Takanori Yokota

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. pmc Delayed-onset ataxia in mice lacking alpha -tocopherol transfer protein: model for neuronal degeneration caused by chronic oxidative stress
    T Yokota
    Department of Neurology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Proc Natl Acad Sci U S A 98:15185-90. 2001
  2. pmc Can regional spreading of amyotrophic lateral sclerosis motor symptoms be explained by prion-like propagation?
    Tadashi Kanouchi
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan
    J Neurol Neurosurg Psychiatry 83:739-45. 2012
  3. pmc Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43
    Azusa Uchida
    Department of Neurology and Neurological Science, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Brain 135:833-46. 2012
  4. ncbi request reprint siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme
    Takanori Yokota
    Department of Neurology, Tokyo Medical and Dental University, Tokyo, Japan
    Biochem Biophys Res Commun 314:283-91. 2004
  5. pmc Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs
    Takanori Yokota
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    EMBO Rep 4:602-8. 2003
  6. ncbi request reprint [Gene therapy of virus replication with RNAi]
    Takanori Yokota
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University
    Uirusu 55:1-7. 2005
  7. ncbi request reprint Efficient regulation of viral replication by siRNA in a non-human primate surrogate model for hepatitis C
    Takanori Yokota
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 361:294-300. 2007
  8. ncbi request reprint Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition
    Takanori Yokota
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8519, Tokyo, Japan
    Biochem Biophys Res Commun 312:1342-8. 2003
  9. ncbi request reprint Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA
    Naoya Sakamoto
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    J Gastroenterol Hepatol 23:1437-47. 2008
  10. pmc Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease
    Yoichiro Nishida
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519 Japan
    J Biol Chem 284:33400-8. 2009

Collaborators

Detail Information

Publications66

  1. pmc Delayed-onset ataxia in mice lacking alpha -tocopherol transfer protein: model for neuronal degeneration caused by chronic oxidative stress
    T Yokota
    Department of Neurology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Proc Natl Acad Sci U S A 98:15185-90. 2001
    ..Moreover, alpha-TTP(-/-) mice may prove to be excellent animal models of delayed onset, slowly progressive neuronal degeneration caused by chronic oxidative stress...
  2. pmc Can regional spreading of amyotrophic lateral sclerosis motor symptoms be explained by prion-like propagation?
    Tadashi Kanouchi
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan
    J Neurol Neurosurg Psychiatry 83:739-45. 2012
    ....
  3. pmc Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43
    Azusa Uchida
    Department of Neurology and Neurological Science, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Brain 135:833-46. 2012
    ....
  4. ncbi request reprint siRNA-based inhibition specific for mutant SOD1 with single nucleotide alternation in familial ALS, compared with ribozyme and DNA enzyme
    Takanori Yokota
    Department of Neurology, Tokyo Medical and Dental University, Tokyo, Japan
    Biochem Biophys Res Commun 314:283-91. 2004
    ..Our results support the feasibility of utilizing siRNA-based gene therapy of familial ALS with mutant SOD1...
  5. pmc Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs
    Takanori Yokota
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    EMBO Rep 4:602-8. 2003
    ..Our results support the feasibility of using siRNA-based gene therapy to inhibit HCV replication, which may prove to be valuable in the treatment of hepatitis C...
  6. ncbi request reprint [Gene therapy of virus replication with RNAi]
    Takanori Yokota
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University
    Uirusu 55:1-7. 2005
    ..There are still important problems for application of gene therapy including off-target effect and gene delivery of siRNA, but a rapid progress can be expected because of the extremely high efficiency of siRNA...
  7. ncbi request reprint Efficient regulation of viral replication by siRNA in a non-human primate surrogate model for hepatitis C
    Takanori Yokota
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 361:294-300. 2007
    ..Our results suggest the feasibility of systemic administration of CL-siRNA as an antiviral strategy...
  8. ncbi request reprint Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition
    Takanori Yokota
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8519, Tokyo, Japan
    Biochem Biophys Res Commun 312:1342-8. 2003
    ..These results suggest that loss of protective activity of DJ-1 from neuro-toxicity induced by these stresses contributes to neuronal cell death in AR-EOP with mutant DJ-1...
