Masayuki Yoshida

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. pmc In vivo imaging of leukocyte recruitment to the atheroprone femoral artery reveals anti-inflammatory effects of rosuvastatin
    Mizuko Osaka
    Department of Life Sciences and Bioethics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Biomed Res Int 2013:962369. 2013
  2. pmc Adipose inflammation initiates recruitment of leukocytes to mouse femoral artery: role of adipo-vascular axis in chronic inflammation
    Sumihiko Hagita
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    PLoS ONE 6:e19871. 2011
  3. ncbi request reprint E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions
    Masayuki Yoshida
    Department of Vascular Medicine and Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima Bldg D 256, Bunkyo ku, Tokyo 113 8519, Japan
    Arterioscler Thromb Vasc Biol 23:783-8. 2003
  4. pmc High serum bicarbonate level within the normal range prevents the progression of chronic kidney disease in elderly chronic kidney disease patients
    Eiichiro Kanda
    Department of Nephrology, Tokyo Kyosai Hospital, Meguroku, Japan
    BMC Nephrol 14:4. 2013
  5. ncbi request reprint Pitavastatin inhibits remnant lipoprotein-induced macrophage foam cell formation through ApoB48 receptor-dependent mechanism
    Akio Kawakami
    Department of Geriatrics and Vascular Medicine, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 25:424-9. 2005
  6. doi request reprint Inhibition of hepatic Niemann-Pick C1-like 1 improves hepatic insulin resistance
    Mitsunori Nomura
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, 1 5 45, Yushima D9, Bunkyo ku, Tokyo, 113 8510 Japan
    Am J Physiol Endocrinol Metab 297:E1030-8. 2009
  7. doi request reprint Reduction of indoxyl sulfate by AST-120 attenuates monocyte inflammation related to chronic kidney disease
    Shunsuke Ito
    Department of International Health Development, Tokyo Medical and Dental University, Tokyo, Japan
    J Leukoc Biol 93:837-45. 2013
  8. ncbi request reprint Cilostazol inhibits monocytic cell adhesion to vascular endothelium via upregulation of cAMP
    Daisuke Mori
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, Tokyo, Japan
    J Atheroscler Thromb 14:213-8. 2007
  9. ncbi request reprint Dynamic observation of mechanically-injured mouse femoral artery reveals an antiinflammatory effect of renin inhibitor
    Jun Ino
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 29:1858-63. 2009
  10. doi request reprint Combination of amlodipine and atorvastatin synergistically reduces leukocyte recruitment to mechanically injured mouse femoral artery
    Sumihiko Hagita
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, Tokyo, Japan
    Hypertens Res 34:450-5. 2011

Detail Information

Publications61

  1. pmc In vivo imaging of leukocyte recruitment to the atheroprone femoral artery reveals anti-inflammatory effects of rosuvastatin
    Mizuko Osaka
    Department of Life Sciences and Bioethics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Biomed Res Int 2013:962369. 2013
    ..To monitor the anti-inflammatory effect of rosuvastatin in leukocyte endothelial interactions in the atheroprone femoral artery in vivo...
  2. pmc Adipose inflammation initiates recruitment of leukocytes to mouse femoral artery: role of adipo-vascular axis in chronic inflammation
    Sumihiko Hagita
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    PLoS ONE 6:e19871. 2011
    ..In the present study, we examined the direct effects of adipose tissue on macro-vascular inflammation using intravital microscopic analysis of the femoral artery after adipose tissue transplantation...
  3. ncbi request reprint E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions
    Masayuki Yoshida
    Department of Vascular Medicine and Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima Bldg D 256, Bunkyo ku, Tokyo 113 8519, Japan
    Arterioscler Thromb Vasc Biol 23:783-8. 2003
    ..We investigated the Ser128Arg polymorphism in the E-selectin gene in Japanese patients with myocardial infarction and its functional significance...
  4. pmc High serum bicarbonate level within the normal range prevents the progression of chronic kidney disease in elderly chronic kidney disease patients
    Eiichiro Kanda
    Department of Nephrology, Tokyo Kyosai Hospital, Meguroku, Japan
    BMC Nephrol 14:4. 2013
    ..For serum bicarbonate level to be clinically useful as a therapeutic target marker, it is necessary to investigate the target serum bicarbonate level within the normal range to prevent CKD progression...
