Affiliation: Tokyo University of Pharmacy and Life Science
Tatsumi Y, Matsumoto N, Iibe N, Watanabe N, Torii T, Sango K, et al
. CMT type 2N disease-associated AARS mutant inhibits neurite growth that can be reversed by valproic acid. Neurosci Res. 2018;: pubmed publisher
..Taken together, the N71Y mutation of AARS leads to abnormal intracellular localization, inhibiting process growth, yet this inhibition is reversed by valproic acid. ..
Urai Y, Yamawaki M, Watanabe N, Seki Y, Morimoto T, Tago K, et al
. Pull down assay for GTP-bound form of Sar1a reveals its activation during morphological differentiation. Biochem Biophys Res Commun. 2018;503:2047-2053 pubmed publisher
Matsumoto N, Kaneko M, Watanabe N, Itaoka M, Seki Y, Morimoto T, et al
. Treacher Collins syndrome 3 (TCS3)-associated POLR1C mutants are localized in the lysosome and inhibits chondrogenic differentiation. Biochem Biophys Res Commun. 2018;499:78-85 pubmed publisher
Miyamoto Y, Torii T, Tanoue A, Kawahara K, Arai M, Tsumura H, et al
. Neuregulin-1 type III knockout mice exhibit delayed migration of Schwann cell precursors. Biochem Biophys Res Commun. 2017;486:506-513 pubmed publisher
..These results indicate that in mice, NRG1 type III plays a key role not only in myelination but also in migration. ..
Watanabe N, Itakaoka M, Seki Y, Morimoto T, Homma K, Miyamoto Y, et al
. Dystonia-4 (DYT4)-associated TUBB4A mutants exhibit disorganized microtubule networks and inhibit neuronal process growth. Biochem Biophys Res Commun. 2018;495:346-352 pubmed publisher
..Together, DYT4-associated TUBB4A mutants themselves form aberrant tubulin networks and inhibit neuronal process growth, possibly explaining progress through the pathological states at cellular levels. ..