  9. ncbi request reprint Inhibition of hepatitis C virus infection and expression in vitro and in vivo by recombinant adenovirus expressing short hairpin RNA
    Naoya Sakamoto
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan
    J Gastroenterol Hepatol 23:1437-47. 2008
    ..In this study, we investigated the effects of the siRNA targeting HCV-RNA in vivo...
  10. pmc Depletion of vitamin E increases amyloid beta accumulation by decreasing its clearances from brain and blood in a mouse model of Alzheimer disease
    Yoichiro Nishida
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519 Japan
    J Biol Chem 284:33400-8. 2009
    ..These results suggest that lipid peroxidation due to depletion of alpha-tocopherol impairs Abeta clearances from the brain and from the blood, possibly causing increased Abeta accumulation in Ttpa(-/-)APPsw mouse brain and plasma...
  11. ncbi request reprint Transgenic small interfering RNA halts amyotrophic lateral sclerosis in a mouse model
    Yuki Saito
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519
    J Biol Chem 280:42826-30. 2005
    ..Our findings clearly proved the principle that siRNA-mediated gene silencing can stop the development of familial ALS with SOD1 mutation...
  12. pmc Intraperitoneal administration of AAV9-shRNA inhibits target gene expression in the dorsal root ganglia of neonatal mice
    Akira Machida
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Mol Pain 9:36. 2013
    ..We have developed a highly efficient method for in vivo gene silencing in dorsal root ganglia (DRG) by using short hairpin RNA-expressing single-stranded adeno-associated virus 9 (ssAAV9-shRNA)...
  13. doi request reprint In vivo application of an RNAi strategy for the selective suppression of a mutant allele
    Takayuki Kubodera
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan
    Hum Gene Ther 22:27-34. 2011
    ..Our method may prove useful for siRNA-based gene therapy for dominantly inherited diseases...
  14. ncbi request reprint Escape from the interferon response associated with RNA interference using vectors that encode long modified hairpin-RNA
    Hideo Akashi
    Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo, 7 3 1 Hongo, Tokyo, Japan
    Mol Biosyst 1:382-90. 2005
    ..Our findings should enhance the exploitation of RNAi in mammalian cells, especially in the field of RNAi therapy against pathogenic viruses...
  15. doi request reprint Silencing efficiency differs among tissues and endogenous microRNA pathway is preserved in short hairpin RNA transgenic mice
    Hiroki Sasaguri
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    FEBS Lett 583:213-8. 2009
    ..Neither endogenous miRNAs nor their target gene levels were altered, indicating the preservation of endogenous miRNA pathways. We think that the shRNA transgenic mice can be utilized for gene analysis...
  16. doi request reprint Intrathecal shRNA-AAV9 inhibits target protein expression in the spinal cord and dorsal root ganglia of adult mice
    Takashi Hirai
    Department of Orthopedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Hum Gene Ther Methods 23:119-27. 2012
    ....
  17. ncbi request reprint [Gene therapy of ALS with RNA interference]
    Takanori Yokota
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University
    Rinsho Shinkeigaku 49:821-3. 2009
    ..There are still important problems for application of gene therapy including off-target effect and gene delivery of siRNA, but a rapid progress can be expected because of the extremely high efficiency of siRNA...
  18. ncbi request reprint Deletion of vitamin E enhances phenotype of Alzheimer disease model mouse
    Yoichiro Nishida
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 350:530-6. 2006
    ..In this report we provide clear evidence indicating that chronic lipid peroxidation due to alpha-Toc depletion enhances AD phenotype in a mouse model...
  19. doi request reprint Efficient in vivo delivery of siRNA to the liver by conjugation of alpha-tocopherol
    Kazutaka Nishina
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    Mol Ther 16:734-40. 2008
    ..These findings indicate that Toc-siRNA is effective and safe for RNA interference-mediated gene silencing in vivo...
  20. doi request reprint Motor nerve conduction study in cauda equina with high-voltage electrical stimulation in multifocal motor neuropathy and amyotrophic lateral sclerosis
    Miho Akaza
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University Graduate School, Tokyo 113 8519, Japan
    Muscle Nerve 43:274-82. 2011
    ..Cauda equina motor conduction is better evaluated by HV-ES than with F-wave study or magnetic stimulation. HV-ES can help to distinguish MMN and "MMN without CB" from ALS...
