K Yamamoto

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. ncbi request reprint Assignment of IL12RB1 and IL12RB2, interleukin-12 receptor beta 1 and beta 2 chains, to human chromosome 19 band p13.1 and chromosome 1 band p31.2, respectively, by in situ hybridization
    K Yamamoto
    First Department of Internal Medicine, Tokyo Medical and Dental University, Japan
    Cytogenet Cell Genet 77:257-8. 1997
  2. ncbi request reprint cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2-->q32.3
    K Yamamoto
    First Department of Internal Medicine, Tokyo Medical and Dental University, Japan
    Cytogenet Cell Genet 77:207-10. 1997
  3. ncbi request reprint Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus
    K Yamamoto
    First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Biochem Biophys Res Commun 257:400-4. 1999
  4. ncbi request reprint Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion
    A Arai
    Department of Hematology and Oncology and the Department of Bioregulatory Medicine and Rheumatology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyoku, Tokyo 113, Japan
    J Biol Chem 276:10453-62. 2001
  5. ncbi request reprint Quantification of human herpesvirus 6 in healthy volunteers and patients with lymphoproliferative disorders by PCR-ELISA
    J H Ohyashiki
    Department of Virology, Medical Research Institute, Tokyo Medical and Dental University, Japan
    Leuk Res 23:625-30. 1999
  6. ncbi request reprint Use of real-time PCR to monitor human herpesvirus 6 reactivation after allogeneic bone marrow transplantation
    J H Ohyashiki
    Department of Virology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8510, Japan
    Int J Mol Med 6:427-32. 2000
  7. ncbi request reprint Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice
    S Kawasaki
    Department of Respiratory Medicine, School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 166:2055-62. 2001
  8. ncbi request reprint Experimental disseminated trichosporonosis in mice: tissue distribution and therapy with antifungal agents
    K Yamamoto
    Teikyo University Institute of Medical Mycology, Tokyo, Japan
    J Med Vet Mycol 35:411-8. 1997
  9. ncbi request reprint Regulation of human eotaxin generation by Th1-/Th2-derived cytokines
    M Miyamasu
    Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 122:54-8. 2000
  10. ncbi request reprint Regulation of murine protein C gene expression in vivo: effects of tumor necrosis factor-alpha, interleukin-1, and transforming growth factor-beta
    K Yamamoto
    First Department of Internal Medicine, Nagoya University School of Medicine, Showa, Japan
    Thromb Haemost 82:1297-301. 1999

Collaborators

Detail Information

Publications119 found, 100 shown here

  1. ncbi request reprint Assignment of IL12RB1 and IL12RB2, interleukin-12 receptor beta 1 and beta 2 chains, to human chromosome 19 band p13.1 and chromosome 1 band p31.2, respectively, by in situ hybridization
    K Yamamoto
    First Department of Internal Medicine, Tokyo Medical and Dental University, Japan
    Cytogenet Cell Genet 77:257-8. 1997
  2. ncbi request reprint cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2-->q32.3
    K Yamamoto
    First Department of Internal Medicine, Tokyo Medical and Dental University, Japan
    Cytogenet Cell Genet 77:207-10. 1997
    ..However, human STAT1 is expressed ubiquitously, whereas human STAT4 is expressed in several tissues including spleen, heart, brain, peripheral blood cells, and testis...
  3. ncbi request reprint Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus
    K Yamamoto
    First Department of Internal Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Biochem Biophys Res Commun 257:400-4. 1999
    ..The amino-terminus of Jak2 is necessary for association with IL-12R beta 2...
  4. ncbi request reprint Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion
    A Arai
    Department of Hematology and Oncology and the Department of Bioregulatory Medicine and Rheumatology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyoku, Tokyo 113, Japan
    J Biol Chem 276:10453-62. 2001
    ....
  5. ncbi request reprint Quantification of human herpesvirus 6 in healthy volunteers and patients with lymphoproliferative disorders by PCR-ELISA
    J H Ohyashiki
    Department of Virology, Medical Research Institute, Tokyo Medical and Dental University, Japan
    Leuk Res 23:625-30. 1999
    ....
  6. ncbi request reprint Use of real-time PCR to monitor human herpesvirus 6 reactivation after allogeneic bone marrow transplantation
    J H Ohyashiki
    Department of Virology, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8510, Japan
    Int J Mol Med 6:427-32. 2000
    ....
  7. ncbi request reprint Intervention of thymus and activation-regulated chemokine attenuates the development of allergic airway inflammation and hyperresponsiveness in mice
    S Kawasaki
    Department of Respiratory Medicine, School of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 166:2055-62. 2001
    ..This study also represents the first success in controlling Th2 cytokine production in vivo by targeting a chemokine...
  8. ncbi request reprint Experimental disseminated trichosporonosis in mice: tissue distribution and therapy with antifungal agents
    K Yamamoto
    Teikyo University Institute of Medical Mycology, Tokyo, Japan
    J Med Vet Mycol 35:411-8. 1997
    ..The serum level of (1-->3)-beta-D-glucan was reduced by antifungal therapy and correlated well with the CFU/organ in kidney, but not CFU/ml in blood...
  9. ncbi request reprint Regulation of human eotaxin generation by Th1-/Th2-derived cytokines
    M Miyamasu
    Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 122:54-8. 2000
    ..Accumulating evidence indicates that eotaxin is the primary mediator of tissue eosinophilia. In the present study, we analyzed the mechanisms of eotaxin generation by Th1-/Th2-derived cytokines in vitro...
