Kiyotsugu Yoshida

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. pmc c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage
    Kiyotsugu Yoshida
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 22:3292-300. 2002
  2. ncbi Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage
    Kiyotsugu Yoshida
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    J Biol Chem 281:5734-40. 2006
  3. ncbi PKCdelta signaling: mechanisms of DNA damage response and apoptosis
    Kiyotsugu Yoshida
    Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Cell Signal 19:892-901. 2007
  4. ncbi Enabling death by the Abl tyrosine kinase: mechanisms for nuclear shuttling of c-Abl in response to DNA damage
    Kiyotsugu Yoshida
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Cell Cycle 4:777-9. 2005
  5. ncbi JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage
    Kiyotsugu Yoshida
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Nat Cell Biol 7:278-85. 2005
  6. doi Nuclear trafficking of pro-apoptotic kinases in response to DNA damage
    Kiyotsugu Yoshida
    Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8510, Japan
    Trends Mol Med 14:305-13. 2008
  7. doi Role for DYRK family kinases on regulation of apoptosis
    Kiyotsugu Yoshida
    Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Biochem Pharmacol 76:1389-94. 2008
  8. pmc Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage
    Kiyotsugu Yoshida
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Mol Cell Biol 26:3414-31. 2006
  9. doi The cell death machinery governed by the p53 tumor suppressor in response to DNA damage
    Kiyotsugu Yoshida
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 101:831-5. 2010
  10. ncbi Regulation for nuclear targeting of the Abl tyrosine kinase in response to DNA damage
    Kiyotsugu Yoshida
    Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Adv Exp Med Biol 604:155-65. 2007

Collaborators

  • Yoshio Miki
  • Junko Kimura
  • Ken Uchida
  • T Natsume
  • Lei Huang
  • Keiichi I Nakayama
  • Tomoko Yamaguchi
  • Naoe Taira
  • Zheng Guang Lu
  • Hanshao Liu
  • Hoi Chin Hew
  • Rei Mimoto
  • Kazuho Suzuki
  • Donald Kufe
  • Takuya Kudoh
  • Go Tomiyoshi
  • Hirokuni Shinagawa
  • Deepak Raina
  • Andrzej Sobota
  • Jian Ren
  • Tarek Abbas
  • Surender Kharbanda
  • Yongqing Li
  • Hongshi Xu
  • Xinping Ren
  • Hiroyuki Takahashi
  • Masataka Okabe
  • Masanobu Kitagawa
  • Nurmaa Dashzeveg
  • Morito Kurata
  • Hiroyuki Yamamoto
  • Akira Nakanishi
  • Katsuya Takenaka
  • Keishi Nihira
  • Shailendra Kumar
  • Rehan Ahmad
  • Kazimiera Mrozińska
  • Agnieszka Strzelecka-Kiliszek
  • Katarzyna Kwiatkowska
  • Ewelina Gładkowska
  • David White
  • Li Hui
  • David A Foster
  • Jill Bargonetti
  • Jean Baptiste Roullet
  • Wen Chen
  • David M Cohen
  • Wei Tian
  • Hongyu Zhao
  • Quan Li
  • Wei Hsuan Yu
  • Ralph Weichselbaum
  • Liben Zhu
  • Cheng Cao

Detail Information

Publications38

  1. pmc c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage
    Kiyotsugu Yoshida
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 22:3292-300. 2002
    ..These findings indicate that Rad9 is regulated by a c-Abl-dependent mechanism in the apoptotic response to genotoxic stress...
  2. ncbi Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage
    Kiyotsugu Yoshida
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    J Biol Chem 281:5734-40. 2006
    ..These findings indicate that PKCdelta regulates p53 to induce apoptotic cell death in the cellular response to DNA damage...
  3. ncbi PKCdelta signaling: mechanisms of DNA damage response and apoptosis
    Kiyotsugu Yoshida
    Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Cell Signal 19:892-901. 2007
    ..This review is focused on the current views regarding the regulation of cell fate by PKCdelta signaling in response to DNA damage...
