Toshiyuki Yamamoto

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. ncbi Monocyte chemoattractant protein-1 enhances gene expression and synthesis of matrix metalloproteinase-1 in human fibroblasts by an autocrine IL-1 alpha loop
    T Yamamoto
    Department of Dermatology, University of Cologne, Germany
    J Immunol 164:6174-9. 2000
  2. ncbi Animal model of sclerotic skin. III: Histopathological comparison of bleomycin-induced scleroderma in various mice strains
    T Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Japan
    Arch Dermatol Res 292:535-41. 2000
  3. ncbi Bleomycin increases steady-state levels of type I collagen, fibronectin and decorin mRNAs in human skin fibroblasts
    T Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Japan
    Arch Dermatol Res 292:556-61. 2000
  4. ncbi Unusual annular erythema associated with myelodysplastic syndrome
    T Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan
    Dermatology 202:70-2. 2001
  5. ncbi Expression of monocyte chemoattractant protein-1 in the lesional skin of systemic sclerosis
    T Yamamoto
    Department of Dermatology, University of Cologne, Joseph Stelzmann Street 9, 50924, Cologne, Germany
    J Dermatol Sci 26:133-9. 2001
  6. ncbi Nodular scleroderma: increased expression of connective tissue growth factor
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Japan
    Dermatology 211:218-23. 2005
  7. ncbi Role of mast cells in dermatofibroma: recent viewpoints into the pathogenesis
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Eur J Dermatol 13:419-23. 2003
  8. ncbi High expression and autoinduction of monocyte chemoattractant protein-1 in scleroderma fibroblasts
    T Yamamoto
    Department of Dermatology, University of Cologne, Cologne, Germany
    Eur J Immunol 31:2936-41. 2001
  9. ncbi Increased expression of p53 and p21 (Waf1/Cip1) in the lesional skin of bleomycin-induced scleroderma
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Arch Dermatol Res 296:509-13. 2005
  10. ncbi Animal model of sclerotic skin induced by bleomycin: a clue to the pathogenesis of and therapy for scleroderma?
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Clin Immunol 102:209-16. 2002

Detail Information

Publications139 found, 100 shown here

  1. ncbi Monocyte chemoattractant protein-1 enhances gene expression and synthesis of matrix metalloproteinase-1 in human fibroblasts by an autocrine IL-1 alpha loop
    T Yamamoto
    Department of Dermatology, University of Cologne, Germany
    J Immunol 164:6174-9. 2000
    ..These data demonstrate that MCP-1 up-regulates MMP-1 mRNA expression and synthesis in human skin fibroblasts at a transcriptional level and provide evidence that this is mediated by an IL-1 alpha autocrine loop...
  2. ncbi Animal model of sclerotic skin. III: Histopathological comparison of bleomycin-induced scleroderma in various mice strains
    T Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Japan
    Arch Dermatol Res 292:535-41. 2000
    ..Taken together, we conclude that C3H/He and B10.A mouse strains are bleomycin-'susceptible', and these strains are considered to be a suitable experimental model of bleomycin-induced scleroderma...
  3. ncbi Bleomycin increases steady-state levels of type I collagen, fibronectin and decorin mRNAs in human skin fibroblasts
    T Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Japan
    Arch Dermatol Res 292:556-61. 2000
    ..Our results indicate that bleomycin modulates gene expression of extracellular matrix proteins in dermal fibroblasts, and this effect may be mediated by TGF-beta and CTGF...
  4. ncbi Unusual annular erythema associated with myelodysplastic syndrome
    T Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan
    Dermatology 202:70-2. 2001
    ..84 pg/ml, normal < 2.0 pg/ml), whereas other cytokines including G-CSF, IL-6, and IL-8 were within normal limits. Skin manifestations were much improved by systemic mepitiostane, and serum GM-CSF level returned to normal levels...
  5. ncbi Expression of monocyte chemoattractant protein-1 in the lesional skin of systemic sclerosis
    T Yamamoto
    Department of Dermatology, University of Cologne, Joseph Stelzmann Street 9, 50924, Cologne, Germany
    J Dermatol Sci 26:133-9. 2001
    ..These findings suggest that MCP-1 plays a role in recruiting monocyte/macrophages in the lesional skin of scleroderma and that activated fibroblasts in scleroderma are involved in this process...
  6. ncbi Nodular scleroderma: increased expression of connective tissue growth factor
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Japan
    Dermatology 211:218-23. 2005
    ..Objective: In this study, we report 3 cases of nodular scleroderma, and the expression of CTGF is also investigated...
  7. ncbi Role of mast cells in dermatofibroma: recent viewpoints into the pathogenesis
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Eur J Dermatol 13:419-23. 2003
    ..Further elucidation of the role of mast cells may lend support to the understanding of the mechanism of DF...
  8. ncbi High expression and autoinduction of monocyte chemoattractant protein-1 in scleroderma fibroblasts
    T Yamamoto
    Department of Dermatology, University of Cologne, Cologne, Germany
    Eur J Immunol 31:2936-41. 2001
    ..Moreover, increased responsiveness of scleroderma fibroblasts to MCP-1 could result in a continuation of the fibrotic response...
