Shinichiro Uchiyama

Summary

Affiliation: Tokyo Women's Medical University
Country: Japan

Publications

  1. doi request reprint Clopidogrel two doses comparative 1-year assessment of safety and efficacy (COMPASS) study in Japanese patients with ischemic stroke
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Cerebrovasc Dis 34:229-39. 2012
  2. doi request reprint Dabigatran and factor Xa inhibitors for stroke prevention in patients with nonvalvular atrial fibrillation
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Stroke Cerebrovasc Dis 21:165-73. 2012
  3. ncbi request reprint New modalities and aspects of antiplatelet therapy for stroke prevention
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Cerebrovasc Dis 21:7-16. 2006
  4. ncbi request reprint Effect of sarpogrelate, a 5-HT(2A) antagonist, on platelet aggregation in patients with ischemic stroke: clinical-pharmacological dose-response study
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Cerebrovasc Dis 24:264-70. 2007
  5. doi request reprint The safety and efficacy of clopidogrel versus ticlopidine in Japanese stroke patients: combined results of two Phase III, multicenter, randomized clinical trials
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo, 162 8666, Japan
    J Neurol 256:888-97. 2009
  6. doi request reprint Risk factors for stroke and lipid-lowering effect of pravastatin on the risk of stroke in Japanese patients with hypercholesterolemia: analysis of data from the MEGA Study, a large randomized controlled trial
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    J Neurol Sci 284:72-6. 2009
  7. doi request reprint Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: results from 1-year outcomes in the Japanese REACH Registry
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    J Neurol Sci 287:45-51. 2009
  8. doi request reprint Stroke prevention by cilostazol in patients with atherothrombosis: meta-analysis of placebo-controlled randomized trials
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Stroke Cerebrovasc Dis 18:482-90. 2009
  9. doi request reprint The Japanese aggrenox (extended-release dipyridamole plus aspirin) stroke prevention versus aspirin programme (JASAP) study: a randomized, double-blind, controlled trial
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University, Japan
    Cerebrovasc Dis 31:601-13. 2011
  10. doi request reprint Risk factor profiles of stroke, myocardial infarction, and atrial fibrillation: a Japanese Multicenter Cooperative Registry
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University, Tokyo, Japan
    J Stroke Cerebrovasc Dis 19:190-7. 2010

Collaborators

Detail Information

Publications92

  1. doi request reprint Clopidogrel two doses comparative 1-year assessment of safety and efficacy (COMPASS) study in Japanese patients with ischemic stroke
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Cerebrovasc Dis 34:229-39. 2012
    ..This study compared the safety of both 75- and 50-mg doses of clopidogrel in patients with noncardioembolic ischemic stroke...
  2. doi request reprint Dabigatran and factor Xa inhibitors for stroke prevention in patients with nonvalvular atrial fibrillation
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Stroke Cerebrovasc Dis 21:165-73. 2012
    ..We also discuss precautions for the use of dabigatran and future perspectives with a view to reducing the risk of stroke with new oral anticoagulants, including factor Xa inhibitors in AF patients...
  3. ncbi request reprint New modalities and aspects of antiplatelet therapy for stroke prevention
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Cerebrovasc Dis 21:7-16. 2006
    ..Progress in antiplatelet therapy should be directed at further reducing the risk of ischaemic events including ischaemic stroke without increasing the risk of haemorrhagic events including haemorrhagic stroke...
  4. ncbi request reprint Effect of sarpogrelate, a 5-HT(2A) antagonist, on platelet aggregation in patients with ischemic stroke: clinical-pharmacological dose-response study
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Cerebrovasc Dis 24:264-70. 2007
    ....
  5. doi request reprint The safety and efficacy of clopidogrel versus ticlopidine in Japanese stroke patients: combined results of two Phase III, multicenter, randomized clinical trials
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo, 162 8666, Japan
    J Neurol 256:888-97. 2009
    ..This was the first combined analysis of direct comparison of clopidogrel with ticlopidine in the clinical setting...
  6. doi request reprint Risk factors for stroke and lipid-lowering effect of pravastatin on the risk of stroke in Japanese patients with hypercholesterolemia: analysis of data from the MEGA Study, a large randomized controlled trial
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    J Neurol Sci 284:72-6. 2009
    ....
