H Watanabe

Summary

Affiliation: Tokyo Medical and Dental University
Country: Japan

Publications

  1. ncbi request reprint Prediction of functional recovery in patients with myocardial infarction after revascularization--comparison of low-dose dobutamine stress echocardiography with fluorine-18 fluorodeoxyglucose positron emission tomography
    T Tani
    First Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Jpn Circ J 65:177-81. 2001
  2. ncbi request reprint Molecular diagnosis of hypophosphatasia with severe periodontitis
    H Watanabe
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University, Japan
    J Periodontol 70:688-91. 1999
  3. ncbi request reprint A novel point mutation (C571T) in the tissue-non-specific alkaline phosphatase gene in a case of adult-type hypophosphatasia
    H Watanabe
    Department of Hard Tissue Engineering Periodontology, Graduate School, Tokyo Medical and Dental University, Yushima, Japan
    Oral Dis 7:331-5. 2001
  4. ncbi request reprint The effects of retinoic acid on alkaline phosphatase activity and tissue-non-specific alkaline phosphatase gene expression in human periodontal ligament cells and gingival fibroblasts
    S M San Miguel
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University, Japan
    J Periodontal Res 33:428-33. 1998
  5. ncbi request reprint Number and position of mutations in the interferon (IFN) sensitivity-determining region of the gene for nonstructural protein 5A correlate with IFN efficacy in hepatitis C virus genotype 1b infection
    H Watanabe
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
    J Infect Dis 183:1195-203. 2001
  6. pmc Sequences in the NS5A protein of hepatitis C virus and the serum alanine aminotransferase response to interferon therapy in Japanese patients
    K Nagayama
    Second Department of Internal Medicine, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan, 113-8519
    Gut 48:830-5. 2001
  7. ncbi request reprint Tissue-non-specific alkaline phosphatase mRNA expression and alkaline phosphatase activity following application of retinoic acid in cultured human dental pulp cells
    S M San Miguel
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University, Japan
    Arch Oral Biol 44:861-9. 1999
  8. ncbi request reprint In vitro evaluation of Er:YAG laser scaling of subgingival calculus in comparison with ultrasonic scaling
    A Aoki
    Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Japan
    J Periodontal Res 35:266-77. 2000
  9. ncbi request reprint The complete DNA sequence of the O antigen gene region of Plesiomonas shigelloides serotype O17 which is identical to Shigella sonnei form I antigen
    T Chida
    Department of Clinical Microbiology and Immunology, School of Allied Health Sciences, Tokyo Medical and Dental University, Japan
    Microbiol Immunol 44:161-72. 2000
  10. doi request reprint Role of lysine in interaction between surface protein peptides of Streptococcus gordonii and agglutinin peptide
    H Koba
    Department of Cariology and Operative Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
    Oral Microbiol Immunol 24:162-9. 2009

Detail Information

Publications74

  1. ncbi request reprint Prediction of functional recovery in patients with myocardial infarction after revascularization--comparison of low-dose dobutamine stress echocardiography with fluorine-18 fluorodeoxyglucose positron emission tomography
    T Tani
    First Department of Internal Medicine, Osaka City University Medical School, Osaka, Japan
    Jpn Circ J 65:177-81. 2001
    ....
  2. ncbi request reprint Molecular diagnosis of hypophosphatasia with severe periodontitis
    H Watanabe
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University, Japan
    J Periodontol 70:688-91. 1999
    ..Both of them are new missense point mutations and appear to cause significant changes in the structure and function of TNSALP...
  3. ncbi request reprint A novel point mutation (C571T) in the tissue-non-specific alkaline phosphatase gene in a case of adult-type hypophosphatasia
    H Watanabe
    Department of Hard Tissue Engineering Periodontology, Graduate School, Tokyo Medical and Dental University, Yushima, Japan
    Oral Dis 7:331-5. 2001
    ..The gene for TNSALP is located on chromosome 1p34-36.1 and consists of 12 exons and 11 introns. In this study we analysed the genomic TNSALP gene from a patient with HOPS, her family, and unrelated normal controls...
  4. ncbi request reprint The effects of retinoic acid on alkaline phosphatase activity and tissue-non-specific alkaline phosphatase gene expression in human periodontal ligament cells and gingival fibroblasts
    S M San Miguel
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University, Japan
    J Periodontal Res 33:428-33. 1998
    ..These results indicated that the upregulation of ALP activity in HPDL cells by RA was due to the increased transcription of bone-type mRNA of the TNSALP gene...