  9. ncbi Increased expression of p53 and p21 (Waf1/Cip1) in the lesional skin of bleomycin-induced scleroderma
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Arch Dermatol Res 296:509-13. 2005
    ..Our findings suggest that apoptotic processes are involved in the pathophysiology of bleomycin-induced scleroderma, which may be mediated, in part, by the upregulation of p53 and p21...
  10. ncbi Animal model of sclerotic skin induced by bleomycin: a clue to the pathogenesis of and therapy for scleroderma?
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Clin Immunol 102:209-16. 2002
  11. ncbi Animal model of sclerotic skin. V: Increased expression of alpha-smooth muscle actin in fibroblastic cells in bleomycin-induced scleroderma
    Toshiyuki Yamamoto
    Department of Dermatology, School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Clin Immunol 102:77-83. 2002
    ..Blockade of TGF-beta may be a therapeutic intervention for scleroderma...
  12. ncbi Possible role of apoptosis in the pathogenesis of bleomycin-induced scleroderma
    Toshiyuki Yamamoto
    Tokyo Medical and Dental University School of Medicine, Department of Dermatology, Tokyo, Japan
    J Invest Dermatol 122:44-50. 2004
    ..These findings suggest that excessive apoptosis, which is mediated by Fas/Fas ligand pathway and caspase-3 activation, is involved in the pathogenesis of bleomycin-induced scleroderma, possibly by playing an inflammatory role...
  13. ncbi Topical tacrolimus: an effective therapy for facial psoriasis
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Eur J Dermatol 13:471-3. 2003
    ..95 to 0.24, respectively. These data demonstrate that topical tacrolimus is effective for facial lesions of psoriasis without occlusion. We conclude that topical tacrolimus is an effective treatment for facial psoriasis...
  14. ncbi Role of monocyte chemoattractant protein-1 and its receptor,CCR-2, in the pathogenesis of bleomycin-induced scleroderma
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Invest Dermatol 121:510-6. 2003
    ....
  15. ncbi Potential roles of CCL2/monocyte chemoattractant protein-1 in the pathogenesis of cutaneous sclerosis
    T Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Clin Exp Rheumatol 21:369-75. 2003
    ..This review summarizes recent findings of the potential roles of CCL2 in cutaneous sclerosis in experimental animal models of scleroderma as well as human scleroderma...
  16. ncbi Alteration of the expression of Bcl-2, Bcl-x, Bax, Fas, and Fas ligand in the involved skin of psoriasis vulgaris following topical anthralin therapy
    T Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan
    Skin Pharmacol Appl Skin Physiol 16:50-8. 2003
    ..These in vivo results may reflect improvement of the psoriatic skin following effective anthralin therapy...
  17. ncbi Cellular and molecular mechanisms of bleomycin-induced murine scleroderma: current update and future perspective
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan
    Exp Dermatol 14:81-95. 2005
    ..This review summarizes recent progress of the cellular and molecular events in the pathogenesis of bleomycin-induced scleroderma; moreover, further perspective by using this mouse model has been discussed...
  18. ncbi Effect of interleukin-10 on the gene expression of type I collagen, fibronectin, and decorin in human skin fibroblasts: differential regulation by transforming growth factor-beta and monocyte chemoattractant protein-1
    T Yamamoto
    Department of Dermatology, University of Cologne, Joseph Stelzmann Strasse 9, Cologne, 50924, Germany
    Biochem Biophys Res Commun 281:200-5. 2001
    ..Our data indicate that IL-10 differentially regulates TGF-beta and MCP-1 in the modulation of ECM proteins and therefore suggest that IL-10 plays a role in the regulation of tissue remodeling...
  19. ncbi Increased expression of TGF-beta1 in the sclerotic skin in bleomycin-'susceptible' mouse strains
    Mieko Oi
    Department of Environmental Immunodermatology, Tokyo Medical and Dental University, Post Graduate School, Japan
    J Med Dent Sci 51:7-17. 2004
    ..Thus we conclude that C3H/HeJ and B10.A mice are susceptible to bleomycin-induced scleroderma, which may be, in part, due to increased TGF-beta1 gene expression and protein production...
  20. ncbi Phenotypic overlapping of trisomy 12p and Pallister-Killian syndrome
    Eisuke Inage
    Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
    Eur J Med Genet 53:159-61. 2010
    ..The microblepharon identified in our patient is a characteristic feature of 12p trisomy. Further patients are needed to establish the phenotypic difference between trisomy 12p and Pallister-Killian syndrome...
  21. ncbi Fas- and FasL-deficient mice are resistant to the induction of bleomycin-induced scleroderma
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
    Arch Dermatol Res 298:465-8. 2007
    ..Our findings that lpr and gld mice were resistant to the induction of dermal sclerosis by bleomycin further suggest that Fas/FasL pathway is an important contributor involved in the pathophysiology of bleomycin-induced dermal sclerosis...
  22. ncbi Clinical manifestations of the deletion of Down syndrome critical region including DYRK1A and KCNJ6
    Toshiyuki Yamamoto
    Tokyo Women s Medical University Institute for Integrated Medical Sciences, Tokyo, Japan
    Am J Med Genet A 155:113-9. 2011
    ....