  7. doi request reprint Cardiovascular event rates in patients with cerebrovascular disease and atherothrombosis at other vascular locations: results from 1-year outcomes in the Japanese REACH Registry
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    J Neurol Sci 287:45-51. 2009
    ..9 were significant predisposing factors for stroke. Patients with CVD and co-existing atherothrombotic diseases had a high risk of recurrent events, including events arising in other vascular beds than originally diagnosed...
  8. doi request reprint Stroke prevention by cilostazol in patients with atherothrombosis: meta-analysis of placebo-controlled randomized trials
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Stroke Cerebrovasc Dis 18:482-90. 2009
    ....
  9. doi request reprint The Japanese aggrenox (extended-release dipyridamole plus aspirin) stroke prevention versus aspirin programme (JASAP) study: a randomized, double-blind, controlled trial
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University, Japan
    Cerebrovasc Dis 31:601-13. 2011
    ..DP has an established benefit in the treatment of heart disease in Japan; however, for the prevention of stroke, the fixed-dose combination of ER-DP plus ASA has only been investigated in a small number of patients in Japan...
  10. doi request reprint Risk factor profiles of stroke, myocardial infarction, and atrial fibrillation: a Japanese Multicenter Cooperative Registry
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University, Tokyo, Japan
    J Stroke Cerebrovasc Dis 19:190-7. 2010
    ....
  11. doi request reprint Clopidogrel resistance: identifying and overcoming a barrier to effective antiplatelet treatment
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Cardiovasc Ther 29:e100-11. 2011
    ....
  12. doi request reprint Usefulness of pravastatin in primary prevention of cardiovascular events in women: analysis of the Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (MEGA study)
    Kyoichi Mizuno
    Department of Internal Medicine, Nippon Medical School, 1 1 5, Sendagi, Bunkyo ku, Tokyo, 113 8603, Japan
    Circulation 117:494-502. 2008
    ..We conducted an exploratory analysis of the effect of diet plus pravastatin therapy on the primary prevention of cardiovascular events in women with data from a large-scale primary prevention trial with pravastatin...
  13. ncbi request reprint Prevalence, awareness and treatment of cardiovascular risk factors in patients at high risk of atherothrombosis in Japan
    Tsutomu Yamazaki
    Department of Clinical Epidemiology and Systems, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Circ J 71:995-1003. 2007
    ..Japanese patients were analyzed to clarify national prevalence and treatment...
  14. ncbi request reprint The relationship between the effect of pravastatin and risk factors for coronary heart disease in Japanese patients with hypercholesterolemia
    Toshitsugu Ishikawa
    Occupational Health Department, Sony Corporation, Tokyo, Japan
    Circ J 72:1576-82. 2008
    ..The present analysis determined the risk factors for CHD in the MEGA Study, a large primary prevention trial with pravastatin in Japanese with hypercholesterolemia...
  15. ncbi request reprint Clinical characteristics of stroke patients with antiphospholipid antibodies
    Hiromi Terashi
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Cerebrovasc Dis 19:384-90. 2005
    ..Antiphospholipid syndrome is important as a cause of ischemic stroke, although clinical characteristics of the syndrome are not well documented...
  16. doi request reprint Clinical features and functional outcome of stroke after transient ischemic attack
    TAKAO HOSHINO
    Department of Neurology, Tokyo Women s Medical University, Tokyo, Japan
    J Stroke Cerebrovasc Dis 22:260-6. 2013
    ..Transient ischemic attacks (TIAs) greatly increase the risk of stroke, but few reports have examined subsequent stroke in patients with history of TIA...
  17. doi request reprint Risk factors for small cortical infarction on diffusion-weighted magnetic resonance imaging in patients with acute ischemic stroke
    Chisako Yano
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    J Stroke Cerebrovasc Dis 20:68-74. 2011
    ..No borderzone lesions were found in SCI patients with cardiac sources. Our findings suggest that carotid disease and coagulopathy are independent risk factors for SCI. Localization of SCI varies depending on the underlying diseases...
  18. doi request reprint Sarpogrelate-Aspirin Comparative Clinical Study for Efficacy and Safety in Secondary Prevention of Cerebral Infarction (S-ACCESS): A randomized, double-blind, aspirin-controlled trial
    Yukito Shinohara
    Department of Neurology, Federation of National Public Service Personnel Mutual Aid Associations, Tachikawa Hospital, 4 2 22 Nishikicho, Tachikawa, Tokyo 190 8531, Japan
    Stroke 39:1827-33. 2008
    ..The antiplatelet agent sarpogrelate is a selective inhibitor of 5-hydroxytryptamine receptors. The purpose of this study was to compare the efficacy and safety of sarpogrelate with those of aspirin in Japanese ischemic stroke patients...
