Sumihisa Orita

Summary

Affiliation: Toranomon Hospital
Country: Japan

Publications

  1. pmc Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain
    Sumihisa Orita
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    BMC Musculoskelet Disord 12:134. 2011
  2. doi request reprint Brain-derived neurotrophic factor inhibition at the punctured intervertebral disc downregulates the production of calcitonin gene-related peptide in dorsal root ganglia in rats
    Sumihisa Orita
    Department of Orthopaedic Surgery, Chiba Rosai Hospital, Chiba, Japan
    Spine (Phila Pa 1976) 36:1737-43. 2011
  3. doi request reprint Radiographic evaluation of monocortical versus tricortical purchase approaches in lumbosacral fixation with sacral pedicle screws: a prospective study of ninety consecutive patients
    Sumihisa Orita
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 35:E1230-7. 2010
  4. doi request reprint The effects of risedronate and exercise on osteoporotic lumbar rat vertebrae and their sensory innervation
    Sumihisa Orita
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 35:1974-82. 2010
  5. doi request reprint Inhibiting nerve growth factor or its receptors downregulates calcitonin gene-related peptide expression in rat lumbar dorsal root ganglia innervating injured intervertebral discs
    Sumihisa Orita
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Orthop Res 28:1614-20. 2010
  6. ncbi request reprint Percutaneously absorbed NSAIDs attenuate local production of proinflammatory cytokines and suppress the expression of c-Fos in the spinal cord of a rodent model of knee osteoarthritis
    Sumihisa Orita
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Orthop Sci 17:77-86. 2012
  7. pmc Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee
    Sumihisa Orita
    Department of Orthopaedic Surgery, Chiba Rosai Hospital, Chiba, Japan
    BMC Musculoskelet Disord 12:144. 2011
  8. ncbi request reprint Direct evidence for sensory innervation of the dorsal portion of the Co5/6 coccygeal intervertebral disc in rats
    Sumihisa Orita
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 35:1346-52. 2010
  9. ncbi request reprint Assessment of pain behavior in a rat model of intervertebral disc injury using the CatWalk gait analysis system
    Masayuki Miyagi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 38:1459-65. 2013
  10. doi request reprint Uni- and bilateral instrumented posterolateral fusion of the lumbar spine with local bone grafting: a prospective study with a 2-year follow-up
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiiba University, Japan
    Spine (Phila Pa 1976) 36:E1744-8. 2011

Collaborators

Detail Information

Publications70

  1. pmc Pain-related sensory innervation in monoiodoacetate-induced osteoarthritis in rat knees that gradually develops neuronal injury in addition to inflammatory pain
    Sumihisa Orita
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    BMC Musculoskelet Disord 12:134. 2011
    ..We aimed to investigate pain-related sensory innervation in a monoiodoacetate (MIA)-induced model of OA...
  2. doi request reprint Brain-derived neurotrophic factor inhibition at the punctured intervertebral disc downregulates the production of calcitonin gene-related peptide in dorsal root ganglia in rats
    Sumihisa Orita
    Department of Orthopaedic Surgery, Chiba Rosai Hospital, Chiba, Japan
    Spine (Phila Pa 1976) 36:1737-43. 2011
    ..Retrograde neurotracing and immunohistochemical investigation of brain-derived neurotrophic factor (BDNF)-related sensory innervation of punctured lumbar intervertebral discs (IVDs) in rat dorsal root ganglia (DRG)...
  3. doi request reprint Radiographic evaluation of monocortical versus tricortical purchase approaches in lumbosacral fixation with sacral pedicle screws: a prospective study of ninety consecutive patients
    Sumihisa Orita
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 35:E1230-7. 2010
    ..Prospective radiographic outcome analysis...
  4. doi request reprint The effects of risedronate and exercise on osteoporotic lumbar rat vertebrae and their sensory innervation
    Sumihisa Orita
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 35:1974-82. 2010
    ..Investigation of sensory innervation of rat osteoporotic lumbar vertebrae using in vitro and in vivo models...
  5. doi request reprint Inhibiting nerve growth factor or its receptors downregulates calcitonin gene-related peptide expression in rat lumbar dorsal root ganglia innervating injured intervertebral discs
    Sumihisa Orita
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Orthop Res 28:1614-20. 2010
    ..05). Direct intradiscal application of antibody to NGF or its receptors suppressed CGRP expression, and p75(NTR) antagonism induced the most profound suppression...