  5. ncbi request reprint Number and position of mutations in the interferon (IFN) sensitivity-determining region of the gene for nonstructural protein 5A correlate with IFN efficacy in hepatitis C virus genotype 1b infection
    H Watanabe
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
    J Infect Dis 183:1195-203. 2001
    ..ISDR sequence analysis would allow the prediction of clinical IFN efficacy in individual patients...
  6. pmc Sequences in the NS5A protein of hepatitis C virus and the serum alanine aminotransferase response to interferon therapy in Japanese patients
    K Nagayama
    Second Department of Internal Medicine, Faculty of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, Japan, 113-8519
    Gut 48:830-5. 2001
    ..0; 95% confidence interval 5.0-286) in multivariate analyses. CONCLUSIONS: A HCV genomic region that correlates with the ALT response to IFN therapy appears to be present in virologically IFN ineffective patients...
  7. ncbi request reprint Tissue-non-specific alkaline phosphatase mRNA expression and alkaline phosphatase activity following application of retinoic acid in cultured human dental pulp cells
    S M San Miguel
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University, Japan
    Arch Oral Biol 44:861-9. 1999
    ..These findings suggest that the high alkaline phosphatase activity of retinoic acid-treated dental pulp cells is associated with increased transcription of the bone-type mRNA of the TNSALP gene and not with liver-type...
  8. ncbi request reprint In vitro evaluation of Er:YAG laser scaling of subgingival calculus in comparison with ultrasonic scaling
    A Aoki
    Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Japan
    J Periodontal Res 35:266-77. 2000
    ..The laser scaling provided a level of calculus removal that was similar to that provided by the ultrasonic scaling. However, the Er:YAG laser produced superficial, structural and thermal microchanges on the root cementum...
  9. ncbi request reprint The complete DNA sequence of the O antigen gene region of Plesiomonas shigelloides serotype O17 which is identical to Shigella sonnei form I antigen
    T Chida
    Department of Clinical Microbiology and Immunology, School of Allied Health Sciences, Tokyo Medical and Dental University, Japan
    Microbiol Immunol 44:161-72. 2000
    ..shigelloides and S. sonnei, suggesting that both P. shigelloides O17 and S. sonnei form I antigen genes had been derived from the same origin with a low G+C content...
  10. doi request reprint Role of lysine in interaction between surface protein peptides of Streptococcus gordonii and agglutinin peptide
    H Koba
    Department of Cariology and Operative Dentistry, Tokyo Medical and Dental University, Tokyo, Japan
    Oral Microbiol Immunol 24:162-9. 2009
    ..To determine the role of lysine in the binding of the Ssp(A11K) peptide to SRCRP2, we investigated whether an additional substitution by lysine influenced the binding of Ssp(A11K) peptide to SRCRP2 using a BIAcore biosensor assay...
  11. pmc Disease control using low-dose-rate brachytherapy is unaffected by comorbid severity in oral cancer patients
    R Yoshimura
    Department of Diagnostic Radiology and Oncology, Head and Neck Reconstruction Division, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Br J Radiol 84:930-8. 2011
    ..The aim of this study was to evaluate the outcome and complications of low-dose-rate brachytherapy (LDR-BT) for oral cancer according to comorbidity...
  12. ncbi request reprint Overexpression of a single helix-loop-helix-type transcription factor, scleraxis, enhances aggrecan gene expression in osteoblastic osteosarcoma ROS17/2.8 cells
    Y Liu
    Department of Molecular Pharmacology, Division of Functional Disorder Research, Medical Research Institute, Tokyo Medical and Dental University, 3 10 Kanda Surugadai 2 Chome, Chiyoda ku, Tokyo 101, Japan
    J Biol Chem 272:29880-5. 1997
    ..These results indicate that overexpression of a single helix-loop-helix-type transcription factor, scleraxis, enhances aggrecan gene expression via binding to the E-box-containing AgE sequence in ROS17/2.8 cells...
  13. ncbi request reprint Site-specific mutation of the interferon sensitivity-determining region (ISDR) modulates hepatitis C virus replication
    T Kohashi
    Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Yushima, Bunkyo, Tokyo, Japan
    J Viral Hepat 13:582-90. 2006
    ..ISDR sequences associated with a clinical IFN response and viral load modulated the replication of HCV replicons, suggesting the importance of the ISDR sequence in HCV infection...