  10. ncbi request reprint Regulation of murine protein C gene expression in vivo: effects of tumor necrosis factor-alpha, interleukin-1, and transforming growth factor-beta
    K Yamamoto
    First Department of Internal Medicine, Nagoya University School of Medicine, Showa, Japan
    Thromb Haemost 82:1297-301. 1999
    ..These observations suggest that TNF-alpha and IL-1 may contribute to an increase in the procoagulant potential by downregulation of protein C synthesis in the tissues during inflammatory processes...
  11. ncbi request reprint The NK cell MHC class I receptor Ly49A detects mutations on H-2Dd inside and outside of the peptide binding groove
    N Matsumoto
    Laboratory of Molecular Medicine, Department of Integrated Biosciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan
    J Immunol 166:4422-8. 2001
    ..Our results also provide insight into the molecular basis of Ly49A to distinguish MHC class I polymorphism...
  12. ncbi request reprint Regulation of surface FcepsilonRI expression on human eosinophils by IL-4 and IgE
    M Iikura
    Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 124:470-7. 2001
    ..CONCLUSIONS: IL-4 and IgE can affect the levels of surface FcepsilonRI on normal human eosinophils. FcepsilonRI expression on eosinophils may be regulated by a mechanism similar to that in mast cells...
  13. doi request reprint Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung
    M Imamura
    University of Tokyo, Department of Allergy and Rheumatology, Graduate School of Medicine, Tokyo, Japan
    Thorax 64:44-9. 2009
    ..The effect of pravastatin on allergic airway inflammation in a mouse model was examined to elucidate the mechanism of action, focusing on its effect on IL17 production...
  14. ncbi request reprint Homozygous protein C deficiency: identification of a novel missense mutation that causes impaired secretion of the mutant protein C
    K Yamamoto
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    J Lab Clin Med 119:682-9. 1992
    ....
  15. ncbi request reprint Aberrant expression of cytokeratin 7 as a histological marker of progression in primary biliary cirrhosis
    K Yabushita
    First Department of Internal Medicine, Okayama University Medical School, Japan
    Liver 21:50-5. 2001
    ..CONCLUSIONS: These results suggest that the aberrant expression of CK-7 in hepatocytes may be a marker of chronic cholestasis and progression in PBC...
  16. ncbi request reprint Erythromycin suppresses nuclear factor-kappaB and activator protein-1 activation in human bronchial epithelial cells
    M Desaki
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 267:124-8. 2000
    ..Our findings support the concept that the recruitment of neutrophils in airway diseases may be regulated by NF-kappaB and AP-1...
  17. doi request reprint A single nucleotide polymorphism in the IRF5 promoter region is associated with susceptibility to rheumatoid arthritis in the Japanese population
    K Shimane
    Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Ann Rheum Dis 68:377-83. 2009
    ..Here, we assessed the genetic role of IRF5 in susceptibility to rheumatoid arthritis (RA) in Japanese subjects...
  18. ncbi request reprint Aggressive NK cell lymphoma/leukemia with clonal der(3)t(1;3) (q12;p25), del(6)(q13) and del(13)(q12q14)
    H Hamaguchi
    Department of Hematology, Musashino Red Cross Hospital, 1 26 1 Kyonan cho, Musashino, 180 8610, Tokyo, Japan
    Cancer Genet Cytogenet 130:150-4. 2001
    ..Deletion 6q and deletion 13q have been frequently reported in NK cell lymphoma/leukemia. Thus, some tumor suppressor genes involving NK cell malignancies may be present in these regions...
  19. doi request reprint Comparison of prognosis of separated and non-separated tooth autotransplantation
    K Yoshino
    Department of Epidemiology and Public Health, Tokyo Dental College, Chiba, Japan Kyushikai, Kuroda Dental Clinic, Tokyo, Japan
    J Oral Rehabil 40:33-42. 2013
    ..Although transplantation of teeth with complete root formation has limited prognosis, transplantation of upper first and second molars, whether separated or non-separated, is a viable option to replace missing teeth...
  20. ncbi request reprint Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells
    H Chin
    First Department of Internal Medicine, Tokyo Medical and Dental University, Japan
    Biochem Biophys Res Commun 239:412-7. 1997
    ..These results suggest that CrkL is involved in the signaling pathways from the receptors for Epo and IL-3, most likely by modulating the activity of the Ras family GTPases through its interaction with C3G...
  21. pmc High frequency of circulating HBcAg-specific CD8 T cells in hepatitis B infection: a flow cytometric analysis
    S Matsumura
    First Department of Internal Medicine, Okayama University Medical School, Okayama, Japan
    Clin Exp Immunol 124:435-44. 2001
    ..HBcAg-specific T cells can be detected at high frequency by a sensitive flow cytometric analysis, and these cells are important for controlling HBV replication...
  22. ncbi request reprint Eosinophil degranulation in the presence of lung fibroblasts
    S Takafuji
    Department of Medicine and Physical Therapy, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Int Arch Allergy Immunol 117:52-4. 1998
    ..In this study, we have examined eosinophil cationic protein (ECP) release from human Eos cultured in the presence of human lung Fb...
  23. ncbi request reprint Molecular identification of the antigens recognized by monoclonal antibody JT95 specific for thyroid carcinomas
    N Kimura
    Faculty of Engineering, Institute of Life Science, Soka University, 1 236 Tangi cho, Hachioji, Tokyo, 192 8577, Japan
    Biochem Biophys Res Commun 251:449-53. 1998
    ..These results show that MAb JT95 recognized a novel antigenic epitope on a glycochain carried by both fibronectin and by a ganglioside produced by thyroid carcinoma cells...