  21. doi request reprint Intraperitoneal AAV9-shRNA inhibits target expression in neonatal skeletal and cardiac muscles
    Azat Mayra
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 405:204-9. 2011
    ..This novel method may be useful for generating gene knockdown in skeletal and cardiac mouse tissues, thus providing mouse models useful for analyzing diseases caused by loss-of-function of target genes...
  22. ncbi request reprint In vivo delivery of small interfering RNA targeting brain capillary endothelial cells
    Taro Hino
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Biochem Biophys Res Commun 340:263-7. 2006
    ..The in vivo siRNA-silencing method with hydrodynamic technique may be useful for the study of BBB function and gene therapy targeting BCECs...
  23. ncbi request reprint Chronic inflammatory demyelinating polyradiculoneuropathy in a patient with Crohn's disease
    Masaki Ohyagi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Japan
    Intern Med 52:125-8. 2013
    ..Plasma exchanges were initially effective; however, the effects gradually declined starting 10 days after the plasma exchange (PE). These results suggest that humoral factors may play an important role in CIDP associated with CD...
  24. pmc Efficient in vivo delivery of siRNA into brain capillary endothelial cells along with endogenous lipoprotein
    Hiroya Kuwahara
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Mol Ther 19:2213-21. 2011
    ..These findings indicate that siRNA can be delivered into BCECs in vivo by using endogenous lipoprotein, which could make this strategy useful as a new gene silencing therapy for diseases involving BCECs...
  25. pmc ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1
    Hideki Nishitoh
    Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Corporation, Bunkyo ku, Tokyo 113 0033, Japan
    Genes Dev 22:1451-64. 2008
    ..These findings demonstrate that ER stress-induced ASK1 activation, which is triggered by the specific interaction of Derlin-1 with SOD1(mut), is crucial for disease progression of familial ALS...
  26. ncbi request reprint Genetic vitamin E deficiency does not affect MPTP susceptibility in the mouse brain
    Yong Ri Ren
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    J Neurochem 98:1810-6. 2006
    ..Our results suggest that vitamin E does not play a major protective role in MPTP-induced nigrostriatal dopaminergic neurodegeneration in the brain...
  27. ncbi request reprint [Gene therapy of ALS with short interfering RNA]
    Takanori Yokota
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Brain Nerve 59:1187-94. 2007
    ..There are still important problems for application of gene therapy including off-target effect and gene delivery of siRNA, but a rapid progress can be expected because of the extremely high efficiency of siRNA...
  28. pmc High-density lipoprotein facilitates in vivo delivery of α-tocopherol-conjugated short-interfering RNA to the brain
    Yoshitaka Uno
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 0034, Japan
    Hum Gene Ther 22:711-9. 2011
    ..These results suggest exogenous siRNA could be used clinically for otherwise incurable neurological diseases...
  29. doi request reprint Intrathecal AAV serotype 9-mediated delivery of shRNA against TRPV1 attenuates thermal hyperalgesia in a mouse model of peripheral nerve injury
    Takashi Hirai
    Department of Orthopaedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Mol Ther 22:409-19. 2014
    ....
  30. doi request reprint Circulating microRNAs in the cerebrospinal fluid of patients with brain diseases
    Akira Machida
    Department of Neurology and Neurological Science, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Methods Mol Biol 1024:203-9. 2013
    ..This chapter describes the feasibility of miRNAs in CSF as biomarkers for the diagnosis of brain diseases and the methods of miRNA isolation from CSF...
  31. ncbi request reprint [RNAi and neurological disease]
    Takanori Yokota
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University
    Rinsho Shinkeigaku 45:973-5. 2005
    ..Our results support the feasibility of utilizing siRNA-based gene therapy of neurodegenerative diseases of autosomal dominant inheritance...
  32. ncbi request reprint New RNAi strategy for selective suppression of a mutant allele in polyglutamine disease
    Takayuki Kubodera
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Oligonucleotides 15:298-302. 2005
    ..Here, we applied this method to spinocerebellar ataxia type 6 (SCA6). We discuss its feasibility and problems for future gene therapy...
  33. doi request reprint Spreading of amyotrophic lateral sclerosis lesions--multifocal hits and local propagation?
