Taisuke Tomita

Summary

Country: Japan

Publications

  1. pmc Structural biology of presenilins and signal peptide peptidases
    Taisuke Tomita
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    J Biol Chem 288:14673-80. 2013
  2. ncbi request reprint Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions
    Manabu Niimura
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    J Biol Chem 280:12967-75. 2005
  3. ncbi request reprint The role of presenilin cofactors in the gamma-secretase complex
    Nobumasa Takasugi
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyoku, Tokyo 113 0033, Japan
    Nature 422:438-41. 2003
  4. ncbi request reprint C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester)
    Yuichi Morohashi
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 281:14670-6. 2006
  5. ncbi request reprint Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors
    Haruhiko Fuwa
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo ku, Japan
    Bioorg Med Chem Lett 16:4184-9. 2006
  6. ncbi request reprint Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation
    Yasuko Takahashi
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 278:18664-70. 2003
  7. ncbi request reprint Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate
    Noriko Isoo
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    J Biol Chem 282:12388-96. 2007
  8. pmc Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1
    Yu Ohki
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    EMBO J 30:4815-24. 2011
  9. ncbi request reprint Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1
    Naoto Watanabe
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 280:41967-75. 2005
  10. ncbi request reprint Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines
    Chihiro Sato
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    J Neurosci 26:12081-8. 2006