  24. pmc Expression of telomerase-associated protein 1 and telomerase reverse transcriptase in hepatocellular carcinoma
    N Toshikuni
    First Department of Internal Medicine, Okayama University Medical School, Okayama City, Japan
    Br J Cancer 82:833-7. 2000
    ..The present study revealed that hTERT is strongly expressed in most HCCs, and that hTERT but not hTEP1 is a key component regulating telomerase activity in human liver...
  25. ncbi request reprint Identification of genes upregulated in the inflamed colonic lesions of Crohn's disease
    K Hagiwara
    Department of Allergy and Rheumatology, University of Tokyo, Tokyo, 113-0033, Japan
    Biochem Biophys Res Commun 283:130-5. 2001
    ..In addition, this study provided evidence for a possible role of several previously unsuspected genes in the pathogenesis of CD...
  26. ncbi request reprint Prediction of midazolam-CYP3A inhibitors interaction in the human liver from in vivo/in vitro absorption, distribution, and metabolism data
    K Yamano
    Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Drug Metab Dispos 29:443-52. 2001
    ..6-fold increase in the plasma concentration of MDZ. The estimated extent of increase in MDZ concentration in our study correlated well with the observed value based on metabolic inhibition by EM from published results...
  27. ncbi request reprint Expression of ID family genes in the synovia from patients with rheumatoid arthritis
    D Sakurai
    Department of Human Genetics, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 284:436-42. 2001
    ..The expression of Id family genes in the synovium constitutes a new finding of particular interest. Their functional role as well as their contribution to the genetic susceptibility to RA requires further investigation...
  28. ncbi request reprint High diagnostic performance of ELISA detection of antibodies to citrullinated antigens in rheumatoid arthritis
    K Suzuki
    Department of Allergy and Rheumatology, University of Tokyo School of Medicine, Tokyo, Japan
    Scand J Rheumatol 32:197-204. 2003
    ..We investigated the rheumatoid arthritis (RA) diagnostic performances of anti-cyclic citrullinated peptide antibody (anti-CCP) and antifilaggrin antibody (AFA) in comparison with RF and matrix metalloproteinase-3 (MMP-3)...
  29. ncbi request reprint Regulation of chemokine receptor expression in eosinophils
    H Nagase
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 125:29-32. 2001
    ..The balance between the biological effects of these chemokine systems may affect the distribution and migration of eosinophils...
  30. ncbi request reprint Serovar, pathogenicity and antimicrobial susceptibility of erysipelothrix rhusiopathiae isolates from farmed wild boars (Sus scrofa) affected with septicemic erysipelas in Japan
    K Yamamoto
    National Veterinary Assay Laboratory, Tokyo, 185 8511, Japan
    Res Vet Sci 67:301-3. 1999
    ..All of the isolates were resistant to oxytetracycline and/or dihydrostreptomycin. These observations suggest that E. rhusiopathiae strains isolated from wild boars may have aetiological significance in swine erysipelas...
  31. ncbi request reprint T cell repertoire in primary biliary cirrhosis: a common T cell clone and repertoire change after treatment
    R Okamoto
    First Department of Internal Medicine, Okayama University Medical School, Japan
    J Clin Immunol 21:278-85. 2001
    ..The number of expanded T cell clones in PBL decreased markedly after the treatment with prednisolone. These results suggest that common T cell clones may play a pathogenic role in PBC...
  32. ncbi request reprint Molecular cloning of a novel type 1 cytokine receptor similar to the common gamma chain
    K Fujio
    Department of Hematopoietic Factors, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Blood 95:2204-10. 2000
    ..These results suggest that delta1 is a subunit of cytokine receptor that may be involved in multiple receptor systems and play a regulatory role in the immune system and hematopoiesis...
  33. ncbi request reprint Detection and quantification of human herpesvirus 6 genomes using bronchoalveolar lavage fluid in immunocompromised patients with interstitial pneumonia
    A Nagate
    First Department of Internal Medicine, Tokyo Medical University, Tokyo 113-8510, Japan
    Int J Mol Med 8:379-83. 2001
    ..Our results suggest that measurement of HHV-6 genomes in BALF using real-time PCR may be useful in management of the care of respiratory complications in immunocompromised patients...
  34. doi request reprint Gender difference in tooth autotransplantation with complete root formation: a retrospective survey
    K Yoshino
    Department of Epidemiology and Public Health, Tokyo Dental College, Chiba, Japan Members of Kyushikai, Kuroda Dental Clinic, Tokyo, Japan
    J Oral Rehabil 40:368-74. 2013
    ..These results indicate that males require more attention during the autotransplantation process, particularly at the stage of pre-operation evaluation and that of follow-up maintenance...
  35. ncbi request reprint Nuclear factor-kappa b activation in silica-induced interleukin 8 production by human bronchial epithelial cells
    M Desaki
    Department of Respiratory Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cytokine 12:1257-60. 2000
    ..These data suggest that reactive oxygen species may be involved in the activation of NF-kappaB induced by silica...
  36. ncbi request reprint Influence of antibiotics used as feed additives on the immune effect of erysipelas live vaccine in swine
    K Yamamoto
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Tokyo, Japan
    J Vet Med B Infect Dis Vet Public Health 47:453-60. 2000
    ..Therefore, the present results suggest that these selected antibiotics would not interfere with the immune effect of the vaccine if given at the usual concentrations used for feed additives...