  5. ncbi request reprint Pitavastatin inhibits remnant lipoprotein-induced macrophage foam cell formation through ApoB48 receptor-dependent mechanism
    Akio Kawakami
    Department of Geriatrics and Vascular Medicine, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 25:424-9. 2005
    ..We examined the involvement of apoB48 receptor (apoB48R), a novel receptor for RLPs, in that process in vitro and its potential regulation by pitavastatin...
  6. doi request reprint Inhibition of hepatic Niemann-Pick C1-like 1 improves hepatic insulin resistance
    Mitsunori Nomura
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, 1 5 45, Yushima D9, Bunkyo ku, Tokyo, 113 8510 Japan
    Am J Physiol Endocrinol Metab 297:E1030-8. 2009
    ..These results indicate that NPC1L1 contributes to hepatic insulin resistance through cholesterol accumulation, and its inhibition could be a potential therapeutic target of hepatic insulin resistance...
  7. doi request reprint Reduction of indoxyl sulfate by AST-120 attenuates monocyte inflammation related to chronic kidney disease
    Shunsuke Ito
    Department of International Health Development, Tokyo Medical and Dental University, Tokyo, Japan
    J Leukoc Biol 93:837-45. 2013
    ..The main finding of this study was that AST-120 inhibited monocyte activation by reducing IS in vivo. This provides new insights on how AST-120 attenuates the progression of atherosclerosis in CKD...
  8. ncbi request reprint Cilostazol inhibits monocytic cell adhesion to vascular endothelium via upregulation of cAMP
    Daisuke Mori
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, Tokyo, Japan
    J Atheroscler Thromb 14:213-8. 2007
    ..We thus examined the potential role of cilostazol towards monocyte endothelial interaction under physiological flow conditions...
  9. ncbi request reprint Dynamic observation of mechanically-injured mouse femoral artery reveals an antiinflammatory effect of renin inhibitor
    Jun Ino
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 29:1858-63. 2009
    ..To investigate the effects of a direct renin inhibitor aliskiren on vascular inflammation, we conducted leukocyte adhesion assays in vivo and in vitro using a novel real-time imaging system...
  10. doi request reprint Combination of amlodipine and atorvastatin synergistically reduces leukocyte recruitment to mechanically injured mouse femoral artery
    Sumihiko Hagita
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, Tokyo, Japan
    Hypertens Res 34:450-5. 2011
    ..The underlying mechanisms of their effect involve, at least in part, stabilizing oxidative stress at the point of injury, suggesting the clinical efficacy of this drug combination for the treatment of vascular diseases...
  11. ncbi request reprint Oxidative stress in mononuclear cells plays a dominant role in their adhesion to mouse femoral artery after injury
    Sumihiko Hagita
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, Tokyo, Japan
    Hypertension 51:797-802. 2008
    ..Treatment with olmesartan blocked leukocyte recruitment by antagonizing mononuclear cells-associated oxidative stress...
  12. ncbi request reprint Remnant lipoprotein-induced smooth muscle cell proliferation involves epidermal growth factor receptor transactivation
    Akio Kawakami
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima, Building D 256, Bunkyo ku, Tokyo 113 8519, Japan
    Circulation 108:2679-88. 2003
    ..We examined the direct effect of RLPs on the proliferation and signal transduction of SMCs...
  13. ncbi request reprint E-selectin blockade decreases adventitial inflammation and attenuates intimal hyperplasia in rat carotid arteries after balloon injury
    Ryo Gotoh
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 24:2063-8. 2004
    ..Because the role of E-selectin in this process is not fully understood, we studied the role of E-selectin in vascular injury with a flow chamber model and a rat model of carotid artery injury...
  14. ncbi request reprint MMP-9 inhibition by ACE inhibitor reduces oxidized LDL-mediated foam-cell formation
    Chiari Kojima
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    J Atheroscler Thromb 17:97-105. 2010
    ..To investigate the contribution of ACEIs to foam cell formation, we studied the effects of an ACEI, imidaprilat, on THP-1 macrophages and the underlying molecular mechanisms in vitro...