    Teruhiko Sekiguchi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Neurol Neurosurg Psychiatry 85:85-91. 2014
    ....
  34. ncbi request reprint Efficient in vivo delivery of antisense oligonucleotide to choroid plexus
    Wenying Piao
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Med Dent Sci 60:9-16. 2013
    ..This strategy should be useful for investigations of the function of CP, and for the development of new gene-silencing therapies for diseases with pathophysiology related to the CP. ..
  35. doi request reprint Proliferating immature Schwann cells contribute to nerve regeneration after ischemic peripheral nerve injury
    Masaki Kobayashi
    Department of Neurology and Neurological Science, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    J Neuropathol Exp Neurol 71:511-9. 2012
    ..The manipulation of this population of proliferating immature Schwann cells may be a useful strategy for treating ischemic peripheral neuropathy...
  36. ncbi request reprint Sequence-dependent and independent inhibition specific for mutant ataxin-3 by small interfering RNA
    Yi Li
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Ann Neurol 56:124-9. 2004
    ..5%) by this siRNA possibly due to difference of the secondary structure of the target RNA. This is the first report of sequence-independent discrimination of mutant and wild-type alleles by siRNA...
  37. ncbi request reprint Down-regulation of alpha-synuclein expression can rescue dopaminergic cells from cell death in the substantia nigra of Parkinson's disease rat model
    Hiromi Hayashita-Kinoh
    Research Institute for Diseases of Old Age, Juntendo University, Tokyo, Japan
    Biochem Biophys Res Commun 341:1088-95. 2006
    ..Down-regulation of alpha-synuclein expression could be potentially a suitable target for gene therapy of Parkinson's disease...
  38. pmc An autosomal dominant cerebellar ataxia linked to chromosome 16q22.1 is associated with a single-nucleotide substitution in the 5' untranslated region of the gene encoding a protein with spectrin repeat and Rho guanine-nucleotide exchange-factor domains
    Kinya Ishikawa
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Yushima, Tokyo, Japan
    Am J Hum Genet 77:280-96. 2005
    ....
  39. ncbi request reprint Introduction of short interfering RNA to silence endogenous E-selectin in vascular endothelium leads to successful inhibition of leukocyte adhesion
    Yasunobu Nishiwaki
    Department of Medical Biochemistry, Tokyo Medical and Dental University, Tokyo, Japan
    Biochem Biophys Res Commun 310:1062-6. 2003
    ..03). This technique provides a powerful strategy to dissect a specific function of a given molecule in leukocyte-endothelial interaction...
  40. doi request reprint Elevated platelet microparticle levels after acute ischemic stroke with concurrent idiopathic thrombocytopenic purpura
    Masahiko Ichijo
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan
    J Stroke Cerebrovasc Dis 23:587-9. 2014
    ..Immunosuppressive therapy to decrease plasma PMP levels is warranted after acute ischemic stroke in the context of idiopathic thrombocytopenic purpura. ..
  41. ncbi request reprint [Optic nerve swelling and gadolinium contrast enhancement on magnetic resonance imaging in the subacute stage of Leber's hereditary optic neuropathy: a case report]
    Misako Furuki
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University
    Rinsho Shinkeigaku 52:102-5. 2012
    ..The present case also suggests that mitochondrial dysfunction may trigger the onset of MS-like extraocular symptoms in patients with LHON...
  42. ncbi request reprint [Blood-brain barrier and Alzheimer's disease]
    Hiroya Kuwahara
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan
    Brain Nerve 65:145-51. 2013
    ..This review highlights the roles of the BBB in AD pathomechanism and its importance in designing therapeutic strategies...
  43. doi request reprint Short interfering RNA and the central nervous system: development of nonviral delivery systems
    Kazutaka Nishina
    Tokyo Medical and Dental University, Graduate School, Department of Neurology and Neurological Science, Tokyo 113 8519, Japan
    Expert Opin Drug Deliv 10:289-92. 2013
    ..This editorial describes different approaches that are being used to efficiently deliver siRNA to the CNS via intravenous, intracerebroventricular, or intranasal administration...
