin...
  34. ncbi request reprint Prevention of topical surfactant-induced itch-related responses by chlorogenic acid through the inhibition of increased histamine production in the epidermis
    Yoshihiro Inami
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    J Pharmacol Sci 121:242-5. 2013
    ..The inhibitory activity of chlorogenic acid may be due to the inhibition of an increase in histamine in the epidermis...
  35. doi request reprint Involvement of leukotriene B4 in spontaneous itch-related behaviour in NC mice with atopic dermatitis-like skin lesions
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Exp Dermatol 20:894-8. 2011
    ..BLT1 receptor and 5-lipoxygenase in the skin may be effective pharmacological targets for the treatment of itch in atopic dermatitis...
  36. ncbi request reprint Macrophage-mediated inhibitory effect of Zingiber officinale Rosc, a traditional oriental herbal medicine, on the growth of influenza A/Aichi/2/68 virus
    Nobuko Imanishi
    Department of Oriental Medicine, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Am J Chin Med 34:157-69. 2006
    ..These data suggested that ZOR itself has no inhibitory effect on the growth of influenza virus, but could exert its effect via macrophage activation leading to production of TNF-alpha...
  37. ncbi request reprint Thromboxane A2 induces itch-associated responses through TP receptors in the skin in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    J Invest Dermatol 127:2042-7. 2007
    ..Thus, thromboxane synthase inhibitor and TP receptor antagonists will be candidates for antipruritic medicines...
  38. doi request reprint Involvement of increased expression of transient receptor potential melastatin 8 in oxaliplatin-induced cold allodynia in mice
    Punam Gauchan
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Neurosci Lett 458:93-5. 2009
    ..These results suggest that cold allodynia induced by oxaliplatin is at least partly due to the increased expression of TRPM8 in the primary afferents...
  39. ncbi request reprint [Importance of epidermal keratinocytes in itching]
    Tsugunobu Andoh
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Yakugaku Zasshi 126:403-8. 2006
    ..The identification of keratinocyte stimulus factors and of products in keratinocytes could lead to developing new antipruritic medicines...
  40. ncbi request reprint Potent pruritogenic action of tryptase mediated by PAR-2 receptor and its involvement in anti-pruritic effect of nafamostat mesilate in mice
    Haruna Ui
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical Sciences, Japan
    Eur J Pharmacol 530:172-8. 2006
    ..1 ng/site) and compound 48/80 (10 microg/site). These results suggest that mast cell tryptase elicits itch through PAR-2 receptor and that NFM inhibits itch-associated responses mainly through the inhibition of mast cell tryptase...
  41. ncbi request reprint Expression of BLT1 leukotriene B4 receptor on the dorsal root ganglion neurons in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Brain Res Mol Brain Res 137:263-6. 2005
    ..Many BLT1-immunoreactive neurons were small in size and positive for TRPV1. BLT1-immunoreactive fibers are present in the skin. The results suggest the expression of functional BLT1 receptors in the sensory neurons...
  42. doi request reprint Contribution of sensory C-fiber neuron injury to mechanical dynamic allodynia in a murine model of postherpetic neuralgia
    Atsushi Sasaki
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Neuroreport 24:137-41. 2013
    ..These results suggest that postherpetic dynamic allodynia is associated with injury to sensory C-fiber neurons and little damage to A-fiber neurons...
  43. doi request reprint Noradrenergic regulation of itch transmission in the spinal cord mediated by α-adrenoceptors
    Yoshikazu Gotoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Neuropharmacology 61:825-31. 2011
    ..Both α(1)- and α(2)-adrenoceptors may be involved in the tonic inhibition of itch signaling and the stimulation of either α-adrenoceptor subtype may result in the inhibition of itch...
  44. doi request reprint Bradykinin increases the secretion and expression of endothelin-1 through kinin B2 receptors in melanoma cells
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Peptides 31:238-41. 2010
    ..These results suggest that bradykinin regulates the secretion and biosynthesis of ET-1 through kinin B(2) receptor in tumor cells, especially melanoma cells...
  45. doi request reprint Clonidine inhibits itch-related response through stimulation of α(2)-adrenoceptors in the spinal cord in mice
    Yoshikazu Gotoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930 0194, Japan
    Eur J Pharmacol 650:215-9. 2011
    ..These results suggest that clonidine is an effective antipruritic agent and that the effect is mainly mediated by the stimulation of α(2)-adrenoceptors in the dorsal horn...
  46. doi request reprint BB2 bombesin receptor-expressing spinal neurons transmit herpes-associated itch by BB2 receptor-independent signaling
    Atsushi Sasaki
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Neuroreport 24:652-6. 2013
    ..The present results suggest that BB2 receptor-expressing spinal neurons transmit herpes-associated itch by BB2 receptor-independent signaling...
  47. ncbi request reprint Milnacipran inhibits itch-related responses in mice through the enhancement of noradrenergic transmission in the spinal cord
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    J Pharmacol Sci 123:199-202. 2013
    ..These results suggest that milnacipran suppresses itching through the inhibition of noradrenaline reuptake in the spinal cord. ..