  37. ncbi request reprint A physical origin for functional domain structure in nucleic acids as evidenced by cross-linking entropy: II
    W Dawson
    Department of Bioactive Molecules, National Institute of Infectious Diseases, 1 23 1 Toyama, Shinjuku ku, Tokyo, 162 8640, Japan
    J Theor Biol 213:387-412. 2001
    ..A two-state kinetic model based on the CLE principle is used to help elucidate the folding kinetics of functional domains in the group I introns...
  38. ncbi request reprint Taxonomic evidence that serovar 7 of Erysipelothrix strains isolated from dogs with endocarditis are Erysipelothrix tonsillarum
    T Takahasi
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Tokyo, Japan
    J Vet Med B Infect Dis Vet Public Health 47:311-3. 2000
    ..tonsillarum. These results strongly indicate that some strains of genomic E. tonsillarum are a canine pathogen...
  39. ncbi request reprint Structure-function analysis of vitamin D and VDR model
    S Yamada
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2 3 10 Kanda surugadai, Chiyoda ku, Tokyo, 101 0062, Japan
    Curr Pharm Des 6:733-48. 2000
    ..This VDR-LBD/1,25-(OH)2D3 docking model was firmly substantiated by mutation analysis. Using this VDR model, the structure-function relationship of highly potent vitamin D analogs was discussed...
  40. ncbi request reprint Bloody cerebrospinal fluid from patients with subarachnoid hemorrhage alters intracellular calcium regulation in cultured human vascular endothelial cells
    K Nakagawa
    Department of Neurosurgery, Tokyo Medical and Dental University, Japan
    Neurol Res 22:588-96. 2000
    ..It is concluded that bCSF collected from SAH patients contains some substances which enhance endothelial cell proliferation and sensitivity to inflammatory mediator...
  41. ncbi request reprint Interaction of microcrystalline cellulose and water in granules prepared by a high-shear mixer
    T Suzuki
    Pharmaceutical Technology Research Laboratories, Daiichi Pharmaceutical Co, Ltd, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 49:373-8. 2001
    ..It was suggested that MCC formed a network which caught water within its structure during the wet granulation process...
  42. ncbi request reprint Peptidylarginine deiminase 4 (PADI4) identified as a conformation-dependent autoantigen in rheumatoid arthritis
    Y Takizawa
    Department of Allergy and Rheumatology, University of Tokyo School of Medicine, Tokyo, Japan
    Scand J Rheumatol 34:212-5. 2005
    ..The PADI4 gene has recently been identified as a risk factor for RA. We aimed to determine whether PADI4 constitutes an autoantigen in RA...
  43. ncbi request reprint Gene-transferred oligoclonal T cells predominantly persist in peripheral blood from an adenosine deaminase-deficient patient during gene therapy
    Y Misaki
    Department of Allergy and Rheumatology, Graduate School of Medicine, Tokyo, 113 8655, Japan
    Mol Ther 3:24-7. 2001
    ....
  44. ncbi request reprint Frequent rearrangements of retinoic acid receptor alpha gene and myl gene, and rare mutations of RAS and FMS genes in acute promyelocytic leukemia
    K Yamamoto
    First Department of Medicine, Tokyo Medical and Dental University, Japan
    Am J Hematol 40:252-8. 1992
    ..It may be suggested that leukemogenesis of APL is different from other subtypes of acute myelogenous leukemia, and multistep leukemogenesis may not be a prevalent feature in APL...
  45. ncbi request reprint Present status of anticoagulation treatment in Japanese patients with atrial fibrillation: a report from the J-RHYTHM Registry
    Hirotsugu Atarashi
    Department of Internal Medicine, Nippon Medical School Tama Nagayama Hospital, Tokyo, Japan
    Circ J 75:1328-33. 2011
    ..Underuse and an inadequate range for the international normalized ratio (INR) for warfarin use are still problems in the management of the patients with atrial fibrillation (AF) in Japan...
  46. doi request reprint Subacute cerebellar ataxia and atrophy developed in a young woman with systemic lupus erythematosus whose cerebrospinal fluid was positive for antineuronal cell antibody
    Y Iwasaki
    Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Lupus 21:324-8. 2012
    ..The cerebellar ataxia improved markedly following high-dose corticosteroid administration. This suggests that a relationship exists between autoantibodies and subacute atrophic processes in CNS lupus...
  47. ncbi request reprint Good correlation between cerebral oxygenation measured using near infrared spectroscopy and stump pressure during carotid clamping
    K Yamamoto
    Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Int Angiol 26:262-5. 2007
    ..The aim of this study was to determine criteria that can be used to insert shunt tubes...
  48. ncbi request reprint Expression of protein S in the murine heart and cultured mouse cardiomyocytes is down-regulated by cytokines
    T Shimokawa
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Thromb Haemost 86:623-9. 2001
    ....
  49. ncbi request reprint Involvement of disregulated c-myc but not c-sis/PDGF in atypical and anaplastic meningiomas
    G Nagashima
    Department of Neurosurgery, Tokyo Medical and Dental University, Tokyo, Japan
    Clin Neurol Neurosurg 103:13-8. 2001
    ..Our findings suggest that c-myc, but not c-sis/PDGF, has some concern to the malignancy of meningiomas...
