Y Kishimoto

Summary

Affiliation: Tottori University
Country: Japan

Publications

  1. ncbi request reprint Effects of trimebutine maleate on delayed rectifier K+ currents in guinea-pig ventricular myocytes
    T Morisawa
    Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago, Japan
    J Pharm Pharmacol 52:403-8. 2000
  2. ncbi request reprint Reduced Fhit expression occurs in the early stage of esophageal tumorigenesis: no correlation with p53 expression and apoptosis
    A Kitamura
    Second Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan
    Oncology 61:205-11. 2001
  3. ncbi request reprint Circular stapling procedure for mucosal prolapse of the rectum associated with outlet obstruction
    Y Araki
    Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan
    Kurume Med J 48:201-4. 2001
  4. pmc Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma
    H Andachi
    Second Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683 8504, Japan
    Br J Cancer 87:441-5. 2002
  5. pmc Sulindac and a cyclooxygenase-2 inhibitor, etodolac, increase APC mRNA in the colon of rats treated with azoxymethane
    Y Kishimoto
    Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, 86 Nishicho, Yonago 683 8503, Japan
    Gut 47:812-9. 2000
  6. ncbi request reprint Effects of long-term administration of sulindac on APC mRNA and apoptosis in colons of rats treated with azoxymethane
    Y Kishimoto
    Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University, 86 Nishicho, Yonago 683 8503, Japan
    J Cancer Res Clin Oncol 128:589-95. 2002
  7. ncbi request reprint Molecular changes in the early stage of colon carcinogenesis in rats treated with azoxymethane
    Y Kishimoto
    Dept of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago, Japan
    J Exp Clin Cancer Res 21:203-11. 2002
  8. pmc Fhit expression in human gastric adenomas and intramucosal carcinomas: correlation with Mlh1 expression and gastric phenotype
    K Kawaguchi
    Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Yonago 683 8504, Japan
    Br J Cancer 90:672-7. 2004
  9. ncbi request reprint Effects of sucralfate on acute gastric mucosal injury and gastric ulcer induced by ischemia-reperfusion in rats
    K Wada
    Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago, Japan
    Pharmacology 54:57-63. 1997
  10. ncbi request reprint A new gastric ulcer model induced by ischemia-reperfusion in the rat: role of leukocytes on ulceration in rat stomach
    K Wada
    Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago, Japan
    Life Sci 59:PL295-301. 1996

