Research Topics
Genomes and Genes | Hirozumi SawaiSummaryAffiliation: Toranomon Hospital Country: Japan Publications
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Publications
Expression of integrins in intraductal papillary-mucinous tumors of the pancreas as an indicator of malignancyHirozumi Sawai
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Science, Nagoya, Japan
Pancreas 28:20-4. 2004..We examined clinicopathological features and immunohistochemical findings to investigate the malignancy of IPMTs...
Gastrointestinal stromal tumor of the rectum with liver metastasis: report of a caseHirozumi Sawai
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences Nagoya, Japan
Hepatogastroenterology 54:1113-5. 2007..The patients with a rectal GIST may have an increased risk of liver metastasis and a poor prognosis independent of the size of the tumor...
Surgical treatment for relief of severe pain with chronic pancreatitis that is resistant to conservative treatmentHirozumi Sawai
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku Nagoya 4678601, Japan
Hepatogastroenterology 53:438-41. 2006..To evaluate the surgical treatment, we investigated that performed for chronic pancreatitis patients suffering from severe pain resistant to conservative treatments...
Clinicopathological and immunohistochemical analysis of malignant features in mucinous cystic tumors of the pancreasHirozumi Sawai
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences Nagoya, Japan
Hepatogastroenterology 53:286-90. 2006..To investigate the malignancy of mucinous cystic tumors (MCTs) of the pancreas, we examined clinicopathological features and immunohistochemical findings of MCT...
Combined gemcitabine and alpha-interferon therapy for pancreatic cancer: report of a caseHirozumi Sawai
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Japan, 4678601
Dig Dis Sci 51:1285-9. 2006
Integrin-linked kinase activity is associated with interleukin-1 alpha-induced progressive behavior of pancreatic cancer and poor patient survivalH Sawai
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Oncogene 25:3237-46. 2006..Our results suggest that ILK is involved with aggressive capability in pancreatic cancer and that these regulations can be helpful to understand biological processes for a better translational treatment for pancreatic cancer patients...
Anaplastic carcinoma of the pancreas with squamous features: report of a case and immunohistochemical studyHirozumi Sawai
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Med Sci Monit 11:CS65-8. 2005..We herein present our experience with a case of anaplastic carcinoma of the pancreas with squamous features in order that allowed us to delineate the clinicopathologic and immunohistochemical features of this rare entity...
Interleukin-1alpha enhances IL-8 secretion through p38 mitogen-activated protein kinase and reactive oxygen species signaling in human pancreatic cancer cellsHirozumi Sawai
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya, Japan
Med Sci Monit 11:BR343-50. 2005..In here, we investigated effect of IL-1alpha on IL-8 secretion in human pancreatic cancer cells and underlying signal transduction pathways...
Immunohistochemical analysis of molecular biological factors in intraductal papillary-mucinous tumors and mucinous cystic tumors of the pancreasH Sawai
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Science, Nagoya 467 8601, Japan
Scand J Gastroenterol 39:1159-65. 2004..To investigate the malignancy and differentiation of intraductal papillary-mucinous tumors (IPMTs) and mucinous cystic tumors (MCTs) of the pancreas, clinicopathologic characteristics and immunohistochemical features were analyzed...
Interleukin-1alpha enhances integrin alpha(6)beta(1) expression and metastatic capability of human pancreatic cancerHirozumi Sawai
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Oncology 65:167-73. 2003....
Expression of integrins in tumour tissue of a patient with cancer of the Vater's ampulla complicated by pancreas divisumHirozumi Sawai
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Japan
Eur J Gastroenterol Hepatol 16:421-4. 2004..We demonstrate that there is a risk that pancreas divisum will co-exist with malignant disease in the pancreaticobiliary area, causing a potential risk of complicating malignant diseases in the pancreas...
Activation of focal adhesion kinase enhances the adhesion and invasion of pancreatic cancer cells via extracellular signal-regulated kinase-1/2 signaling pathway activationHirozumi Sawai
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 4678601, Japan
Mol Cancer 4:37. 2005....
Interleukin-1alpha enhances the aggressive behavior of pancreatic cancer cells by regulating the alpha6beta1-integrin and urokinase plasminogen activator receptor expressionHirozumi Sawai
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 4678601, Japan
BMC Cell Biol 7:8. 2006..We hypothesize that the alterations of integrin subunits and uPA/uPAR expression make an important role in signaling pathways responsible for biological behavior of pancreatic cancer cells...
Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathwayAkira Yasuda
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya 4678601, Japan
Dig Dis Sci 52:2292-300. 2007..In conclusion, the SCF-enhanced proliferation and invasion of KIT-positive colorectal cancer cells is achieved mainly through the PI3K/Akt pathway...
PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cellsJiachi Ma
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Science, Kawasumi 1, Mizuho cho, Mizuhoku, Nagoya, 467 8601, Japan
Mol Cell Biochem 331:161-71. 2009..In addition, PTEN modulated VEGF-mediated signaling and affected tumor angiogenesis through PI3K/Akt/VEGF/eNOS pathway...
IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cellsJiachi Ma
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Surg Res 160:90-101. 2010..We investigated the mechanism by which IGF-1 affects cell proliferation and invasion by suppression of PTEN phosphorylation and interaction with PI3K/PTEN/Akt/NF-small ka, CyrillicB signaling pathway in pancreatic cancer...
Basement membrane proteins play an important role in the invasive processes of human pancreatic cancer cellsHirozumi Sawai
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Surg Res 144:117-23. 2008..Furthermore, we examined the roles of beta(1)-integrins and arginine-glycine-aspartic (RGD)-containing oligopeptide in cell-matrix interactions...
The role of glial cell line-derived neurotrophic factor (GDNF) and integrins for invasion and metastasis in human pancreatic cancer cellsHitoshi Funahashi
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Surg Oncol 91:77-83. 2005..We investigated whether glial cell lined-derived neurotrophic factor (GDNF) enhances the invasive and adhesive behaviors of pancreatic cancer cells by altering of the expression of integrins...
Interleukin-1alpha enhances angiogenesis and is associated with liver metastatic potential in human gastric cancer cell linesJiachi Ma
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
J Surg Res 148:197-204. 2008....
Glial cell line-derived neurotrophic factor enhances nuclear factor-kappaB activity and invasive potential in human pancreatic cancer cellsHiroki Takahashi
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Pancreas 29:22-7. 2004....
IL-1alpha secreted by colon cancer cells enhances angiogenesis: the relationship between IL-1alpha release and tumor cells' potential for liver metastasisYoichi Matsuo
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 4678601, Japan
J Surg Oncol 99:361-7. 2009..Interleukin (IL)-1alpha plays an important role in colon cancer progression and angiogenesis. We here asked whether IL-1alpha derived from cancer cells modulates vascular endothelial cell growth, migration and tubule formation...
Vascular endothelial growth factor-C secreted by pancreatic cancer cell line promotes lymphatic endothelial cell migration in an in vitro model of tumor lymphangiogenesisNobuo Ochi
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya, Japan
Pancreas 34:444-51. 2007..To investigate mechanisms underlying lymphatic node metastasis in pancreatic cancer, we examined roles of vascular endothelial growth factor-C (VEGF-C) in tumor lymphangiogenesis...
Alteration of integrin expression by glial cell line-derived neurotrophic factor (GDNF) in human pancreatic cancer cellsHitoshi Funahashi
First Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Pancreas 27:190-6. 2003..Pancreatic cancer cells express a number of functionally active integrins that are related to their adhesive and invasive abilities...
Granulocyte-colony stimulating factor producing rectal cancerHiroki Takahashi
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya, Japan
World J Surg Oncol 6:70. 2008..Granulocyte-colony stimulating factor (G-CSF)-producing cancer has been reported to occur in various organs, especially the lung. However, G-CSF-producing colorectal cancer (CRC) has never been reported in the English literature...
Enhanced angiogenesis due to inflammatory cytokines from pancreatic cancer cell lines and relation to metastatic potentialYoichi Matsuo
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Pancreas 28:344-52. 2004..To investigate the mechanisms of metastasis formation in human pancreatic carcinoma, we examined the angiogenic capabilities of human pancreatic cancer cell lines with different metastatic potentials and the roles of inflammatory cytokines...