  50. ncbi request reprint Antimicrobial susceptibilities of Erysipelothrix rhusiopathiae isolated from pigs with swine erysipelas in Japan, 1988-1998
    K Yamamoto
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, 1 15 1, Tokura, Kokubunji, Tokyo, 185 8511, Japan
    J Vet Med B Infect Dis Vet Public Health 48:115-26. 2001
    ..It was suggested that the strains resistant to dihydrostreptomycin and oxytetracycline were distributed over almost all districts of Japan...
  51. ncbi request reprint Inhibition of L-leucine methyl ester mediated killing of THP-1, a human monocytic cell line, by a new anti-inflammatory drug, T614
    T Sawada
    Department of Allergy and Rheumatology, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo, 113, Tokyo, Japan
    Immunopharmacology 49:285-94. 2000
    ..Based on the similarity of T614 and PMSF, we suggest that, besides their roles as COX-2 inhibitors, T614 and other mNSAIDs may act as lysosomal protease inhibitors...
  52. ncbi request reprint Variations in the human CC chemokine eotaxin gene
    M Miyamasu
    Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Genes Immun 2:461-3. 2001
    ..Significant linkage disequilibrium was observed between positions -426 and -384, and also between -384 and +67. No significant association was observed between these variations and susceptibility to asthma...
  53. ncbi request reprint Expression of transforming growth factor-beta and tumor necrosis factor-alpha in the plasma and tissues of mice with lupus nephritis
    K Yamamoto
    First Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Lab Invest 80:1561-70. 2000
    ..The fact that TGF-beta is specifically induced in the kidney whereas TNF-alpha increases in a variety of tissues, supports the hypothesis that the renal specificity of this disorder reflects the abnormal expression of TGF-beta...
  54. ncbi request reprint Inhibitory effect of baicalein, a flavonoid in Scutellaria Root, on eotaxin production by human dermal fibroblasts
    T Nakajima
    Department of Bioregulatory Function, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Planta Med 67:132-5. 2001
    ..These results help explain the pharmacological efficacy of Scutellaria Root in the treatment of bronchial asthma since it would suppress eotaxin associated recruitment of eosinophils...
  55. ncbi request reprint Inhibitory effect of sulphur-containing purine nucleoside analogues on replication of RNA viruses: selective antiviral activity against influenza viruses
    K Yamamoto
    Department of Virology and Rickettsiology, National Institute of Health, Tokyo, Japan
    Acta Virol 32:386-92. 1988
    ..All compounds extensively inhibited the replication of influenza viruses but had no inhibitory effect on other RNA viruses: Sendai, RS, vesicular stomatitis and western equine encephalitis viruses...
  56. ncbi request reprint Influence of various hemodialysis membranes on the plasma (1-->3)-beta-D-glucan level
    H Kanda
    Department of Internal Medicine, University of Tokyo, Tokyo, Japan
    Kidney Int 60:319-23. 2001
    ..In this study, we analyzed the alteration of the plasma (1-->3)-beta-D-glucan concentration by using different kinds of hemodialysis (HD) membranes in end-stage renal disease (ESRD) patients and estimated its half-life...
  57. ncbi request reprint (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assays showed a lack of toxicity of ganciclovir (GCV), C.OXTs, and their derivatives, to TaY(OK) cells at 1 microM. Therefore we compared the antiviral potencies of these drugs at 1 microM by
    P Wang
    Department of Virology, Medical Research Institute, Tokyo Medical and Dental University, Japan
    Microbiol Immunol 45:457-66. 2001
    ..oxts)...
  58. ncbi request reprint Cloning of bullfrog thyroid-stimulating hormone (TSH) beta subunit cDNA: expression of TSHbeta mRNA during metamorphosis
    R Okada
    Department of Biology, School of Education, Waseda University, Nishi waseda 1 6 1, Shinjuku ku, Tokyo, 169 8050, Japan
    Gen Comp Endocrinol 119:224-31. 2000
    ..These results, together with previously obtained data on plasma prolactin and pituitary prolactin mRNA levels, as well as thyroid hormone levels, are discussed in relation to metamorphic changes occurring in the bullfrog larvae...
  59. ncbi request reprint Risk factors and prophylactic tenosynovectomy for extensor tendon ruptures in the rheumatoid hand
    J Ryu
    Department of Orthopaedic Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Hand Surg Br 23:658-61. 1998
    ..Prophylactic surgery effectively prevented rupture of the tendons in patients who had two or more risk factors for extensor tendon rupture...
  60. ncbi request reprint Ligand recognition by the vitamin D receptor
    M Choi
    Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10, Surugadai Kanda, Chiyoda-ku, Tokyo 101-0062, Japan
    Bioorg Med Chem 9:1721-30. 2001
    ..Furthermore, the docking models coincided well with our proposed active space-region theory of vitamin D based on the conformational analyses of ligands...
  61. ncbi request reprint Characterization of carbohydrate-binding protein p33/41: relation with annexin IV, molecular basis of the doublet forms (p33 and p41), and modulation of the carbohydrate binding activity by phospholipids
    K Kojima
    Department of Chemistry, Faculty of Science, Ochanomizu University, Otsuka, Bunkyo ku, Tokyo, Japan
    J Biol Chem 271:7679-85. 1996
    ..These results suggest that p33/41 binds two types of ligands via different sites and that phospholipids modulate the carbohydrate binding activity of p33/41...