  15. ncbi request reprint Functional impact of IgA nephropathy-associated selectin gene haplotype on leukocyte-endothelial interaction
    Takashi Takei
    Department of Medicine, Kidney Center, Tokyo Women s Medical University, Tokyo, Japan
    Immunogenetics 58:355-61. 2006
    ....
  16. ncbi request reprint Apolipoprotein CIII links hyperlipidemia with vascular endothelial cell dysfunction
    Akio Kawakami
    Department of Geriatrics and Vascular Medicine, Life Science and Bioethics Research Center, Tokyo Medical and Dental University, Tokyo, Japan
    Circulation 118:731-42. 2008
    ..Because PKCbeta impairs the response of vascular endothelial cells to insulin, we tested the hypothesis that apoCIII affects insulin signaling in vascular endothelial cells and its function in vitro and in vivo...
  17. ncbi request reprint MCP-1-induced enhancement of THP-1 adhesion to vascular endothelium was modulated by HMG-CoA reductase inhibitor through RhoA GTPase-, but not ERK1/2-dependent pathway
    Megumi Hiraoka
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima Building D 256, Bunkyo, Tokyo 113 8519, Japan
    Life Sci 75:1333-41. 2004
    ..These findings indicate a role for pitavastatin in modulating the MCP-1-induced phenotypic changes of monocyte-endothelial interactions, which may account for the anti-inflammatory effects of statins...
  18. ncbi request reprint HIV envelope protein gp120-triggered CD4+ T-cell adhesion to vascular endothelium is regulated via CD4 and CXCR4 receptors
    Yoshio Takano
    Department of Vascular Medicine, Tokyo Medical and Dental University, Japan
    Biochim Biophys Acta 1772:549-55. 2007
    ..These findings indicate novel mechanisms of CD4+ T-cells recruitment to activated endothelium via CD4 and CXCR4, which are modulated by statin...
  19. ncbi request reprint Sphingosine 1-phosphate (S1P) inhibits monocyte-endothelial cell interaction by regulating of RhoA activity
    Mariko Tani
    Bioethics Research Center, Tokyo Medical and Dental University, 1 5 45, Yushima, Bldg D 809, Bunkyo ku, Tokyo 113 8519, Japan
    FEBS Lett 581:4621-6. 2007
    ..In conclusion, S1P inhibited monocyte-endothelial interactions by inhibiting RhoA activity which may explain its anti-atherogenic effects...
  20. doi request reprint In vivo and in vitro inhibition of monocyte adhesion to endothelial cells and endothelial adhesion molecules by eicosapentaenoic acid
    Hideto Yamada
    Department of Molecular Medicine and Metabolism, Tokyo Medical and Dental University, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 28:2173-9. 2008
    ..Here we investigated in vivo and in vitro effect of EPA on monocyte adhesion to endothelial cells and adhesion molecules...
  21. ncbi request reprint Amlodipine modulates THP-1 cell adhesion to vascular endothelium via inhibition of protein kinase C signal transduction
    Tao Yu
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Hypertension 42:329-34. 2003
    ..These findings suggest a potential role for amlodipine in monocyte-endothelial interactions by modulation of protein kinase C- and RhoA-dependent mechanisms, which might account for its vascular protective effects...
  22. ncbi request reprint Angiotensin-converting enzyme inhibitor attenuates monocyte adhesion to vascular endothelium through modulation of intracellular zinc
    Chiari Kojima
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, 1 5 45 Yushima Bldg D 9, Bunkyo ku, Tokyo 113 8519, Japan
    J Pharmacol Exp Ther 323:855-60. 2007
    ..These data suggest that ACEI reduces MCP-1 or PMA-triggered monocyte adhesion to activated HUVECs by modulating labile zinc in monocytes. Our findings may point out a novel anti-inflammatory mechanism of ACEIs in atherogenesis...
  23. doi request reprint Pioglitazone reduces systematic inflammation and improves mortality in apolipoprotein E knockout mice with sepsis
    Go Haraguchi
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 113 8519, Tokyo, Japan
    Intensive Care Med 34:1304-12. 2008
    ..ApoE knockout mice have a high mortality rate due to sepsis because the endotoxin is not cleared...