  6. ncbi request reprint Percutaneously absorbed NSAIDs attenuate local production of proinflammatory cytokines and suppress the expression of c-Fos in the spinal cord of a rodent model of knee osteoarthritis
    Sumihisa Orita
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Orthop Sci 17:77-86. 2012
    ..There have been no studies that report the effect of percutaneous administration of NSAIDs on chronic pain in animal models. This study aimed to investigate the effect of percutaneously absorbed NSAIDs on a rodent model of OA...
  7. pmc Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee
    Sumihisa Orita
    Department of Orthopaedic Surgery, Chiba Rosai Hospital, Chiba, Japan
    BMC Musculoskelet Disord 12:144. 2011
    ..In the present study, correlations between proinflammatory cytokines in knee synovial fluid and radiographic changes and functional scores and pain scores among OA patients were examined...
  8. ncbi request reprint Direct evidence for sensory innervation of the dorsal portion of the Co5/6 coccygeal intervertebral disc in rats
    Sumihisa Orita
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 35:1346-52. 2010
    ..We examined the sensory innervation of the coccygeal (Co) 5/6 intervertebral disc in rats using a retrograde neurotracing method and immunohistochemistry...
  9. ncbi request reprint Assessment of pain behavior in a rat model of intervertebral disc injury using the CatWalk gait analysis system
    Masayuki Miyagi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 38:1459-65. 2013
    ..Pain behavior and immunohistological analysis in intervertebral disc (IVD) injury model...
  10. doi request reprint Uni- and bilateral instrumented posterolateral fusion of the lumbar spine with local bone grafting: a prospective study with a 2-year follow-up
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiiba University, Japan
    Spine (Phila Pa 1976) 36:E1744-8. 2011
    ..Prospective trial...
  11. ncbi request reprint Effect of applying p75NTR saporin to a punctured intervertebral disc on calcitonin gene-related peptide expression in rat dorsal root ganglion neurons
    Ai Sugiura
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    J Orthop Sci 15:407-13. 2010
    ....
  12. doi request reprint Comparison of CatWalk analysis and von Frey testing for pain assessment in a rat model of nerve crush plus inflammation
    Takafumi Sakuma
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 38:E919-24. 2013
    ..Assessment of pain-related behavior and immunohistology of the dorsal root ganglion in a rat model...
  13. doi request reprint Epidural administration of spinal nerves with the tumor necrosis factor-alpha inhibitor, etanercept, compared with dexamethasone for treatment of sciatica in patients with lumbar spinal stenosis: a prospective randomized study
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 37:439-44. 2012
    ..Prospective randomized trial...
  14. pmc Proinflammatory cytokines in the cerebrospinal fluid of patients with lumbar radiculopathy
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Eur Spine J 20:942-6. 2011
    ....
  15. doi request reprint Disk injury in rats produces persistent increases in pain-related neuropeptides in dorsal root ganglia and spinal cord glia but only transient increases in inflammatory mediators: pathomechanism of chronic diskogenic low back pain
    Masayuki Miyagi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 36:2260-6. 2011
    ..Immunohistological analysis in an injured intervertebral disk (IVD) model...
  16. doi request reprint Tumor necrosis factor-α-immunoreactive cells in nucleus pulposus in adolescent patients with lumbar disc herniation
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba 260 8670, Japan
    Spine (Phila Pa 1976) 38:459-62. 2013
    ..Immunohistochemistry for tumor necrosis factor (TNF)-α in nucleus pulposus of adolescent patients with lumbar disc herniation...
  17. doi request reprint Comparison of teriparatide and bisphosphonate treatment to reduce pedicle screw loosening after lumbar spinal fusion surgery in postmenopausal women with osteoporosis from a bone quality perspective
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 38:E487-92. 2013
    ..Prospective study...
  18. doi request reprint Difficulty of diagnosing the origin of lower leg pain in patients with both lumbar spinal stenosis and hip joint osteoarthritis
    Junya Saito
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 37:2089-93. 2012
    ..Case series...
  19. doi request reprint Teriparatide accelerates lumbar posterolateral fusion in women with postmenopausal osteoporosis: prospective study
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 37:E1464-8. 2012
    ..Prospective trial...
  20. doi request reprint A case of symptomatic extra-foraminal lumbosacral stenosis ("far-out syndrome") diagnosed by diffusion tensor imaging
    Mitsuhiro Kitamura
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Inohana, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 37:E854-7. 2012
    ..Case report...