  62. ncbi request reprint A rapid monitoring system of human herpesviruses reactivation by LightCycler in stem cell transplantation
    K Aritaki
    Department of Pediatrics, Tokyo Medical University, Tokyo, Japan
    Bone Marrow Transplant 28:975-80. 2001
    ..Therefore, it may contribute in clarifying the pathological potential of human herpesviruses using a large number of clinical samples. Our results suggest that this system may be useful for monitoring viral reactivation...
  63. ncbi request reprint Impact of drug alteration to maintain rhythm control in paroxysmal atrial fibrillation. - Subanalysis from J-RHYTHM study -
    Ayaka Endo
    Keio University School of Medicine, Tokyo, Japan
    Circ J 74:870-5. 2010
    ..The aim was to describe how antiarrhythmics (AAs) were altered in the rhythm control arm and whether altering AAs would impact long-term outcomes...
  64. ncbi request reprint Deletion of 16q11 is a recurrent cytogenetic aberration in acute myeloblastic leukemia during disease progression
    K Yamamoto
    Department of Hematology, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, Musashino, 180-8610, Tokyo, Japan
    Cancer Genet Cytogenet 131:65-8. 2001
    ..Our results, together with three previously reported cases, suggest that del(16)(q11) may be one of the recurrent aberrations in AML and that it could be associated with clonal evolution or disease progression...
  65. ncbi request reprint Activation of basophils by stem cell factor: comparison with insulin-like growth factor-I
    R Koketsu
    Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Investig Allergol Clin Immunol 18:293-9. 2008
    ..Basophils are an active participant in the pathogenesis of local inflammation in allergic diseases such as asthma, but it is not fully known how basophil activation is regulated in inflamed tissue...
  66. pmc Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated
    F X Farrell
    Division of Cell Biology, Burroughs Wellcome Co, Research Triangle Park, NC 27709
    Biochem J 289:349-55. 1993
    ..Thus rap2a and rap2b, despite showing 90% sequence identity, incorporate different isoprenoid groups. Thus glutamine is a signal for farnesylation, and rap2a is the first non-ras member of the ras superfamily that is farnesylated...
  67. ncbi request reprint Selective apoptosis of tandemly duplicated FLT3-transformed leukemia cells by Hsp90 inhibitors
    Y Minami
    Department of Infectious Diseases, Nagoya University School of Medicine, Nagoya, Japan
    Leukemia 16:1535-40. 2002
    ..These findings imply that targeting of Hsp90 will facilitate the development of anti-TDFLT3 therapy, and that Hsp90 is closely involved in the oncogenic activation of FLT3...
  68. ncbi request reprint Heat shock protein 27 was up-regulated in cisplatin resistant human ovarian tumor cell line and associated with the cisplatin resistance
    K Yamamoto
    Food and Pharmaceutical Research and Development Laboratories, Asahi Breweries, Ltd, 1-1-21 Midori Moriya-machi Kitasoma-gun, 302-0106, Ibaraki, Japan
    Cancer Lett 168:173-81. 2001
    ..Further, transient transfection with the HSP27 sense gene made the sensitive cell more resistant, while transient transfection with the antisense gene made it more sensitive...
  69. pmc GATA3 abnormalities and the phenotypic spectrum of HDR syndrome
    K Muroya
    Department of Paediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Med Genet 38:374-80. 2001
    ..The triad of HDR syndrome was variably manifested by patients with GATA3 abnormalities. The results suggest that HDR syndrome is primarily caused by GATA3 haploinsufficiency and is associated with a wide phenotypic spectrum...
  70. ncbi request reprint Clinical significance of TAL1 gene alteration in childhood T-cell acute lymphoblastic leukemia and lymphoma
    A Kikuchi
    Division of Hematology Oncology, Saitama Children s Medical Center, Japan
    Leukemia 7:933-8. 1993
    ..We conclude that tald rearrangement is restricted to T-cell ALL, for which it provides a useful clonal marker. Such patients with this rearrangement may constitute a subgroup of T-cell ALL with a good prognosis...
  71. ncbi request reprint Molecular cloning of a novel actin-binding protein, p57, with a WD repeat and a leucine zipper motif
    K Suzuki
    Pharmaceutical Basic Research Laboratories, Japan Tobacco Inc, Kanagawa
    FEBS Lett 364:283-8. 1995
    ..From these results, we conclude that p57 is a coronin-like novel actin-binding protein in mammalian cells but may also have a different function from coronin...
  72. doi request reprint Onecut transcription factor OC2 is a direct target of T-bet in type-1 T-helper cells
    K Furuno
    Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Genes Immun 9:302-8. 2008
    ..These results suggest that not only cell-extrinsic regulation via the IFN-gamma/STAT1 pathway, but also cell-intrinsic transcriptional positive feedback loop between T-bet and OC2 could be involved in Th1 development...
  73. ncbi request reprint Chicken pineal clock genes: implication of BMAL2 as a bidirectional regulator in circadian clock oscillation
    T Okano
    Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Genes Cells 6:825-36. 2001
    ..The chicken pineal gland represents a photosensitive clock tissue, but the pineal clock genes constituting the oscillator loop have been less well characterized...
  74. ncbi request reprint Characterization of the promoter region of the human c-kit proto-oncogene
    K Yamamoto
    Department of Genetics, University of Tokyo
    Jpn J Cancer Res 84:1136-44. 1993
    ..In addition, a negative regulatory element(s) is suggested to be involved in the regulation of the c-kit gene expression in mammals...