Collaborators

Detail Information

Publications44

  1. pmc Structural biology of presenilins and signal peptide peptidases
    Taisuke Tomita
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    J Biol Chem 288:14673-80. 2013
    ..Recently, the x-ray structures of some archaeal GxGD proteases have been determined. We review the recent progress in biochemical and biophysical probing of the structure of these atypical proteases...
  2. ncbi request reprint Aph-1 contributes to the stabilization and trafficking of the gamma-secretase complex through mechanisms involving intermolecular and intramolecular interactions
    Manabu Niimura
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    J Biol Chem 280:12967-75. 2005
    ..nicastrin subcomplex with presenilin is the prerequisite for the trafficking as well as the enzymatic activity of the gamma-secretase complex and that Aph-1 functions as a stabilizing scaffold in the assembly of this complex...
  3. ncbi request reprint The role of presenilin cofactors in the gamma-secretase complex
    Nobumasa Takasugi
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyoku, Tokyo 113 0033, Japan
    Nature 422:438-41. 2003
    ..Thus, APH-1 stabilizes the presenilin holoprotein in the complex, whereas PEN-2 is required for endoproteolytic processing of presenilin and conferring gamma-secretase activity to the complex...
  4. ncbi request reprint C-terminal fragment of presenilin is the molecular target of a dipeptidic gamma-secretase-specific inhibitor DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester)
    Yuichi Morohashi
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 281:14670-6. 2006
    ..These data illustrate the DAPT binding site as a novel functional domain within the PS C-terminal fragment that is distinct from the catalytic site or the substrate binding site...
  5. ncbi request reprint Synthesis of biotinylated photoaffinity probes based on arylsulfonamide gamma-secretase inhibitors
    Haruhiko Fuwa
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo ku, Japan
    Bioorg Med Chem Lett 16:4184-9. 2006
    ..Design, synthesis, and biological evaluation of multifunctional molecular probes harboring a benzophenone photophore as a cross-linking group and a biotin tag are also reported...
  6. ncbi request reprint Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation
    Yasuko Takahashi
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 278:18664-70. 2003
    ..Notably, SSide displayed linear noncompetitive inhibition profiles for gamma(42)-secretase in vitro. Our data suggest that SSide is a direct inhibitor of gamma-secretase that preferentially affects the gamma(42)-secretase activity...
  7. ncbi request reprint Abeta42 overproduction associated with structural changes in the catalytic pore of gamma-secretase: common effects of Pen-2 N-terminal elongation and fenofibrate
    Noriko Isoo
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    J Biol Chem 282:12388-96. 2007
    ..These data suggest a unique mechanism of Abeta42 overproduction associated with structural changes in the catalytic pore of presenilins caused commonly by the N-terminal elongation of Pen-2 and fenofibrate...
  8. pmc Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1
    Yu Ohki
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    EMBO J 30:4815-24. 2011
    ..These data indicate an allosteric action of GSM-1 by directly binding to the TMD1 of PS1, pinpointing the target structure of the phenylpiperidine-type GSMs...
  9. ncbi request reprint Pen-2 is incorporated into the gamma-secretase complex through binding to transmembrane domain 4 of presenilin 1
    Naoto Watanabe
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 280:41967-75. 2005
    ..Pen-2 may contribute to the activation of the gamma-secretase complex by directly binding to the TMD4 of PS1...
  10. ncbi request reprint Structure of the catalytic pore of gamma-secretase probed by the accessibility of substituted cysteines
    Chihiro Sato
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    J Neurosci 26:12081-8. 2006
    ..Collectively, our data suggest that the active site of gamma-secretase resides in a catalytic pore filled with water within the lipid bilayer and is tapered around the catalytic aspartates...
  11. doi request reprint Development of photoaffinity probes for gamma-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker
    Satoshi Yokoshima
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Bioorg Med Chem Lett 19:6869-71. 2009
    ..We have developed photoaffinity probes for gamma-secretase with a nitrobenzenesulfonamide-type linker that can be cleaved with 2-mercaptoethanol under physiological conditions...
  12. ncbi request reprint Association of active gamma-secretase complex with lipid rafts
    Yasuomi Urano
    Department of Molecular Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153 8904, Japan
    J Lipid Res 46:904-12. 2005
    ..This effect was partially abrogated by the addition of geranylgeraniol. These results suggest that both cholesterol and protein isoprenylation influence the active gamma-secretase complex association with lipid rafts...
  13. pmc Contribution of the γ-secretase subunits to the formation of catalytic pore of presenilin 1 protein
    Koji Takeo
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Biol Chem 287:25834-43. 2012
    ..We propose a model in which the γ-secretase subunits restrict the arrangement of the transmembrane domains of PS during the formation of the functional structure of the catalytic pore...
  14. pmc Functional analysis of the transmembrane domains of presenilin 1: participation of transmembrane domains 2 and 6 in the formation of initial substrate-binding site of gamma-secretase
    Naoto Watanabe