  24. ncbi request reprint [Platelets, coagulation, and fibrinolysis in atherosclerosis formation]
    Hideto Ishii
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University
    Nihon Rinsho 69:50-4. 2011
    ..We showed annexin A2 can inhibit formation of thrombus in injured blood vessel. Thus, platelets, coagulation, and fibrinolysis may be key factors in inflamed blood wall...
  25. pmc Apolipoprotein CIII induces monocyte chemoattractant protein-1 and interleukin 6 expression via Toll-like receptor 2 pathway in mouse adipocytes
    Yasuko Abe
    Department of Geriatrics and Vascular Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 1138519, Japan
    Arterioscler Thromb Vasc Biol 30:2242-8. 2010
    ..To examine the direct effect of apolipoprotein CIII (apoCIII) on adipokine expressions that are involved in obesity, insulin resistance, or metabolic syndrome...
  26. ncbi request reprint SDF-1-induced adhesion of monocytes to vascular endothelium is modulated by azelnidipine via protein kinase C inhibition
    Keiko Takahashi
    Department of Medical Biochemistry and Vascular Medicine, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
    Eur J Pharmacol 552:162-9. 2006
    ..These findings imply a protective role of azelnidipine against inflammation in atherosclerosis...
  27. pmc Indoxyl sulfate induces leukocyte-endothelial interactions through up-regulation of E-selectin
    Shunsuke Ito
    Department of Life Science and Medical Ethics, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    J Biol Chem 285:38869-75. 2010
    ..These findings suggest that indoxyl sulfate enhances leukocyte-endothelial interactions through up-regulation of E-selectin, presumably via the JNK- and NF-κB-dependent pathway...
  28. ncbi request reprint Ezetimibe improves liver steatosis and insulin resistance in obese rat model of metabolic syndrome
    Michiyo Deushi
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, Tokyo, Japan
    FEBS Lett 581:5664-70. 2007
    ..Further, ezetimibe enhanced insulin signaling in cultured hepatocytes. Our results indicate the potential of ezetimibe in treating the metabolic syndrome and NAFLD...
  29. ncbi request reprint Small dense LDL enhances THP-1 macrophage foam cell formation
    Mariko Tani
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, Tokyo, Japan
    J Atheroscler Thromb 18:698-704. 2011
    ..Increased levels of small dense low-density lipoproteins (sd-LDL) have been reported more atherogenic compared to total low-density lipoprotein (LDL); however, no definitive experiments using macrophages have examined this concept in vitro...
  30. ncbi request reprint Remnant lipoproteins and atherogenesis
    Akio Kawakami
    Department of Geriatrics and Vascular Medicine, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima D809, Bunkyo ku, Tokyo, Japan
    J Atheroscler Thromb 12:73-6. 2005
    ..More recently, we reported that apoB48 receptor was involved in RLP-induced foam cell formation in macrophages. The current review focused on the molecular mechanisms for the atherogenicity of RLPs...
  31. ncbi request reprint Pioglitazone reduces monocyte adhesion to vascular endothelium under flow by modulating RhoA GTPase and focal adhesion kinase
    Yasutoshi Toriumi
    Department of Vascular Medicine, Tokyo Medical and Dental University, 1 5 45, Yushima Bldg D 256, Bunkyo ku, 113 8519 Tokyo, Japan
    FEBS Lett 553:419-22. 2003
    ..These results indicate a novel anti-inflammatory role for this compound...
  32. ncbi request reprint Extended exposure of lipopolysaccharide fraction from Porphyromonas gingivalis facilitates mononuclear cell adhesion to vascular endothelium via Toll-like receptor-2 dependent mechanism
    Naokazu Nakamura
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo, Japan
    Atherosclerosis 196:59-67. 2008
    ..Our findings provide new evidence that the TLR-2 pathway may contribute to atherogenesis by mediating P.g.-LPS signal transduction...