  21. doi request reprint Effectiveness of L2 spinal nerve infiltration for selective discogenic low back pain patients
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Orthop Sci 15:731-6. 2010
    ..The purpose of the current study was to evaluate L2 spinal nerve block for DLBP patients retrospectively based on MRI findings and surgical results...
  22. ncbi request reprint Low back pain after lumbar discectomy in patients showing endplate modic type 1 change
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 35:E596-600. 2010
    ..Prospective cohort study...
  23. ncbi request reprint Nerve growth factor of cultured medium extracted from human degenerative nucleus pulposus promotes sensory nerve growth and induces substance p in vitro
    Kazuyo Yamauchi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 34:2263-9. 2009
    ..We investigated the mechanism of discogenic low back pain using an in vitro model...
  24. doi request reprint Direct single injection of p38 mitogen-activated protein kinase inhibitor does not affect calcitonin gene-related peptide expression in dorsal root ganglion neurons innervating punctured discs in rats
    Yasushi Hayashi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 34:2843-7. 2009
    ..However, a direct single application of p38 inhibitor did not suppress CGRP expression in innervating DRG neurons. Future research with p38 inhibitor in this model should evaluate multiple or systemic administration of inhibitor...
  25. ncbi request reprint The effect of platelet-rich plasma on posterolateral lumbar fusion in a rat model
    Hiroto Kamoda
    Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Bone Joint Surg Am 95:1109-16. 2013
    ....
  26. pmc Efficacy of epidural administration of anti-interleukin-6 receptor antibody onto spinal nerve for treatment of sciatica
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, Japan
    Eur Spine J 21:2079-84. 2012
    ..The purpose of the current study was to examine the effect of the anti-IL-6 receptor monoclonal antibody, tocilizumab, on radicular pain by its epidural administration onto spinal nerves in patients with lumbar spinal stenosis...
  27. pmc Single-level instrumented posterolateral fusion of the lumbar spine with a local bone graft versus an iliac crest bone graft: a prospective, randomized study with a 2-year follow-up
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Eur Spine J 20:635-9. 2011
    ..If single-level posterolateral fusion was performed, local bone graft technique has the same bone union rate compared with ICBG, requires less surgical time, and has fewer complications...
  28. doi request reprint Direct application of the tumor necrosis factor-α inhibitor, etanercept, into a punctured intervertebral disc decreases calcitonin gene-related peptide expression in rat dorsal root ganglion neurons
    Manato Horii
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 36:E80-5. 2011
    ....
  29. doi request reprint Results of surgery for discogenic low back pain: a randomized study using discography versus discoblock for diagnosis
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 34:1345-8. 2009
    ..Randomized, controlled study...
  30. ncbi request reprint Direct application of the TNF-alpha inhibitor, etanercept, does not affect CGRP expression and phenotypic change of DRG neurons following application of nucleus pulposus onto injured sciatic nerves in rats
    Masaki Norimoto
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Japan
    Spine (Phila Pa 1976) 33:2403-8. 2008
    ..Immunohistological and behavioral analysis of the effect of a tumor necrosis factor alpha (TNF-alpha) inhibitor in an injured-nerve model...
  31. doi request reprint Differences between tumor necrosis factor-α receptors types 1 and 2 in the modulation of spinal glial cell activation and mechanical allodynia in a rat sciatic nerve injury model
    Tetsuhiro Ishikawa
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 38:11-6. 2013
    ..Immunohistological analysis of spinal glial cells and analysis of pain behavior in the rat neuropathic pain model were investigated to clarify the function of tumor necrosis factor (TNF)-α receptors p55 type 1 and p75 type 2...
  32. pmc L5 spinal nerve injury caused by misplacement of outwardly-inserted S1 pedicle screws
    Masahiro Inoue
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Eur Spine J 22:S461-5. 2013
    ..Despite this risk, to our knowledge this type of injury has never been reported as a case series...
  33. ncbi request reprint ISSLS prize winner: disc dynamic compression in rats produces long-lasting increases in inflammatory mediators in discs and induces long-lasting nerve injury and regeneration of the afferent fibers innervating discs: a pathomechanism for chronic discogeni
    Masayuki Miyagi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 37:1810-8. 2012
    ..Animal model of intravertebral disc (IVD) degeneration...