  19. doi request reprint Rationale, design, and baseline data of the Japanese Primary Prevention Project (JPPP)-a randomized, open-label, controlled trial of aspirin versus no aspirin in patients with multiple risk factors for vascular events
    Tamio Teramoto
    Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
    Am Heart J 159:361-369.e4. 2010
    ..Prevention of atherosclerotic disease has become an important public health priority in Japan due to the aging of the population and changes in diet and lifestyle factors...
  20. doi request reprint Cardioembolic stroke is frequent in late recurrence after transient ischemic attack
    TAKAO HOSHINO
    Department of Neurology, Tokyo Women s Medical University, Tokyo, Japan
    J Stroke Cerebrovasc Dis 22:822-7. 2013
    ..Transient ischemic attack (TIA) is often followed by a stroke episode. Differences between early and late recurrent stroke, however, have not been elucidated...
  21. ncbi request reprint [Antiphospholipid syndrome]
    Shinichiro Uchiyama
    Department of Neurolgy, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    No To Shinkei 58:953-60. 2006
  22. doi request reprint One-year atherothrombotic vascular events rates in outpatients with recent non-cardioembolic ischemic stroke: the EVEREST (Effective Vascular Event REduction after STroke) registry
    Norihiro Suzuki
    Department of Neurology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Stroke Cerebrovasc Dis 21:245-53. 2012
    ..Our aims were to investigate 1-year atherothrombotic vascular event rates and to assess the risk factors for recurrent ischemic stroke in this population...
  23. ncbi request reprint Randomized, multicenter, warfarin-controlled phase II study of edoxaban in Japanese patients with non-valvular atrial fibrillation
    Takeshi Yamashita
    Division of Cardiology, The Cardiovascular Institute, Tokyo, Japan
    Circ J 76:1840-7. 2012
    ..The aim of this study was to evaluate the safety of edoxaban in Japanese patients with NVAF...
  24. doi request reprint The MG-QOL15 Japanese version: validation and associations with clinical factors
    Masayuki Masuda
    Department of Neurology, Tokyo Medical University, Tokyo, Japan
    Muscle Nerve 46:166-73. 2012
    ..Our study aim was to produce a Japanese translation of the 15-item Myasthenia Gravis Quality-of-Life Scale (MG-QOL15), assess its reliability and validity, and examine clinical factors affecting self-perceived QOL in MG...
  25. doi request reprint Cilostazol for prevention of secondary stroke (CSPS 2): an aspirin-controlled, double-blind, randomised non-inferiority trial
    Yukito Shinohara
    Federation of National Public Service Personnel Mutual Aid Associations Tachikawa Hospital, Tachikawa, Tokyo, Japan
    Lancet Neurol 9:959-68. 2010
    ....
  26. ncbi request reprint [EBM of cerebral infarction: message from mega-studies]
    Shinichiro Uchiyama
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University
    Rinsho Shinkeigaku 43:884-6. 2003
    ..PICSS, a substudy of WARSS, also did not show any efficacy of warfarin over aspirin in stroke patients with patent foramen ovale (PFO), although warfarin might be recommended in PFO patients with deep vein thrombosis...
  27. doi request reprint Renin-angiotensin system blockade safely reduces blood pressure in patients with minor ischemic stroke during the acute phase
    Tomomi Nakamura
    Department of Neurology, Tokyo Women s Medical University, Tokyo, Japan
    J Stroke Cerebrovasc Dis 19:435-40. 2010
    ..Our findings indicate that low doses of candesartan or perindopril safely reduce SBP in hypertensive patients with acute ischemic stroke...
  28. ncbi request reprint Effect of remnant-like particle on shear-induced platelet activation and its inhibition by antiplatelet agents
    Masako Yamazaki
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1, Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Thromb Res 115:211-8. 2005
    ..Aspirin inhibited only the enhancement of SIPA by RLPs, while cilostazol inhibited the enhancement of not only SIPA but also p-selectin expression and PMP generation by RLPs...
  29. doi request reprint Plasma osteopontin levels are associated with disease activity in the patients with multiple sclerosis and neuromyelitis optica
    Yuko Shimizu
    Department of Neurology, Tokyo Women s Medical University, School of Medicine, Tokyo, Japan Electronic address
    J Neuroimmunol 263:148-51. 2013
    ..These are the first results to suggest that plasma OPN in NMO patients may be a useful marker, playing an important role in inflammation, disease activity, and disease progression, as well as MS. ..