  44. ncbi request reprint Skeletal muscle MRI in complex regional pain syndrome
    Yoichiro Nishida
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo
    Intern Med 48:209-12. 2009
    ..The aim of this study was to clarify whether or not the affected muscles in CRPS patients show abnormal MRI signal intensities or signal enhancement by gadolinium dimeglumine during the acute phase...
  45. ncbi request reprint Posthyperventilatory steal response in chronic cerebral hemodynamic stress: a positron emission tomography study
    T Nariai
    Department of Neurosurgery, School of Medicine, Tokyo Medical and Dental University, and the Positron Medical Center, Japan
    Stroke 29:1281-92. 1998
    ....
  46. ncbi request reprint High voltage electrical stimulation of the proximal hypoglossal nerve in normal subjects
    A Inaba
    Department of Neurology, Tokyo Medical and Dental University, 5 45, Yushima 1 chome, Bunkyo ku, Tokyo, Japan
    Clin Neurophysiol 113:925-9. 2002
    ..Therefore, we tested an improved method of stimulating the proximal hypoglossal nerve, using high voltage electrical stimulation...
  47. ncbi request reprint [Two distinct types of neuropathy associated with Sjögren's syndrome developed in one patient. The importance of the selection of an appropriate therapeutic regimen]
    Yoshimasa Noguchi
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University
    Rinsho Shinkeigaku 43:539-43. 2003
    ....
  48. ncbi request reprint [MicroRNA and central nervous system]
    Takanori Yokota
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Brain Nerve 61:167-76. 2009
    ..Research on miRNAs in the context of neurodegeneration has been rapidly advancing, and the goal of this review is to provide perspective for new data that may aid specialists in this field...
  49. pmc Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells
    Shigeru Oshima
    Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Mol Cell Biol 24:6298-310. 2004
    ....
  50. ncbi request reprint Proteolytic cleavage and cellular toxicity of the human alpha1A calcium channel in spinocerebellar ataxia type 6
    Takayuki Kubodera
    Department of Neurology and Neurological Science, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Neurosci Lett 341:74-8. 2003
    ..We speculate that the toxic C-terminal fragment, in which resistance to proteolysis is rendered by the expanded polyglutamine, has a key role in the pathological mechanism of SCA6...
  51. ncbi request reprint [Rapid progressive HTLV-1-associated myelopathy with bronchoalveolar lesions and a long spinal cord lesion extending to almost the entire spinal cord]
    Ryo Itami
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University
    Rinsho Shinkeigaku 51:130-4. 2011
    ..Further, careful investigation to detect pulmonary lesions, which are reported to be asymptomatic in most cases, is useful to confirm a diagnosis of HAM...
  52. doi request reprint Distal hyperintense vessels on FLAIR images predict large-artery stenosis in patients with transient ischemic attack
    Kotaro Yoshioka
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo 113 0034, Japan
    Neuroradiology 55:165-9. 2013
    ..Despite its relevance to patient care outcomes, the presence of DHV has not been evaluated in patients with transient ischemic attack (TIA)...
  53. pmc Spinal epidural abscess caused by bacteroides fragilis group after dilation and curettage for incomplete abortion
    Masaki Ohyagi
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo, Japan
    J Glob Infect Dis 4:132-4. 2012
    ..The diagnosis of SEA was done by MRI and pus was drained after the cervical discectomy. Bacteroides fragilis group was cultured from the aspirated pus sample. The patient responded to surgical drainage and antibiotics...
  54. pmc Electrophysiological features of central motor conduction in spinocerebellar atrophy type 1, type 2, and Machado-Joseph disease
    T Yokota
    Department of Neurology, Tokyo Medical and Dental University, Japan
    J Neurol Neurosurg Psychiatry 65:530-4. 1998
    ..To characterise electrophysiologically the central motor conduction of spinocerebellar atrophy type 1 (SCA1), type 2 (SCA2), and Machado-Joseph disease (MJD)...
  55. ncbi request reprint [Multiple cerebral embolism caused by a patent foramen ovale and a uterine myoma]
    Zen Kobayashi
    Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Graduate School of Medicine Tokyo, Japan
    No To Shinkei 55:705-8. 2003
    ..An uterine myoma should be considered as an important risk factor for an embolic source in case of cerebral embolism with PFO...