  23. ncbi CDKL5 alterations lead to early epileptic encephalopathy in both genders
    Jao Shwann Liang
    Tokyo Women s Medical University Institute for Integrated Medical Sciences, Shinjuku Ward, Tokyo, Japan
    Epilepsia 52:1835-42. 2011
    ..We investigated the clinical relevance of CDKL5 alterations in both genders...
  24. ncbi Pathogenic role of CCL2/MCP-1 in scleroderma
    Toshiyuki Yamamoto
    Department of Dermatology, Fukushima Medical University, Fukushima, Japan
    Front Biosci 13:2686-95. 2008
    ..This review will focus on the roles of CCL2 and its receptor during the process of cutaneous sclerosis, and also provide a current insight into the potential mechanisms of scleroderma...
  25. ncbi Role of cytokines and proteases in murine scleroderma
    Mariko Matsushita
    Department of Dermatology, Graduate School Tokyo Medical and Dental University, Tokyo, Japan
    J Med Dent Sci 55:215-25. 2008
    ....
  26. ncbi The bleomycin-induced scleroderma model: what have we learned for scleroderma pathogenesis?
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical University, 6 7 1 Nishi shinjuku, 160 0023 Tokyo, Japan
    Arch Dermatol Res 297:333-44. 2006
    ..In this review, we introduce current insights into the pathogenesis of bleomycin-induced scleroderma, and discuss its contribution to our understanding of the pathogenesis of, and treatments for, human scleroderma...
  27. ncbi Loss-of-function mutation of collybistin is responsible for X-linked mental retardation associated with epilepsy
    Keiko Shimojima
    Tokyo Women s Medical University Institute for Integrated Medical Sciences, 8 1 Kawada cho, Shinjuku, Tokyo, Japan
    J Hum Genet 56:561-5. 2011
    ..The common phenotypic effects of all ARHGEF9 mutations were mental retardation and epilepsy. Therefore, ARHGEF9 is likely to be responsible for syndromic X-linked mental retardation associated with epilepsy...
  28. ncbi Upregulation of interleukin-13 and its receptor in a murine model of bleomycin-induced scleroderma
    Mariko Matsushita
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo, Japan
    Int Arch Allergy Immunol 135:348-56. 2004
    ..Previously, a murine model for scleroderma has been established by repeated local injections of bleomycin. This animal model enabled us to study local expression and production of IL-13 in skin lesions during disease progression...
  29. ncbi Proximal interstitial 1p36 deletion syndrome: the most proximal 3.5-Mb microdeletion identified on a dysmorphic and mentally retarded patient with inv(3)(p14.1q26.2)
    Keiko Shimojima
    International Research and Educational Institute for Integrated Medical Sciences IREIIMS, Tokyo Women s Medical University, Tokyo, Japan
    Brain Dev 31:629-33. 2009
    ..Compared to the previously reported patients, abnormally shaped teeth, delayed tooth eruption, and leg malformation are unique phenotypes only to this patient, which might be due to the centromeric unique deletion region with 0.8-Mb...
  30. ncbi Serum levels of CA15-3, KL-6 and BCA225 are positively correlated with each other in the general population
    Gyokuto Ri
    International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, 162 8666, Japan
    Anticancer Res 29:4239-42. 2009
    ..Carbohydrate antigen 15-3 (CA15-3), Kerbs von den Lungen (KL-6) and breast cancer antigen 225 (BCA225) are widely used tumor markers for breast and lung cancer respectively...
  31. ncbi A functional analysis of GABARAP on 17p13.1 by knockdown zebrafish
    Yuta Komoike
    International Research and Educational Institute for Integrated Medical Sciences IREIIMS, Tokyo Women s Medical University, Tokyo, Japan
    J Hum Genet 55:155-62. 2010
    ..Although there were no pathogenic mutations in DLG4/PSD95 or GABARAP in a cohort study with 142 patients with idiopathic developmental delay with/without epilepsy, further studies would be required for genes included in this region...
  32. ncbi Chemokines and chemokine receptors in scleroderma
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical University, Tokyo, Japan
    Int Arch Allergy Immunol 140:345-56. 2006
    ..This review will focus on the roles of chemokines and their receptors during the process of cutaneous sclerosis and will also provide a current insight into the potential mechanisms of scleroderma...
  33. ncbi Animal model of sclerotic skin. VI: Evaluation of bleomycin-induced skin sclerosis in nude mice
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, 1-5-45 Yushima, Bunkyo-ku, 113-8519 Tokyo, Japan
    Arch Dermatol Res 295:453-6. 2004
  34. ncbi A new microdeletion syndrome of 5q31.3 characterized by severe developmental delays, distinctive facial features, and delayed myelination
    Keiko Shimojima
    Tokyo Women s Medical University Institute for Integrated Medical Sciences, Tokyo, Japan
    Am J Med Genet A 155:732-6. 2011
    ..We need further investigations to determine which genes are responsible for the patients' characteristic features...
  35. ncbi Hepatocyte growth factor both prevents and ameliorates the symptoms of dermal sclerosis in a mouse model of scleroderma
    M-H Wu
    Department of Dermatology and Immunodermatology, Tokyo Medical and Dental University, Graduate School, Tokyo, Japan
    Gene Ther 11:170-80. 2004
    ..These results indicated that gene therapy by the transfection of the human HGF cDNA may thus be a useful therapy for SSc and lung fibrosis involved with SSc...