  34. ncbi request reprint Platelet-rich plasma combined with hydroxyapatite for lumbar interbody fusion promoted bone formation and decreased an inflammatory pain neuropeptide in rats
    Hiroto Kamoda
    Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 37:1727-33. 2012
    ..A prospective interventional trial, using a rat model of lumbar interbody fusion...
  35. ncbi request reprint Differences in damage to CGRP immunoreactive sensory nerves after two lumbar surgical approaches: investigation using humans and rats
    Seiji Ohtori
    Department of Orthopaedic Surgery, Chiba University, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 37:168-73. 2012
    ..Immunohistochemical study...
  36. doi request reprint One, two-, and three-level instrumented posterolateral fusion of the lumbar spine with a local bone graft: a prospective study with a 2-year follow-up
    Kazuhide Inage
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Japan
    Spine (Phila Pa 1976) 36:1392-6. 2011
    ..Prospective trial...
  37. ncbi request reprint Diffusion-weighted magnetic resonance imaging of symptomatic nerve root of patients with lumbar disk herniation
    Yawara Eguchi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Neuroradiology 53:633-41. 2011
    ....
  38. ncbi request reprint Low affinity NGF receptor (p75 neurotrophin receptor) inhibitory antibody reduces pain behavior and CGRP expression in DRG in the mouse sciatic nerve crush model
    Yu Fukui
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Orthop Res 28:279-83. 2010
    ..01). Application of the p75 NTR inhibitory antibody to the pinched sciatic nerve suppressed CGRP and p75 NTR expression and pain behavior...
  39. ncbi request reprint Primary sensory neurons with dichotomizing axons projecting to the facet joint and the low back muscle in rats
    Ken Wakai
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    J Orthop Sci 15:402-6. 2010
    ..However, these neurons, which have dichotomizing axons to the lumbar facet joints and to the lumbar muscle, have not been fully investigated...
  40. ncbi request reprint Vertebral compression exacerbates osteoporotic pain in an ovariectomy-induced osteoporosis rat model
    Miyako Suzuki
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan Department of Orthopaedic Surgery, Teikyo University Chiba Medical Center, Ichihara, Japan Department of Orthopaedic Surgery, Toho University Sakura Medical Center, Sakura, Japan Department of Orthopaedic Surgery, Wakayama Medical University Kihoku Hospital, Wakayama, Japan and Department of Orthopaedic Surgery, Kitasato University School of Medicine, Kanagawa, Japan
    Spine (Phila Pa 1976) 38:2085-91. 2013
    ..Basic pain study using osteoporotic rodent models...
  41. doi request reprint Sensory and autonomic innervation of the cervical intervertebral disc in rats: the pathomechanics of chronic discogenic neck pain
    Kazuki Fujimoto
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 37:1357-62. 2012
    ..An immunohistological analysis of the cervical intervertebral disc (IVD)...
  42. pmc Clinical incidence of sacroiliac joint arthritis and pain after sacropelvic fixation for spinal deformity
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Yonsei Med J 53:416-21. 2012
    ..On the other hand, there is a potential for clinical problems related to iliac fixation, including late sacroiliac joint arthritis and pain...
  43. doi request reprint Assessment of gait in a rat model of myofascial inflammation using the CatWalk system
    Masayuki Miyagi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Japan
    Spine (Phila Pa 1976) 36:1760-4. 2011
    ..Gait analysis and immunohistological analysis in a rat model of myofascial inflammation in low back...
  44. ncbi request reprint Change in Modic type 1 and 2 signals after posterolateral fusion surgery
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 35:1231-5. 2010
    ..Prospective cohort study...
  45. ncbi request reprint Transfection of rat cells with proopiomeranocortin gene, precursor of endogenous endorphin, using radial shock waves suppresses inflammatory pain
    Masaomi Yamashita
    Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 34:2270-7. 2009
    ..The effect of proopiomelanocortin (POMC) gene transfer with radial shock waves (RSW) was investigated in vitro and in vivo rat pain models...
  46. doi request reprint Single-level instrumented posterolateral fusion versus non-instrumented anterior interbody fusion for lumbar spondylolisthesis: a prospective study with a 2-year follow-up
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    J Orthop Sci 16:352-8. 2011
    ..However, there have been no reports comparing posterolateral and anterior interbody fusion prospectively. We compared instrumented posterolateral fusion with anterior interbody fusion for L4 spondylolisthesis in a prospective study...