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    J Biol Chem 285:19738-46. 2010
    ..Taken together, our data suggest that TMD2 and the luminal side of TMD6 are involved in the formation of the initial substrate-binding site of the gamma-secretase complex...
  15. pmc Single chain variable fragment against nicastrin inhibits the gamma-secretase activity
    Ikuo Hayashi
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 284:27838-47. 2009
    ..The engineered intrabodies may serve as rationally designed, molecular targeting tools for the discovery of novel actions of the membrane proteins...
  16. pmc FTY720/fingolimod, a sphingosine analogue, reduces amyloid-β production in neurons
    Nobumasa Takasugi
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    PLoS ONE 8:e64050. 2013
    ..These results suggest that S1PR modulators are novel type of regulators for Aβ metabolisms that are active in vitro and in vivo...
  17. pmc Binding of longer Aβ to transmembrane domain 1 of presenilin 1 impacts on Aβ42 generation
    Yu Ohki
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Mol Neurodegener 9:7. 2014
    ..Although γ-secretase is a responsible protease to generate Aβ through a processive cleavage, the proteolytic mechanism of γ-secretase at molecular level is poorly understood...
  18. doi request reprint Activity-dependent proteolytic cleavage of neuroligin-1
    Kunimichi Suzuki
    Department of Neuropathology and Neuroscience, The University of Tokyo, Hongo 7 3 1, Bunkyo, Tokyo 113 0033, Japan
    Neuron 76:410-22. 2012
    ..Collectively, neuronal activity-dependent proteolytic processing of NLG1 may negatively regulate the remodeling of spines at excitatory synapses...
  19. ncbi request reprint Parallel synthesis of DAPT derivatives and their gamma-secretase-inhibitory activity
    Toshiyuki Kan
    Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Bioorg Med Chem Lett 14:1983-5. 2004
    ..Among the analogues, the benzophenonemethyl amide derivative 6o showed 30 times more potent activity than the original DAPT (1)...
  20. ncbi request reprint Selective reconstitution and recovery of functional gamma-secretase complex on budded baculovirus particles
    Ikuo Hayashi
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    J Biol Chem 279:38040-6. 2004
    ....
  21. doi request reprint Protein trafficking and maturation regulate intramembrane proteolysis
    Yuichi Morohashi
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    Biochim Biophys Acta 1828:2855-61. 2013
    ..In this review, we will discuss recent advances in our understanding of how each i-CLiP proteolysis is regulated by intracellular vesicle trafficking. This article is part of a Special Issue entitled: Intramembrane Proteases. ..
  22. ncbi request reprint Novel gamma-secretase inhibitors discovered by library screening of in-house synthetic natural product intermediates
    Yasuko Takahashi
    Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Tokyo 113 0033, Japan
    Bioorg Med Chem Lett 16:3813-6. 2006
    ..Structure-activity relationship studies of these compounds were also developed...
  23. doi request reprint Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition
    Yuki Imamura
    Department of Bioorganic Inorganic Chemistry, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi, Japan
    J Med Chem 56:1443-54. 2013
    ..The substrate selectivity of the inhibitory activity was also quite sensitive to the class of side chain group incorporated. ..
  24. ncbi request reprint gamma-secretase as a therapeutic target for treatment of Alzheimer's disease
    Taisuke Tomita
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo ku, Japan
    Curr Pharm Des 12:661-70. 2006
    ..Moreover, we review the recent development of inhibitors and provide a direction for the effective treatment of AD through inhibition of gamma-secretase activity...
  25. doi request reprint BACE1 activity is modulated by cell-associated sphingosine-1-phosphate
    Nobumasa Takasugi
    Department of Neuropathology and Neuroscience, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    J Neurosci 31:6850-7. 2011
    ..Notably, the relative activity of SphK2 was upregulated in the brains of patients with Alzheimer's disease. The unique modulatory effect of cellular S1P on BACE1 activity is a novel potential therapeutic target for Alzheimer's disease...
  26. ncbi request reprint The inhibition of gamma-secretase as a therapeutic approach to Alzheimer's disease
    Taisuke Tomita
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    Drug News Perspect 17:321-5. 2004
    ..This review focuses on studies of the gamma-secretase biology and provides the direction for developing effective and selective gamma-secretase inhibitors as drugs for the treatment of Alzheimer's disease...
  27. ncbi request reprint [Recent advances in Alzheimer's disease-related gamma-secretase complex]
    Taisuke Tomita
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1, Hongo, Bunkyo, Tokyo 113 0033, Japan
    Seikagaku 76:666-70. 2004
  28. ncbi request reprint The mechanism of gamma-secretase activities through high molecular weight complex formation of presenilins is conserved in Drosophila melanogaster and mammals
    Nobumasa Takasugi
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 277:50198-205. 2002
    ....
  29. ncbi request reprint New photocleavable linker: α-thioacetophenone-type linker
    Hirotaka Yonezawa
    Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Bioorg Med Chem Lett 24:2831-3. 2014
    ..This novel linker would serve as an effective tool in chemical biology...
  30. ncbi request reprint The C-terminal PAL motif and transmembrane domain 9 of presenilin 1 are involved in the formation of the catalytic pore of the gamma-secretase
