Yoshida K, Liu H, Miki Y. Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage. J Biol Chem. 2006;281:5734-40 pubmed
..These findings indicate that PKCdelta regulates p53 to induce apoptotic cell death in the cellular response to DNA damage. ..
Yoshida K. Nuclear trafficking of pro-apoptotic kinases in response to DNA damage. Trends Mol Med. 2008;14:305-13 pubmed publisher
..The potential implications for novel therapies are also discussed. ..
Yoshida K, Yamaguchi T, Natsume T, Kufe D, Miki Y. JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat Cell Biol. 2005;7:278-85 pubmed
..These findings indicate that 14-3-3 proteins are pivotal regulators of intracellular c-Abl localization and of the apoptotic response to genotoxic stress. ..
Yoshida K, Yamaguchi T, Shinagawa H, Taira N, Nakayama K, Miki Y. Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage. Mol Cell Biol. 2006;26:3414-31 pubmed
..These findings indicate that PKCdelta regulates topoisomerase IIalpha and thereby cell fate in the genotoxic stress response. ..
Yoshida K. Regulation for nuclear targeting of the Abl tyrosine kinase in response to DNA damage. Adv Exp Med Biol. 2007;604:155-65 pubmed
..This review summarizes the implications of these findings on our understanding of Abl-regulated cellular functions and potential therapeutic strategies to modulate the aberrant kinase. ..