  33. pmc Toll-like receptor 2 mediates apolipoprotein CIII-induced monocyte activation
    Akio Kawakami
    Department of Geriatrics and Vascular Medicine, Tokyo Medical and Dental University, Japan
    Circ Res 103:1402-9. 2008
    ..The present study identifies a novel mechanism for proinflammatory and proatherogenic effects of apoCIII and a role for TLR2 in atherosclerosis induced by atherogenic lipoproteins...
  34. ncbi request reprint Endothelial E-selectin potentiates neovascularization via endothelial progenitor cell-dependent and -independent mechanisms
    Yasunobu Nishiwaki
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 27:512-8. 2007
    ....
  35. ncbi request reprint Real-time imaging of mechanically injured femoral artery in mice reveals a biphasic pattern of leukocyte accumulation
    Mizuko Osaka
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, School of Medicine, Keio University, Tokyo, Japan
    Am J Physiol Heart Circ Physiol 292:H1876-82. 2007
    ..Our system revealed a previously undetected, unique profile of leukocyte recruitment during vascular injury...
  36. ncbi request reprint Enhanced adhesion of early endothelial progenitor cells to radiation-induced senescence-like vascular endothelial cells in vitro
    Nuttawut Sermsathanasawadi
    Department of Vascular and Applied Surgery, Tokyo Medical and Dental University, Tokyo, Japan
    J Radiat Res 50:469-75. 2009
    ..Our findings are first to implicate the complex effects of this phenotype on tumor neovascularization following irradiation...
  37. pmc Efficient in vivo delivery of siRNA into brain capillary endothelial cells along with endogenous lipoprotein
    Hiroya Kuwahara
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Mol Ther 19:2213-21. 2011
    ..These findings indicate that siRNA can be delivered into BCECs in vivo by using endogenous lipoprotein, which could make this strategy useful as a new gene silencing therapy for diseases involving BCECs...
  38. pmc Efficacy of recombinant annexin 2 for fibrinolytic therapy in a rat embolic stroke model: a magnetic resonance imaging study
    Yoji Tanaka
    Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan
    Brain Res 1165:135-43. 2007
    ..We concluded that rAN II at 0.25 mg/kg significantly reduced infarct size and improved CBF without hemorrhagic complications. rAN II is a novel compound that has the potential to be a promising fibrinolytic agent to treat embolic stroke...
  39. ncbi request reprint Novel role of NPC1L1 in the regulation of hepatic metabolism: potential contribution of ezetimibe in NAFLD/NASH treatment
    Masayuki Yoshida
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 1138519, Japan
    Curr Vasc Pharmacol 9:121-3. 2011
    ..This raises a potential possibility that ezetimibe may improve fatty liver formation. In this review, potential role of lipid metabolism in NAFLD and its possible modulation through NPC1L1 blockade is discussed...
  40. ncbi request reprint Introduction of short interfering RNA to silence endogenous E-selectin in vascular endothelium leads to successful inhibition of leukocyte adhesion
    Yasunobu Nishiwaki
    Department of Medical Biochemistry, Tokyo Medical and Dental University, Tokyo, Japan
    Biochem Biophys Res Commun 310:1062-6. 2003
    ..03). This technique provides a powerful strategy to dissect a specific function of a given molecule in leukocyte-endothelial interaction...
  41. ncbi request reprint Angiotensin II type-I receptor blocker, candesartan, improves brachial-ankle pulse wave velocity independent of its blood pressure lowering effects in type 2 diabetes patients
    Hideto Ishii
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University, Tokyo
    Intern Med 47:2013-8. 2008
    ....
  42. ncbi request reprint Intensive lipid-lowering therapy for slowing progression as well as inducing regression of atherosclerosis in Japanese patients: subanalysis of the JART study
    Tsutomu Yamazaki
    Clinical Research Support Center, The University of Tokyo Hospital, Tokyo, Japan
    Int Heart J 54:33-9. 2013
    ..These findings suggest that more intensive control of LDL-C to levels lower than those in current JAS guidelines should be required to achieve slowing of progression as well as induction of regression of atherosclerosis...