  14. doi request reprint Inhibiting effects of Streptococcus salivarius on competence-stimulating peptide-dependent biofilm formation by Streptococcus mutans
    S Tamura
    Dentistry for Persons with Disabilities, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Oral Microbiol Immunol 24:152-61. 2009
    ..The effects of Streptococcus salivarius on the competence-stimulating peptide (CSP)-dependent biofilm formation by Streptococcus mutans were investigated...
  15. doi request reprint Pocket epithelium in the pathological setting for HMGB1 release
    N Ebe
    Section of Periodontology, Department of Hard Tissue Engineering, Biochemistry, Division of Bio Matrix, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo, Tokyo 113 8549, Japan
    J Dent Res 90:235-40. 2011
    ..Thus, the periodontal epithelium may provide a unique pathological setting for HMGB1 release by bacterial insult...
  16. ncbi request reprint Er:YAG laser irradiation increases prostaglandin E production via the induction of cyclooxygenase-2 mRNA in human gingival fibroblasts
    A Pourzarandian
    Periodontology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Periodontal Res 40:182-6. 2005
    ..We have then investigated the effect of Er:YAG laser irradiation on PGE2 production and COX-2 gene expression in human gingival fibroblast in vitro...
  17. ncbi request reprint Evidence for an association of the R485K polymorphism in the coagulation factor V gene with severe preeclampsia from screening 35 polymorphisms in 27 candidate genes
    H Watanabe
    Thromb Haemost 86:1594-5. 2001
  18. ncbi request reprint CT findings as a significant predictive factor for the curability of mandibular osteomyelitis: multivariate analysis
    M Ida
    Department of Oral and Maxillofacial Radiology, Graduate School, Tokyo Medical and Dental University, 5 45, Yushima 1 chome, Tokyo 1138549, Japan
    Dentomaxillofac Radiol 34:86-90. 2005
    ..To re-evaluate computed tomographic (CT) imaging as a diagnostic tool for mandibular osteomyelitis and to assess the clinical significance of CT findings...
  19. ncbi request reprint Sequence-based structural features between Kvlqt1 and Tapa1 on mouse chromosome 7F4/F5 corresponding to the Beckwith-Wiedemann syndrome region on human 11p15.5: long-stretches of unusually well conserved intronic sequences of kvlqt1 between mouse and huma
    H Yatsuki
    Department of Biochemistry, Saga Medical School, Saga, Japan
    DNA Res 7:195-206. 2000
    ..Further characterization of this locus based on the sequence comparison between mouse and human will contribute valuable information towards resolving the mechanism of the occurrence of BWS and the associated childhood tumor...
  20. ncbi request reprint Caries risk tests and salivary levels of immunoglobulins to Streptococcus mutans and Candida albicans in mouthbreathing syndrome patients
    C Y Koga-Ito
    Departamento de Biociências e Diagnóstico Bucal, Disciplina de Microbiologia e Immunologia, Faculdade de Odontologia de Piracicaba UNICAMP, Brazil
    Caries Res 37:38-43. 2003
    ..No differences were observed for anti-S. mutans and anti-Candida IgA levels among the groups. The findings suggest that mouthbreathing cannot be considered a risk factor for dental caries...
  21. ncbi request reprint Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency: two pathogenic mutations, V133E and C456F, in Japanese siblings
    X Q Song
    Department of Pediatrics, Gifu University School of Medicine, Japan
    Hum Mutat 12:83-8. 1998
    ..Expression of mutant SCOT cDNAs more accurately reflects the residual activity of SCOT than do currently available assays in cell or tissue homogenates...
  22. ncbi request reprint Dynamic changes in subnuclear NP95 location during the cell cycle and its spatial relationship with DNA replication foci
    M Miura
    Molecular Diagnosis and Therapeutics, Oral and Maxillofacial Radiology, Department of Oral Restitution, Graduate School, Tokyo, Japan
    Exp Cell Res 263:202-8. 2001
    ....
  23. ncbi request reprint Hop bract polyphenols reduced three-day dental plaque regrowth
    K Shinada
    Department of Oral Health Promotion, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo, Japan
    J Dent Res 86:848-51. 2007
    ..05). These findings suggested that HBP, delivered in a mouthrinse, successfully reduced dental plaque regrowth in humans...
