O Yamada

Summary

Affiliation: Tokyo Women's Medical University
Country: Japan

Publications

  1. doi JAK-STAT and JAK-PI3K-mTORC1 pathways regulate telomerase transcriptionally and posttranslationally in ATL cells
    Osamu Yamada
    Medical Research Institute and Department of Hematology, Tokyo Women s Medical University, Tokyo, Japan
    Mol Cancer Ther 11:1112-21. 2012
  2. pmc Combined analysis of cell growth and apoptosis-regulating proteins in HPVs associated anogenital tumors
    Tsuyoshi Mitsuishi
    Department of Dermatology, Nippon Medical School, 1 1 5 Sendagi, Bunkyou ku, Tokyo, 113 8603, Japan
    BMC Cancer 10:118. 2010
  3. doi Activation of STAT5 confers imatinib resistance on leukemic cells through the transcription of TERT and MDR1
    Osamu Yamada
    Department of Hematology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, Japan
    Cell Signal 23:1119-27. 2011
  4. doi Akt and PKC are involved not only in upregulation of telomerase activity but also in cell differentiation-related function via mTORC2 in leukemia cells
    Osamu Yamada
    Department of Hematology, Medical Research Institute, Tokyo Women s Medical University, Tokyo, Japan
    Histochem Cell Biol 134:555-63. 2010
  5. doi Leukemic cells with increased telomerase activity exhibit resistance to imatinib
    Osamu Yamada
    Department of Hematology, Tokyo Women s Medical University, Tokyo, Japan
    Leuk Lymphoma 49:1168-77. 2008
  6. doi Multistep regulation of telomerase during differentiation of HL60 cells
    Osamu Yamada
    Department of Hematology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    J Leukoc Biol 83:1240-8. 2008
  7. ncbi Overexpression of telomerase confers a survival advantage through suppression of TRF1 gene expression while maintaining differentiation characteristics in K562 cells
    Osamu Yamada
    Medical Research Institute and Department of Hematology, Tokyo Women s Medical University, Japan
    Cell Transplant 12:365-77. 2003
  8. ncbi Killer T-cell induction in patients with blastic natural killer cell lymphoma/leukaemia: implications for successful treatment and possible therapeutic strategies
    O Yamada
    Department of Haematology, Tokyo Women s Medical University, Japan
    Br J Haematol 113:153-60. 2001
  9. ncbi Establishment of a stable HL60 subline having the potential for monocytic differentiation using granulocyte-macrophage colony-stimulating factor: possible use for the study of monocytic differentiation and oxidative stress
    M Ujihara
    Institute of Clinical Endocrinology, Department of Medicine, Tokyo Women s Medical University, Japan
    Atherosclerosis 139:301-6. 1998
  10. ncbi Clinical and cytogenetic remission induced by interferon-alpha in a patient with chronic eosinophilic leukemia associated with a unique t(3;9;5) translocation
    O Yamada
    Department of Hematology, Tokyo Women s Medical College, Japan
    Am J Hematol 58:137-41. 1998