    Chihiro Sato
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo, Tokyo 113 0033, Japan
    J Neurosci 28:6264-71. 2008
    ..Our results provide mechanistic insights into the role of TMD9 in the formation of the catalytic pore and the substrate entry, crucial to the unusual mode of intramembrane proteolysis by gamma-secretase...
  31. ncbi request reprint [Alzheimer's disease treatment by inhibition/modulation of the gamma-secretase activity]
    Taisuke Tomita
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo
    Rinsho Shinkeigaku 49:845-7. 2009
    ..This review focuses on the recent development of inhibitors/modulators and provides a direction for the effective treatment of AD through inhibition/modulation of the gamma-secretase activity...
  32. doi request reprint Participation of transmembrane domain 1 of presenilin 1 in the catalytic pore structure of the γ-secretase
    Shizuka Takagi
    Department of Neuropathology and Neuroscience, The University of Tokyo, Tokyo 113 0033, Japan
    J Neurosci 30:15943-50. 2010
    ..Our results provide mechanistic insights into the functional role of TMD1 of PS1 in the intramembrane-cleaving activity of the γ-secretase...
  33. pmc Experimental detection of proteolytic activity in a signal peptide peptidase of Arabidopsis thaliana
    Masako Hoshi
    Department of Applied Biological Chemistry, The University of Tokyo, Tokyo, Japan
    BMC Biochem 14:16. 2013
    ..In this study, we have investigated the proteolytic activity of AtSPP to define the function of SPPs in plants...
  34. ncbi request reprint [Targeting the structure and function relationships of the gamma-secretase for the development of Alzheimer's disease]
    Taisuke Tomita
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo
    Rinsho Shinkeigaku 48:907-9. 2008
    ..I will review our structural studies on the gamma-secretase complex, and envision the direction for developing effective and selective gamma-secretase inhibitors as therapeutics for AD...
  35. ncbi request reprint Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments
    Taisuke Tomita
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 0033, Japan
    FEBS Lett 520:117-21. 2002
    ....
  36. pmc Three-dimensional structure of the signal peptide peptidase
    Hiroyuki Miyashita
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    J Biol Chem 286:26188-97. 2011
    ..These data suggest that the homotetramer is the functional unit of SPP and that its N-terminal region, which works as the structural scaffold, has a novel modulatory function for the intramembrane-cleaving activity of SPP...
  37. doi request reprint Inhibition of γ-secretase activity by a monoclonal antibody against the extracellular hydrophilic loop of presenilin 1
    Shizuka Takagi-Niidome
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan
    Biochemistry 52:61-9. 2013
    ..Our data suggest that the juxtamembrane region of TMD1 of PS1 is a novel molecular target for the mechanism-based inhibition of γ-secretase and the development of the anticancer drug...
  38. ncbi request reprint At the frontline of Alzheimer's disease treatment: gamma-secretase inhibitor/modulator mechanism
    Taisuke Tomita
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Naunyn Schmiedebergs Arch Pharmacol 377:295-300. 2008
    ..This review focuses on the structure and function relationship of gamma-secretase complex and the mode of action of the gamma-secretase inhibitors...
  39. ncbi request reprint [Molecular targeted therapy in Alzheimer disease]
    Yuichi Morohashi
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo
    Nihon Rinsho 68:1906-10. 2010
    ..Finally potential mechanism-based adverse effects of these treatments and the strategies to tackle these problems will be discussed...
  40. doi request reprint Secretase inhibitors and modulators for Alzheimer's disease treatment
    Taisuke Tomita
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    Expert Rev Neurother 9:661-79. 2009
    ..Moreover, this review discusses the recent development of inhibitors, and provides a direction for the effective treatment of AD through inhibition/modulation of beta- and gamma-secretase activities...
  41. doi request reprint Decreased CALM expression reduces Aβ42 to total Aβ ratio through clathrin-mediated endocytosis of γ-secretase
    Kunihiko Kanatsu
    1 Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113 0033, Japan 2
    Nat Commun 5:3386. 2014
    ..Our study identifies CALM as an endogenous modulator of γ-secretase activity by regulating its endocytosis and also as an excellent target for Aβ42-lowering AD therapeutics. ..
  42. doi request reprint Attenuation of the aggregation and neurotoxicity of amyloid-β peptides by catalytic photooxygenation
    Atsuhiko Taniguchi
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 0033 Japan Japan Science and Technology Agency JST, ERATO, Kanai Life Science Catalysis Project, Bunkyo ku, Tokyo 113 0033 Japan
    Angew Chem Int Ed Engl 53:1382-5. 2014
    ..Furthermore, oxygenated Aβ1-42 inhibited the aggregation and cytotoxicity of native Aβ. ..
  43. ncbi request reprint [Development of Alzheimer's disease treatment based on the molecular mechanism of γ-secretase activity]
    Taisuke Tomita
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Science, The University of Tokyo
    Rinsho Shinkeigaku 52:1165-7. 2012
    ....
  44. ncbi request reprint Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4
    Yuichi Morohashi
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo 113 0033, Japan
    J Biol Chem 277:14965-75. 2002
    ..Taken together, CALP/KChIP4 is a novel EF-hand protein interacting with PS as well as with Kv4 that may modulate functions of a subset of membrane proteins in brain...