  4. ncbi Enabling death by the Abl tyrosine kinase: mechanisms for nuclear shuttling of c-Abl in response to DNA damage
    Kiyotsugu Yoshida
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Cell Cycle 4:777-9. 2005
    ..In this review, we focus on the implications of these findings on our understanding of Abl-regulated cellular functions and on potential therapeutic strategies to manipulate the aberrant kinase...
  5. ncbi JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage
    Kiyotsugu Yoshida
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Nat Cell Biol 7:278-85. 2005
    ..These findings indicate that 14-3-3 proteins are pivotal regulators of intracellular c-Abl localization and of the apoptotic response to genotoxic stress...
  6. doi Nuclear trafficking of pro-apoptotic kinases in response to DNA damage
    Kiyotsugu Yoshida
    Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8510, Japan
    Trends Mol Med 14:305-13. 2008
    ..The potential implications for novel therapies are also discussed...
  7. doi Role for DYRK family kinases on regulation of apoptosis
    Kiyotsugu Yoshida
    Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Biochem Pharmacol 76:1389-94. 2008
    ..This progress review highlights recent efforts demonstrating that DYRKs could be novel and essential regulatory molecules for the regulation of cell fate including apoptosis...
  8. pmc Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage
    Kiyotsugu Yoshida
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Mol Cell Biol 26:3414-31. 2006
    ..These findings indicate that PKCdelta regulates topoisomerase IIalpha and thereby cell fate in the genotoxic stress response...
  9. doi The cell death machinery governed by the p53 tumor suppressor in response to DNA damage
    Kiyotsugu Yoshida
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Sci 101:831-5. 2010
    ..This review is focused on the current views regarding the regulation of cell fate by p53 in the apoptotic response to DNA damage...
  10. ncbi Regulation for nuclear targeting of the Abl tyrosine kinase in response to DNA damage
    Kiyotsugu Yoshida
    Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Adv Exp Med Biol 604:155-65. 2007
    ..This review summarizes the implications of these findings on our understanding of Abl-regulated cellular functions and potential therapeutic strategies to modulate the aberrant kinase...
  11. pmc ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage
    Naoe Taira
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8510, Japan
    J Biol Chem 285:4909-19. 2010
    ..These findings indicate that ATM controls stability and pro-apoptotic function of DYRK2 in response to DNA damage...
  12. doi Protein kinase Cdelta activates RelA/p65 and nuclear factor-kappaB signaling in response to tumor necrosis factor-alpha
    Zheng Guang Lu
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Res 69:5927-35. 2009
    ..These findings provide evidence that PKCdelta orchestrates RelA/p65 transactivation, a requisite for NF-kappaB signaling pathway in the nucleus...
  13. pmc Protein kinase C delta induces transcription of the TP53 tumor suppressor gene by controlling death-promoting factor Btf in the apoptotic response to DNA damage
    Hanshao Liu
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Mol Cell Biol 27:8480-91. 2007
    ..These findings provide evidence that activation of TP53 gene transcription by PKCdelta triggers TP53-dependent apoptosis in response to DNA damage...
  14. doi DNA damage signalling recruits RREB-1 to the p53 tumour suppressor promoter
    Hanshao Liu
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Biochem J 422:543-51. 2009
    ..We also show that, upon exposure to genotoxic stress, RREB-1 controls apoptosis in a p53-dependent manner. These findings provide evidence that RREB-1 participates in modulating p53 transcription in response to DNA damage...
  15. ncbi DYRK2 is targeted to the nucleus and controls p53 via Ser46 phosphorylation in the apoptotic response to DNA damage
    Naoe Taira
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8510, Japan
    Mol Cell 25:725-38. 2007
    ..Consistent with these results, DYRK2 induces p53AIP1 expression and apoptosis in a Ser46 phosphorylation-dependent manner. These findings indicate that DYRK2 regulates p53 to induce apoptosis in response to DNA damage...