  24. pmc Suppression of cell transformation by the cyclin-dependent kinase inhibitor p57KIP2 requires binding to proliferating cell nuclear antigen
    H Watanabe
    Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, and Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599 3280, USA
    Proc Natl Acad Sci U S A 95:1392-7. 1998
    ..Thus, control of cell cycle and suppression of cell transformation by p57 require both CDK and PCNA inhibitory activity, and disruption of either or both functions may lead to uncontrolled cell growth...
  25. ncbi request reprint Granular corneal dystrophy with homozygous mutations in the kerato-epithelin gene
    M Okada
    Department of Ophthalmology, Osaka University Medical School, Suita, Japan
    Am J Ophthalmol 126:169-76. 1998
    ..Three members of the family were affected with a severe placoid type of corneal dystrophy. To determine the relationship between gene mutations and phenotypic variations of the disease, we analyzed the kerato-epithelin gene...
  26. ncbi request reprint Expression of the mutant (1735T-DEL) tissue-nonspecific alkaline phosphatase gene from hypophosphatasia patients
    M Goseki-Sone
    Department of Food and Nutrition, Japan Women s University, Tokyo, Japan
    J Bone Miner Res 13:1827-34. 1998
    ..The detection of TNSALP in cells transfected with 1735T-del using an immunofluorescent method exhibited only a faint signal on the cell surface, but an intense intracellular fluorescence after permeabilization...
  27. ncbi request reprint A time-dependent effect of PDGF-BB on adhesion and growth of cultured fibroblasts to root surfaces
    M H Belal
    Department of Oral Medicine and Periodontology, Faculty of Dentistry, El Minya University, El Minya, Egypt
    Oral Dis 12:543-52. 2006
    ..This study aimed at assessing the effectiveness of PDGF-BB application on periodontally diseased root surfaces through attachment and growth of fibroblast cells...
  28. ncbi request reprint Two distinct kerato-epithelin mutations in Reis-Bücklers corneal dystrophy
    M Okada
    Department of Ophthalmology, Osaka University Medical School, Japan
    Am J Ophthalmol 126:535-42. 1998
    ..To see whether there was a genetic basis for these phenotypic variations, we analyzed beta ig-h3, the gene that codes for kerato-epithelin and that contains a mutation (Arg555Gln) that causes RBCD...
  29. ncbi request reprint Transcriptional cross-talk between Smad, ERK1/2, and p38 mitogen-activated protein kinase pathways regulates transforming growth factor-beta-induced aggrecan gene expression in chondrogenic ATDC5 cells
    H Watanabe
    Craniofacial Developmental Biology and Regeneration Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 276:14466-73. 2001
    ....
  30. ncbi request reprint Mitochondrial sequence variation in Carlos capensis (Neumann), a parasite of seabirds, collected on Torishima Island in Japan
    Y Ushijima
    Laboratory of Molecular Microbiology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Fukuyama, Hiroshima 729 0292 Japan
    J Parasitol 89:196-8. 2003
    ..Sequence comparison analysis indicated that the C. capensis ticks are on the branch with C. marginatus and C. mexicanus ticks and not with Ornithodoros. This supports the revision suggested by Klompen and Oliver (1993)...
  31. pmc Chronic subdural haematoma after snowboard head injury
    M Uzura
    Division of Neurosurgery, St Marianna University Yokohama City Seibu Hospital, Yokohama, Kanagawa, Japan
    Br J Sports Med 37:82-3. 2003
    ..Evaluation of a snowboarder with a history of head injury, albeit mild, who complains of headaches should include computed tomography or magnetic resonance imaging to allow rapid identification of any intracranial pathology...
  32. ncbi request reprint Persistent gene expression in mouse vagina exposed neonatally to diethylstilbestrol
    S Miyagawa
    School of Life Science, The Graduate University for Advanced Studies, 5 1 Higashiyama, Myodaiji, Okazaki, 444 8585, Japan
    J Mol Endocrinol 32:663-77. 2004
    ..These findings give insight into persistent activation in the vagina of mice exposed neonatally to DES...
  33. pmc Hypoxia enhances the expression of autocrine motility factor and the motility of human pancreatic cancer cells
    H Niizeki
    Division of Cancer Pathobiology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    Br J Cancer 86:1914-9. 2002
    ....