  48. ncbi request reprint Direct action of immunoglobulin G on primary sensory neurons through Fc gamma receptor I
    Tsugunobu Andoh
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    FASEB J 18:182-4. 2004
    ..Thus, IgG and antigen combine on primary sensory neurons to directly activate them, which may be a novel type of immune-neuron linkage...
  49. ncbi request reprint Expression of Fc epsilon receptor I on primary sensory neurons in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Neuroreport 15:2029-31. 2004
    ..FcepsilonRI-like immunoreactivity was localized on nerve fibers in the skin. The results suggest that IgE acts directly on primary sensory neurons as well as mast cells...
  50. doi request reprint Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    J Pharmacol Exp Ther 343:91-6. 2012
    ..The present results suggest that serine protease secreted by dermatophytes causes itching through activation of the PAR(2) receptors, which may be a causal mechanism of dernatophytosis itch...
  51. doi request reprint Gastrin-releasing peptide induces itch-related responses through mast cell degranulation in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Peptides 32:2098-103. 2011
    ....
  52. ncbi request reprint Protective effect of IL-18 on kainate- and IL-1 beta-induced cerebellar ataxia in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Uniuversity of Toyama, 2630 Sugitani, Toyama, Japan
    J Immunol 180:2322-8. 2008
    ..Our data firstly show that IL-18 and IL-1beta display differential direct regulation in kainate-induced ataxia in mice. Our results might contribute toward the development of a new therapeutic strategy for cerebellar ataxia in humans...
  53. ncbi request reprint Induction of inducible nitric oxide (NO) synthase mRNA and NO production in macrophages infected with influenza A/PR/8 virus and stimulated with its ether-split product
    Nobuko Imanishi
    Department of Japanese Oriental Medicine, Toyama Medical and Pharmaceutical University, Toyama, Toyama, Japan
    Microbiol Immunol 49:41-8. 2005
    ....
  54. ncbi request reprint Mechanical hypersensitivity and alterations in cutaneous nerve fibers in a mouse model of skin cancer pain
    Hong Wei Zhang
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama, Japan
    J Pharmacol Sci 91:167-70. 2003
    ..When using this pain model, one should consider the tumor site-dependent responses...
  55. ncbi request reprint Inhibitory effect of azelastine on allergic itch-associated response in mice sensitized with mosquito salivary glands extract
    Eiji Ohtsuka
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Pharmacol Sci 91:263-6. 2003
    ..Direct inhibition by azelastine of sensory neurons may be at least involved in the anti-pruritic effect of azelastine. Histamine, substance P, and leukotriene B(4) may not play a key role in the itching of mosquito allergy...
  56. ncbi request reprint Involvement of leukotriene B4 in dermatophyte-related itch in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Japan
    Pharmacol Rep 66:699-703. 2014
    ..We investigated whether PAR2-mediated LTB4 production is involved in dermatophyte-induced scratching...
  57. ncbi request reprint Topical E6005, a novel phosphodiesterase 4 inhibitor, attenuates spontaneous itch-related responses in mice with chronic atopy-like dermatitis
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Exp Dermatol 23:359-61. 2014
    ..These results suggest that E6005 increases the cutaneous concentration of cAMP to relieve dermatitis-associated itching. Thus, E6005 may be a useful therapy for pruritic dermatitis such as atopic dermatitis. ..
  58. ncbi request reprint Gabapentin inhibits bortezomib-induced mechanical allodynia through supraspinal action in mice
    Ryo Kitamura
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    J Pharmacol Sci 124:502-10. 2014
    ..These results suggest that gabapentin inhibits bortezomib-induced mechanical allodynia, most likely through the activation of the descending noradrenergic system...
  59. pmc A novel rabbit immunospot array assay on a chip allows for the rapid generation of rabbit monoclonal antibodies with high affinity
    Tatsuhiko Ozawa
    Department of Immunology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    PLoS ONE 7:e52383. 2012
    ..Our system provides a new method for the comprehensive and rapid production of RaMoAbs, which may contribute to laboratory research and clinical applications...
  60. ncbi request reprint Roles of alpha-adrenoceptors and sympathetic nerve in acute herpetic pain induced by herpes simplex virus inoculation in mice
    Atsushi Sasaki
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Pharmacol Sci 92:329-36. 2003
    ..Clonidine suppresses the responses probably through the action on alpha(2)-adrenoceptors in the dorsal horn...
  61. doi request reprint Effects of xaliproden, a 5-HT₁A agonist, on mechanical allodynia caused by chemotherapeutic agents in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930 0194, Japan
    Eur J Pharmacol 721:231-6. 2013
    ..These results suggest that xaliproden produces acute inhibition of mechanical allodynia induced by paclitaxel, but not by vincristine and oxaliplatin, via inhibition of the hyper-response of the primary afferent neurons. ..