  47. doi request reprint Diffusion magnetic resonance imaging to differentiate degenerative from infectious endplate abnormalities in the lumbar spine
    Yawara Eguchi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 36:E198-202. 2011
    ..A retrospective observational study of healthy volunteers and patients with degenerative and infectious endplate abnormalities in the lumbar spine...
  48. pmc Existence of pyogenic spondylitis in Modic type 1 change without other signs of infection: 2-year follow-up
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Eur Spine J 19:1200-5. 2010
    ..2% of patients with Modic type 1 change, but without other signs of infection were diagnosed as having pyogenic spondylitis during the 2-year follow-up, therefore, it is important to consider this before treating Modic type 1 change...
  49. doi request reprint IκB kinase β inhibitor downregulates pain-related neuropeptide production in the sensory neurons innervating injured lumbar intervertebral discs in the dorsal root ganglia of rats
    Sumihisa Orita
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Spine J 13:284-8. 2013
    ..Phosphorylation of IκB protein through IκB kinase (IKK) is the first step in the activation of NF-κB activation and the upregulation of NF-κB-responsive genes...
  50. doi request reprint In-vivo transfection of the proopiomelanocortin gene, precursor of endogenous endorphin, by use of radial shock waves alleviates neuropathic pain
    Tetsuhiro Ishikawa
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Orthop Sci 18:636-45. 2013
    ..The purpose of this study was to investigate the efficacy of proopiomelanocortin (POMC, a precursor of the endogenous opioid peptide β-endorphin) gene transfer by use of radial shock waves (RSWs) in a rat neuropathic pain model...
  51. pmc Postoperative lumbar spinal stenosis after intertransverse fusion with granules of hydroxyapatite: a case report
    Gen Inoue
    Department of Orthopaedic Surgery, Kitasato University, School of Medicine, Minami Ku, Sagamihara, Kanagawa, Japan
    Diagn Pathol 7:153. 2012
    ..No tartrate-resistant acid phosphate (TRAP) -positive osteoclasts could be seen in the new bone, suggesting that the activity of osteoclasts in the new bone decreased during the seven years after the primary surgery...
  52. doi request reprint Acute lumbar spinal pseudogout attack after instrumented surgery
    Yuya Ogawa
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 37:E1529-33. 2012
    ..A case report...
  53. pmc Transdermal fentanyl for chronic low back pain
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Yonsei Med J 53:788-93. 2012
    ..The purpose of the current study was to examine the efficacy of transdermal fentanyl in the treatment of chronic low back pain...
  54. doi request reprint Investigation of dichotomizing sensory nerve fibers projecting to the lumbar multifidus muscles and intervertebral disc or facet joint or sacroiliac joint in rats
    Tomotaka Umimura
    School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 37:557-62. 2012
    ..Immunohistological analysis of dichotomizing sensory nerve fibers projecting to the lumbar multifidus muscles and intervertebral disc (IVD), facet joint (FJ), or sacroiliac joint (SIJ) in rats...
  55. pmc Nuclear factor-kappa B decoy suppresses nerve injury and improves mechanical allodynia and thermal hyperalgesia in a rat lumbar disc herniation model
    Munetaka Suzuki
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8670, Japan
    Eur Spine J 18:1001-7. 2009
    ..NF-kappaB decoy was transduced into DRGs in vivo. NF-kappaB decoy may be useful as a target for clarifying the mechanism of sciatica caused by lumbar disc herniation...
  56. doi request reprint Long-term intravenous administration of antibiotics for lumbar spinal surgery prolongs the duration of hospital stay and time to normalize body temperature after surgery
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 33:2935-7. 2008
    ..Comparative study of differing durations of antibiotics for spinal surgery...
  57. pmc Rotational hypermobility of disc wedging using kinematic CT: preliminary study to investigate the instability of discs in degenerated scoliosis in the lumbar spine
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8670, Japan
    Eur Spine J 19:989-94. 2010
    ..For surgical planning of degenerative L4-L5 disc wedging, it is important to consider rotational hypermobility using kinematic CT or X-ray imaging findings of lateral bending...
  58. pmc Evaluation of behavior and neuropeptide markers of pain in a simple, sciatic nerve-pinch pain model in rats
    Kazutoshi Hirose
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Eur Spine J 19:1746-52. 2010
    ..Upregulation of the pain-marker expression in the nerve-injury model suggested it could be used as a model of pain. However, it was not considered as suitable for long-term studies...