  34. ncbi request reprint Recovery of Deinococcus radiodurans from radiation damage was enhanced under microgravity
    Y Kobayashi
    Biotechnology Laboratory, Takasaki Radiation Chemistry Research Establishment, Japan Atomic Energy Research Institute, Gunma, Japan
    Biol Sci Space 10:97-101. 1996
    ..The survival of the cells incubated in space increased significantly compared with the ground controls, suggesting that the recovery of this bacterium from radiation damage was enhanced under microgravity...
  35. ncbi request reprint Ultrastructural changes in calvarial osteoblast cytoskeleton after prostaglandin E2 administration in rats
    K Yamakura
    Department of Ultrastructural Science, Tokyo Dental College, Chiba, Japan
    Anat Histol Embryol 30:301-7. 2001
    ....
  36. ncbi request reprint Inhibition of the extracellular signal-regulated kinase (ERK) pathway and the induction of radioresistance in rat 3Y1 cells
    H Watanabe
    Oral and Maxillofacial Radiology and Molecular Diagnosis and Therapeutics, Department of Oral Restitution, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8549, Japan
    Int J Radiat Biol 80:451-7. 2004
    ..However, the potential involvement of this pathway in cellular radiosensitivity remains unclear. The study was designed to examine whether the ERK pathway affects intrinsic radiosensitivity in mammalian cells...
  37. doi request reprint The CYP2A6*4 allele is determinant of S-1 pharmacokinetics in Japanese patients with non-small-cell lung cancer
    Y Kaida
    The Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Clin Pharmacol Ther 83:589-94. 2008
    ..6 +/- 32.9 ng/ml) for 5-FU than patients without the CYP2A6*4C allele (157.0 +/- 65.5 ng/ml, P < 0.05). Genotyping of CYP2A6 polymorphisms may provide vital information for effective cancer therapy using S-1...
  38. pmc Nontypeable Haemophilus influenzae strain 2019 produces a biofilm containing N-acetylneuraminic acid that may mimic sialylated O-linked glycans
    L L Greiner
    Department of Microbiology, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
    Infect Immun 72:4249-60. 2004
    ..Our data indicate that NTHI strain 2019 produces a biofilm containing alpha2,6-linked sialic acid and that the sialic acid content of the lipooligosaccharides increases concomitant with the transition of organisms to a biofilm form...
  39. ncbi request reprint Differential expression and pathological significance of autocrine motility factor/glucose-6-phosphate isomerase expression in human lung carcinomas
    Y Dobashi
    Department of Pathology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan
    J Pathol 210:431-40. 2006
    ..Furthermore, higher mRNA expression may be related to the high metastatic potential of NSCLC and increased protein secretion, leading to a more aggressive phenotype, such as the invasiveness of SmCC and LCC...
  40. ncbi request reprint Developmental malformations and intrauterine deaths in gamma-ray-irradiated scid mouse embryos
    S Shoji
    Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
    Int J Radiat Biol 73:705-9. 1998
    ..To examine the induction by radiation of developmental malformations and intrauterine deaths in severe combined immunodeficiency (scid) mice...
  41. ncbi request reprint Human T-cell responses to oral streptococci in human PBMC-NOD/SCID mice
    M A Salam
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    Oral Microbiol Immunol 21:169-76. 2006
    ..These results may contribute to a better understanding of human lymphocyte interactions to biofilm bacteria, along with their impact on dental and mucosal inflammatory diseases, as well as endocarditis...
  42. pmc Beneficial effect of short term intake of red wine polyphenols on coronary microcirculation in patients with coronary artery disease
    T Hozumi
    Heart 92:681-2. 2006
  43. ncbi request reprint The estrogen-responsive adrenomedullin and receptor-modifying protein 3 gene identified by DNA microarray analysis are directly regulated by estrogen receptor
    H Watanabe
    Okazaki Institute for Integrative Bioscience, National Institutes of Natural Science, 5 1 Higashiyama, Myodaiji, Okazaki 444 8787, Japan
    J Mol Endocrinol 36:81-9. 2006
    ....
  44. ncbi request reprint Osteoid osteoma treated with computed tomography-guided percutaneous radiofrequency ablation: a case series
    T Shinozaki
    Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Orthop Surg (Hong Kong) 13:317-22. 2005
    ..This case series shows that the computed tomography-guided percutaneous radiofrequency ablation is a simple, minimally invasive, and highly effective technique for the treatment of osteoid osteoma...