  62. pmc Nitric oxide enhances substance P-induced itch-associated responses in mice
    Tsugunobu Andoh
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Br J Pharmacol 138:202-8. 2003
    ..7 We conclude that intradermal SP increases NO in the skin, possibly through the action on NK(1) tachykinin receptors on the epidermal keratinocytes and that NO enhances SP-induced itch-associated responses...
  63. ncbi request reprint Potential ability of morphine to inhibit the adhesion, invasion and metastasis of metastatic colon 26-L5 carcinoma cells
    Yuko Harimaya
    Department of Pathogenic Biochemistry, Institute of Natural Medicine, 2630 Sugitani, 930 0194 Toyama, Japan
    Cancer Lett 187:121-7. 2002
    ..These results suggest that morphine inhibited the adhesive and invasive properties of tumor cells by different inhibitory mechanisms that involved the mediation of an opioid receptor...
  64. ncbi request reprint 17beta-estradiol activates ICI 182,780-sensitive estrogen receptors and cyclic GMP-dependent thioredoxin expression for neuroprotection
    Sang Y Lee
    Department of Neuroscience and Anatomy, Penn State University College of Medicine, M S Hershey Medical Center, Hershey, Pennsylvania, USA
    FASEB J 17:947-8. 2003
    ..We conclude that cGMP-dependent expression of Trx--the redox protein with potent antioxidative and antiapoptotic properties--may play a pivotal role in estrogen-induced neuroprotection...
  65. ncbi request reprint Roles of thioredoxin in nitric oxide-dependent preconditioning-induced tolerance against MPTP neurotoxin
    Chuang C Chiueh
    School of Pharmacy, Taipei Medical University, Taipei 110, Taiwan, ROC
    Toxicol Appl Pharmacol 207:96-102. 2005
    ..It is concluded that Trx plays a pivotal role in ()NO-dependent preconditioning hormesis against MPTP/MPP(+)...
  66. ncbi request reprint Neuroprotective properties of nitric oxide and S-nitrosoglutathione
    Pekka Rauhala
    Institute of Biomedicine, Pharmacology, Biomedicum Helsinki, P O Box 63, University of Helsinki 00014, Helsinki, Finland
    Toxicol Appl Pharmacol 207:91-5. 2005
    ....
  67. ncbi request reprint The roles of thioredoxin in protection against oxidative stress-induced apoptosis in SH-SY5Y cells
    Tsugunobu Andoh
    Laboratory of Biochemistry, National Heart, Lung, and Blood Institute and the Laboratory of Clinical Science, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    J Biol Chem 277:9655-60. 2002
    ..This effect of Trx-mediated hormesis against oxidative stress-induced apoptosis is striking. It induced a 30-fold shift in LD(50) in the MPP(+)-induced neurotoxicity...
  68. ncbi request reprint Contradictory effects of sodium nitroprusside and S-nitroso-N-acetylpenicillamine on oxidative stress in brain dopamine neurons in vivo
    Pekka Rauhala
    Institute of Biomedicine, Pharmacology, University of Helsinki, Helsinki, Finland
    Ann N Y Acad Sci 962:60-72. 2002
    ..g., GSNO and SNAP) can scavenge reactive oxygen species and activate the heme moiety of guanylyl cyclase, resulting in protection of brain dopamine neurons through both antioxidative and antiapoptotic mechanisms...
  69. ncbi request reprint Cyclic GMP-dependent protein kinase regulates the expression of thioredoxin and thioredoxin peroxidase-1 during hormesis in response to oxidative stress-induced apoptosis
    Tsugunobu Andoh
    Laboratory of Biochemistry, NHLBI, National Institutes of Health, Bethesda, Maryland 20892 8012, USA
    J Biol Chem 278:885-90. 2003
    ..Thus, the cytoprotective effect of NO in SH-SY5Y cells appears to proceed via the PKG-mediated pathway, and S-nitrosylation of caspases plays a minimal role...
  70. ncbi request reprint Induction of antioxidative and antiapoptotic thioredoxin supports neuroprotective hypothesis of estrogen
    Chuang Chiueh
    Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Endocrine 21:27-31. 2003
    ....
  71. ncbi request reprint [Mechanisms of cutaneous itch: new itch mediators and enhancement factors produced by keratinocytes]
    Tsugunobu Andoh
    Nihon Yakurigaku Zasshi 131:361-6. 2008
  72. ncbi request reprint Induction of thioredoxin and mitochondrial survival proteins mediates preconditioning-induced cardioprotection and neuroprotection
    Chuang C Chiueh
    School of Pharmacy, Taipei Medical University, 250 Wu Hsing Street, Taipei 100, Taiwan
    Ann N Y Acad Sci 1042:403-18. 2005
    ..Preconditioning-induced adaptive tolerance may be signaling through a cGMP-dependent induction of cytosolic redox protein Trx1 and subsequently mitochondrial proteins such as Bcl-2, MnSOD, and perhaps Trx2 or HSP70...