  43. ncbi request reprint Recombinant annexin-2 inhibits the progress of diabetic nephropathy in a diabetic mouse model via recovery of hypercoagulability
    Hideto Ishii
    Bioethics Research Centre, Tokyo Medical and Dental University, 1 5 45 Yushima, D 809, Bunkyo ku, Tokyo 113 8519, Japan
    Thromb Haemost 97:124-8. 2007
    ....
  44. ncbi request reprint Risk factors for cardiovascular events in Japanese patients treated with fluvastatin from the long-term event monitoring (LEM) study
    Ryuichi Morishita
    Department of Clinical Gene Therapy, Osaka University, Graduate School of Medicine, Yamada oka, Suita, Osaka, Japan
    Curr Vasc Pharmacol 10:178-86. 2012
    ..The long-term event monitoring (LEM) study evaluated the lipid-lowering efficacy and safety of fluvastatin in Japanese patients with hypercholesterolemia. The present sub-analysis focused on the impact of risk factors on event prevention...
  45. ncbi request reprint [Inflammatory cytokines]
    Hideto Ishii
    Life Science and Bioethics Research Center, Tokyo Medical and Dental University
    Nihon Rinsho 68:819-22. 2010
    ..Inflammatory cytokines are not the only factor in diabetic macroangiopathy, however, it is certain that inflammation plays important role in diabetes and diabetic vascular complication...
  46. ncbi request reprint Atorvastatin attenuates remnant lipoprotein-induced monocyte adhesion to vascular endothelium under flow conditions
    Akio Kawakami
    Department of Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Japan
    Circ Res 91:263-71. 2002
    ..Atorvastatin attenuated this enhanced monocyte adhesion to HUVECs, suggesting an antiinflammatory role for this compound...
  47. ncbi request reprint P-selectin expression, but not GPIIb/IIIa activation, is enhanced in the inflammatory stage of Takayasu's arteritis
    Natsuko Kasuya
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Circ J 70:600-4. 2006
    ..To investigate the link between platelet activation and disease activity, flow cytometric analyses of platelet P-selectin and activated GPIIb/IIIa expression were performed in patients with TA...
  48. ncbi request reprint Blockade of cell adhesion by a small molecule selectin antagonist attenuates myocardial ischemia/reperfusion injury
    Yasuyuki Onai
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo, Tokyo 113 8519, Japan
    Eur J Pharmacol 481:217-25. 2003
    ..This study demonstrates for the first time that bimosiamose, a novel small molecule selectin antagonist, attenuates significantly ischemia/reperfusion injury...
  49. ncbi request reprint High fat and high cholesterol diet induces DPP-IV activity in intestinal lymph
    Miku Toyozaki
    Institute of Environmental Science for Human Life, Ochanomizu University, Tokyo, Japan
    J Oleo Sci 62:201-5. 2013
    ..In conclusion, HFHC diets increased DPP-IV expression in intestinal lymph; these results indicate the applicability of a previously unrecognized role for DPP-IV in metabolic disorders, including diabetes...
  50. ncbi request reprint Potential role of statins in inflammation and atherosclerosis
    Masayuki Yoshida
    Department of Vascular Medicine and Medical Biochemistry, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo Japan
    J Atheroscler Thromb 10:140-4. 2003
    ..Herein, we discuss recent progress in this area of study, with special focus on the biological function of statins...
  51. ncbi request reprint Mucinous breast carcinoma with a lobular neoplasia component: a subset with aberrant expression of cell adhesion and polarity molecules and lack of neuroendocrine differentiation
    Kenjiro Jimbo
    Breast Surgery Division, National Cancer Center Hospital, Tokyo, Japan
    Pathol Int 64:217-23. 2014
    ..133). MUCs associated with LN components appear to be a biologically characteristic subset that frequently shows decreased cell-cell adhesion, cell polarity molecules and lack of neuroendocrine differentiation. ..
  52. doi request reprint Basophils play a pivotal role in immunoglobulin-G-mediated but not immunoglobulin-E-mediated systemic anaphylaxis
    Yusuke Tsujimura
    Department of Immune Regulation and Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Immunity 28:581-9. 2008
    ....