  36. ncbi De novo microdeletion of 5q14.3 excluding MEF2C in a patient with infantile spasms, microcephaly, and agenesis of the corpus callosum
    Keiko Shimojima
    Tokyo Women s Medical University Institute for Integrated Medical Sciences, Tokyo, Japan
    Am J Med Genet A 158:2272-6. 2012
    ..We consider that a positional effect is the likely explanation for this evidence. To study the precise mechanism of this positional effect, further information is required on patients showing atypical deletions neighboring MEF2C...
  37. ncbi Marfanoid hypermobility caused by an 862 kb deletion of Xq22.3 in a patient with Sotos syndrome
    Keiko Shimojima
    Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Tokyo, Japan
    Am J Med Genet A 155:2293-7. 2011
    ....
  38. ncbi TULIP1 (RALGAPA1) haploinsufficiency with brain development delay
    Keiko Shimojima
    International Research and Educational Institute for Integrated Medical Sciences IREIIMS, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku Ward, Tokyo, 162 8666, Japan
    Genomics 94:414-22. 2009
    ..Tulip1 was highly expressed in zebrafish brain, and knockdown of which resulted in brain developmental delay. Therefore, we suggest that TULIP1 is a candidate gene for developmental delay...
  39. ncbi Spinocerebellar ataxias type 27 derived from a disruption of the fibroblast growth factor 14 gene with mimicking phenotype of paroxysmal non-kinesigenic dyskinesia
    Keiko Shimojima
    Tokyo Women s Medical University Institute for Integrated Medical Sciences, Shinjuku Ward, Tokyo, Japan
    Brain Dev 34:230-3. 2012
    ..Further studies should be conducted on the phenotypic heterogeneity of FGF14 mutations and/or haploinsufficiency in SCA27 and PNKD...
  40. ncbi Genomic copy number variations at 17p13.3 and epileptogenesis
    Keiko Shimojima
    International Research and Educational Institute for Integrated Medical Sciences IREIIMS, Tokyo Women s Medical University, Tokyo, Japan
    Epilepsy Res 89:303-9. 2010
    ..In this study, it was suggested that the identified gain or loss of genomic copy numbers within 17p13.3 result in epileptogenesis and that triplication of LIS1 can cause symptomatic West syndrome...
  41. ncbi Zebrafish gene knockdowns imply roles for human YWHAG in infantile spasms and cardiomegaly
    Yuta Komoike
    International Research and Educational Institute for Integrated Medical Sciences IREIIMS, Tokyo Women s Medical University, Shinjuku Ward, Tokyo, Japan
    Genesis 48:233-43. 2010
    ....
  42. ncbi Folliculotropic mycosis fungoides and a leonine clinical appearance of the face
    Tomonobu Ito
    Department of Dermatology, Tokyo Medical University, Tokyo, Japan
    Dermatol Online J 14:6. 2008
    ..EPOCH therapy was very effective and the lesions of the forehead and forearm showed a decrease in tumor elevation; the histology showed a precipitous decrease in the number of the atypical lymphocytes...
  43. ncbi Refractory neonatal epilepsy with a de novo duplication of chromosome 2q24.2q24.3
    Akihisa Okumura
    Department of Pediatrics, Juntendo University Faculty of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    Epilepsia 52:e66-9. 2011
    ..3-Mb duplication of 2q24.2q24.3, where at least 22 genes including a cluster of voltage-gated sodium channel genes (SCN1A, SCN2A, SCN3A, SCN7A, and SCN9A) and one noncoding RNA are located...
  44. ncbi Poroma with sebaceous differentiation: report of three cases
    Yuta Kurashige
    Department of Dermatology, Tokyo Medical University, Tokyo, Japan
    Australas J Dermatol 51:131-4. 2010
    ..None of them occurred in acral regions, where typical eccrine poromas predominate. The majority of cases were benign. This review indicates that some poromas may show sebaceous differentiation and be of apocrine lineage...
  45. ncbi Discoid lupus erythematosus in a patient with scleroderma and hepatitis C virus infection
    Mami Yamamoto
    Department of Dermatology, Tokyo Medical University, 6 7 1 Nishi shinjuku, Shinjuku ku, Tokyo, 160 0023, Japan
    Rheumatol Int 30:969-71. 2010
    ..Our patient was positive for hepatitis C virus infection. Racial predisposition and immune imbalance are proposed to have played a role in the development of these lesions in our case...
  46. ncbi STXBP1 mutations cause not only Ohtahara syndrome but also West syndrome--result of Japanese cohort study
    Motoko Otsuka
    Department of Pediatrics, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Epilepsia 51:2449-52. 2010
    ..This is the first case report showing that STXBP1 mutations caused West syndrome from the onset of epilepsy. STXBP1 analysis should be considered as an etiology of symptomatic West syndrome without explainable cause...
  47. ncbi An unmasked mutation of EIF2B2 due to submicroscopic deletion of 14q24.3 in a patient with vanishing white matter disease
    Shino Shimada
    Tokyo Women s Medical University Institute of Integrated Medical Sciences, Tokyo, Japan
    Am J Med Genet A 158:1771-7. 2012
    ..Some distinctive features including small palpebral fissures, bushy eyebrows, ear abnormalities, small upturned nose, downturned corners of the mouth, and micrognathia may be the common features of the patients with 14q24.3 deletions...