  30. doi request reprint Ulcerated carotid plaques with ultrasonic echolucency are causatively associated with thromboembolic cerebrovascular events
    Tomomi Nakamura
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, Tokyo, Japan
    J Stroke Cerebrovasc Dis 22:93-9. 2013
    ....
  31. doi request reprint Cerebrovascular disease and intracranial artery stenosis in patients with symptomatic peripheral artery disease
    Hitoshi Aizawa
    Department of Neurology, National Hospital Organization, Tokyo National Hospital, Kiyose, Tokyo, Japan
    J Stroke Cerebrovasc Dis 21:825-31. 2012
    ....
  32. pmc Factors associated with depressive state in patients with myasthenia gravis: a multicentre cross-sectional study
    Yasushi Suzuki
    Department of Neurology, Sendai Medical Center, Sendai, Japan
    BMJ Open 1:e000313. 2011
    ..Unchanged status despite treatment and early disease stage are also significant background factors for depressive state, along with disease severity...
  33. doi request reprint Association of Th1/Th2-related chemokine receptors in peripheral T cells with disease activity in patients with multiple sclerosis and neuromyelitis optica
    Yuko Shimizu
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Shinjuku ku, Tokyo, Japan
    Eur Neurol 66:91-7. 2011
    ..Furthermore, this ratio was more strongly linked to immune and inflammatory activity in NMO patients than in MS patients, and may represent an important factor in differentiating the pathogenesis of MS and NMO...
  34. doi request reprint Correlative magnetic resonance imaging and autopsy findings in a patient with coagulation necrosis treated with tissue plasminogen activator
    Miki Suzuki
    Department of Neurology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    J Stroke Cerebrovasc Dis 21:512-4. 2012
    ..This is an autopsy report of coagulation necrosis 6 months after thrombolytic tissue plasminogen activator therapy against massive cerebral embolism in an 84-year-old man with atrial fibrillation...
  35. ncbi request reprint [Pathophysiology of carotid stenosis]
    Masako Yamazaki
    Department of Neurology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Brain Nerve 62:1269-75. 2010
    ..In patients at a high risk of developing cerebral infarction, carotid endoarterectomy or stenting with the best medical treatment is useful in reducing cerebrovascular events...
  36. ncbi request reprint Synergistic effect of cilostazol and dipyridamole mediated by adenosine on shear-induced platelet aggregation
    Tomomi Nakamura
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, Tokyo, Japan
    Thromb Res 119:511-6. 2007
    ....
  37. doi request reprint CHADS2 score predicts functional outcome of stroke in patients with a history of coronary artery disease
    TAKAO HOSHINO
    Department of Neurology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    J Neurol Sci 331:57-60. 2013
    ..The aim of this study was to evaluate the efficacy of the CHADS2 scoring system as a prognostic tool for stroke patients with a prior history of coronary artery disease (CAD)...
  38. ncbi request reprint [Dabigatran, a new oral anticoagulant]
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University, Shinjuku ku, Tokyo, Japan
    Brain Nerve 63:411-5. 2011
    ..Randomized controlled trials of many factor Xa inhibitors in comparison with warfarin are also ongoing in patients with atrial fibrillation...
  39. doi request reprint Silent cerebral infarcts and cerebral white matter lesions in patients with nonvalvular atrial fibrillation
    Akiko Kobayashi
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    J Stroke Cerebrovasc Dis 21:310-7. 2012
    ..We investigated silent cerebral infarcts (SCIs) and cerebral white matter lesions and risk factors for stroke in NVAF patients...
  40. ncbi request reprint Flow cytometric analysis of reticulated platelets in patients with ischemic stroke
    Tomomi Nakamura
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku, Tokyo 162 8666, Japan
    Thromb Res 106:171-7. 2002
    ..We concluded that %RP is increased in patients with cardioembolic stroke, which may reflect increased platelet turnover as a consequence of platelet consumption during thrombogenesis...
  41. doi request reprint Cardiac sympathetic degeneration correlates with olfactory function in Parkinson's disease
    Mutsumi Iijima
    Department of Neurology, Tokyo Women s Medical University, Kawada cho Shinjuku, Tokyo, Japan
    Mov Disord 25:1143-9. 2010
    ..The results suggest that the cardiac sympathetic nervous system might degenerate in parallel with the olfactory system in patients with early PD, and that these two systems might degenerate at a different rate of speed in advanced PD...
