Affiliation: Tottori University
Ikeguchi M, Fukuda K, Yamaguchi K, Kondo A, Tsujitani S, Kaibara N. Quantitative analysis of heparanase gene expression in esophageal squamous cell carcinoma. Ann Surg Oncol. 2003;10:297-304 pubmed
..Moreover, low hep expression correlated with poor patient survival. Reduced hep mRNA expression might result in abnormal cell growth and correlate with ESCC progression. ..
Ikeguchi M, Hirooka Y, Kaibara N. Quantitative reverse transcriptase polymerase chain reaction analysis for KiSS-1 and orphan G-protein-coupled receptor (hOT7T175) gene expression in hepatocellular carcinoma. J Cancer Res Clin Oncol. 2003;129:531-5 pubmed
Ikeguchi M, Ohoro S, Maeda Y, Yamaguchi K, Fukuda K, Shirai H, et al
. Protein and gene expression of tumor-associated antigen RCAS1 in esophageal squamous cell carcinoma. Oncol Rep. 2003;10:1891-4 pubmed
..8, p=0.131). RCAS1 gene and protein expressions did not correlate with tumor size, depth of invasion, lymph node metastasis, or patient prognosis. Thus, RCAS1 gene or protein expression may not correlate with tumor progression in ESCC. ..
Ikeguchi M, Hirooka Y, Kaibara N. Gene and protein expression of RCAS1 in hepatocellular carcinoma. Anticancer Res. 2003;23:4967-71 pubmed
..RCAS1 protein expression in primary tumor may be a good marker for the effectiveness of TAE treatment in patients who develop new tumors in the residual livers. ..
Ikeguchi M, Matsumoto S, Yoshioka S, Murakami D, Kanaji S, Ohro S, et al
. Laparoscopic-assisted intraperitoneal chemotherapy for patients with scirrhous gastric cancer. Chemotherapy. 2005;51:15-20 pubmed
..267). IPC effectiveness may correlate with elevation of gene expression of inflammatory cytokines, such as IL-2 and IL-6 in the peritoneal cavity after IPC. However, the prognostic benefits of IPC for SGC patients remain unclear. ..
Ikeguchi M, Kaibara N. Changes in survivin messenger RNA level during cisplatin treatment in gastric cancer. Int J Mol Med. 2001;8:661-6 pubmed
..These findings indicate that survivin may play an important role for the chemoresistance of this cancer cell line. However, the clinical importance of survivin expression remains unclear in patients with gastric cancer. ..
Ikeguchi M, Liu J, Kaibara N. Expression of survivin mRNA and protein in gastric cancer cell line (MKN-45) during cisplatin treatment. Apoptosis. 2002;7:23-9 pubmed
..1 or 1 microg/ml of CDDP was 3 to 6.5 fold higher than that of the survivin protein of untreated cells. These results indicate that survivin expression may correlate with the chemo-resistance of malignant cells. ..
Ikeguchi M, Ueta T, Yamane Y, Hirooka Y, Kaibara N. Inducible nitric oxide synthase and survivin messenger RNA expression in hepatocellular carcinoma. Clin Cancer Res. 2002;8:3131-6 pubmed
Ikeguchi M, Yamamoto O, Kaibara N. Management protocol for scirrhous gastric cancer. In Vivo. 2004;18:577-80 pubmed
..However, the management protocol for this type of cancer has not been well discussed. In this study, we retrospectively evaluated the management of SGC and we introduced a new treatment protocol for SGC...