  45. ncbi request reprint SWI/SNF complex is essential for NRSF-mediated suppression of neuronal genes in human nonsmall cell lung carcinoma cell lines
    H Watanabe
    1Division of Host Parasite Interaction, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Nagasaki, Tokyo, Japan
    Oncogene 25:470-9. 2006
    ....
  46. doi request reprint Manganese superoxide dismutase Ala16Val polymorphism is associated with the development of type 2 diabetes in Japanese-Americans
    S Nakanishi
    Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan
    Diabetes Res Clin Pract 81:381-5. 2008
    ..We aimed to test the hypothesis that the Ala16Val variant could be associated with the development of type 2 diabetes...
  47. ncbi request reprint Usefulness of supernatant of pancreatic juice for genetic analysis of K-ras in diagnosis of pancreatic carcinoma
    A Ha
    Department of Internal Medicine and Medical Oncology, Cancer Research Institute, Kanazawa University, 4-86, Yoneizumi, Kanazawa 921-8044, Japan
    Pancreas 23:356-63. 2001
    ..CONCLUSION: These results suggest that the positive rate of KRM in the supernatant is not lower than that in the sediment, and simultaneous analysis of KRM in the supernatant and sediment of PPJ enhances the genetic diagnosis of PCa...
  48. ncbi request reprint Prevention of the development of preneoplastic lesions, aberrant crypt foci, by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male F344 rats
    H Lu
    Department of Environment and Mutation, Research Institute for Radiation Biology and Medicine, Hiroshima University, Minami-ku, Hiroshima 734-8553, Japan
    Oncol Rep 8:1341-5. 2001
    ..In an additional in vitro experiment, MAK inhibited anchorage-independent growth of several colon carcinoma cell lines. The present results thus indicate that dietary MAK could act as a preventive agent for colon carcinogenesis...
  49. ncbi request reprint Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability
    H Watanabe
    Pharmaceutical Frontier Research Laboratories, Japan Tobacco, Yokohama Department of Neurology, School of Medicine, Keio University, Tokyo, Japan
    J Neurochem 75:28-33. 2000
    ..These data indicate that the decreased expression of KCNQ2 might cause a hyperexcitability of the CNS, which accounts for the mechanism of BFNC...
  50. ncbi request reprint Molecular basis of very long chain acyl-CoA dehydrogenase deficiency in three Israeli patients: identification of a complex mutant allele with P65L and K247Q mutations, the former being an exonic mutation causing exon 3 skipping
    H Watanabe
    Department of Pediatrics, Gifu University School of Medicine, Gifu, Japan
    Hum Mutat 15:430-8. 2000
    ..The P65L mutation locates 11 bases upstream of a splice donor site of intron 3. This is an example of an exonic mutation which affects exon-splicing...
  51. ncbi request reprint Molecular analysis of the Deinococcus radiodurans recA locus and identification of a mutation site in a DNA repair-deficient mutant, rec30
    I Narumi
    Biotechnology Laboratory, Takasaki Radiation Chemistry Research Establishment, Japan Atomic Energy Research Institute, 1233 Watanuki, Takasaki, Japan
    Mutat Res 435:233-43. 1999
    ..coli recA mutants. In contrast with the wild-type gene, the mutant recA gene derived from strain rec30 did not complement E. coli recA1, suggesting that the mutant RecA protein lacks functional activity for recombinational repair...
  52. pmc Ablation of a specific cell population by the replacement of a uniquely expressed gene with a toxin gene
    K Arase
    Department of Molecular Genetics, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    Proc Natl Acad Sci U S A 96:9264-8. 1999
    ....
  53. ncbi request reprint Genomic structure and functional characterization of NBPhox (PMX2B), a homeodomain protein specific to catecholaminergic cells that is involved in second messenger-mediated transcriptional activation
    M Yokoyama
    Pharmaceutical Frontier Research Laboratories, Japan Tobacco, Inc, 13 2, Fukuura 1 chome, Kanazawa Ku, Yokohama, Kanagawa, 236, Japan
    Genomics 59:40-50. 1999
    ..These data suggest that this family of proteins may be involved in determining and maintaining a cell-specific phenotype through regulation of certain genes responsive to second messenger-mediated signals...
  54. ncbi request reprint The Krüppel-type zinc finger family gene, HKR1, is induced in lung cancer by exposure to platinum drugs
    T Oguri
    Second Department of Internal Medicine, Hiroshima University School of Medicine, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8551, Japan
    Gene 222:61-7. 1998
    ..These results suggest that HKR1 may be associated with the regulation of a signaling pathway involved in the progression of lung cancer or the acquisition of resistance to platinum drugs...