Multiple primary cancers of the duodenum and sigmoid colon: report of two casesHirozumi Sawai
First Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Dig Dis Sci 48:1268-72. 2003
Loss of PTEN expression is associated with colorectal cancer liver metastasis and poor patient survivalHirozumi Sawai
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 4678601, Japan
BMC Gastroenterol 8:56. 2008....
Antiproteases in preventing the invasive potential of pancreatic cancer cellsHiroki Takahashi
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya, Japan
JOP 8:501-8. 2007..Recent studies on the role of proteases and protease inhibitors in pancreatic cancer invasion are also reviewed...
Successful paclitaxel-based chemotherapy for an alpha-fetoprotein-producing gastric cancer patient with multiple liver metastasesHiromitsu Takeyama
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya 4678601, Japan
World J Surg Oncol 5:79. 2007..Alpha-fetoprotein (AFP)-producing gastric cancer is known to frequently cause multiple liver metastases and to have an extremely poor prognosis...
Enhancement of integrins by interleukin-1alpha, and their relationship with metastatic and invasive behavior of human pancreatic ductal adenocarcinoma cellsHirozumi Sawai
First Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
J Surg Oncol 82:51-6. 2003..CONCLUSIONS: The enhancement of alpha6beta1-integrin by Il-1alpha acting through IL-1RI, as well as the expression of alpha6beta1-integrin, plays an important role in metastasis formation in pancreatic cancer..
Expression and prognostic roles of integrins and interleukin-1 receptor type I in patients with ductal adenocarcinoma of the pancreasHirozumi Sawai
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences Nagoya, Japan
Dig Dis Sci 48:1241-50. 2003..Our present results indicate that alpha6beta1- and alpha5beta1-integrin expression can be a significant prognostic indicator in pancreatic cancer...
Clinicopathologic study of intraductal papillary-mucinous tumors and mucinous cystic tumors of the pancreasMoritsugu Tanaka
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Science, Japan
Hepatogastroenterology 53:783-7. 2006..CONCLUSIONS: The main duct type and an elevation of serum CA19-9 level suggested malignancy in IPMTs...
The stem cell factor/c-kit receptor pathway enhances proliferation and invasion of pancreatic cancer cellsAkira Yasuda
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, 4678601, Japan
Mol Cancer 5:46. 2006..Finally, we also analyzed KIT and SCF expression in pancreatic cancer tissues using immunohistochemistry and correlated the results with clinical features...
Synthetic serine protease inhibitor, gabexate mesilate, prevents nuclear factor-kappaB activation and increases TNF-alpha-mediated apoptosis in human pancreatic cancer cellsHiroki Takahashi
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, 467 8601, Nagoya, Japan
Dig Dis Sci 52:2646-52. 2007..Furthermore, GM also suppressed the invasive potential of both cell lines. These results indicate that GM inhibits TNF-alpha-induced NF-kappaB activation and enhances apoptosis in human pancreatic cancer cell lines...
Tumor-forming pancreatitis diagnosed preoperatively as intraductal papillary-mucinous tumor: report of a caseHirozumi Sawai
First Department of Surgery, Nagoya City University Medical School, Nagoya, Japan
Pancreas 26:207-10. 2003
[Molecular mechanism in pathogenesis in pancreatic neoplasms: NF-kappaB]Yoichi Matsuo
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences
Nippon Rinsho 64:44-7. 2006
Complete extragastric growth in a giant gastrointestinal stromal tumor: report of a caseHitoshi Funahashi
Gastroenterological Surgery, Nagoya City University Graduated School of Medical Sciences, Mizuho ku, Nagoya, Japan
Int Surg 93:45-9. 2008..From these findings, the tumor was diagnosed as an uncommitted type of GIST with high-grade malignancy. This case needs careful and long-term follow-up to monitor for signs of local recurrence or distant metastasis...
Malignant solitary fibrous tumor originating from the peritoneum and review of the literatureMoritsugu Tanaka
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Med Sci Monit 12:CS95-8. 2006..To diagnose the malignant potential of this type of tumor accurately may have value to direct the appropriate therapeutic operations after surgery and postoperative progress observation...
Reactive lymphoid hyperplasia of the liver in a patient with colon cancer: report of two casesHiroki Takahashi
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya, Japan
BMC Gastroenterol 6:25. 2006..Reactive lymphoid hyperplasia (RLH) of the liver is very rarely reported, and we encountered two cases of RLH of the liver in a patient with colon cancer...