  16. doi DYRK2 controls the epithelial-mesenchymal transition in breast cancer by degrading Snail
    Rei Mimoto
    Department of Biochemistry, The Jikei University School of Medicine, Tokyo, Japan Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan Department of Anatomy, The Jikei University School of Medicine, Tokyo, Japan
    Cancer Lett 339:214-25. 2013
    ..Patients with low DYRK2-expressing tumors had a worse outcome than those with high DYRK2-expressing tumors. These findings revealed that DYRK2 regulates cancer invasion and metastasis by degrading Snail...
  17. doi Programmed cell death 6, a novel p53-responsive gene, targets to the nucleus in the apoptotic response to DNA damage
    Kazuho Suzuki
    Department of Molecular Genetics, Tokyo Medical and Dental University, Japan
    Cancer Sci 103:1788-94. 2012
    ..Therefore, we conclude that a novel p53-responsive gene PDCD6 is accumulated in the nucleus and induces apoptosis in response to DNA damage...
  18. ncbi [Mechanisms for induction of apoptosis in response to DNA damage]
    Kiyotsugu Yoshida
    Medical Research Institute, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Seikagaku 80:619-31. 2008
  19. pmc DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells
    Naoe Taira
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Clin Invest 122:859-72. 2012
    ..These results reveal that DYRK2 regulates tumor progression through modulation of c-Jun and c-Myc...
  20. doi Novel BRCA2-interacting protein BJ-HCC-20A inhibits the induction of apoptosis in response to DNA damage
    Go Tomiyoshi
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 34 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Cancer Sci 99:747-54. 2008
    ..Therefore, we speculate that targeting BJ-HCC-20A may aid in the treatment of breast tumors...
  21. doi Identification of Evi-1 as a novel effector of PKCδ in the apoptotic response to DNA damage
    Hoi Chin Hew
    Department of Molecular Genetics, Medical Research Institute Tokyo Medical and Dental University, Tokyo, Japan
    Biochim Biophys Acta 1809:285-94. 2011
    ..Taken together, we have discovered a novel regulation of Evi-1, which transactivates PLZF, by PKCδ to induce cell death in response to genotoxic stress...
  22. doi Identification of dihydropyrimidinase-related protein 4 as a novel target of the p53 tumor suppressor in the apoptotic response to DNA damage
    Junko Kimura
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    Int J Cancer 128:1524-31. 2011
    ..We also found that genotoxic-induced apoptosis was repressed in cells silenced for DPYSL4. These findings indicate that DPYSL4 is a novel apoptosis-inducible factor controlled by p53 in response to DNA damage...
  23. ncbi BRCA1-mediated ubiquitination inhibits topoisomerase II alpha activity in response to oxidative stress
    Hirokuni Shinagawa
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Antioxid Redox Signal 10:939-49. 2008
    ..Furthermore, the retinoblastoma protein (pRb) was required for the ubiquitination of topoisomerase IIalpha by BRCA1. We conclude that the functions of topoisomerase IIalpha are regulated by ubiquitination on exposure to oxidative stress...
  24. ncbi The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha)
    Tomoko Yamaguchi
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo, Japan
    J Biol Chem 282:33943-8. 2007
    ..Importantly, the ectopic expression of IKKalpha into cells silenced for USP11 restores p53 expression, demonstrating that USP11 functions as an upstream regulator of an IKKalpha-p53 signaling pathway...
  25. doi The c-Abl tyrosine kinase stabilizes Pitx1 in the apoptotic response to DNA damage
    Tomoko Yamaguchi
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Japan
    Apoptosis 15:927-35. 2010
    ..Importantly, inhibition of c-Abl kinase activity substantially attenuates Pitx1-mediated apoptosis. These findings provide evidence that c-Abl participates in modulating Pitx1 expression in the apoptotic response to DNA damage...
  26. pmc A functional genome-wide RNAi screen identifies TAF1 as a regulator for apoptosis in response to genotoxic stress
    Junko Kimura
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8510, Japan
    Nucleic Acids Res 36:5250-9. 2008
    ..These results suggest that TAF1 regulates apoptosis by controlling p27(Kip1) expression. Our system provides a novel approach to identifying candidate genes that modulate apoptosis...