Detail Information

Publications33

  1. ncbi request reprint Effects of trimebutine maleate on delayed rectifier K+ currents in guinea-pig ventricular myocytes
    T Morisawa
    Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago, Japan
    J Pharm Pharmacol 52:403-8. 2000
    ..These results suggested that trimebutine maleate has weak inhibitory effects on I(Kr), I(Ks) and I(Ca) at concentrations much higher than those in clinical use...
  2. ncbi request reprint Reduced Fhit expression occurs in the early stage of esophageal tumorigenesis: no correlation with p53 expression and apoptosis
    A Kitamura
    Second Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan
    Oncology 61:205-11. 2001
    ..These results indicate that abnormal Fhit expression is a common event in the early stage of ESC development and may occur independently of p53 expression and apoptosis mechanisms...
  3. ncbi request reprint Circular stapling procedure for mucosal prolapse of the rectum associated with outlet obstruction
    Y Araki
    Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan
    Kurume Med J 48:201-4. 2001
    ..However, long-term outcomes of recurrence, continence, and constipation need to be evaluated in a more extended follow-up...
  4. pmc Reduced Fhit expression is associated with mismatch repair deficiency in human advanced colorectal carcinoma
    H Andachi
    Second Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago 683 8504, Japan
    Br J Cancer 87:441-5. 2002
    ..These results suggested that reduced Fragile histidine triad expression might be correlated with mismatch repair expression, but not with p53 expression...
  5. pmc Sulindac and a cyclooxygenase-2 inhibitor, etodolac, increase APC mRNA in the colon of rats treated with azoxymethane
    Y Kishimoto
    Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, 86 Nishicho, Yonago 683 8503, Japan
    Gut 47:812-9. 2000
    ..Non-steroidal anti-inflammatory drugs (NSAIDs) have been reported to protect against the development of colon cancer. However, the mechanism(s) by which NSAIDs exert their effects is not clear...
  6. ncbi request reprint Effects of long-term administration of sulindac on APC mRNA and apoptosis in colons of rats treated with azoxymethane
    Y Kishimoto
    Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Faculty of Medicine, Tottori University, 86 Nishicho, Yonago 683 8503, Japan
    J Cancer Res Clin Oncol 128:589-95. 2002
    ..Therefore, we examined the anti-colon carcinogenesis effects of sulindac after prolonged administration...
  7. ncbi request reprint Molecular changes in the early stage of colon carcinogenesis in rats treated with azoxymethane
    Y Kishimoto
    Dept of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago, Japan
    J Exp Clin Cancer Res 21:203-11. 2002
    ..These findings may help to identify key targets in the early steps of colon carcinogenesis, against which drugs that would be broadly effective for chemoprevention of colon cancer could be developed...
  8. pmc Fhit expression in human gastric adenomas and intramucosal carcinomas: correlation with Mlh1 expression and gastric phenotype
    K Kawaguchi
    Division of Medicine and Clinical Science, Faculty of Medicine, Tottori University, Yonago 683 8504, Japan
    Br J Cancer 90:672-7. 2004
    ..0018). These results suggested that reduced Fhit expression occurs in the early stage of gastric carcinogenesis and could be correlated with a lack of Mlh1 expression and gastric phenotype...
  9. ncbi request reprint Effects of sucralfate on acute gastric mucosal injury and gastric ulcer induced by ischemia-reperfusion in rats
    K Wada
    Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago, Japan
    Pharmacology 54:57-63. 1997
    ..However, the protective mechanism may involve an inhibitory action on superoxide and hydroxyl radicals at high doses...
  10. ncbi request reprint A new gastric ulcer model induced by ischemia-reperfusion in the rat: role of leukocytes on ulceration in rat stomach
    K Wada
    Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago, Japan
    Life Sci 59:PL295-301. 1996
    ..This model may be used to investigate the mechanisms of the development of gastric ulcer and evaluate antiulcer drugs in a preclinical setting...
  11. ncbi request reprint Inhibition by cigarette smoke of lipid peroxidation-induced neurotransmitter release
    Y Kamisaki
    Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago, Japan
    Life Sci 60:PL229-33. 1997
    ..These data suggest that cigarette smoke may possess antioxidant properties to reduce oxidation-induced enhancement of transmitter release from nerve terminals...