  42. doi request reprint Transient neurological attack before vertebrobasilar stroke
    TAKAO HOSHINO
    Department of Neurology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    J Neurol Sci 325:39-42. 2013
    ..According to previously accepted classifications, typical TIA does not occur with VB symptom such as vertigo, diplopia, or dysarthria in isolation. However, there is a lack of evidence to support this hypothesis...
  43. ncbi request reprint [Stiff-person syndrome with elevated anti-Epstein-Barr virus antibody]
    Kuniko Ohara
    Department of Neurology, Tokyo Women s Medical University School of Medicine
    Rinsho Shinkeigaku 47:434-6. 2007
    ..However, a few cases of this syndrome associated with viral infection were recently reported and viral gene mimicity with GAD has been postulated. Viral infection might be considered as a probable cause of this syndrome...
  44. ncbi request reprint [Primary prevention of stroke]
    Shinichiro Uchiyama
    Neurological Institute, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    No To Shinkei 56:907-19. 2004
  45. ncbi request reprint Pharmacoeconomic analysis of cilostazol for the secondary prevention of cerebral infarction
    Tadao Inoue
    Department of Pharmacy, St Luke s International Hospital, Tokyo, Japan
    Circ J 70:453-8. 2006
    ..The antiplatelet agent, cilostazol, is known to reduce the risk of subsequent cerebral infarction. However, the cost effectiveness of such treatment in comparison to aspirin has not been studied...
  46. ncbi request reprint [Cerebral infarction]
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University
    Nihon Rinsho 64:2039-44. 2006
    ....
  47. doi request reprint Cilostazol combined with aspirin prevents early neurological deterioration in patients with acute ischemic stroke: a pilot study
    Tomomi Nakamura
    Department of Neurology, Tokyo Women s Medical University, Tokyo, Japan
    J Neurol Sci 313:22-6. 2012
    ..Patients treated with aspirin plus cilostazol during the acute phase of stroke had less neurological deterioration and more favorable functional status than those treated with aspirin alone...
  48. ncbi request reprint A case of adenoid cystic carcinoma presenting as Garcin's syndrome without mass formation
    Yuri Inose
    Department of Neurology, Tokyo Women s Medical University, Japan
    Intern Med 51:87-91. 2012
    ..The neurological manifestations were considered to be attributed to the perineural spread of ACC. It is extremely rare for ACC to show Garcin's syndrome without mass formation...
  49. doi request reprint Slow sinus heart rate as a potential predictive factor of paroxysmal atrial fibrillation in stroke patients
    TAKAO HOSHINO
    Department of Neurology, Tokyo Women s Medical University, Tokyo, Japan
    Cerebrovasc Dis 36:120-5. 2013
    ..In the present study, we aimed to identify predictors of PAF in stroke patients by continuous ECG monitoring of the heart rate in sinus rhythm...
  50. ncbi request reprint [Bucillamine-induced dermatomyositis-like clinical features in a patient with rheumatoid arthritis]
    Takahiro Takeda
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University School of Medicine
    Rinsho Shinkeigaku 45:45-8. 2005
    ..In conclusion, when RA patients treated with BUC show a clinical picture compatible with dermatomyositis, its causative relationship has to be considered...
  51. ncbi request reprint [Transient ischemic attack, a medical emergency]
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Brain Nerve 61:1013-22. 2009
    ..A large international, multicenter cooperative, observational study (TIA Registry. Org.) on 5,000 patients with TIA or minor stroke within 7 days of onset is being initiated. Now, we should say "Time is TIA"...
  52. ncbi request reprint Therapeutic efficacy of interferon β-1b in Japanese patients with optic-spinal multiple sclerosis
    Yuko Shimizu
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    Tohoku J Exp Med 223:211-4. 2011
    ..59 ± 0.34 → 0.13 ± 0.15) (P = 0.027) after IFNβ-1b therapy. These results suggest that IFNβ is therapeutically effective in inhibiting functional worsening and reducing relapse rate in "genuine" OSMS...
  53. ncbi request reprint Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome accompanied by Parkinson's disease
    Eiichi Ito
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University
    Intern Med 46:1139-42. 2007
    ....