  27. ncbi Protein kinase C delta activates IkappaB-kinase alpha to induce the p53 tumor suppressor in response to oxidative stress
    Tomoko Yamaguchi
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
    Cell Signal 19:2088-97. 2007
    ..These findings collectively support a novel mechanism in which the PKCdelta-->IKKalpha signaling pathway contributes to ROS-induced activation of the p53 tumor suppressor...
  28. doi D4S234E, a novel p53-responsive gene, induces apoptosis in response to DNA damage
    Takuya Kudoh
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    Exp Cell Res 316:2849-58. 2010
    ..We thus concluded that a novel p53-responsive gene D4S234E is accumulated in the ER and induces apoptosis in response to DNA damage...
  29. ncbi Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage
    Kiyotsugu Yoshida
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 113 8510
    Cancer Sci 95:866-71. 2004
    ..Elucidation of the precise molecular functions of BRCAs is expected to improve our understanding of hereditary as well as sporadic mammary carcinogenesis...
  30. doi PKCδ regulates Mdm2 independently of p53 in the apoptotic response to DNA damage
    Hoi Chin Hew
    Department of Molecular Genetics, Medical Research Institute, Tokyo Medical and Dental University, Japan
    Mol Carcinog 50:719-31. 2011
    ....
  31. pmc MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage
    Deepak Raina
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    EMBO J 25:3774-83. 2006
    ..These findings indicate that MUC1 sequesters c-Abl in the cytoplasm and thereby inhibits apoptosis in the response to genotoxic anticancer agents...
  32. ncbi Activation of SAPK/JNK signaling by protein kinase Cdelta in response to DNA damage
    Kiyotsugu Yoshida
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:48372-8. 2002
    ..These findings indicate that PKCdelta functions in the activation of SAPK through a Lyn --> PKCdelta --> MEKK1 --> MKK7 --> SAPK signaling cascade in response to DNA damage...
  33. pmc Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9
    Kiyotsugu Yoshida
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 22:1431-41. 2003
    ..These findings demonstrate that PKCdelta is responsible for the regulation of Rad9 in the Hus1-Rad1 complex and in the apoptotic response to DNA damage...
  34. ncbi Lyn tyrosine kinase inhibits nuclear export of the p53 tumor suppressor
    Xinping Ren
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Biol Ther 1:703-8. 2002
    ..In concert with these results, Lyn reverses Mdm2-mediated degradation of p53 and increases p53-dependent apoptosis. Our findings support a previously undefined role for nuclear Lyn in both activation and Mdm2-mediated regulation of p53...
  35. ncbi DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7
    Yongqing Li
    Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Biol Ther 2:187-93. 2003
    ..These findings indicate that IL-7 regulates MUC1 expression and function in multiple myeloma cells...
  36. ncbi Inhibition of human p53 basal transcription by down-regulation of protein kinase Cdelta
    Tarek Abbas
    Institute for Biomolecular Structure and Function and Department of Biological Sciences, Hunter College and Graduate School, City University of New York, New York 10021, USA
    J Biol Chem 279:9970-7. 2004
    ..Therefore, the tumor-suppressing effects of PKC delta are mediated at least in part through activating p53 transcription...
  37. ncbi Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress
    Hongshi Xu
    Division of Nephrology, Department of Medicine, Oregon Health and Science University and the Portland Veterans Affairs Medical Center, Portland, Oregon 97201, USA
    J Biol Chem 278:11520-7. 2003
    ..This is the first example of direct regulation of TRP channel function through tyrosine phosphorylation...
  38. ncbi Binding of IgG-opsonized particles to Fc gamma R is an active stage of phagocytosis that involves receptor clustering and phosphorylation
    Andrzej Sobota
    Department of Cell Biology, Nencki Institute of Experimental Biology, Warsaw, Poland
    J Immunol 175:4450-7. 2005
    ..The results indicate that phosphorylation of Fc gammaR and accompanying proteins, dependent on Src kinase activity, facilitates the clustering of activated receptors that is required for efficient particle binding...