  48. ncbi Endothelin receptor antagonist bosentan improves the dermal sclerosis in a patient with systemic sclerosis
    Akiko Nishibu
    Department of Dermatology, Fukushima Medical University, Fukushima, Japan
    Australas J Dermatol 53:e32-3. 2012
    ..Within a short period of administration of the bosentan the skin sclerosis improved...
  49. ncbi Pelizaeus-Merzbacher disease caused by a duplication-inverted triplication-duplication in chromosomal segments including the PLP1 region
    Keiko Shimojima
    Tokyo Women s Medical University Institute for Integrated Medical Sciences, Tokyo, Japan
    Eur J Med Genet 55:400-3. 2012
    ..This is the first report of a patient with PLP1 triplication caused by a DUP-TRP/INV-DUP structure. This study adds additional evidence about the consequences of PLP1 triplication...
  50. ncbi Tetralogy of Fallot associated with pulmonary atresia and major aortopulmonary collateral arteries in a patient with interstitial deletion of 16q21-q22.1
    Toshiyuki Yamamoto
    International Research and Educational Institute for Integrated Medical Sciences, Tokyo Women s Medical University, Tokyo, Japan
    Am J Med Genet A 146:1575-80. 2008
    ..Since over 50% of patients with the deletion of 16q22 region have congenital heart disease, there may be a responsible gene in this region...
  51. ncbi Multiple cutaneous fibrous histiocytomas in association with systemic lupus erythematosus
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Yushima, Tokyo, Japan
    J Dermatol 32:645-9. 2005
    ..Although multiple dermatofibromas are occasionally seen in patients with SLE, benign fibrous histiocytoma of the skin showing deeper invasion than dermatofibroma is rarely associated with SLE...
  52. ncbi Case of acute generalized exanthematous pustulosis caused by ampicillin/cloxacillin sodium in a pregnant woman
    Yuka Matsumoto
    Department of Dermatology, Tokyo Medical University, Tokyo, Japan
    J Dermatol 35:362-4. 2008
    ..To our knowledge, this is only the second case ever reported in the Japanese language published work of AGEP induced by ABPC/MCIPC...
  53. ncbi Severe pulmonary emphysema in a girl with interstitial deletion of 2q24.2q24.3 including ITGB6
    Shinichi Takatsuki
    The First Department of Pediatrics, Toho University Omori Medical Center, Tokyo, Japan
    Am J Med Genet A 152:1020-5. 2010
    ..2 showed poor outcomes because of respiratory failure. These observations suggest the possibility of a strong relationship between haploinsufficiency of ITGB6 and pulmonary dysfunction...
  54. ncbi Vesiculo-bullous dermatomyositis: report of three cases
    Katsuyuki Nishigori
    Department of Dermatology, Tokyo Medical and Dental University, Tokyo, Japan
    Dermatol Online J 15:6. 2009
    ..Prior reports suggest that internal malignancy is much higher in patients with vesiculo-bullous DM than in those unassociated with bullous lesions. Clinicians should be aware of vesiculo-bullous type DM...
  55. ncbi Plasminogen activator inhibitor-1 is elevated, but not essential, in the development of bleomycin-induced murine scleroderma
    M Matsushita
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan
    Clin Exp Immunol 139:429-38. 2005
    ....
  56. ncbi Glucocorticoids stimulate p21(CIP1) in mesangial cells and in anti-GBM glomerulonephritis
    Y Terada
    Second Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Kidney Int 59:1706-16. 2001
    ..Glucocorticoids are widely used for the treatment of glomerulonephritis, but the mechanism of cell cycle inhibition by glucocorticoids is poorly understood at a molecular level...
  57. ncbi Cloning and characterization of the mouse tob2 gene
    R Ajima
    Department of Oncology, The Institute of Medical Science, The University of Tokyo, Minato ku, 108 8639, Tokyo, Japan
    Gene 253:215-20. 2000
    ..Collectively, Tob2 is suggested to play roles both during embryogenesis and in adults...
  58. ncbi Local injection of latency-associated peptide, a linker propeptide specific for active form of transforming growth factor-beta1, inhibits dermal sclerosis in bleomycin-induced murine scleroderma
    Taeko Nakamura-Wakatsuki
    Department of Dermatology, Fukushima Medical University, Fukushima, Japan
    Exp Dermatol 21:189-94. 2012
    ..Our data may have novel therapeutic implications regarding in vivo TGF-β1 inactivation in human scleroderma, and the post-transcriptional interrelationship between major fibrogenic cytokines in the autoimmune aspects of the disease...
  59. ncbi Tandem configurations of variably duplicated segments of 22q11.2 confirmed by fiber-FISH analysis
    Keiko Shimojima
    Tokyo Women s Medical University Institute for Integrated Medical Sciences, Tokyo, Japan
    J Hum Genet 56:810-2. 2011
    ..These results support the hypothesized mechanism of non-allelic homologous recombination with flanking LCRs and add additional evidence that many interstitial duplications are aligned as tandem configurations...
  60. ncbi Nodular cystic fat necrosis with systemic sclerosis
    Miho Toritsugi
    Department of Dermatology, Tsuchiura Kyodo General Hospital, 11-7 Manabe-Shinmachi, Tsuchiura City, Ibaraki 300-0053, Japan
    Eur J Dermatol 14:353-5. 2004
    ....