  55. ncbi request reprint Promoter analysis of the neuronal nicotinic acetylcholine receptor alpha4 gene: methylation and expression of the transgene
    H Watanabe
    Neurobiologie moleculaire, CNRS URA 1284, Institut Pasteur, Paris, France
    Eur J Neurosci 10:2244-53. 1998
    ..8-kb upstream sequence alone did not elicit any significant expression. These results show that both upstream and intronic sequences are important for cell-specific expression of the nAChR alpha4 gene...
  56. ncbi request reprint p53 gene mutation and loss of heterozygosity of chromosome 11 in methylcholanthrene-induced mouse sarcomas
    K Shimokado
    Second Department of Surgery, School of Medicine, Hiroshima University
    Jpn J Cancer Res 89:269-77. 1998
    ..In nine of these 10 cases, the loss involved all 5 markers. In addition, the loss was biased toward the C57BL allele (9 cases). The present study establishes the pattern of mutation of the p53 gene in MCA-induced mouse sarcomas...
  57. ncbi request reprint Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1
    Y Sowa
    Department of Preventive Medicine, Kyoto Prefectural University of Medicine, Kamigyo ku, Japan
    Cancer Res 57:3145-8. 1997
    ..As expected, hGABP/E4TF1 enhanced the core RB promoter activity, whereas it did not stimulate a mutant RBF-1 site. We therefore conclude that the most essential transcription factor in the human RB gene is likely to be hGABP/E4TF1...
  58. ncbi request reprint High sensitivity to hepato-tumorigenesis in hypocatalasemic C3H/C(s)b/Gen mice exposed to low doses of 252Cf fission neutrons and 60Co gamma-rays
    K Yamada
    Department of Cancer Research, Hiroshima University, Japan
    Anticancer Res 17:2041-7. 1997
    ..Therefore, the implication of oxygen radicals in hepato-tumorigenesis was strongly suggested and high sensitivity of C(s)b to low doses of radiation would be useful to investigate the mechanism of radiation tumorigenesis...
  59. ncbi request reprint [Rapid detection of the hemolysin genes in Aeromonas sobria by the polymerase chain reaction]
    M Shibata
    Department of Microbiology, Kyorin University School of Health Sciences
    Kansenshogaku Zasshi 70:1266-70. 1996
    ..The PCR technique for detection of two hemolysin genes suggested the possibility of application of this method for detection of A. sobria in A. sobria-associated infections...
  60. ncbi request reprint Assignment of the E4TF1-60 gene to human chromosome 21q21.2-q21.3
    M Goto
    Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan
    Gene 166:337-8. 1995
    ..We report here that E4TF1-60 locates in the long arm of chromosome 21 at q21.2-q21.3 and contains a total of ten exons...
  61. ncbi request reprint Sisters homozygous for the spinocerebellar ataxia type 6 (SCA6)/CACNA1A gene associated with different clinical phenotypes
    T Kato
    Department of Neurology, Kasugai Municipal Hospital, Japan
    Clin Genet 58:69-73. 2000
    ..These findings strongly suggest that the gene dosage influences the age of onset, but other unknown factors are also important in the phenotypic expression of homozygous SCA6...
  62. ncbi request reprint Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene
    T O Akama
    Glycobiology Program, The Burnham Institute, La Jolla, California, USA
    Nat Genet 26:237-41. 2000
    ..In situ hybridization analysis did not detect CHST6 transcripts in corneal epithelium in an MCD type II patient, suggesting that the mutations found in type II lead to loss of cornea-specific expression of CHST6...
  63. ncbi request reprint Antiapoptotic activity is dispensable for insulin-like growth factor I receptor-mediated clonogenic radioresistance after gamma-irradiation
    M Tezuka
    Molecular Diagnosis and Therapeutics, Department of Oral Restitution, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan
    Clin Cancer Res 7:3206-14. 2001
    ..This study provides clinical implications in the evaluation of apoptotic activities observed during the course of radiotherapy to predict accurate tumor response or local control...
  64. ncbi request reprint flaB-polymerase chain reaction (flaB-PCR) and its restriction fragment length polymorphism (RFLP) analysis are an efficient tool for detection and identification of Leptospira spp
    H Kawabata
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    Microbiol Immunol 45:491-6. 2001
    ..These results suggested that PCR-RFLP based on the flaB gene was an efficient tool for rapid detection and identification of species of infected Leptospira from clinical specimens...