  54. ncbi request reprint [Case report of HTLV-1 associated myelopathy (HAM) manifested after renal transplantation]
    Yuri Inose
    Department of Neurology, Tokyo Women s Medical University, School of Medicine
    Rinsho Shinkeigaku 50:241-5. 2010
    ..More investigations are needed to clarify the mechanisms in the development of HAM associated with renal transplantation...
  55. doi request reprint Adversive seizures associated with periodic lateralised epileptiform discharges (PLEDs) after left orbital contusion
    Takahiro Takeda
    Department of Neurology, School of Medicine, Tokyo Women s Medical University, Tokyo, Japan
    Epileptic Disord 14:422-5. 2012
    ..Further studies are warranted to determine the role of subcortical structures in the generation of PLEDs and adversive seizures. [Published with video sequences]...
  56. ncbi request reprint [Expectation to and problems of thrombin inhibitor]
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University
    Rinsho Shinkeigaku 51:1004-6. 2011
    ..Use of dabigatran should be contraindicated in NVAF patients with renal insufficiency because some cases with fatal bleeding have been reported in a post marketing survey...
  57. ncbi request reprint [Beta2-glycoprotein I polymorphism]
    Hiromi Terashi
    Department of Neurology, Tokyo Wemens University, School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Brain Nerve 60:1333-8. 2008
    ..The results suggested that V247 beta2-GPI allele is one of the genetic risk factors for the development of cerebral infarction through platelet activation...
  58. doi request reprint Posterior circulation ASPECTS on diffusion-weighted MRI can be a powerful marker for predicting functional outcome
    Hideaki Tei
    Department of Neurology, Toda Central General Hospital, 1 19 3 Hon cho, Toda, Saitama 335 0023, Japan
    J Neurol 257:767-73. 2010
    ..pc-ASPECTS appears to be a powerful marker for predicting functional outcome, along with clinical severity and END. Leukoaraiosis may also be an independent predictor of functional outcome...
  59. doi request reprint Metabolic syndrome and its components as risk factors for first-ever acute ischemic noncardioembolic stroke
    Kenji Maruyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    J Stroke Cerebrovasc Dis 18:173-7. 2009
    ..Metabolic syndrome (MetS) has been studied as a cardiovascular risk factor. We evaluated MetS and its individual components as risk factors for acute ischemic noncardioembolic stroke (AINS)...
  60. ncbi request reprint [Multiple cerebral white matter lesions following head trauma with eyeball contusion]
    Tomomi Nakamura
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University School of Medicine
    Rinsho Shinkeigaku 44:108-10. 2004
    ..There has been a controversy concerning the causal relationship between trauma and multiple sclerosis (MS). In this case, MS-like multiple cerebral white matter lesions are considered to be relevant to the head trauma...
  61. doi request reprint Supranuclear ophthalmoparesis and vacuolar degeneration of the cerebral white matter in amyotrophic lateral sclerosis: a clinicopathological study
    Takahiro Takeda
    Department of Neurology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Amyotroph Lateral Scler 13:74-83. 2012
    ....
  62. ncbi request reprint [Hemostatic abnormalities]
    Masako Yamazaki
    Department of Neurology, Tokyo Women s Medical University
    Nihon Rinsho 64:204-8. 2006
  63. ncbi request reprint Carotid ultrasonographic appearance of the rupture of an unstable atheromatous plaque in a patient with acute ischemic stroke
    Miki Suzuki
    Department of Neurology, Tokyo Women s Medical University, Japan
    Intern Med 44:1320-1. 2005
  64. doi request reprint Charcot-Marie-Tooth disease type 4C in Japan: report of a case
    Masahiro Iguchi
    Department of Neurology, Tokyo Women s Medical University School of Medicine, Kawada cho 8 1, Shinjuku ku, Tokyo, Japan
    Muscle Nerve 47:283-6. 2013
    ..We report the first documented case of CMT4C in East Asia. Furthermore, we estimate the proportion of CMT4C in Japan and compare the same with that in European countries...
  65. ncbi request reprint [Results of the Cilostazol Stroke Prevention Study II (CSPS II): a randomized controlled trial for the comparison of cilostazol and aspirin in stroke patients]
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University
    Rinsho Shinkeigaku 50:832-4. 2010
    ....
  66. ncbi request reprint Arterial hypertension in patients with left primary hemifacial spasm is associated with neurovascular compression of the left rostral ventrolateral medulla
    Tomomi Nakamura
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University, Tokyo, Japan
    Eur Neurol 57:150-5. 2007
    ..These results are of potential clinical importance for the treatment of primary hemifacial spasm with arterial hypertension...