  61. ncbi Leukemia cutis originating in the extravasation site of i.v. gabexate mesilate infusion
    Takashi Miyakura
    Department of Dermatology, Tokyo Medical University, Tokyo, Japan
    J Dermatol 35:29-32. 2008
    ..We speculate that the gabexate mesilate might have played a role in the induction of leukemia cutis via adhesion molecules in our case...
  62. ncbi Psoriasis arthropathy and HLA-B51: report of 5 cases
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Japan
    J Dermatol 32:606-10. 2005
    ..Our observations suggest that HLA-B51 may play a role in the pathogenesis of PsA in the Japanese population...
  63. ncbi Scleroderma--pathophysiology
    Toshiyuki Yamamoto
    Department of Dermatology, Fukushima Medical University, Fukushima 960 1295, Japan
    Eur J Dermatol 19:14-24. 2009
    ....
  64. ncbi An atypical case of atypical lipomatous tumor
    Takashi Miyakura
    Department of Dermatology, Tokyo Medical University, Miyamoto Dermatology Clinic, Tokyo, Japan
    Am J Dermatopathol 30:590-2. 2008
    ..We considered our case to be a variant of atypical lipomatous tumor, although it did not correspond to any of the 4 atypical lipomatous tumor subgroups. There has been no recurrence to date...
  65. ncbi Successful treatment of vulvar lichen sclerosus in a child with low-concentration topical tacrolimus ointment
    Yuka Matsumoto
    Department of Dermatology, Tokyo Medical University, Tokyo, Japan
    J Dermatol 34:114-6. 2007
    ..This is the first report of topical low-concentration tacrolimus treatment showing a dramatic effect in the treatment of childhood vulvar lichen sclerosus...
  66. ncbi Amyloid deposition associated with generalized morphea-like scleroderma
    Koji Sumi
    Department of Environmental Immunodermatology, Tokyo Medical and Dental University Postgraduate School, Yushima 1 5 45, Bunkyo ku, Tokyo, Japan
    Eur J Dermatol 13:509-11. 2003
    ..As far as we know, amyloid deposition associated with generalized morphea-like scleroderma has not been reported until now...
  67. ncbi Localized involutional lipoatrophy: report of six cases
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Japan
    J Dermatol 29:638-43. 2002
    ..We consider that localized involutional lipoatrophy is more common than has been reported, and is occasionally induced by local injections...
  68. ncbi Role of stem cell factor and monocyte chemoattractant protein-1 in the interaction between fibroblasts and mast cells in fibrosis
    T Yamamoto
    Department of Dermatology, University of Cologne, Cologne, Germany
    J Dermatol Sci 26:106-11. 2001
    ..Our data may indicate an important interaction of fibroblasts and mast cells, via SCF and MCP-1, in the induction of fibrosis...
  69. ncbi Proteasome-mediated degradation of Tob is pivotal for triggering UV-induced apoptosis
    T Suzuki
    Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Oncogene 28:401-11. 2009
    ..Thus, proteasomal clearance of Tob provides a novel p53-independent pathway for UV-induced apoptosis...
  70. ncbi Clinical analysis of 21 patients with psoriasis arthropathy
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
    J Dermatol 32:84-90. 2005
    ..These results are consistent with earlier observations suggesting a different subpopulation of inflammatory cells in the skin than the joint...
  71. ncbi A de novo 22q11.22q11.23 interchromosomal tandem duplication in a boy with developmental delay, hyperactivity, and epilepsy
    Keiko Shimojima
    Tokyo Women s Medical University Institute for Integrated Medical Sciences TIIMS, Tokyo, Japan
    Am J Med Genet A 152:2820-6. 2010
    ..Thus, the gain of the genomic copy number of this region may have epileptogenesis...
  72. ncbi Successful treatment of plasma cell cheilitis with topical tacrolimus: report of two cases
    Yuka Hanami
    Department of Dermatology, Fukushima Medical University, Fukushima, Japan
    Dermatol Online J 17:6. 2011
    ..We present herein two cases of plasma cell cheilitis, in which topical tacrolimus showed beneficial effects, suggesting that this immunomodulatory agent is a promising option for plasma cell cheilitis...
  73. ncbi An indication for correlation between the serum ADA level and gastric cancer risk
    Gyokuto Ri
    International Research and Educational Institute for Integrated Medical Sciences IREIIMS, Tokyo Women s Medical University, Tokyo, Japan
    Anticancer Res 30:2347-9. 2010
    ..Gastric atrophy caused by Helicobacter pylori (H. pylori) infection is a risk factor for gastric cancer. We aimed to evaluate the relationship between gastric cancer risk and tumor markers in the general population...
  74. ncbi Syringocystadenoma papilliferum arising on the thigh without connection to the overlying epidermis
    Toshiyuki Yamamoto
    Department of Dermatology, Tsuchiura Kyodo General Hospital, Ibaraki, Japan
    Am J Dermatopathol 30:84-5. 2008
  75. ncbi Animal model of systemic sclerosis
    Toshiyuki Yamamoto
    Department of Dermatology, Fukushima Medical University, Fukushima 960 1295, Japan
    J Dermatol 37:26-41. 2010
    ....