Collaborators

Detail Information

Publications17

  1. doi JAK-STAT and JAK-PI3K-mTORC1 pathways regulate telomerase transcriptionally and posttranslationally in ATL cells
    Osamu Yamada
    Medical Research Institute and Department of Hematology, Tokyo Women s Medical University, Tokyo, Japan
    Mol Cancer Ther 11:1112-21. 2012
    ..These signaling proteins represent novel and promising molecular therapeutic targets for IL-2-dependent ATL...
  2. pmc Combined analysis of cell growth and apoptosis-regulating proteins in HPVs associated anogenital tumors
    Tsuyoshi Mitsuishi
    Department of Dermatology, Nippon Medical School, 1 1 5 Sendagi, Bunkyou ku, Tokyo, 113 8603, Japan
    BMC Cancer 10:118. 2010
    ..Here we evaluated molecules that are relevant to cellular proliferation and regulation of apoptosis in HPV associated anogenital tumors...
  3. doi Activation of STAT5 confers imatinib resistance on leukemic cells through the transcription of TERT and MDR1
    Osamu Yamada
    Department of Hematology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo, Japan
    Cell Signal 23:1119-27. 2011
    ..Together, these findings indicate a novel mechanism that contributes toward multidrug resistance involving STAT5 as a sensor for cytotoxic drugs in CML patients...
  4. doi Akt and PKC are involved not only in upregulation of telomerase activity but also in cell differentiation-related function via mTORC2 in leukemia cells
    Osamu Yamada
    Department of Hematology, Medical Research Institute, Tokyo Women s Medical University, Tokyo, Japan
    Histochem Cell Biol 134:555-63. 2010
    ....
  5. doi Leukemic cells with increased telomerase activity exhibit resistance to imatinib
    Osamu Yamada
    Department of Hematology, Tokyo Women s Medical University, Tokyo, Japan
    Leuk Lymphoma 49:1168-77. 2008
    ....
  6. doi Multistep regulation of telomerase during differentiation of HL60 cells
    Osamu Yamada
    Department of Hematology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    J Leukoc Biol 83:1240-8. 2008
    ..These results indicate that telomerase activity is regulated by at least two mechanisms during granulocytic and monocytic differentiation, with one mechanism being transcriptional and the other being post-translational...
  7. ncbi Overexpression of telomerase confers a survival advantage through suppression of TRF1 gene expression while maintaining differentiation characteristics in K562 cells
    Osamu Yamada
    Medical Research Institute and Department of Hematology, Tokyo Women s Medical University, Japan
    Cell Transplant 12:365-77. 2003
    ..These data suggest that ectopic expression of hTERT by normal hematopoietic stem cells may confer a survival advantage without changing their innate biological characteristics...
  8. ncbi Killer T-cell induction in patients with blastic natural killer cell lymphoma/leukaemia: implications for successful treatment and possible therapeutic strategies
    O Yamada
    Department of Haematology, Tokyo Women s Medical University, Japan
    Br J Haematol 113:153-60. 2001
    ....
  9. ncbi Establishment of a stable HL60 subline having the potential for monocytic differentiation using granulocyte-macrophage colony-stimulating factor: possible use for the study of monocytic differentiation and oxidative stress
    M Ujihara
    Institute of Clinical Endocrinology, Department of Medicine, Tokyo Women s Medical University, Japan
    Atherosclerosis 139:301-6. 1998
    ..HL60/DU-1 cell line is a promising model for the study of monocytic differentiation and the effects of oxygen radicals...
  10. ncbi Clinical and cytogenetic remission induced by interferon-alpha in a patient with chronic eosinophilic leukemia associated with a unique t(3;9;5) translocation
    O Yamada
    Department of Hematology, Tokyo Women s Medical College, Japan
    Am J Hematol 58:137-41. 1998
    ....
  11. ncbi Granulocyte-macrophage colony-stimulating factor ensures macrophage survival and generation of the superoxide anion: a study using a monocytic-differentiated HL60 subline
    M Ujihara
    Department of Medicine, Institute of Clinical Endocrinology, Tokyo, Japan
    Free Radic Biol Med 31:1396-404. 2001
    ..This unique function may play an important role in ensuring survival and promoting function in atherosclerotic lesions...
  12. ncbi Selective effect of cyclosporine monotherapy for pure red cell aplasia not associated with granular lymphocyte-proliferative disorders
    O Yamada
    Department of Haematology, Tokyo Women s Medical College, Tokyo, Japan
    Br J Haematol 106:371-6. 1999
    ..An examination of the lymphocytes in patients with pure red cell aplasia could potentially be used to plan better therapeutic modalities and assess prognosis...
  13. ncbi Granzyme-B-containing lymphocyte involvement in epidermal injury in graft-versus-host disease
    Y Higaki
    Department of Dermatology, Tokyo Women s Medical University, Tokyo, Japan
    Dermatology 202:94-8. 2001
    ..Skin lesions from graft-versus-host disease (GVHD) show histological features of epidermal cell death with lymphocyte infiltration. Perforin and granzyme B are involved in the process of apoptosis induced by cytotoxic T lymphocytes (CTL)...
  14. ncbi Transient posttranslational up-regulation of telomerase activity during megakaryocytic differentiation of K562 cells
    M Nakatake
    Department of Biology, Faculty of Science, Ochanomizu University, Japan
    Biochem Biophys Res Commun 314:1080-5. 2004
    ..These results suggest that PKC acts as a transient post-translational activator of telomerase during megakaryocytic differentiation...
  15. ncbi Identification and cornification-related gene expression of canine keratinocyte differentiation-associated protein, Kdap
    H Yagihara
    Department of Veterinary Clinical Pathology, Nippon Veterinary and Animal Science University, 1 7 1 Kyonan cho, Musashino shi, Tokyo 180 8602, Japan
    Vet J 172:141-6. 2006
    ....
  16. ncbi Cell cycle analysis and expression of cell cycle regulator genes in myeloma cells overexpressing cyclin D1
    K Yata
    Division of Haematology, Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan
    Br J Haematol 114:591-9. 2001
    ....
  17. ncbi A three-dimensional cell culture model for bovine endometrium: regeneration of a multicellular spheroid using ascorbate
    N Yamauchi
    Laboratory of Reproductive Biology and Technology, Department of Developmental Biology, National Institute of Agrobiological Sciences, Ikenodai 2, Kukizaki, Inashiki Gun, Ibaraki 305 8602, Japan
    Placenta 24:258-69. 2003
    ..The spheroid displays an endometrium-mimic feature. Thus, we conclude that spheroids formed by BES and BEE are a useful in vitro model of bovine endometrium...