  75. ncbi request reprint Amplified UvrA protein can ameliorate the ultraviolet sensitivity of an Escherichia coli recA mutant
    K Kiyosawa
    Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai 980-8578, Japan
    Mutat Res 487:149-56. 2001
    ....
  76. ncbi request reprint Functional expression of a chimeric myosin-containing motor domain of Chara myosin and neck and tail domains of Dictyostelium myosin II
    T Kashiyama
    Department of Biology, Chiba University, Chiba, Inage-ku, 263-8522, Japan
    J Mol Biol 311:461-6. 2001
    ..It was suggested, therefore, that the motor domain of Chara myosin has the potential for performing fast sliding movement...
  77. ncbi request reprint Effect of carbohydrate structure on biological activity of artificially N-glycosylated eel calcitonin
    M Tagashira
    Analytical Research Laboratory, Asahi Kasei Corporation, Fuji, Shizuoka 416-8501, Japan
    Glycoconj J 18:449-55. 2001
    ..Thus, the glycosylation was shown to modulate the biological activity of calcitonin depending on the carbohydrate structure without a change in the peptide backbone conformation...
  78. pmc Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation
    K Yamamoto
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105
    Mol Cell Biol 14:4342-9. 1994
    ..Nor is Stat4 activated in myeloid cells by a number of cytokines, including erythropoietin, IL-3, granulocyte colony-stimulating factor, stem cell factor, colon-stimulating factor 1, hepatocyte growth factor, IL-2, IL-4, and IL-6...
  79. ncbi request reprint A novel secreted tumor antigen with a glycosylphosphatidylinositol-anchored structure ubiquitously expressed in human cancers
    H Onda
    Discovery Research Laboratories I, Pharmaceutical Research Division, Takeda Chemical Industries, Ltd, 10 Wadai Tsukuba, Ibaraki 300 4293, Japan
    Biochem Biophys Res Commun 285:235-43. 2001
    ..Mutational analysis of ALCAN suggested that the GPI-anchored position was the Ser(216) residue. These findings indicate that ALCAN may be a potential target for cancer diagnosis or therapy...
  80. ncbi request reprint cDNA cloning of nine S alleles and establishment of a PCR-RFLP system for genotyping European pear cultivars
    T Takasaki
    Faculty of Agriculture, Kobe University, Kobe 657 8501, Japan
    Theor Appl Genet 112:1543-52. 2006
    ..These results suggested that the genes cloned represented the S-RNases from European pear, and that there were many cross-incompatible combinations among European pear varieties...
  81. ncbi request reprint Identification of the catalytic residues of bifunctional glycogen debranching enzyme
    A Nakayama
    Nara Prefectural Hospital, Hiramatsu, Nara City, Nara 631-0846, Japan
    J Biol Chem 276:28824-8. 2001
    ..These results strongly indicate that the two activities of GDE, transferase and glucosidase, are independent and located at different sites on the polypeptide chain...
  82. ncbi request reprint Cloning and expression of a murine cDNA homologous to the human RCK/P54, a lymphoma-linked chromosomal translocation junction gene on 11q23
    M Seto
    Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya, Japan
    Gene 166:293-6. 1995
    ..Northern analysis demonstrated a 7.5-kb signal in all tissues tested and in vitro translation analysis showed a 54-kDa polypeptide. These results indicate that both mouse and human RCK/P54 are highly conserved...
  83. ncbi request reprint Expression of prophenoloxidase mRNA during silkworm hemocyte development
    K Yamamoto
    Laboratory of Protein Chemistry and Engineering, Kyushu University Graduate School of Bioresource and Bioenvironmental Sciences, Fukuoka, Japan
    Biosci Biotechnol Biochem 64:1197-202. 2000
    ..A sexual difference was also observed when the content of prophenoloxidase protein in the hemolymph (including hemocytes) was measured by an enzyme-linked immunosorbent assay...
  84. ncbi request reprint Subunit association of gamma-glutamyltranspeptidase of Escherichia coli K-12
    W Hashimoto
    Department of Food Science and Technology, Kyoto University
    J Biochem 118:1216-23. 1995
    ....
  85. ncbi request reprint G-protein coupled receptor from yeast Saccharomyces cerevisiae
    C W Yun
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan
    Biochem Biophys Res Commun 240:287-92. 1997
    ..It is likely that a Gpr1p monitors the extracellular signal such as nutrition and transduce it via Gpa2p a possible positive regulator of cAMP level...
  86. ncbi request reprint Molecular cloning and bacterial expression of a cDNA encoding furostanol glycoside 26-O-beta-glucosidase of Costus speciosus
    K Inoue
    Department of Pharmacognosy and Phytochemistry, Faculty of Pharmaceutical Sciences, The University of Tokyo, Japan
    FEBS Lett 389:273-7. 1996
    ..Cell-free homogenate of Escherichia coli expressing CSF26G1 cDNA showed beta-glucosidase activity specific for cleavage of the C-26 glucosidic bond of furostanol glycosides...
  87. ncbi request reprint Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues
    M Yamamoto
    Department of Neurology, Nagoya University School of Medicine, Japan
    Neurochem Res 21:929-38. 1996
    ....
  88. ncbi request reprint Transcript map of the human chromosome 4p16.3 consisting of 627 cDNA clones derived from 1 Mb of the Huntington's disease locus
    S Hadano
    NeuroGenes, International Research Exchange Project, Research Development Corporation of Japan JRDC, Tokai University School of Medicine, Kanagawa, Japan
    DNA Res 3:239-55. 1996
    ..This collection of cDNA clones will greatly facilitate the construction of the complete map of the transcripts in the HD region...