  76. ncbi Deoxyribonuclease treatment prevents blood-borne liver metastasis of cutaneously transplanted tumour cells in mice
    S Sugihara
    First Department of Surgery, School of Medicine, Kumamoto University, Japan
    Br J Cancer 67:66-70. 1993
    ..These results suggest that DNase I could be a potential therapeutic agent used in conjunction with surgery to prevent clinical blood-borne metastasis...
  77. ncbi [A possible same genetic defect in two Niemann-Pick disease model mice]
    T Yamamoto
    Department of Pediatrics, Jikei University, School of Medicine, Tokyo
    No To Hattatsu 26:318-22. 1994
    ..These data suggest that genetic defects in NCTR-BALB/c and SPM mice are located in the same gene...
  78. ncbi Changes in expression of the mouse homologues of KIAA genes after subchronic methamphetamine treatment
    H Yamamoto
    Department of Molecular Psychiatry, Tokyo Intstitute of Psychiatry, Tokyo, Japan
    Ann N Y Acad Sci 1025:92-101. 2004
    ..These data suggest that long-lasting alterations of the period-related gene expressions in the hippocampus might play an important role in methamphetamine addiction...
  79. ncbi Vascular changes in bleomycin-induced scleroderma
    Toshiyuki Yamamoto
    Department of Dermatology, Fukushima Medical University, Hikarigaoka 1, Fukushima 960 1295, Japan
    Int J Rheumatol 2011:270938. 2011
    ..This paper makes a focus on the vascular involvement in the bleomycin-induced murine scleroderma...
  80. ncbi Cloning, sequencing, and transcriptional analysis of the dnaK heat shock operon of Listeria monocytogenes
    T Hanawa
    Department of Microbiology, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    Cell Stress Chaperones 5:21-9. 2000
    ..9 kb, 3.6 kb, 3.6 kb, and 1.2 kb; the first 2 species were heat inducible. The current results indicate that 4 distinct transcripts directed by 3 promoters are involved in the expression of the dnaK operon of L. monocytogenes...
  81. ncbi Platelet-derived growth factor is involved in the augmentation of airway responsiveness through remodeling of airways in diesel exhaust particulate-treated mice
    N Yamashita
    Department of Medicine, Teikyo University School of Medicine, Tokyo, Japan
    J Allergy Clin Immunol 107:135-42. 2001
    ..CONCLUSION: PDGF plays an important role in the process of remodeling brought about by DEP exposure in mice...
  82. ncbi Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma
    H Usami
    Applied Research Laboratories, Chugai Pharmaceutical Co, Ltd, Tokyo, Japan
    Br J Cancer 57:70-3. 1988
    ..LTA had no direct killing effects on Meth A cells. These results indicate that LTA may be an important antitumour component of OK-432 and that one of the antitumour mechanisms by this streptococcal preparation is the induction of TNF...
  83. ncbi Stimulation of tetrahydrobiopterin synthesis induced by insulin: possible involvement of phosphatidylinositol 3-kinase
    M Ishii
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University, Hatanodai 1-5-8, Shinagawa-ku, Tokyo, 142-8555, Japan
    Int J Biochem Cell Biol 33:65-73. 2001
    ..These results suggest that insulin stimulates BH4 synthesis through the de novo synthetic pathway involving induction of GTPCH, and that the signaling pathway involves the activation of PI3-kinase...
  84. ncbi Production and secretion of nerve growth factor by clonal striated muscle cell line, G8-1
    T Yamamoto
    Department of Neuroscience, Mitsubishi Kasei Institute of Life Sciences, Tokyo, Japan
    Neurochem Int 21:251-8. 1992
    ..Finally, molecular cloning of NGF of G8-1 cells was conducted and confirmed the structure of the gene that consists of 1, 3, and 4 exons deleting exon 2. Thus, G8-1 NGF is derived from transcript B...
  85. ncbi Brain responses to acute withdrawal in phenobarbital-dependent rats
    S Tanaka
    Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa, Tokyo, 142 8555, Japan
    Eur J Pharmacol 421:101-8. 2001
    ..These findings suggest that the induction of HO-1 and HSP27 during withdrawal from phenobarbital dependence may play a role in protection against glutamate toxicity...
  86. ncbi DNA demethylase is expressed in ovarian cancers and the expression correlates with demethylation of CpG sites in the promoter region of c-erbB-2 and survivin genes
    M Hattori
    Department of Obstetrics and Gynecology, Nihon University School of Medicine, 30-1, Oyaguchi, Kamimachi, Itabashi, 173-0861, Tokyo, Japan
    Cancer Lett 169:155-64. 2001
    ..The up-regulation of oncogenes may be the consequence of epigenetic control of gene expression by the dMTase...
  87. ncbi A novel approach to ex vivo gene therapy for familial hypercholesterolemia using human amniotic epithelial cells as a transgene carrier
    S Takahashi
    Department of Inherited Metabolic Disease, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Tohoku J Exp Med 193:279-92. 2001
    ..The temporary nature of the metabolic improvement may be associated with xenograft rejection and transient function of the adenoviral vector...
