- Yamada O, Ozaki K, Furukawa T, Machida M, Wang Y, Motoji T, et al. Activation of STAT5 confers imatinib resistance on leukemic cells through the transcription of TERT and MDR1. Cell Signal. 2011;23:1119-27 pubmed publisher..Together, these findings indicate a novel mechanism that contributes toward multidrug resistance involving STAT5 as a sensor for cytotoxic drugs in CML patients. ..
- Mitsuishi T, Iwabu Y, Tokunaga K, Sata T, Kaneko T, Ohara K, et al. Combined analysis of cell growth and apoptosis-regulating proteins in HPVs associated anogenital tumors. BMC Cancer. 2010;10:118 pubmed publisher..Here we evaluated molecules that are relevant to cellular proliferation and regulation of apoptosis in HPV associated anogenital tumors...
- Yamada O, Ozaki K, Nakatake M, Akiyama M, Kawauchi K, Matsuoka R. Multistep regulation of telomerase during differentiation of HL60 cells. J Leukoc Biol. 2008;83:1240-8 pubmed publisher..These results indicate that telomerase activity is regulated by at least two mechanisms during granulocytic and monocytic differentiation, with one mechanism being transcriptional and the other being post-translational. ..
- Yamada O, Ozaki K, Akiyama M, Kawauchi K. JAK-STAT and JAK-PI3K-mTORC1 pathways regulate telomerase transcriptionally and posttranslationally in ATL cells. Mol Cancer Ther. 2012;11:1112-21 pubmed publisher..These signaling proteins represent novel and promising molecular therapeutic targets for IL-2-dependent ATL. ..