  89. ncbi request reprint A novel Jun N-terminal kinase (JNK)-binding protein that enhances the activation of JNK by MEK kinase 1 and TGF-beta-activated kinase 1
    S Koyano
    Department of Biosciences, School of Science, Kitasato University, 1 15 1 Kitasato, Kanagawa, Japan
    FEBS Lett 457:385-8. 1999
    ..In contrast, JNKBP1 had no or very little effect on the ERK signaling pathway. These results suggest that JNKBP1 functions to facilitate the specific and efficient activation of the JNK signaling pathways...
  90. pmc Fyn and Lck tyrosine kinases regulate tyrosine phosphorylation of p105CasL, a member of the p130Cas docking protein family, in T-cell receptor-mediated signalling
    H Kanda
    The Third Department of Internal Medicine, University of Tokyo, Japan
    Immunology 97:56-61. 1999
    ..Constitutive in vivo binding of CasL to both kinases was also demonstrated in lpr splenocytes. These results strongly suggest that CasL is a substrate for Fyn and Lck PTKs in TCR signal transduction...
  91. ncbi request reprint Protein interaction cloning in yeast of the mouse third largest RNA polymerase II subunit, mRPB31
    I V Korobko
    Department of Biochemistry, Saitama Medical School, Moroyama, Iruma gun, Japan
    Gene 185:1-4. 1997
    ..Indeed, in the yeast two-hybrid system, mRPB31 was shown to fail to form homodimer...
  92. ncbi request reprint Molecular cloning of a rat 49-kDa TBP-interacting protein (TIP49) that is highly homologous to the bacterial RuvB
    M Kanemaki
    Department of Biology, Faculty of Science, Chiba University, Inage Ku, Japan
    Biochem Biophys Res Commun 235:64-8. 1997
    ..These findings suggest that TIP49 is a putative ATP-dependent DNA helicase...
  93. ncbi request reprint Cloning and characterization of a mouse homologue (mNthl1) of Escherichia coli endonuclease III
    A H Sarker
    Institute of Cellular and Molecular Biology, Okayama University Medical School, Okayama 700 8558, Japan
    J Mol Biol 282:761-74. 1998
    ..The mNthl1 gene was shown to lie immediately adjacent to the tuberous sclerosis 2 (Tsc2) gene in a 5'-to-5' orientation by sequence analysis and was assigned to chromosome 17A3 by in situ hybridization...
  94. ncbi request reprint Chimeric MLL products with a Ras binding cytoplasmic protein AF6 involved in t(6;11) (q27;q23) leukemia localize in the nucleus
    T Joh
    Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, Nagoya, Japan
    Oncogene 15:1681-7. 1997
    ..The region in the N-terminal portion of MLL responsible for this nuclear localization was examined and found to be a region containing AT-hook motifs...
  95. pmc Cloning and characterization of a gene (UVR3) required for photorepair of 6-4 photoproducts in Arabidopsis thaliana
    S Nakajima
    Biological Institute, Graduate School of Science, Tohoku University, Sendai 980 77, Japan
    Nucleic Acids Res 26:638-44. 1998
    ....
  96. pmc Genetic characterization of DNA region containing the trh and ure genes of Vibrio parahaemolyticus
    K S Park
    Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565 0871, Japan
    Infect Immun 68:5742-8. 2000
    ....
  97. ncbi request reprint Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
    W E Thierfelder
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 382:171-4. 1996
    ..However, all IL-12 functions tested were disrupted, including the induction of IFN-gamma, mitogenesis, enhancement of natural killer cytolytic function and Th1 differentiation...
  98. ncbi request reprint A novel gene, CRR9, which was up-regulated in CDDP-resistant ovarian tumor cell line, was associated with apoptosis
    K Yamamoto
    Food and Pharmaceutical Research, Development Laboratories, Asahi Breweries, Ltd, 1 1 21 Midori, Moriya machi, Kitasoma gun, Ibaraki, 302 0106, Japan
    Biochem Biophys Res Commun 280:1148-54. 2001
    ..elegans. Transfection assay showed that the CDDP-sensitive strain 2008 with CRR9 was more sensitive to CDDP, indicating that CRR9 was not associated with the CDDP-resistance, but the CDDP-induced apoptosis...
  99. ncbi request reprint Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, STAT3, and AKT in endothelial cells
    H Nakagami
    Department of Geriatric Medicine, Division of Gene Therapy Science, Osaka University, Osaka, Japan
    Hypertension 37:581-6. 2001
    ..These findings provide new perspectives in the role of HGF in cardiovascular disease...
  100. ncbi request reprint Cell cycle-dependent expression of the mouse Rad51 gene in proliferating cells
    A Yamamoto
    Department of Molecular Embryology, Research Institute of Microbial Diseases, Osaka, Japan
    Mol Gen Genet 251:1-12. 1996
    ..Thus, mouse Rad51 expression is closely related to the state of cell proliferation and is presumably involved in DNA repair coupled with DNA replication, as well as in meiotic DNA recombination in spermatocytes...
  101. pmc Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue-type plasminogen activator
    K Yamamoto
    Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Clin Invest 97:2440-51. 1996
    ..Changes in tissue-type plasminogen activator gene expression do not appear to be essential for fibrin deposition/dissolution in this murine model of sepsis...