  88. ncbi Differential screening-selected gene aberrative in neuroblastoma protein modulates inflammatory pain in the spinal dorsal horn
    S Ohtori
    Department of Orthopaedic Surgery, School of Medicine, Chiba University, Japan
    Neuroscience 110:579-86. 2002
    ..Together, these data suggest that the DAN protein may be a novel neuromodulator in primary nociceptive nerve fibers...
  89. ncbi Skeletal muscle regeneration after insulin-like growth factor I gene transfer by recombinant Sendai virus vector
    A Shiotani
    Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan
    Gene Ther 8:1043-50. 2001
    ..These results demonstrate that SeV achieves high-level transgene expression in skeletal muscle, and that hIGF-I gene transfer using SeV vector may therefore have great potential in the treatment of neuromuscular disorders...
  90. ncbi Nemaline (actin) myopathy with myofibrillar dysgenesis and abnormal ossification
    Asako Arai
    Department of Child Neurology, National Center Hospital of Neurology and Psychiatry, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi cho, Kodaira, Tokyo, Japan
    Neuromuscul Disord 19:485-8. 2009
    ..Besides the severe muscle involvement, these clinical findings further broaden the clinical spectrum of actinopathy phenotypes...
  91. ncbi Niemann-Pick type C disease: accelerated neurofibrillary tangle formation and amyloid beta deposition associated with apolipoprotein E epsilon 4 homozygosity
    Yuko Saito
    Department of Neuropathology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Ann Neurol 52:351-5. 2002
    ..Investigation of these patients may provide an important clue for understanding the pathogenesis of Alzheimer's disease...
  92. ncbi Oral psoriasis in a patient with hepatitis C virus infection
    Toshiyuki Yamamoto
    Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
    Eur J Dermatol 12:75-6. 2002
    ..He was also suffering from type C hepatitis, however, he had not been treated with interferons. Oral psoriasis involving the lip is extremely rare...
  93. ncbi Cutaneous manifestations associated with rheumatoid arthritis
    T Yamamoto
    Department of Dermatology, Fukushima Medical University, Hikarigaoka 1, Fukushima, 960 1295, Japan
    Rheumatol Int 29:979-88. 2009
    ..It is important to recognize the common and/or uncommon skin conditions of RA for all clinicians associated with RA therapy...
  94. ncbi Extra-palmoplantar lesions associated with palmoplantar pustulosis
    T Yamamoto
    Department of Dermatology, Fukushima Medical University, Fukushima, Japan
    J Eur Acad Dermatol Venereol 23:1227-32. 2009
    ..By contrast, the pathogenesis of PPP has been poorly investigated. This paper reviews findings of the clinicopathophysiology of PPP, making a focus on the extra-palmoplantar lesions...
  95. ncbi Nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy in 2007: general view of the pathogens' antibacterial susceptibility
    Y Niki
    The JSC Surveillance Committee, Japanese Society of Chemotherapy, Nichinai Kaikan B1, 3 28 8 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    J Infect Chemother 15:156-67. 2009
    ..Continued surveillance is required to prevent the further spread of these antimicrobial resistances...
  96. ncbi Organization of complex transposon Tn2610 carrying two copies of tnpA and tnpR
    T Yamamoto
    Department of Microbiology, School of Medicine, Chiba University, Japan
    Antimicrob Agents Chemother 33:746-50. 1989
    ..Possible evolutionary relationships among class II transposable elements are proposed on the basis of the genetic and structural organization of Tn2610...
  97. ncbi Connatal Pelizaeus-Merzbacher disease associated with the jimpy(msd) mice mutation
    H Komaki
    Department of Child Neurology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Pediatr Neurol 20:309-11. 1999
    ..The mechanism of myelination is partly disturbed by the mutation; therefore jimpy(msd) mice can be used as a suitable model for further studies in connatal Pelizaeus-Merzbacher disease...
  98. ncbi cDNA sequence analysis of monoclonal antibody FU-MK-1 specific for a transmembrane carcinoma-associated antigen, and construction of a mouse/human chimeric antibody
    F Arakawa
    First Department of Biochemistry, School of Medicine, Fukuoka University, Japan
    Hybridoma 18:131-8. 1999
    ....
  99. ncbi Identification of receptor-binding sites of monocyte chemotactic S19 ribosomal protein dimer
    Y Shibuya
    Department of Laboratory Medicine, School of Medicine, Kumamoto University, Kumamoto, Japan
    Am J Pathol 159:2293-301. 2001
    ..The first and second ligand-binding sites of C5a receptor seem to be shared by C5a and the RP S19 dimer, although overall homology between the amino acid sequences of these ligands is only 4%...
  100. ncbi Angiogenesis induced by tissue factor in vitro and in vivo
    T Watanabe
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    Thromb Res 96:183-9. 1999
    ..These results suggest that tissue factor directly induce angiogenesis, independently of the coagulation pathway...
  101. ncbi Involvement of gangliosides in glycosylphosphatidylinositol-anchored neuronal cell adhesion molecule TAG-1 signaling in lipid rafts
    K Kasahara
    Department of Biochemical Cell Research, The Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, Honkomagome, Bunkyo ku, Tokyo 113 8613, Japan
    J Biol Chem 275:34701-9. 2000
    ..These observations suggest that glycosphingolipids are involved in TAG-1-mediated signaling in lipid rafts...