  59. pmc Efficacy of combination of meloxicam and pregabalin for pain in knee osteoarthritis
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Yonsei Med J 54:1253-8. 2013
    ..Pregabalin was developed as a pain killer for NP; however, there are no reports on pregabalin use in OA patients. The purpose of this study was to investigate the efficacy of pregabalin for pain in OA patients...
  60. doi request reprint A prospective randomized controlled study comparing transforaminal lumbar interbody fusion techniques for degenerative spondylolisthesis: unilateral pedicle screw and 1 cage versus bilateral pedicle screws and 2 cages
    Yasuchika Aoki
    Department of Orthopaedic Surgery, Chiba Rosai Hospital, Chiba, Japan
    J Neurosurg Spine 17:153-9. 2012
    ..The authors conducted a prospective randomized controlled trial with a minimum 2-year follow-up to analyze TLIF outcomes for 2 techniques: placement of a unilateral PS and a cage compared with placement of bilateral PSs and 2 cages...
  61. doi request reprint Role of low-affinity nerve growth factor receptor inhibitory antibody in reducing pain behavior and calcitonin gene-related Peptide expression in a rat model of wrist joint inflammatory pain
    Nahoko Iwakura
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    J Hand Surg Am 35:267-73. 2010
    ....
  62. ncbi request reprint 18F-fluorodeoxyglucose-PET for patients with suspected spondylitis showing Modic change
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 35:E1599-603. 2010
    ..Prospective cohort study...
  63. pmc Clinical applications of diffusion magnetic resonance imaging of the lumbar foraminal nerve root entrapment
    Yawara Eguchi
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Eur Spine J 19:1874-82. 2010
    ..We believe that DWI is a potential tool for diagnosis of lumbar nerve entrapment...
  64. ncbi request reprint Existence of nerve growth factor receptors, tyrosine kinase a and p75 neurotrophin receptors in intervertebral discs and on dorsal root ganglion neurons innervating intervertebral discs in rats
    Ai Sugiura
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Spine (Phila Pa 1976) 33:2047-51. 2008
    ..We evaluated 2 types of nerve growth factor (NGF) receptors on dorsal root ganglion (DRG) cells and nerve fibers innervating rat lumbar intervertebral discs...
  65. ncbi request reprint L2 spinal nerve-block effects on acute low back pain from osteoporotic vertebral fracture
    Seiji Ohtori
    Department of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    J Pain 10:870-5. 2009
    ..05). We conclude that L2 spinal nerve block for acute L3 or L4 osteoporotic vertebral body fracture was effective for 2 weeks, but it had no long-term effects on pain and social function...
  66. ncbi request reprint Sensory innervation and inflammatory cytokines in hypertrophic synovia associated with pain transmission in osteoarthritis of the hip: a case-control study
    Munenori Takeshita
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Rheumatology (Oxford) 51:1790-5. 2012
    ..To clarify the sensory innervation and inflammatory cytokines in hypertrophic synovia associated with pain transmission in OA of the hip...
  67. doi request reprint Lumbar disc degeneration induces persistent groin pain
    Yasuhiro Oikawa
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Spine (Phila Pa 1976) 37:114-8. 2012
    ..Prospective study of 212 patients with groin pain but without low back pain...
  68. doi request reprint Risedronate decreases bone resorption and improves low back pain in postmenopausal osteoporosis patients without vertebral fractures
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba 260 8670, Japan
    J Clin Neurosci 17:209-13. 2010
    ..01). A decrease in serum and urinary NTx was associated with improvement of low back pain, suggesting that despite the absence of vertebral fractures, bone resorption due to osteoporosis may cause low back pain...
  69. pmc Existence of a neuropathic pain component in patients with osteoarthritis of the knee
    Seiji Ohtori
    Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Yonsei Med J 53:801-5. 2012
    ..Our objective was to examine NP in the knees of OA patients using painDETECT (an NP questionnaire) and to evaluate the relationship between NP, pain intensity, and stage of OA...
  70. pmc Schwann cell LRP1 regulates remak bundle ultrastructure and axonal interactions to prevent neuropathic pain
    Sumihisa Orita
    Department of Anesthesiology, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 33:5590-602. 2013
    ..Mice in which LRP1 is deficient in Schwann cells represent a model for studying how abnormalities in Schwann cell physiology may facilitate and sustain chronic pain...