  12. ncbi request reprint Quantitative analysis of cyclooxygenase-2 gene expression on acute gastric injury induced by ischemia-reperfusion in rats
    Y Kishimoto
    Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago, Japan
    Life Sci 60:PL127-33. 1997
    ..The expression state of COX-2, which has been ascertained in this study, should be useful in evaluating the effect of various drugs on the expression of COX-2 in acute gastric damage...
  13. ncbi request reprint Effects of cigarette smoke on nitric oxide-induced increase in cyclic GMP in nerve terminals of rat cerebral cortex
    Y Kamisaki
    Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago, Japan
    Brain Res Mol Brain Res 42:39-44. 1996
    ..The interference with NO may explain the part of mechanism in effects of cigarette smoke on neuronal functions...
  14. ncbi request reprint Effect of plaunotol on gastric injury induced by ischaemia-reperfusion in rats
    K Wada
    Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago, Japan
    J Pharm Pharmacol 49:903-7. 1997
    ..Both effects of plaunotol on increase in prostaglandin content in gastric tissues and inhibition of superoxide radical from leucocytes may play important roles on the protection against gastric mucosal injury...
  15. ncbi request reprint Loss of the tumor suppressor p53 gene at the liver cirrhosis stage in Japanese patients with hepatocellular carcinoma
    Y Kishimoto
    Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago, Japan
    Oncology 54:304-10. 1997
    ..The remaining 6 cases without LOH of the p53 gene in HCC showed on p53 loss in any cirrhotic foci. LOH of the p53 gene may occur before the development of HCC...
  16. ncbi request reprint Substances in the aqueous fraction of cigarette smoke inhibit lipid peroxidation in synaptosomes of rat cerebral cortex
    Y Kamisaki
    Department of Clinical Pharmacology, Tottori University, Yonago, Japan
    Biochem Mol Biol Int 42:1-10. 1997
    ..The results suggest that the smoke-substances may possess long half-lives and scavenge the radicals which cause lipid-peroxidation in synaptosome membranes...
  17. ncbi request reprint Sensitive detection of human telomerase reverse transcriptase mRNA in the serum of patients with hepatocellular carcinoma
    N Miura
    Division of Pharmacotherapeutics, Department of Pathophysiological and Therapeutic Science, Tottori University School of Medicine, Yonago, Japan
    Oncology 64:430-4. 2003
    ..We measured serum hTERT mRNA in patients with hepatocellular carcinoma (HCC), and examined its clinical usefulness...
  18. ncbi request reprint Occult hepatitis B virus infection in HBs antigen-negative hepatocellular carcinoma in a Japanese population: involvement of HBx and p53
    G Shiota
    Second Department of Internal Medicine, Faculty of Medicine, Tottori University, Yonago, Japan
    J Med Virol 62:151-8. 2000
    ....
  19. ncbi request reprint Comparison of the kinetic disposition of and serum gastrin change by lansoprazole versus rabeprazole during an 8-day dosing scheme in relation to CYP2C19 polymorphism
    I Ieiri
    Department of Hospital Pharmacy, Faculty of Medicine, Tottori University, Japan
    Eur J Clin Pharmacol 57:485-92. 2001
    ..Little is known about differences in the disposition kinetics and pharmacological effects on gastrin levels between lansoprazole and rabeprazole given in a repeated dosing scheme with respect to the polymorphic CYP2C19...
  20. ncbi request reprint The role of endogenous acid in the development of acute gastric ulcer induced by ischemia-reperfusion in the rat
    K Nakamoto
    Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, Yonago, Japan
    Life Sci 62:PL63-9. 1998
    ..Furthermore, treatment with anti-acid-secretory drugs in the early stage of mucosal damage may be important for the prevention of ulcer...
  21. ncbi request reprint Gene expression relevant to osteoclastogenesis in the synovium and bone marrow of mature rats with collagen-induced arthritis
    Y Kishimoto
    Department of Orthopedic Surgery, Faculty of Medicine, Tottori University, Yonago, Tottori 683 8504, Japan
    Rheumatology (Oxford) 43:1496-503. 2004
    ..To investigate gene expression relevant to osteoclastogenesis in the synovium and bone marrow during the development of collagen-induced arthritis (CIA) in mature rats...
  22. ncbi request reprint Cyclooxygenase-2 expression in hepatocellular carcinoma
    G Shiota
    Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Japan
    Hepatogastroenterology 46:407-12. 1999
    ..To clarify significance of Cox-2 in liver cancer, we immunohistochemically examined expression of this enzyme in cancerous and non-cancerous tissues of hepatocellular carcinoma (HCC)...