  67. ncbi request reprint [Management of NSAIDs and low-dose-aspirin-induced ulcer in patients with cerebral infarction]
    Yumi Kimura
    Department of Neurology, Tokyo Women s Medical University
    Nihon Rinsho 69:1067-71. 2011
    ....
  68. doi request reprint Edaravone (radical scavenger) versus sodium ozagrel (antiplatelet agent) in acute noncardioembolic ischemic stroke (EDO trial)
    Yukito Shinohara
    Federation of National Public Service Personnel Mutual Aid Associations Tachikawa Hospital, Tokyo, Japan
    Cerebrovasc Dis 27:485-92. 2009
    ..We performed a postmarketing clinical trial to provide further reliable evidence concerning edaravone in patients with acute ischemic stroke...
  69. pmc Activation of the non-receptor tyrosine kinase cSrc in macrophage-rich atherosclerotic plaques of human carotid arteries
    Sono Toi
    Department of Neurology, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Acta Histochem Cytochem 40:153-61. 2007
    ..Our results suggest that cSrc activation in lesional cells contributes to plaque destabilization in CAS via persistent inflammation...
  70. doi request reprint Comparison of parameters of (123)I-metaiodobenzylguanidine scintigraphy for differential diagnosis in patients with parkinsonism: correlation with clinical features
    Yumiko Uchiyama
    Department of Neurology, Tokyo Women s Medical University, Kawada cho, Shinjuku ku, Tokyo, Japan
    Ann Nucl Med 25:478-85. 2011
    ....
  71. ncbi request reprint [Spinal epidural abscess with persistent increase in cerebrospinal fluid protein: a case study]
    Kenjiro Mitsuhashi
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    No To Shinkei 56:805-9. 2004
    ..Intensive antibiotic chemotherapy especially targeted for MRSA could eradicate abscesses and improve clinical status. However, persistent high protein level in the cerebrospinal fluid could suggest SEA...
  72. ncbi request reprint [QuantiFERON: an early diagnostic tool for cerebral tuberculosis]
    Masahiro Iguchi
    Department of Neurology, Tokyo Women s Medical University School of Medicine
    Rinsho Shinkeigaku 48:259-62. 2008
    ..QuantiFERON were positive prior to the culture results in both cases. This reaction suggested tuberculous infection. QuantiFERON is useful for diagnosing cerebral tuberculosis at an early stage...
  73. ncbi request reprint [Stroke in cancer patients]
    Hiromi Terashi
    Department of Neurology, Tokyo Women s University School of Medicine, 8 1 Kawada cho, Shinjuku ku, Tokyo 162 8666, Japan
    Brain Nerve 60:143-7. 2008
    ..Understanding these factors is important for stroke prevention and provision in this population...
  74. doi request reprint Topical naphazoline in the treatment of myasthenic blepharoptosis
    Yuriko Nagane
    Department of Neurology, Hanamaki General Hospital, 4 28 Kajoh chou, Hanamaki 025 0075, Japan
    Muscle Nerve 44:41-4. 2011
    ..We examined the efficacy of topical naphazoline in the treatment of myasthenic blepharoptosis...
  75. ncbi request reprint Low-dose aspirin for prevention of stroke in low-risk patients with atrial fibrillation: Japan Atrial Fibrillation Stroke Trial
    Hiroshi Sato
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Stroke 37:447-51. 2006
    ..We examined the efficacy and safety of aspirin therapy in Japanese patients with NVAF in a prospective randomized multicenter trial...
  76. ncbi request reprint A randomized, double-blind study comparing the safety and efficacy of clopidogrel versus ticlopidine in Japanese patients with noncardioembolic cerebral infarction
    Yasuo Fukuuchi
    Ashikaga Red Cross Hospital, Ashikaga, Japan
    Cerebrovasc Dis 25:40-9. 2008
    ..A comparison of both agents was therefore conducted in Japanese stroke patients...
  77. ncbi request reprint [Prevention of recurrence in cerebral infarction]
    Shinichiro Uchiyama
    Nihon Naika Gakkai Zasshi 91:77-83. 2002
  78. doi request reprint Dual antithrombotic therapy increases severe bleeding events in patients with stroke and cardiovascular disease: a prospective, multicenter, observational study
    Kazunori Toyoda
    Cerebrovascular Division, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan toyoda hsp ncvc go jp
    Stroke 39:1740-5. 2008
    ....