  56. ncbi request reprint Electrophysiological evaluation of conduction in the most proximal motor root segment
    Akira Inaba
    Department of Neurology, Tokyo Medical and Dental University, 5 45, Yushima 1 chome, Bunkyo ku, Tokyo, 113 8519 Japan
    Muscle Nerve 25:608-11. 2002
    ..These findings suggest that the RCT and minimal threshold for CMS might be additional parameters for evaluating motor nerve conduction in IDP...
  57. ncbi request reprint [Detection of the primary tumor site in tumor-induced osteomalacia by indium-111 octreotide scintigraphy: a case report]
    Makoto Takahashi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University
    Rinsho Shinkeigaku 48:120-4. 2008
    ..This is the first case report in Japan describing the detection of the primary tumor site by indium-111 octreotide scintigraphy...
  58. pmc Postmortem study of ataxia with retinitis pigmentosa by mutation of the alpha-tocopherol transfer protein gene
    T Yokota
    Department of Neurology, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Neurol Neurosurg Psychiatry 68:521-5. 2000
    ..It is therefore considered that oral supplementation of vitamin E should effectively counteract the progression of ataxia...
  59. ncbi request reprint Somatosensory-evoked cortical potential during attacks of paroxysmal dysesthesia in multiple sclerosis
    S Toru
    Department of Neurology, Tokyo Medical and Dental University, Tokyo, Japan
    Eur J Neurol 12:233-4. 2005
    ..We report the interesting finding of somatosensory-evoked potentials (SEPs) in a patient with MS during a paroxysmal dysesthesia attack...
  60. ncbi request reprint Proximal motor conduction evaluated by transcranial magnetic stimulation in acquired inflammatory demyelinating neuropathies
    A Inaba
    Clinical Laboratory, Tokyo Medical and Dental University Medical Hospital, 5-45 Yushima 1-chome, Bunkyo-ku, 113-8519, Tokyo, Japan
    Clin Neurophysiol 112:1936-45. 2001
    ....
  61. ncbi request reprint Cefpodoxime proxetil, its in vitro antibacterial activity, affinity to bacterial penicillin-binding proteins, and synergy of bactericidal activity with serum complement and mouse-cultured macrophages
    T Yokota
    Department of Bacteriology, School of Medicine, Juntendo University, Tokyo, Japan
    Drugs Exp Clin Res 14:495-500. 1988
    ..aureus 209P were well engulfed and rapidly digested by mouse-cultured macrophages in the presence of greater than 1/8 MIC of R-3746. Good clinical efficacy can be expected of CS-807 provided its pharmacokinetics prove to be good...
  62. ncbi request reprint Molecular cloning of a novel Xenopus spalt gene (Xsal-3)
    Y Onuma
    Department of Life Sciences, CREST Project, University of Tokyo, Komaba, Meguro ku, Tokyo, 153 8902, Japan
    Biochem Biophys Res Commun 264:151-6. 1999
    ..These findings suggest that Xsal-3 may have distinct roles in early Xenopus development...
  63. ncbi request reprint Clinicopathological report of retinitis pigmentosa with vitamin E deficiency caused by mutation of the alpha-tocopherol transfer protein gene
    J Pang
    Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Graduate School, Tokyo, Japan
    Jpn J Ophthalmol 45:672-6. 2001
    ..The mild Friedreich-type ataxia accompanying the RP may be helpful in identifying this disease...
  64. ncbi request reprint Selective gene silencing of rat ATP-binding cassette G2 transporter in an in vitro blood-brain barrier model by short interfering RNA
    Satoko Hori
    Department of Molecular Biopharmacy and Genetics, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    J Neurochem 93:63-71. 2005
    ..This should be a useful and novel strategy for clarifying the contribution of rABCG2 to brain-to-blood transport of substrate drugs and endogenous compounds across the blood-brain barrier...
  65. ncbi request reprint Increase of disease duration of amyotrophic lateral sclerosis in a mouse model by transgenic small interfering RNA
    Takanori Yokota
    Arch Neurol 64:145-6. 2007
  66. ncbi request reprint Coupling endoplasmic reticulum stress to the cell death program: role of the ER chaperone GRP78
    Rammohan V Rao
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945 1400, USA
    FEBS Lett 514:122-8. 2002
    ..These results define a novel protective role for GRP78 in preventing ER stress-induced cell death...