  23. ncbi request reprint Adult-type neuroblastoma originated in retroperitoneum beginning with obstructive jaundice
    M Kawakami
    Second Department of Internal Medicine, Faculty of Medicine, Tottori University, 36-1 Nishi-machi, Yonago, Tottori 683-0802, Japan
    Clin Imaging 25:284-7. 2001
    ..The tumor originated from retroperitoneum. The enlarged gall bladder and dilatation of intrahepatic bile ducts were noted by ultrasonography and computed tomography. We report the first adult-type neuroblastoma with obstructive jaundice...
  24. ncbi request reprint Influence of angiotensin II type 1 receptor polymorphism on hypertension in patients with hypercholesterolemia
    T Morisawa
    Department of Clinical Pharmacology, Faculty of Medicine, Tottori University, 86 Nishicho, Yonago 683 8503, Japan
    Clin Chim Acta 304:91-7. 2001
    ..005). These results suggested that high concentration of total cholesterol was an important risk factor to the occurrence of essential hypertension for patients who carried the C allele of the AT(1) gene...
  25. ncbi request reprint The association between cancer risk and age at onset of smoking in Japanese
    Megumi Hara
    Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan
    J Epidemiol 20:128-35. 2010
    ..Young age at onset of smoking is a known risk factor for cancer; however, few studies have investigated the risk of cancer associated with onset of smoking during adolescence in Japan...
  26. ncbi request reprint [A case of lung metastasis from colon cancer treated successfully with combined chemotherapy of CPT-11 and 5'-DFUR]
    Y Ogata
    Dept. of Surgery, Kurume University School of Medicine
    Gan To Kagaku Ryoho 28:1917-21. 2001
    ..This was considered to be a valuable case suggestive of the significance of combination chemotherapy of CPT-11 and 5'-DFUR and the importance of appropriate administration of CPT-11...
  27. ncbi request reprint A case of early gastric cancer accompanied by a hamartomatous inverted polyp and successfully managed with endoscopic submucosal dissection
    S Ono
    Department of Internal Medicine, Hitachi General Hospital, Hitachi, Japan
    Endoscopy 39:E202. 2007
  28. ncbi request reprint IL-4-producing CD8(+) T cells may be an immunological hallmark of chronic GVHD
    K Nakamura
    1st Department of Internal Medicine, Kansai Medical University, Moriguchi, Osaka, Japan
    Bone Marrow Transplant 36:639-47. 2005
    ..By contrast, the percentage of IL-4-producing CD4(+) T cells was not different among patients with and without cGVHD and normal controls. These findings suggest that IL-4-producing CD8(+) T cells may be an immunological marker of cGVHD...
  29. ncbi request reprint Detection of a common mutation of the catalase gene in Japanese acatalasemic patients
    Y Kishimoto
    Oncogene Division, National Cancer Center Research Institute, Tokyo, Japan
    Hum Genet 88:487-90. 1992
    ..This finding strongly suggests that only a single mutated allele has spread in the Japanese population...
  30. ncbi request reprint Blood dendritic cells are decreased in acute graft-versus-host disease
    M Takebayashi
    First Department of Internal Medicine, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, Osaka 570 8506, Japan
    Bone Marrow Transplant 33:989-96. 2004
    ..Based on these findings, we hypothesize that the PBDCs are recruited to the affected tissues and may thus play important roles in immune responses elicited in aGVHD...
  31. ncbi request reprint Preferential expression of the vasoactive intestinal peptide (VIP) receptor VPAC1 in human cord blood-derived CD34+CD38- cells: possible role of VIP as a growth-promoting factor for hematopoietic stem/progenitor cells
    M Kawakami
    Department of Cancer Immunotherapy, Osaka University Graduate School of Medicine, Osaka, Japan
    Leukemia 18:912-21. 2004
    ..Furthermore, in Dexter-type long-term cultures, VIP increased colony-forming cells at week 5 of culture. These results suggest that VIP functions as a growth-promoting factor of CB-derived hematopoetic progenitor cells...
  32. pmc Characterization of a mutation in a family with saposin B deficiency: a glycosylation site defect
    K A Kretz
    Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla 92093
    Proc Natl Acad Sci U S A 87:2541-4. 1990
    ....
  33. pmc Binding and transport of gangliosides by prosaposin
    M Hiraiwa
    Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla 92093
    Proc Natl Acad Sci U S A 89:11254-8. 1992
    ..Prosaposin exists as a secretory protein and as an integral membrane protein, and we propose that prosaposin is active as a ganglioside binding and transport protein in vivo...