  53. ncbi request reprint Apolipoprotein CIII links dyslipidemia with atherosclerosis
    Akio Kawakami
    Department of Geriatrics and Vascular Medicine, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    J Atheroscler Thromb 16:6-11. 2009
    ..Here, we propose a novel role for apoCIII that links dyslipidemia with atherosclerosis...
  54. ncbi request reprint Oral administration of the milk casein-derived tripeptide Val-Pro-Pro attenuates high-fat diet-induced adipose tissue inflammation in mice
    Kotaro Aihara
    Department of Life Science and Bioethics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, M and D Tower S954, 1 5 45 Yushima, Bunkyo ku, Tokyo113 8519, Japan
    Br J Nutr 112:513-9. 2014
    ..These observations indicate that oral administration of VPP exerts an anti-inflammatory effect on the adipose tissue of HFD-fed mice, which may eventually lead to the primary prevention of chronic inflammation-related diseases. ..
  55. pmc Cell density impacts epigenetic regulation of cytokine-induced e-selectin gene expression in vascular endothelium
    Katsuhiko Hamada
    Department of Life Sciences and Bioethics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 9:e90502. 2014
    ..Our data suggest that the inflammatory response may change during blood vessel maturation via epigenetic mechanisms that affect the accessibility of chromatin. ..
  56. pmc Protein-bound uremic toxins: new culprits of cardiovascular events in chronic kidney disease patients
    Shunsuke Ito
    Life Science and Bioethics, Department of International Health Development, Tokyo Medical and Dental University, 953 M and D tower, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Toxins (Basel) 6:665-78. 2014
    ..The aim of this review is to provide novel insights into the effects of indoxyl sulfate and p-cresyl sulfate on the pathogenesis of atherosclerosis. ..
  57. doi request reprint Dietary acid intake and kidney disease progression in the elderly
    Eiichiro Kanda
    Department of Nephrology, Tokyo Kyosai Hospital, Tokyo, Japan
    Am J Nephrol 39:145-52. 2014
    ..We investigated the role of dietary acid load, in terms of net endogenous acid production (NEAP), in chronic kidney disease (CKD) progression...
  58. ncbi request reprint Wide local extension and higher proliferation indices are characteristic features of symptomatic lobular neoplasias (LNs) and LNs with an early invasive component
    Yuka Katsurada
    Department of Basic Pathology, National Defence Medical College, Tokorozawa, Japan Department of Pathology and Clinical Laboratories, National Cancer Centre Hospital, Tokyo, Japan
    Histopathology 64:994-1003. 2014
    ..The aim of this study was to clarify the histopathological characteristics of clinically overt (symptomatic) LNs and early invasive LNs...
  59. ncbi request reprint Lobular endocervical glandular hyperplasia is a neoplastic entity with frequent activating GNAS mutations
    Akiko Matsubara
    Pathology and Clinical Laboratories, National Cancer Center Hospital Molecular Pathology Division, National Cancer Center Research Institute Division of Gynecology, National Cancer Center Hospital, Tokyo, Japan
    Am J Surg Pathol 38:370-6. 2014
    ..Although LEGH has been regarded as a metaplastic lesion, the frequent presence of genetic alterations suggests a neoplastic nature. ..
  60. ncbi request reprint Stability of fat-soluble and water-soluble vitamins in artificially prepared, vitamin-enriched, lyophilized serum
    Hiroshi Ihara
    Department of Laboratory Medicine, Ohashi Hospital, School of Medicine, Toho University, Tokyo, Japan
    J Clin Lab Anal 18:240-6. 2004
    ..Our VES is the first preparation of lyophilized control serum that contains water-soluble and fat-soluble vitamins...
  61. pmc Applicability of fibroblast growth factor 23 for evaluation of risk of vertebral fracture and chronic kidney disease-mineral bone disease in elderly chronic kidney disease patients
    Eiichiro Kanda
    Department of Nephrology, Tokyo Kyosai Hospital, Nakameguro 2 3 8, Meguroku, Tokyo, 153 8934, Japan
    BMC Nephrol 13:122. 2012
    ..It has been reported that FGF23 is related to the overall fracture risk. We investigated the usefulness of FGF23 as a marker for evaluating the risk of vertebral fracture and CKD-MBD in elderly CKD patients...