  65. ncbi request reprint Autocrine motility factor enhances hepatoma cell invasion across the basement membrane through activation of beta1 integrins
    T Torimura
    The Second Department of Medicine and Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume City, Japan
    Hepatology 34:62-71. 2001
    ..Our results indicate that AMF/PHI enhances hepatoma cell invasion through Matrigel in an autocrine manner by stimulating the adhesion, motility, and MMP-2 secretion of these cells through activation of beta1 integrins...
  66. ncbi request reprint The effect of TGF-beta1 on differential gene expression profiles in human corneal epithelium studied by cDNA expression array
    S Hayashida-Hibino
    Department of Ophthalmology, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
    Invest Ophthalmol Vis Sci 42:1691-7. 2001
    ..These results strongly suggest that TGF-beta1 is critically involved in the maintenance of the corneal epithelium through the control of a network of various signal-transduction pathways...
  67. ncbi request reprint Expression of bone formation-related molecules in a newly established protein-independent osteosarcoma
    T Yanagawa
    Department of Orthopedic Surgery, Gunma University Faculty of Medicine, Gunma 371-8511, Japan
    Int J Oncol 18:1195-205. 2001
    ....
  68. ncbi request reprint Myosin light chain kinase regulates capacitative ca(2+) entry in human monocytes/macrophages
    Q K Tran
    Departments of Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Arterioscler Thromb Vasc Biol 21:509-15. 2001
    ..These data strongly indicate that MLCK regulates CCE in human monocytes/macrophages. The study suggests a possible involvement of MLCK in many Ca(2+)-dependent activities of monocytes/macrophages...
  69. ncbi request reprint A myxoid liposarcoma in the lower leg, with a large intra-abdominal metastasis
    H Watanabe
    Department of Orthopaedic Surgery, School of Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    J Orthop Sci 6:95-7. 2001
    ..Ileus and respiratory distress, caused by compression by the abdominal mass, gradually worsened, and she died in 1999, at the age of 34. The girth of her abdomen was 135 cm at the time of death...
  70. ncbi request reprint Expression of p8 in human pancreatic cancer
    S B Su
    Department of Internal Medicine and Medical Oncology, Cancer Research Institute, Kanazawa University, Japan
    Clin Cancer Res 7:309-13. 2001
    ..p8 was overexpressed also in human pancreatic cancer cell lines (MIA PaCa-2 and PANC-1). These results suggest that p8 is involved in the development of pancreatic cancer, reflecting its mitogenic activity...
  71. ncbi request reprint PKCeta associates with cyclin E/cdk2/p21 complex, phosphorylates p21 and inhibits cdk2 kinase in keratinocytes
    M Kashiwagi
    Institute of Molecular Oncology, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Oncogene 19:6334-41. 2000
    ..Among the known regulatory mechanisms of cdk2 activity, dephosphorylation of Thr160 was demonstrated. Oncogene (2000) 19, 6334 - 6341...
  72. ncbi request reprint Role of endothelial Ni(2+)-sensitive Ca(2+) entry pathway in regulation of EDHF in porcine coronary artery
    H Tomioka
    Deartments of Pharmacology and Cardiovascular Medicine, Hokkaido University School of Medicine, Sapporo 060-8638, Japan
    Am J Physiol Heart Circ Physiol 280:H730-7. 2001
    ..These results suggest that Ca(2+) influx into endothelial cells through nonselective cation channels plays a crucial role in the regulation of EDHF...
  73. ncbi request reprint Myopathic form of very-long chain acyl-coa dehydrogenase deficiency: evidence for temperature-sensitive mild mutations in both mutant alleles in a Japanese girl
    T Fukao
    Department of Pediatrics, Gifu University School of Medicine, Gifu 500 8075, Japan
    Pediatr Res 49:227-31. 2001
    ..These results indicate that both mutations were temperature-sensitive mild mutations, the result being the mildest phenotype of very-long chain acyl-CoA dehydrogenase deficiency...
  74. pmc cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs
    H Watanabe
    Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Japan
    Mol Cell Biol 13:1385-91. 1993
    ..Nucleotide and predicted amino acid sequences were highly homologous to GABP-alpha and -beta, which is further supported by the observation that GABP-specific antibody can recognize human E4TF1...