  79. ncbi request reprint Platelet function under aspirin, clopidogrel, and both after ischemic stroke: a case-crossover study
    Masako Yamazaki
    Stroke 34:e227-8; author reply e227-8. 2003
  80. ncbi request reprint Ticlopidine alone versus ticlopidine plus aspirin for preventing recurrent stroke
    Eiichi Ito
    Department of Neurology, Higashi Nagoya National Sanatorium Hospital, Umemorisaka, Meito, Nagoya
    Intern Med 42:793-9. 2003
    ..To compare the efficacy and safety of two antiplatelet regimens, ticlopidine alone (200 mg daily) and ticlopidine (100 mg daily) plus aspirin (81 mg daily), in patients with ischemic stroke from the Tokai district of Japan...
  81. ncbi request reprint Impact of metabolic syndrome as a risk factor for atherothrombotic stroke
    Shinichiro Uchiyama
    Intern Med 44:1021-2. 2005
  82. ncbi request reprint [Prevention of and therapy for cerebral infarction in the aged]
    Shinichiro Uchiyama
    Nihon Naika Gakkai Zasshi 95:420-5. 2006
  83. ncbi request reprint A sensitive marker for left atrial dysfunction as a risk factor of cardioembolic stroke after cessation of paroxysmal atrial fibrillation
    Shinichiro Uchiyama
    Intern Med 42:1059-60. 2003
  84. ncbi request reprint [Antithrombotic therapy in acute ischemic stroke]
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine
    Rinsho Shinkeigaku 46:844-6. 2006
    ..Clinical trials of dual antiplatelet therapy with aspirin and another antiplatelet agent are ongoing to compare efficacy and safety with aspirin monotherapy in Japan and overseas...
  85. ncbi request reprint [Drug abuse and stroke]
    Kazuhide Miyazaki
    Department of Neurology, Shiseikai Daini Hospital
    Rinsho Shinkeigaku 46:906-8. 2006
    ..Marijuana may have accelerated stroke onset, but essential cause of stroke in this case must be protein S mutation. Medical examination for young stroke should include screening of drug abuse and searching for coagulation disorder...
  86. ncbi request reprint [Aspirin]
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine
    Nihon Rinsho 64:562-9. 2006
  87. ncbi request reprint [Molecular mechanism of atherothrombosis]
    Masako Yamazaki
    Department of Neurology, Tokyo Women s Medical University
    Nihon Rinsho 64:91-6. 2006
  88. ncbi request reprint [Antiplatelet therapy]
    Shinichiro Uchiyama
    Department of Neurology, Tokyo Women s Medical University School of Medicine
    Nihon Rinsho 64:75-80. 2006
  89. doi request reprint Risk factor profile and management of cerebrovascular patients in the REACH Registry
    Joachim Rother
    Department of Neurology, Klinikum Minden, Hannover Medical School, Minden, Germany
    Cerebrovasc Dis 25:366-74. 2008
    ..We assessed these factors in 18,992 CVD patients within a worldwide registry of stable outpatients...
  90. ncbi request reprint The Japan Thrombosis Registry for Atrial Fibrillation, Coronary or Cerebrovascular Events (J-TRACE): a nation-wide, prospective large cohort study; the study design
    Hideki Origasa
    Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930 0194, Japan
    Circ J 72:991-7. 2008
    ....
  91. doi request reprint Pravastatin reduces the risk for cardiovascular disease in Japanese hypercholesterolemic patients with impaired fasting glucose or diabetes: diabetes subanalysis of the Management of Elevated Cholesterol in the Primary Prevention Group of Adult Japanese (
    Naoko Tajima
    Department of Internal Medicine, Jikei University School of Medicine 3 25 8, Nishi Shimbashi, Minato ku, 105 8461 Tokyo, Japan
    Atherosclerosis 199:455-62. 2008
    ..In conclusion, pravastatin reduces the risk of CVD in subjects with hypercholesterolemia and abnormal fasting glucose in the primary prevention setting in Japan...
  92. ncbi request reprint [Search and appraisal of literatures and methods to use Internets in evidence based neurology]
    Shinichiro Uchiyama
    Department of Neurology, Neurological Institute, Tokyo Women s Medical University
    Rinsho Shinkeigaku 42:1182-5. 2002
    ..Quality-adjusted life years (QALY) and disability-adjusted years (DALY) have recently been proposed by the World Health Organization as the indices for the effect on quality of life as well...