Expression of glial cell line-derived neurotrophic factor family members and their receptors in pancreatic cancersYoshinori Ito
Department of Gastroenterological Surgery, Nagoya City University, Graduate School of Medical Sciences, Kawasumi, Japan
Surgery 138:788-94. 2005..The purpose of this study was to investigate GDNF family expression and the status of related receptors in actual cancer tissues, and assess correlations with clinicopathologic behavior...
Laparoscopic surgery for diagnosis and treatment of bowel obstruction: case report of paracecal herniaTakahisa Hirokawa
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Med Sci Monit 13:CS79-82. 2007..Small bowel obstruction cased by paracecal hernia is rare, and the condition is difficult to diagnose preoperatively. We herein report a case of paracecal hernia that was successfully diagnosed and treated with laparoscopic surgery...
Biological effect of irradiation on adhesion molecules in human colon cancer cells in vitroTakeshi Hasegawa
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Anticancer Res 25:875-9. 2005..Currently, preoperative radiotherapy is used to prevent local recurrence of rectal cancer. We investigated the effects of X-ray irradiation on the carbohydrate antigens s-Le(a) and s-Le(x) in vitro...
Limiting vein puncture to three needle passes in subclavian vein catheterization by the infraclavicular approachHiromitsu Takeyama
Department of Gastroenterological Surgery, Nagoya City University, Graduate School of Medical Sciences, Kawasumi, Mizuho-ku, Nagoya 467-8601, Japan
Surg Today 36:779-82. 2006..56-0.97; P = 0.028) was associated with a low risk of failure. CONCLUSION: Limiting the number of needle passes to three may therefore prevent mechanical complications. A low body mass index was predictive of vein puncture failure...
Expression of alpha6 integrin subunit is associated with malignancy in gastric gastrointestinal stromal tumorsHiromitsu Takeyama
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya 4678601, Japan
Med Sci Monit 13:CR51-6. 2007....
An anti-stray stylet for subclavian catheterization by the infraclavicular approachHiromitsu Takeyama
First Department of Surgery, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan
Nutrition 21:432-7. 2005..Misplacement of subclavian vein catheters has been reported. We assessed the rate of misplacement of a subclavian vein catheter with and without a novel stylet...
Posterior mediastinal angioleiomyoma: report of a caseAkira Yasuda
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya, Japan
J Thorac Imaging 22:363-5. 2007..Because mediastinal angioleiomyomas are very rare, they are difficult to diagnose preoperatively. However, we believe that CT and MRI can be of significant help in the differential diagnosis...
A new method for constructing an ileal J pouch without an enterotomyHiromitsu Takeyama
Department of Gastroenterological Surgery, Nagoya City University, Graduate School of Medical Sciences, Mizuhoku, Nagoya, Japan
Dig Surg 23:23-5. 2006..We applied this method to two patients who underwent a total colectomy for ulcerative colitis and succeeded in making a J pouch without difficulty. This procedure may represent an improved method of making a J pouch...
Middle-colic artery aneurysm associated with segmental arterial mediolysis, successfully managed by transcatheter arterial embolization: report of a caseTakahisa Hirokawa
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Surg Today 39:144-7. 2009..The ruptured aneurysm was successfully treated with transcatheter arterial embolization. Transcatheter arterial embolization might be one of the best treatments for such a complicated aneurysm occurring in a visceral artery...
Solid variant of serous cystadenoma of the pancreasAkira Yasuda
Department of Gastroenterological Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
Arch Med Sci 7:353-5. 2011..Solid variant of serous cystadenoma of the pancreas is difficult to diagnose preoperatively. More cases must be accumulated and investigated to obtain clues for accurate diagnosis...
Treatment of peritoneal carcinomatosis using carboplatin-loaded hydroxyapatite particlesHiromitsu Takeyama
Department of Gastroenterological Surgery, Nagoya City University, Graduate School of Medical Sciences, Kawasumi 1, Mizuho cho, Mizuho ku, Nagoya, 467 8601, Japan
Anticancer Res 26:4603-6. 2006..The anti-tumor effects and tissue distribution of carboplatin (CBDCA) incorporated into hydroxyapatite (HAP) particles was studied...
